Negative effect of increased body weight on sperm conventional and nonconventional flow cytometric sperm parameters

Journal of Andrology

Volumn 33, Issue 1, 2012, Pages 53-58

  Vignera, Sandro La ^a   Condorelli, Rosita A ^a   Vicari, Enzo ^a   Calogero, Aldo E ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

Chromatin compactness; DNA fragmentation; Mitochondrial membrane potential; Sperm apoptosis

Indexed keywords

PHOSPHATIDYLSERINE;

APOPTOSIS; ARTICLE; BODY WEIGHT; CHROMATIN; CLINICAL ARTICLE; CONTROLLED STUDY; DNA FRAGMENTATION; FLOW CYTOMETRY; HUMAN; MALE; MALE INFERTILITY; MITOCHONDRIAL MEMBRANE POTENTIAL; OBESITY; PRIORITY JOURNAL; SEMEN ANALYSIS; SPERM; SPERMATOZOON;

ADULT; BODY WEIGHT; CASE-CONTROL STUDIES; FLOW CYTOMETRY; HUMANS; IN SITU NICK-END LABELING; MALE; MIDDLE AGED; OBESITY; SPERMATOZOA;

EID: 84856953042     PISSN: 01963635     EISSN: 19394640     Source Type: Journal    
DOI: 10.2164/jandrol.110.012120     Document Type: Article

References (30)

1. Agarwal A, Said TM. Oxidative stress, DNA damage and apoptosis in male infertility: a clinical approach. BJU Int. 2005;95:503-507.
2. Aggerholm AS, Thulstrup AM, Toft G, Ramlau-Hansen CH, Bonde JP. Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile? Fertil Steril. 2008;90:619-626.
3. Bakos HW, Mitchell M, Setchell BP, Lane M. The effect of paternal diet-induced obesity on sperm function and fertilization in a mouse model. Int J Androl. 2010 Jul 23. [Epub ahead of print].
4. Calogero AE, Polosa R, Perdichizzi A, Guarino F, La Vignera S, Scarfia A, Fratantonio E, Condorelli R, Bonanno O, Barone N, Burrello N, D'Agata R, Vicari E. Cigarette smoke extract immobilizes human spermatozoa and induces sperm apoptosis. Reprod Biomed Online. 2009;19:564-571.
5. Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. Body mass index in relation to semen quality, sperm DNA integrity and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril. 2009;93:2222-2231.
6. Cohen-Bacrie P, Belloc S, Menezo YJ, Clement P, Hamidi J, Benkhalifa M. Correlation between DNA damage and sperm parameters: a prospective study of 1,633 patients. Fertil Steril. 2009;91:1801-1805.
7. Coviello AD, Matsumoto AM, Bremner WJ, Hebst KL, Amory JK, Anawalt BD, Sutton PR, Wright WW, Brown TR, Yan X, Zirkin BR, Jarow JP. Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosteroneinduced gonadotropin suppression. J Clin Endocrinol Metab. 2005;90:2595-2602.
8. Dandona P, Aljada A, Chaudhuri A, Mohanty P, Garg R. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation. 2005;111:1448-1454.
9. Du Plessis SS, Cabler S, McAlister DA, Sabanegh E, Agarwal A. The effect of obesity on sperm disorders and male infertility. Nat Rev Urol. 2010;7:153-161.
10. Fejes I, Koloszar S, Szollosi J, Zavaczki Z, Pal A. Is semen quality affected by male body fat distribution? Andrologia. 2005;37:155-159.
11. Hammoud AO, Wilde N, Gibson M, Parks A, Carrell DT, Meikle AW. Male obesity and alteration in sperm parameters. Fertil Steril. 2008;90:2222-2225.
12. Hofny ER, Ali ME, Abdel-Hafez HZ, Kamal Eel-D, Mohamed EE, Abd El-Azeem HG, Mostafa T. Semen parameters and hormonal profile in obese fertile and infertile males. Fertil Steril. 2010;94: 581-584.
13. Jensen TK, Andersson AM, Jørgensen N, Andersen AG, Carlsen E, Petersen JH, Skakkebaek NE. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril. 2004;82:863-870.
14. Kley HK, Deselaers T, Peerenboom H, Kruskemper HL. Enhanced conversion of androstenedione to estrogens in obese males. J Clin Endocrinol Metab. 1980;51:1128-1132.
15. Koloszar S, Fejes I, Zavacki Z, Daru J, Szollosi J. Effect of body weight on sperm concentration in normozoospermic males. Arch Androl. 2005;51:299-304.
16. Kort HI, Massey JB, Elsner CW, Mitchell-Leef D, Shapiro DB, Witt MA, Roudebush WE. Impact of body mass index on sperm quantity and quality. J Androl. 2006;27:450-452.
17. Lanzafame FM, La Vignera S, Vicari E, Calogero AE. Oxidative stress and medical antioxidant treatment in male infertility. Reprod Biomed Online. 2009;19:638-659.
18. Magnusdottir EV, Thorsteinsson T, Thorsteinsdottir S, Heimisdottir M, Olafsdottir K. Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Hum Reprod. 2005; 20:208-215.
19. Nguyen RH, Wilcox AJ, Skjaerven R, Baird D. Men's body mass index and infertility. Hum Reprod. 2007;22:2488-2493.
20. Pauli EM, Legro RS, Demers LM, Kunselman AR, Dodson WC, Lee PA. Diminished paternity and gonadal function with increasing obesity in men. Fertil Steril. 2008;90:346-351.
21. Perdichizzi A, Nicoletti F, La Vignera S, Barone N, D'Agata R, Vicari R, Calogero AE. Effects of tumour necrosis factor-α on human sperm motility and apoptosis. J Clin Immunol. 2007;27:152-162.
22. Rybar R, Kopecka V, Prinosilova P, Markova P, Rubes J. Male obesity and age in relationship to semen parameters and sperm chromatin integrity. Andrologia. 2011;43:286-291.
23. Sakkas D, Alvarez JG. Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis. Fertil Steril. 2010;93:1027-1036.
24. Stewart TM, Liu DY, Garret C, Jørgensen N, Brown EH, Baker HW. Associations between andrological measures, hormones and semen quality in fertile Australian men: inverse relationship betweeen obesity and sperm output. Hum Reprod. 2009;24:1561-1568.
25. World Health Organization (WHO). Physical Status: The Use and Interpretation of Anthropometry. Report of a WHO expert Committee. WHO Technical Report Series 854. Geneva, Switzerland: WHO; 1995.
26. WHO. Laboratory Manual for the Examination of the Human Semen and Sperm-Cervical Mucus Interaction. 4th ed. Cambridge, United Kingdom: Cambridge University Press; 1999.
27. WHO. Obesity and Overweight. http://www.who.int/mediacentre/factsheets/fs311/en/index.html. Accessed April 8, 2009.
28. Zhang HB, Lu SM, Ma CY, Wang L, Li X, Chen ZJ. Early apoptotic changes in human spermatozoa and their relationships with conventional semen parameters and sperm DNA fragmentation. Asian J Androl. 2008;10:227-235.
29. Zini A, Libman J. Sperm DNA damage: importance in the era of assisted reproduction. Curr Opin Urol. 2006;16:428-434.
30. Zorn B, Osredkar J, Meden-Vrtovec H, Majdic G. Leptin levels in infertile male patients are correlated with inhibin B, testosterone and SHBG, but not with sperm characteristics. Int J Androl. 2007;30:439-444.