Role of allelic variants of FK506-binding protein 51 (FKBP5) gene in the development of anxiety disorders

Depression and Anxiety

Volumn 30, Issue 12, 2013, Pages 1170-1176

  Minelli, Alessandra ^a   Maffioletti, Elisabetta ^a   Cloninger, Claude Robert ^b   Magri, Chiara ^a   Sartori, Riccardo ^c   Bortolomasi, Marco ^d   Congiu, Chiara ^a   Bignotti, Stefano ^e   Segala, Matilde ^d   Giacopuzzi, Mario ^d   Gennarelli, Massimo ^a,e  

^a UNIVERSITY OF BRESCIA   (Italy)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF VERONA   (Italy)

^d Psychiatric Hospital Villa Santa Chiara   (Italy)

^e IRCCS ISTITUTO CENTRO SAN GIOVANNI DI DIO FATEBENEFRATELLI   (Italy)

Author keywords

anxiety; FKBP5; harm avoidance; major depressive disorder; temperament character inventory

Indexed keywords

CHAPERONE; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 51; GLUCOCORTICOID RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ANXIETY DISORDER; ARTICLE; AVOIDANCE BEHAVIOR; CASE CONTROL STUDY; CAUCASIAN; CHARACTER; COMORBIDITY; CONTROLLED STUDY; DSM-IV; FEMALE; GENOTYPE; HARM REDUCTION; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MOOD DISORDER; PERSONALITY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PSYCHOLOGICAL RATING SCALE; RISK; SINGLE NUCLEOTIDE POLYMORPHISM; TEMPERAMENT; TEMPERAMENT AND CHARACTER INVENTORY;

ANXIETY; FKBP5; HARM AVOIDANCE; MAJOR DEPRESSIVE DISORDER; TEMPERAMENT & CHARACTER INVENTORY;

ADULT; AGED; ALLELES; ANXIETY DISORDERS; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; PERSONALITY; PERSONALITY INVENTORY; TACROLIMUS BINDING PROTEINS; TEMPERAMENT;

EID: 84889879076     PISSN: 10914269     EISSN: 15206394     Source Type: Journal    
DOI: 10.1002/da.22158     Document Type: Article

References (48)

