Design, synthesis and enzymatic evaluation of 3-O-substituted aryl β-d-galactopyranosides as inhibitors of Trypanosoma cruzi trans-sialidase

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 18, 2014, Pages 4529-4532

  Silva, Bruno L ^a   S Filho, José D ^a   Andrade, Peterson ^b   Carvalho, Ivone ^b   Alves, Ricardo J ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Aryl galactosides; Dibutyltin oxide method; Drug design; Sialic acid; Trypanosoma cruzi trans sialidase

Indexed keywords

4 METHOXYCARBONYL 2 NITROPHENYL 3 O CARBOXYMETHYL BETA GALATOPYRANOSIDE; ANTITRYPANOSOMAL AGENT; AROMATIC NITRO COMPOUND; ARYL BETA GALACTOPYRANOSIDE DERIVATIVE; CARBOHYDRATE; DIBUTYLTIN; GALACTOSIDE; PYRANOSIDE; PYRIDOXAL 5 PHOSPHATE; SIALIDASE INHIBITOR; UNCLASSIFIED DRUG; ENZYME INHIBITOR; GALACTOSE; GLYCOPROTEIN; SIALIDASE; TRANS-SIALIDASE;

ALKYLATION; ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL INVASION; CHEMICAL BOND; DRUG DESIGN; DRUG SYNTHESIS; ENZYMATIC ASSAY; ENZYME ACTIVITY; ENZYME MODIFICATION; HETERONUCLEAR MULTIPLE BOND CORRELATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; SPECTROFLUOROMETRY; TRYPANOSOMA CRUZI; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; ENZYMOLOGY; METABOLISM; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; GALACTOSE; GLYCOPROTEINS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; NEURAMINIDASE; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA CRUZI;

EID: 84906960705     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.07.088     Document Type: Article

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