The impact of male overweight on semen quality and outcome of assisted reproduction

Asian Journal of Andrology

Volumn 16, Issue 5, 2014, Pages 749-754

  Thomsen, Lise ^a   Humaidan, Peter ^a,b   Bungum, Leif ^c   Bungum, Mona ^d  

^a VIBORG HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^d LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

assisted reproductive technology; body mass index; male obesity; sperm chromatin structure assay; sperm quality

Indexed keywords

DNA; CHROMATIN;

ADULT; ANALYTIC METHOD; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; DNA DETERMINATION; EMBRYO TRANSFER; FEMALE; FERTILIZATION; HUMAN; INFERTILITY THERAPY; MAJOR CLINICAL STUDY; MALE; MALE GENITAL TRACT PARAMETERS; OBESITY; OUTCOME ASSESSMENT; PRACTICE GUIDELINE; PREGNANCY OUTCOME; PROSPECTIVE STUDY; SELF REPORT; SEMEN ANALYSIS; SEMINAL VOLUME; SPERM CHROMATIN STRUCTURE ASSAY; SPERM QUALITY; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; UNDERWEIGHT; WORLD HEALTH ORGANIZATION; CHROMATIN; COHORT ANALYSIS; DENMARK; FERTILIZATION IN VITRO; OVERWEIGHT; PREGNANCY; PREGNANCY RATE; STATISTICS AND NUMERICAL DATA;

ADULT; BODY MASS INDEX; CHROMATIN; COHORT STUDIES; DENMARK; FEMALE; FERTILIZATION IN VITRO; HUMANS; MALE; OBESITY; OVERWEIGHT; PREGNANCY; PREGNANCY RATE; REPRODUCTIVE TECHNIQUES, ASSISTED; SEMEN ANALYSIS; THINNESS;

EID: 84907013476     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.4103/1008-682X.125398     Document Type: Article

References (53)

1. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, et al. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006; 295: 1549-55.
2. Ogden CL, Lamb MM, Carroll MD, Flegal KM. Obesity and socioeconomic status in adults: United States, 2005-2008. NCHS Data Brief 2010: 1-8.
3. Maheshwari A, Stofberg L, Bhattacharya S. Effect of overweight and obesity on assisted reproductive technology-a systematic review. Hum Reprod Update 2007; 13: 433-44.
4. Statistics Denmark. Kvinder og Mænd 2011: 30-31. Available from: http://www.dst.dk/da/Statistik/Publikationer/VisPub.aspx?cid=17520 [Last accessed on].
5. Carlsen E, Givercman A, Keiding N, Skakkebæk NE. Evidence of decreasing quality of semen during past 50 years. BMJ 1992; 305: 609-13.
6. Swan SH, Elkin EP, Fenster L. The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996. Environ Health Perspect 2000; 108: 961-6.
7. Pasquali R, Pelusi C, Genghini S, Cacciari M, Gambineri A. Obesity and reproductive disorders in women. Hum Reprod Update 2003; 9: 359-72.
8. Loret de Mola JR. Obesity and its relationship to infertility in men and women. Obstet Gynecol Clin North Am 2009; 36: 333-46.
9. Pasquali R, Patton L, Gambineri A. Obesity and Infertility. Curr Opin Endocrinol Diabetes Obes 2007; 14: 482-7.
10. Pinborg A, Gaarslev C, Hougaard CO, Nyboe Andersen A, Andersen PK, et al. Influence of female bodyweight on IVF outcome: a longitudinal multicentre cohort study of 487 infertile couples. Reprod Biomed Online 2011; 23: 490-9.
11. Zacheriah M, Fleming R, Acharya U. Management of obese women in assisted conception units: a UK survey. Hum Fertil (Camb) 2006; 9: 101-5.
12. Bakos HW, Henshaw RC, Mitchell M, Lane M. Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology. Fertil Steril 2011; 95: 1700-4.
13. Keltz J, Zapantis A, Jindal SK, Lieman HJ, Santoro N, et al. Overweight men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles. J Assist Reprod Genet 2010; 27: 539-44.
14. Kupka MS, Gnoth C, Buehler K, Dahncke W, Kruessel JS. Impact of female and male obesity on IVF/ICSI: results of 700,000 ART-cycles in Germany. Gynecol Endocrinol 2011; 27: 144-9.
15. Håkonsen LB, Thulstrup AM, Aggerholm A, Olsen J, Bonde JP, et al. Does weight loss improve semen quality and reproductive hormons? Results from a cohort of severly obese men. Reprod Health 2011; 8: 24.
16. Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, et al. A prospective study of risk factors for erectile dysfunction. J Urol 2006; 176: 217-21.
17. Hammoud AO, Wilde N, Gibson M, Parks A, Carrell DT, et al. Male obesity and alteration in sperm parameters. Fertil Steril 2008; 90: 2222-5.
18. Aggerholm A, Thulstrup AM, Toft G, Ramlau-Hansen C, Bonde JP. Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile? Fertil Steril 2008; 90: 619-26.
19. MacDonald AA, Herbison GP, Showell M, Farquhar CM. The impact of body mass index on semen parameters and resproductive hormones in human males: a systematic review with meta-analysis. Hum Reprod Update 2010; 16: 293-311.
20. Teerds KJ, de Rooij DG, Keijer J. Functional relationship between obesity and male reproduction: from humans to animal models. Hum Reprod Update 2011; 17: 667-83.
21. Jensen TK, Andersson AM, Jørgensen N, Andersen AG, Carlsen E, et al. Body mass index in relation to semen quality and reproductive hormons among 1,558 Danish men. Fertil Steril 2004; 82: 863-70.
22. Ramlau-Hansen CH, Thulstrup AM, Norhr EA, Bonde JP, Sørensen TI, et al. Subfecundity in overweight and obese couples. Hum Reprod 2007; 22: 1634-7.
23. Kort HI, Massay JB, Elsner CW, Mitchell-Leef D, Shapiro CB, et al. Impact of body mass index values on sperm quantity and quality. J Androl 2006; 27: 450-2.
24. Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormon levels among men attending an infertility clinic. Fertil Steril 2010; 93: 2222-31.
25. La Vignera S, Condorelli RA, Vicari E, Calogero AE. Negative effect of increased body weight on sperm conventional and nonconventional flow cytometric sperm parameters. J Androl 2012; 33: 53-8.
26. Wegner CC, Clifford AL, Jilbert PM, Henry MA, Gentry WL. Abnormally high body mass index and tobacco use are associated with poor sperm quality as revealed by reduced sperm binding to hyaluronan-coated slides. Fertil Steril 2010; 93: 332-4.
27. Petersen GL, Schmidt L, Pinborg A, Kamper-Jorgensen M. The influence of female and male body mass index on live births after assisted reproductive technology treatment: a nationwide register-based cohort study. Fertil Steril 2013; 99: 1654-62.
