Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic

Fertility and Sterility

Volumn 93, Issue 7, 2010, Pages 2222-2231

  Chavarro, Jorge E ^a,b   Toth, Thomas L ^c   Wright, Diane L ^c   Meeker, John D ^d   Hauser, Russ ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

BMI; Hormones; Infertility; Obesity; Semen analysis; Sperm DNA

Indexed keywords

DNA; ESTRADIOL; INHIBIN B; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; SEX HORMONE;

ADULT; ARTICLE; BODY MASS; BODY WEIGHT; CELL STRUCTURE; DNA DAMAGE; EJACULATION; HEALTH CENTER; HORMONE BLOOD LEVEL; HUMAN; INFERTILITY; MAJOR CLINICAL STUDY; MALE; MALE FERTILITY; POPULATION RESEARCH; PRIORITY JOURNAL; SEMEN ANALYSIS; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; SUBFERTILITY; BLOOD; CYTOLOGY; DNA FRAGMENTATION; LIFESTYLE; MALE INFERTILITY; METABOLISM; OBESITY; OUTPATIENT DEPARTMENT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPERM;

ADULT; AMBULATORY CARE FACILITIES; BODY MASS INDEX; DNA FRAGMENTATION; GONADAL STEROID HORMONES; HUMANS; INFERTILITY, MALE; LIFE STYLE; MALE; OBESITY; SEMEN; SEMEN ANALYSIS; SEX HORMONE-BINDING GLOBULIN;

EID: 77952562012     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2009.01.100     Document Type: Article

References (72)

1. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006;295:1549-55.
2. Wang Y, Beydoun MA, Liang L, Caballero B, Kumanyika SK. Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic. Obesity 2008; July 24 [Epub ahead of print].
3. Australian Bureau of Statistics. National Health Survey: summary of results. Australia 2004-05. Canberra: Cat. No. 4364. 0. Available at: http://www.abs.gov.au, 2006.
4. Craig R, Mindell J, eds. Health survey for England. 2006. Leeds: The Information Centre, National Health Service. Available at: http://www.ic.nhs.uk, 2008.
5. Tuan NT, Tuong PD, Popkin BM. Body mass index (BMI) dynamics in Vietnam. Eur J Clin Nutr 2008;62:78-86.
6. Dearth-Wesley T, Wang H, Popkin BM. Under-and overnutrition dynamics in Chinese children and adults (1991-2004). Eur J Clin Nutr 2007; July 18 [Epub ahead of print].
7. Uauy R, Albala C, Kain J. Obesity trends in Latin America: transiting from under-to overweight. J Nutr 2001;131:893S-9S.
8. Villamor E, Msamanga G, Urassa W, Petraro P, Spiegelman D, Hunter DJ, et al. Trends in obesity, underweight and wasting among women attending prenatal clinics in urban Tanzania: 1995-2004. Am J Clin Nutr 2006;83:1387-94.
9. Rivera J, Baquera S, Gonzalez-Cossio T, Olais G, Sepulveda J. Nutrition transition in Mexico and other Latin American countries. Nutr Rev 2004;62:S148-57.
10. Filozof C, Gonzalez C, Sereday M, Mazza C, Braguinsky J. Obesity prevalence and trends in Latin-American countries. Obes Rev 2001;2: 99-106.
11. WHO Consultation on Obesity (1999: Geneva). Obesity: preventing and managing the global epidemic: report of a WHO consultation. Geneva: World Health Organization, 2000.
12. Lementowski PW, Zelicof SB. Obesity and osteoarthritis. Am J Orthop 2008;37:158-61.
13. Shaffe EA. Gallstone disease: Epidemiology of gallbladder stone disease. Best Pract Res Clin Gastroenterol 2006;20:981-96.
14. Eneli IU, Skybo T, Camargo CA. Weight loss and asthma: a systematic review. Thorax 2008;63:671-6.
15. McClean KM, Kee F, Young IS, Elborn JS. Obesity and the lung: 1. Epidemiology. Thorax 2008;63:649-54.
16. Crummy F, Piper AJ, Naughton MT. Obesity and the lung: 2. Obesity and sleep disordered breathing. Thorax 2008;63:738-46.
17. International Agency for Research on Cancer. IARC Handbooks of Cancer Prevention volume 6: Weight control and physical activity. Lyon: IARC Press, 2002.
18. Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Diet and lifestyle in the prevention of ovulatory disorder infertility. Obstet Gynecol 2007;110:1050-8.
19. The ESHRE Capri Workshop Group. Nutrition and reproduction in women. Hum Reprod Update 2006;12:193-207.
20. Villamor E, Cnattingius S. Interpregnancy weight change and risk of adverse pregnancy outcomes: a population study. Lancet 2006;368: 1164-70.
21. Metwally M, Ong KJ, Ledger WL, Li TC. Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence. Fertil Steril 2007; Dec 6 [Epub ahead of print].
22. Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, Rimm EB. A prospective study of risk factors for erectile dysfunction. J Urol 2006;176:217-21.
23. Esposito K, Giugliano F, Di Palo C, Giugliano G, Marfella R, D'Andrea F, et al. Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial. JAMA 2004;291:2978-84.
24. Pasquali R. Obesity and androgens: facts and perspectives. Fertil Steril 2006;85:1319-40.
25. Berga SL, Yen SSC. Reproductive failure due to central nervous system-hypothalamic-pituitary dysfunction. In: Straus III JF, Baribieri RL, eds. Yen and Jaffe's reproductive endocrinology. 5th ed. Philadelphia, PA: Elsevier, 2004.
26. Jensen TK, Andersson A-M, Jorgensen N, Andersen A-G, Carlsen E, Petersen Jo H, et al. Body mass indexinrelationtosemen quality and reproductive hormones among 1, 558 Danish men. Fertil Steril 2004;82:863-70.
27. Aggerholm AS, Thulsttrup AM, Toft G, Ramlau-Hansen CH, Bonde JP. Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile? Fertil Steril, in press.
28. Pauli EM, Legro RS, Demers LM, Kunselman AR, Dodson WC, Lee PA. Diminished paternity and gonadal function with increasing obesity in men. Fertil Steril 2008;90:346-51.
29. Sallmen M, Sandler DP, Hoppin JA, Blair A, Baird DD. Reduced fertility among overweight and obese men. Epidemiology 2006;17:520-3.
30. Kort HI, Massey JB, Elsner CW, Mitchell-Leef D, Shapiro DB, Witt MA, et al. Impact of body mass index values on sperm quantity and quality. J Androl 2006;27:450-2.
31. Trisini A, Singh NP, Duty SM, Hauser R. Relationship between human semen parameters and deoxyribonucleic acid damage assessed by the neutral comet assay. Fertil Steril 2004;82:1623-32.
32. Spano M, Bonde JP, Hjollund HI, Kolstad HA, Cordelli E, Leter G. Sperm chromatin damage impairs human fertility. Fertil Steril 2000;73: 43-50.
33. Hauser R, Meeker JD, Duty S, Silva MJ, Calafat AM. Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites. Epidemiology 2006;17:682-91.
34. Duty SM, Silva MJ, Barr DB, Brock JW, Ryan L, Chen Z, et al. Phthalate exposure and human semen parameters. Epidemiology 2003;14:269-77.
35. Duty SM, Calafat AM, Silva MJ, Brock JW, Ryan L, Chen Z, et al. The relationship between environmental exposure to phthalates and computer-aided sperm analysis motion parameters. J Androl 2004;25:293-302.
36. Kruger TF, Acosta AA, Simmons KF, Swanson RJ, Matta JF, Oehninger S. Predictive value of abnormal sperm morphology in in vitro fertilization. Fertil Steril 1988;49:112-7.
37. Duty SM, Singh NP, Silva JM, Barr DB, Brock JW, Ryan L, et al. The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay. Environ Health Perspect 2003;111:1164-9.
38. Singh NP, Stephens RE. X-ray induced DNA double-strand breaks in human sperm. Mutagenesis 1998;13:75-9.
