The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like Factor 5 (KLF5)-defendent manner

Journal of Biological Chemistry

Volumn 289, Issue 36, 2014, Pages 25306-25316

  Shin, Joongho ^a   Carr, Azadeh ^a   Corner, Georgia A ^b   Tögel, Lars ^b   Dávaos Salas, Mercedes ^b   Tran, Hoanh ^b   Chueh, Anderly C ^b   Al Obaidi, Sheren ^b   Chionh, Fiona ^b   Ahmed, Naseem ^a   Buchanan, Daniel D ^c   Young, Joanne P ^c   Malo, Madhu S ^d   Hodin, Richard A ^d   Arango, Diego ^e,f   Sieber, Oliver M ^g   Augenlicht, Leonard H ^a   Dhillon, Amardeep S ^h   Weber, Thomas K ⁱ   Mariadason, John M ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d HARVARD MEDICAL SCHOOL   (United States)

^e HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^f BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^g WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^h PETER MACCALLUM CANCER CENTRE   (Australia)

ⁱ VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; CELL CULTURE; DISEASES; ENZYME ACTIVITY; PHOSPHATASES; STATISTICAL TESTS;

ALKALINE PHOSPHATASE; CELL DIFFERENTIATION; DIFFERENTIAL SENSITIVITY; DIFFERENTIATION MARKERS; HISTONE DEACETYLASE INHIBITOR; INTESTINAL EPITHELIAL CELLS; KRUPPEL-LIKE FACTORS; TRANSCRIPTIONAL REGULATOR;

CELLS;

ALKALINE PHOSPHATASE; BUTYRIC ACID; ENTINOSTAT; HISTONE DEACETYLASE; KRUPPEL LIKE FACTOR 5; BENZAMIDE DERIVATIVE; HISTONE DEACETYLASE INHIBITOR; KLF5 PROTEIN, HUMAN; KRUPPEL LIKE FACTOR; PROTEIN BINDING; PYRIDINE DERIVATIVE;

ARTICLE; BINDING SITE; CANCER CELL LINE; CELL DIFFERENTIATION; CELL SCREENING; COLON CANCER; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; GENE EXPRESSION PROFILING; GENE SILENCING; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; MICROARRAY ANALYSIS; PHENOTYPE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN METHYLATION; SENSITIVITY ANALYSIS; UPREGULATION; COLON TUMOR; CPG ISLAND; DNA METHYLATION; DNA MICROARRAY; DRUG EFFECTS; DRUG RESISTANCE; EPITHELIUM CELL; GENETICS; HCT116 CELL LINE; HT 29 CELL LINE; METABOLISM; PATHOLOGY; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

ALKALINE PHOSPHATASE; BENZAMIDES; BINDING SITES; BLOTTING, WESTERN; BUTYRIC ACID; CELL DIFFERENTIATION; CELL LINE, TUMOR; COLONIC NEOPLASMS; CPG ISLANDS; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; HCT116 CELLS; HISTONE DEACETYLASE INHIBITORS; HT29 CELLS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PYRIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84906988004     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.557546     Document Type: Article

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