28. Bungum M, Humaidan P, Spano M, Jepson K, Bungum L, et al. The predictive value of sperm chromatin structure assay (SCSA) for the outcome of intrauterine insemination, IVF and ICSI. Hum Reprod 2004; 19: 1401-8.
29. Bungum M, Humaidan P, Axmon A, Spano M, Bungum L, et al. Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome. Hum Reprod 2007; 22: 174-9.
30. Bungum M, Spano M, Humaidan P, Eleuteri P, Rescia M, et al. Sperm chromatin structure assay parameters measured after density gradient centrifugation are not predictive for the outcome of ART. Hum Reprod 2008; 23: 4-10.
31. World Health Organization. WHO Laboratory Manual for the Examination of Human Sperm and Sperm-cervical mucus interaction. Cambridge University Press; 1999.
32. Evenson D, Darzynkiewicz Z, Melamed MR. Relation of mammalian sperm chromatin heterogeneity to fertility. Science 1980; 210: 1131-3.
33. Evenson D, Jost L. Sperm chromatin structure assay is useful for fertility assessment. Methods Cell Sci 2000; 22: 169-89.
34. Magnusdottir EV, Thorsteinsson T, Thorsteinsdottir S, Heimisdottir M, Olafsdottir K. Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Hum Reprod 2005; 20: 208-15.
35. Braga DP, Halpern G, Figueria Rde C, Setti AS, Iaconelli A Jr, et al. Food intake and social habits in male patients and its relationship to intracytoplasmic sperm injection outcomes. Fertil Steril 2012; 97: 53-9.
36. Qin DD, Yuan W, Zhou WJ, Cui YQ, Wu JQ, et al. Do reproductive hormones explain the association between body mass index and semen quality? Asian J Androl 2007; 9: 827-34.
37. Li Y, Lin H, Ma M, Li L, Cai M, et al. Semen quality of 1346 healthy men, results from the Chongqing area of southwest China. Hum Reprod 2009; 24: 459-69.
38. Fejes I, Koloszar S, Zacaczki Z, Daru J, Szöllösi J, et al. Effect of body weigth on testosterone/estradiol ratio in oligozoospermic patients. Arch Androl 2006; 52: 97-102.
39. Pauli EM, Legro RS, Demers LM, Kunselman AR, Dodson WC, et al. Diminished paternity and godadal function with increasing obesity in men. Fertil Steril 2008; 90: 346-50.
40. Bonde JP, Ernst E, Jensen TK, Hjollund NH, Kolstad H, et al. Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners. Lancet 1998; 352: 1172-7.
41. Guzick DS, Overstreeet JW, Factor-Litvak P, Brazil CK, Nakajima ST, et al., National Cooperative Reproductive Medicine Network. Sperm morphology, motility, and concentration in fertile and infertile men. N Engl J 2001; 345: 1388-93.
42. Erinpreiss J, Spano M, Erinpreisa J, Bungum M, Giwercman A. Sperm chromatin structure assay and male fertility: biological and clinical aspects. Asian J Androl 2006; 8: 11-29.
43. Evenson DP, Larson KL, Jost LK. Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. J Androl 2002; 23: 25-43.
44. Spano M, Bonde JP, Hjøllund HI, Kolstad HA, Cordelli E, et al. Sperm chromatin damage impairs human fertility. The Danish First Pregnancy Planner Study Team. Fertil Steril 2000; 73: 43-50.
45. Giwercman A, Lindstedt L, Larsson M, Bungum M, Spano M, et al. Sperm chromatin structure assay as an independent predictor of fertility in vivo: a case-control study. Int J Androl 2010; 33: e221-7.
46. Dupont C, Faure C, Sermondade N, Boubaya M, Eustache F, et al. Obesity leads to higher risk of sperm DNA damage in infertile patients. Asian J Androl 2013; 15: 622-5.
47. Rybar R, Kopecka V, Prinosilova P, Markova P, Rubes J. Male obesity and age in relationship to semen parameters and sperm chromatin integrity. Andrologia 2011; 43: 286-91.
48. Smit M, Romijn JC, Wildhagen MF, Weber RF, Dohle GR. Sperm chromatin structure is associated wiht the quality of spermatogenesis in infertile patients. Fertil Steril 2010; 94: 1748-52.
49. Sermondade N, Dupont C, Faure C, Boubaya M, Cedrin-Durnerin I, et al. Body mass index is not associated with sperm-zona pellucida binding ability in subfertile males. Asian J Androl 2013; 15: 626-9.
50. Connor Gorber S, Tremblay M, Moher D, Gorber B. A comparison of direct vs self-report measures for assessing height, weight and body mass index: a systematic review. Obes Rev 2007; 8: 307-26.
51. Sherry B, Jefferds ME, Grummer-Strawn LM. Accuracy of adolescent self-report of height and weight in assessing overweight status: a literature review. Arch Pediatr Adolesc Med 2007; 161:1154-61.
52. Wise LA, Rothman KJ, Mikkelsen EM, Sorensen HT, Riss A, et al. An internet-based prospective study of body size and time-to-pregnancy. Hum Reprod 2010; 25: 253-64.
53. Reis LO, Zani EL, Saade RD, Chaim EA, de Oliveira LC, et al. Bariatric surgery does not interfere with sperm quality-preliminary long-term study. Reprod Sci 2012; 19: 1057-62.