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Volumn 24, Issue 18, 2014, Pages 4414-4417
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Design and synthesis of non-hydrolyzable homoisoprenoid α-monofluorophosphonate inhibitors of PPAPDC family integral membrane lipid phosphatases
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Author keywords
Farnesyl diphosphate; Isoprenol; Mevalonate pathway; Phosphatase inhibitor; Phosphonate
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Indexed keywords
ENZYME INHIBITOR;
HOMOISOPRENOID ALPHA MONOFLUOROPHOSPHONATE INHIBITOR;
MEMBRANE LIPID;
PHOSPHATASE;
TERPENOID DERIVATIVE;
UNCLASSIFIED DRUG;
ISOPRENOID PHOSPHATE;
ALKYLATION;
AMINATION;
ANIMAL CELL;
ARTICLE;
COLUMN CHROMATOGRAPHY;
COMPETITIVE INHIBITION;
DEPHOSPHORYLATION;
DRUG ACTIVITY;
DRUG DESIGN;
DRUG PURIFICATION;
DRUG SYNTHESIS;
ELECTROPHILICITY;
FLUORINATION;
INHIBITION CONSTANT;
INSECT CELL;
LITHIATION;
NONHUMAN;
OXIDATION;
REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
STRUCTURE ACTIVITY RELATION;
ANTAGONISTS AND INHIBITORS;
CHEMICAL STRUCTURE;
CHEMISTRY;
DOSE RESPONSE;
METABOLISM;
SYNTHESIS;
DOSE-RESPONSE RELATIONSHIP, DRUG;
DRUG DESIGN;
ENZYME INHIBITORS;
MOLECULAR STRUCTURE;
PHOSPHORIC MONOESTER HYDROLASES;
POLYISOPRENYL PHOSPHATES;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 84906965211
PISSN: 0960894X
EISSN: 14643405
Source Type: Journal
DOI: 10.1016/j.bmcl.2014.08.013 Document Type: Article |
Times cited : (3)
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References (35)
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