39. World Health Organization. Physical status: the use and interpretation of anthropometry. Geneva, Switzerland: World Health Organization. 1995.
40. Koenker R, Bassett GW Regression quantiles. Econometrica 1978;46: 33-50
41. World Health Organization. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th ed. Cambridge: Cambridge University Press, 1999.
42. Kley HK, Deselaers T, Peerenboom H, Kruskemper HL. Enhanced conversion of androstenedione to estrogens in obese males. J Clin Endocrinol Metab 1980;51:1128-32.
43. Longcope C, Baker R, Johnston CC Jr. Androgen and estrogen metabolism: relationship to obesity. Metabolism 1986;35:235-7.
44. Plymate SR, Matij LA, Jones RE, Friedl KE. Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin. J Clin Endocrinol Metab 1988;67:460-4.
45. Hautanen A. Synthesis and regulation of sex hormone-binding globulin in obesity. Int J Obes 2000;24(Suppl. 2):S64-70.
46. Giagulli VA, Kaufman JM, Vermeulen A. Pathogenesis of the decreased androgen levels in obese men. J Clin Endocrinol Metab 1994;79: 997-1000.
47. Isidori AM, Caprio M, Strollo F, Moretti C, Frajese G, Isidori A, et al. Lep-tin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels. J Clin Endocrinol Metab 1999;84:3673-80.
48. Caprio M, Fabbrini E, Ricci G, Basciani S, Gnessi L, Arizzi M, et al. Ontogenesis of leptin receptor in rat Leydig cells. Biol Reprod 2003;68: 1199-207.
49. Caminos JE, Nogueiras R, Gaytan F, Pineda R, Gonzalez CR, Barreiro ML, et al. Novel expression and direct effects of adiponectin in the rat testis. Endocrinology 2008;149:3390-402.
50. Lima N, Cavaliere H, Knobel A, Madeiros-Nieto G Decreased androgen levels in massively obese men may be associated with impaired function of the gonadostat. Int J Obes 2000;24:1433-7.
51. Vermeulen A, Kaufman JM, Deslypere JP, Thomas G Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism on obese men. J Clin Endocrinol Metab 1993;76:1140-6.
52. Strain GW, Zumoff B, Kream J, Strain JJ, Deucher R, Rosenfeld RS, et al. Mild hypogonadotropic hypogonadism in obese men. Metabolism 1982;31:871-5.
53. Jarrow JP, Kirkland J, Kotnik DR, Cefalu WT. Effect of obesity and fertility status on sex steroid levels in men. Urology 1993;42:171-4.
54. Wu FCW, Tajar A, Pye SR, Silman AJ, Finn JD, O'Neill TW, et al. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European male aging study. J Clin Endocrinol Metab 2008;93:2737-45.
55. Globerman H, Shen-Orr Z, Karnieli E. Inhibin B in men with severe obesity and after weight reduction following gastroplasty. Endocr Res 2005;31:17-26.
56. Strain GW, Zumoff B, Miller LK, Rosner W, Levit C, Kalin M, et al. Effect of massive weight loss on hypothalamic-pituitary-gonadal function in obese men. J Clin Endocrinol Metab 1988;66:1019-23.
57. Winters SJ, Wang C, Adbdelrahaman E, Hadedd V, Dyky MA, Brufsky A. Inhibin-B levels in healthy young adult men and prepubertal boys: is obesity the cause for contemporary decline in sperm count because of fewer Sertoli cells? J Androl 2006;27:560-4.
58. Qin DD, Yuan E, Zhou WJ, Cui YQ, Wu JQ, Gao ES. Do reproductive hormones explain the association between body mass index and semen quality. Asian J Androl 2007;9:827-34.
59. Strain GW, Zumoff B, Miller LK, Rosner W. Sex difference in the effect of obesity on 24-hour mean serum gonadotropin levels. Horm Metab Res 2003;35:362-6.
60. Hammoud AO, Wilde N, Gibson M, Parks A, Carrell DT, Meikle W. Male obesity and alteration in sperm parameters. Fertil Steril (in press).
61. Fejes I, Koloszar S, Szollosi J, Zavaczki Z, Pal A. Is semen quality affected by male body fat distribution? Andrologia 2005;37:155-9.
62. Jokela M, Kibimaki M, Elovainio M, Viikari J, Raitakari OT, Keltikangas-Jarvinen L. Body mass index in adolescence and number of children in adulthood. Epidemiology 2007;18:599-606.
63. Nguyen RHN, Wilcox A, Skjaerven R, Baird DD. Men's body mass index and infertility. Hum Reprod 2007;22:2488-93.
64. Ramlau-Hansen CH, Thulsttrup AM, Nohr EA, Bonde JP, Sorensen TIA, Olsen J. Subfecundity in overweight and obese couples. Hum Reprod 2007;22:1634-7.
65. Koloszar S, Fejes I, Zavaczki Z, Daru J, Szollosi J, Pal A. Effect of body weight on sperm concentration in normozoospermic males. Arch Androl 2005;51:299-304.
66. Magnusdottir EV, Thorsteinsson T, Thorsteinsdottir S, Heimisdottir M, Olafsdottir K. Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Hum Reprod 2005;20:208-15.
67. Fejes I, Koloszar S, Zavaczki Z, Daru J, Szollosi J, Pal A. Effect of body weight on testosterone/estradiol ratio in oligozoospermic patients. Arch Androl 2006;52:97-102.
68. Vermeulen A, Verdonck G. Representativeness of a single point plasma testosterone level for the long term hormonal milieu in men. J Clin En-docrinol Metab 1992;74:939-42.
69. Andersson AM, Carlsen E, Petersen JH, Skakkebaek NE. Variation in levels of serum inhibin B, testosterone, estradiol, luteinizing hormone, follicle-stimulating hormone and sex hormone-binding globulin in monthly samples from healthy men during a 17-month period: possible effects of seasons. J Clin Endocrinol Metab 2003;88:932-7.
70. Stokes-Riner A, Thurston SW, Brazil C, Guzick D, Liu F, Overstreet JW, et al. One semen sample or 2? Insights from a study of fertile men. J Androl 2007;28:638-43.
71. Uhler ML, Zinaman MJ, Brown CC, Clegg ED. Relationship between sperm characteristics and hormonal parameters in normal couples. Fertil Steril 2003;79(Suppl. 3):1535-42.
72. Carlsen E, Swan SH, Petersen JH, Skakkebaek NE. Longitudinal changes in semen parameters in young Danish men from the Copenha-guen area. Hum Reprod 2005;20:942-9.