1. Fava M, Rankin MA, Wright EC, et al. Anxiety disorders in major depression. Compr Psychiatry 2000; 41 (2): 97-102. (Pubitemid 30149018)
2. Maser JD, Cloninger CR,. Comorbidity of Mood and Anxiety Disorders. Washington DC: American Psychiatric Press; 1990.
3. Fava M, Rush AJ, Alpert JE, et al. Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR*D report. Am J Psychiatry 2008; 165 (3): 342-351. (Pubitemid 351704490)
4. Weisberg RB, Maki KM, Culpepper L, et al. Is anyone really M.A.D.?: the occurrence and course of mixed anxiety-depressive disorder in a sample of primary care patients. J Nerv Ment Dis 2005; 193 (4): 223-230.
5. Tsatsanis C, Dermitzaki E, Venihaki M, et al. The corticotropin-releasing factor (CRF) family of peptides as local modulators of adrenal function. Cell Mol Life Sci 2007; 64 (13): 1638-1655. (Pubitemid 47036937)
6. Binder EB,. The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology 2009; 34 (Suppl 1): S186-S195.
7. Grad I, Picard D,. The glucocorticoid responses are shaped by molecular chaperones. Mol Cell Endocrinol 2007; 275 (1-2): 2-12. (Pubitemid 47260713)
8. Wochnik GM, Ruegg J, Abel GA, et al. FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells. J Biol Chem 2005; 280 (6): 4609-4616. (Pubitemid 40288629)
9. Vermeer H, Hendriks-Stegeman BI, van der Burg B, et al. Glucocorticoid-induced increase in lymphocytic FKBP51 messenger ribonucleic acid expression: a potential marker for glucocorticoid sensitivity, potency, and bioavailability. J Clin Endocrinol Metab 2003; 88 (1): 277-284. (Pubitemid 36115178)
10. Domschke K, Reif A,. Behavioral genetics of affective and anxiety disorders. Curr Top Behav Neurosci 2012; 12: 463-502.
11. Binder EB, Salyakina D, Lichtner P, et al. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat Genet 2004; 36 (12): 1319-1325. (Pubitemid 39577942)
12. Ceulemans S, De Zutter S, Heyrman L, et al. Evidence for the involvement of the glucocorticoid receptor gene in bipolar disorder in an isolated northern Swedish population. Bipolar Disord 2011; 13 (7-8): 614-623.
13. Schosser A, Kasper S,. The role of pharmacogenetics in the treatment of depression and anxiety disorders. Int Clin Psychopharmacol 2009; 24 (6): 277-288.
14. Binder EB, Bradley RG, Liu W, et al. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA 2008; 299 (11): 1291-1305. (Pubitemid 351439075)
15. Xie P, Kranzler HR, Poling J, et al. Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder. Neuropsychopharmacology 2010; 35 (8): 1684-1692.
16. Yehuda R,. Status of glucocorticoid alterations in post-traumatic stress disorder. Ann N Y Acad Sci 2009; 1179: 56-69.
17. Hettema JM,. What is the genetic relationship between anxiety and depression? Am J Med Genet C Semin Med Genet 2008; 148C (2): 140-146. (Pubitemid 351705131)
18. Cloninger CR, Svrakic DM, Przybeck TR,. A psychobiological model of temperament and character. Arch Gen Psychiatry 1993; 50 (12): 975-990. (Pubitemid 23361478)
19. Cloninger CR, Przybeck TR, Svrakic DM, et al. The Temperament and Character Inventory (TCI): A Guide to Its Development and Use. St. Louis, MO: Center for Psychology of Personality, Washington University; 1994.
20. Heath AC, Cloninger CR, Martin NG,. Testing a model for the genetic structure of personality: a comparison of the personality systems of Cloninger and Eysenck. J Pers Soc Psychol 1994; 66 (4): 762-775.
21. Bouchard TJ, Jr., Loehlin JC,. Genes, evolution, and personality. Behav Genet 2001; 31 (3): 243-273. (Pubitemid 33026085)
22. Shibuya N, Suzuki A, Sadahiro R, et al. Association study between a functional polymorphism of FK506-binding protein 51 (FKBP5) gene and personality traits in healthy subjects. Neurosci Lett 2010; 485 (3): 194-197.
23. Sheehan DV, Lecrubier Y, Sheehan KH, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998; 59 (Suppl 20): 22-33;quiz 34-57. (Pubitemid 29001829)
24. Folstein MF, Folstein SE, McHugh PR,. " Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12 (3): 189-198.
25. Barrett JC, Fry B, Maller J, et al. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21 (2): 263-265. (Pubitemid 40202029)
26. Gabriel SB, Schaffner SF, Nguyen H, et al. The structure of haplotype blocks in the human genome. Science 2002; 296 (5576): 2225-2229. (Pubitemid 34680308)
27. Bonnet DG, Wright TA,. Sample size requirements for estimating Pearson, Kendall and Spearman correlations. Psychometrika 2000; 65: 23-28.
28. Rosnow RL, Rosenthal R,. Statistical procedures and the justification of knowledge in psychological science. American Psychologist 1989; 44: 1276-1284.
29. Ising M, Depping AM, Siebertz A, et al. Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls. Eur J Neurosci 2008; 28 (2): 389-398.
30. Cloninger CR, Zohar AH, Hirschmann S, et al. The psychological costs and benefits of being highly persistent: personality profiles distinguish mood disorders from anxiety disorders. J Affect Disord 2012; 136 (3): 758-766.
31. Cloninger CR, Zohar AH,. Personality and the perception of health and happiness. J Affect Disord 2011; 128 (1-2): 24-32.
32. Koenen KC, Saxe G, Purcell S, et al. Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children. Mol Psychiatry 2005; 10 (12): 1058-1059. (Pubitemid 43251094)
33. Boscarino JA, Erlich PM, Hoffman SN, et al. Association of FKBP5, COMT and CHRNA5 polymorphisms with PTSD among outpatients at risk for PTSD. Psychiatry Res 2011; 188 (1): 173-174.
34. Sarapas C, Cai G, Bierer LM, et al. Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks. Dis Markers 2011; 30 (2-3): 101-110.
35. Lekman M, Laje G, Charney D, et al. The FKBP5-gene in depression and treatment response-an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort. Biol Psychiatry 2008; 63 (12): 1103-1110.
36. Papiol S, Arias B, Gasto C, et al. Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment. J Affect Disord 2007; 104 (1-3): 83-90. (Pubitemid 350052308)
37. Lavebratt C, Aberg E, Sjoholm LK, et al. Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort. J Affect Disord 2010; 125 (1-3): 249-255.
38. Zobel A, Schuhmacher A, Jessen F, et al. DNA sequence variants of the FKBP5 gene are associated with unipolar depression. Int J Neuropsychopharmacol 2010; 13 (5): 649-660.
39. Shi J, Potash JB, Knowles JA, et al. Genome-wide association study of recurrent early-onset major depressive disorder. Mol Psychiatry 2011; 16 (2): 193-201.
40. Shyn SI, Shi J, Kraft JB, et al. Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies. Mol Psychiatry 2011; 16 (2): 202-215.
41. Sullivan PF, de Geus EJ, Willemsen G, et al. Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry 2009; 14 (4): 359-375.
42. Muglia P, Tozzi F, Galwey NW, et al. Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts. Mol Psychiatry 2010; 15 (6): 589-601.
43. Lewis CM, Ng MY, Butler AW, et al. Genome-wide association study of major recurrent depression in the U.K. population. Am J Psychiatry 2010; 167 (8): 949-957.
44. Verbeek EC, Bakker IM, Bevova MR, et al. A fine-mapping study of 7 top scoring genes from a GWAS for major depressive disorder. PLoS One 2012; 7 (5): e37384.
45. Hubler TR, Scammell JG,. Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids. Cell Stress Chaperones 2004; 9 (3): 243-252. (Pubitemid 39457428)
46. Schmidt U, Holsboer F, Rein T,. Epigenetic aspects of posttraumatic stress disorder. Dis Markers 2011; 30 (2-3): 77-87.
47. Attwood BK, Bourgognon JM, Patel S, et al. Neuropsin cleaves EphB2 in the amygdala to control anxiety. Nature 2011; 473 (7347): 372-375.
48. Schosser A, Serretti A, Souery D, et al. European Group for the Study of Resistant Depression (GSRD)-where have we gone so far: review of clinical and genetic findings. Eur Neuropsychopharmacol 2012; 22 (7): 453-468.