A heteroglycan from the cyanobacterium Nostoc commune modulates LPS-induced inflammatory cytokine secretion by THP-1 monocytes through phosphorylation of ERK1/2 and Akt

Phytomedicine

Volumn 21, Issue 11, 2014, Pages 1451-1457

  Olafsdottir, Astridur ^a,b   Thorlacius, Gudny Ella ^a,b   Omarsdottir, Sesselja ^a   Olafsdottir, Elin Soffia ^a   Vikingsson, Arnor ^b   Freysdottir, Jona ^a,b   Hardardottir, Ingibjorg ^a  

^a UNIVERSITY OF ICELAND   (Iceland)

^b LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

Author keywords

IL 10 ERK1 2; IL 6; Nostoc commune; Polysaccharides; THP 1 cells

Indexed keywords

ANTIINFLAMMATORY AGENT; GAMMA INTERFERON; HETEROGLYCAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NC 5 S; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN C FOS; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; IL10 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; POLYSACCHARIDE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYANOBACTERIUM; CYTOKINE RELEASE; DNA BINDING; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INFLAMMATION; MONOCYTE; NONHUMAN; NOSTOC COMMUNE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; CELL LINE; CHEMISTRY; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

CHLOROPHYTA; CYANOBACTERIA; NOSTOC; NOSTOC COMMUNE; NOSTOC SP.;

ANTI-INFLAMMATORY AGENTS; CELL LINE; HUMANS; INTERLEUKIN-10; INTERLEUKIN-6; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MONOCYTES; NOSTOC COMMUNE; PHOSPHORYLATION; POLYSACCHARIDES; PROTO-ONCOGENE PROTEINS C-AKT; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84906940039     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.04.023     Document Type: Article

References (33)

1. A. Androulidaki, D. Iliopoulos, A. Arranz, C. Doxaki, S. Schworer, V. Zacharioudaki, A.N. Margioris, P.N. Tsichlis, and C. Tsatsanis The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs Immunity 31 2009 220 231
2. A. Arranz, C. Doxaki, E. Vergadi, Y. Martinez de la Torre, K. Vaporidi, E.D. Lagoudaki, E. Ieronymaki, A. Androulidaki, M. Venihaki, A.N. Margioris, E.N. Stathopoulos, P.N. Tsichlis, and C. Tsatsanis Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization Proc. Natl. Acad. Sci. U. S. A. 109 2012 9517 9522
3. C.P. Bauerfeld, R. Rastogi, G. Pirockinaite, I. Lee, M. Huttemann, B. Monks, M.J. Birnbaum, L. Franchi, G. Nunez, and L. Samavati TLR4-mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages J. Immunol. 188 2012 2847 2857
4. F.M. Brennan, and I.B. McInnes Evidence that cytokines play a role in rheumatoid arthritis J. Clin. Invest. 118 2008 3537 3545
5. Y. Diao, Y. Xin, Y. Zhou, N. Li, X. Pan, S. Qi, Z. Qi, Y. Xu, L. Luo, H. Wan, L. Lan, and Z. Yin Extracellular polysaccharide from Bacillus sp. strain LBP32 prevents LPS-induced inflammation in RAW 264.7 macrophages by inhibiting NF-kappaB and MAPKs activation and ROS production Int. Immunopharmacol. 18 2013 12 19
6. Z. Du, H. Liu, Z. Zhang, and P. Li Antioxidant and anti-inflammatory activities of Radix Isatidis polysaccharide in murine alveolar macrophages Int. J. Biol. Macromol. 58 2013 329 335
7. K. Essafi-Benkhadir, A. Refai, I. Riahi, S. Fattouch, H. Karoui, and M. Essafi Quince (Cydonia oblonga Miller) peel polyphenols modulate LPS-induced inflammation in human THP-1-derived macrophages through NF-kappaB, p38MAPK and Akt inhibition Biochem. Biophys. Res. Commun. 418 2012 180 185
8. R. Gilley, H.N. March, and S.J. Cook ERK1/2, but not ERK5, is necessary and sufficient for phosphorylation and activation of c-Fos Cell. Signal. 21 2009 969 977
9. M. Guha, and N. Mackman The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells J. Biol. Chem. 277 2002 32124 32132 (Pubitemid 34969025)
10. H. Huang, A. Fletcher, Y. Niu, T.T. Wang, and L. Yu Characterization of lipopolysaccharide-stimulated cytokine expression in macrophages and monocytes Inflamm. Res. 61 2012 1329 1338
11. H. Huang, P.H. Park, M.R. McMullen, and L.E. Nagy Mechanisms for the anti-inflammatory effects of adiponectin in macrophages J. Gastroenterol. Hepatol. 23 Suppl. 1 2008 S50 S53
12. J.Y. Jang, J.K. Lee, Y.K. Jeon, and C.W. Kim Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization BMC Cancer 13 2013 421
13. S. Jensen, B.O. Petersen, S. Omarsdottir, B.S. Paulsen, J.O. Duus, and E.S. Olafsdottir Structural characterisation of a complex heteroglycan from the cyanobacterium Nostoc commune Carbohydr. Polym. 91 2013 370 376
14. M.H. Jiang, L. Zhu, and J.G. Jiang Immunoregulatory actions of polysaccharides from Chinese herbal medicine Expert Opin. Ther. Targets 14 2010 1367 1402
15. K. Kanekiyo, J.B. Lee, K. Hayashi, H. Takenaka, Y. Hayakawa, S. Endo, and T. Hayashi Isolation of an antiviral polysaccharide, nostoflan, from a terrestrial cyanobacterium, Nostoc flagelliforme J. Nat. Prod. 68 2005 1037 1041 (Pubitemid 41151758)
16. E.J. Leonard, and T. Yoshimura Neutrophil attractant/activation protein-1 (NAP-1 [interleukin-8]) Am. J. Respir. Cell Mol. Biol. 2 1990 479 486
17. C.J. Liu, and J.Y. Lin Anti-inflammatory and anti-apoptotic effects of strawberry and mulberry fruit polysaccharides on lipopolysaccharide-stimulated macrophages through modulating pro-/anti-inflammatory cytokines secretion and Bcl-2/Bak protein ratio Food Chem. Toxicol. 50 2012 3032 3039
18. M.Y. Md Yusof, and P. Emery Targeting interleukin-6 in rheumatoid arthritis Drugs 73 2013 341 356
19. K. Mizuno, T. Fukami, Y. Toyoda, M. Nakajima, and T. Yokoi Terbinafine stimulates the pro-inflammatory responses in human monocytic THP-1 cells through an ERK signaling pathway Life Sci. 87 2010 537 544
20. M.F. Neurath, and S. Finotto IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer Cytokine Growth Factor Rev. 22 2011 83 89
21. S. Omarsdottir, E.S. Olafsdottir, and J. Freysdottir Immunomodulating effects of lichen-derived polysaccharides on monocyte-derived dendritic cells Int. Immunopharmacol. 6 2006 1642 1650 (Pubitemid 44363053)
22. H. Patterson, R. Nibbs, I. McInnes, and S. Siebert Protein kinase inhibitors in the treatment of inflammatory and autoimmune diseases Clin. Exp. Immunol. 176 2013 1 10
23. M. Rossol, H. Heine, U. Meusch, D. Quandt, C. Klein, M.J. Sweet, and S. Hauschildt LPS-induced cytokine production in human monocytes and macrophages Crit. Rev. Immunol. 31 2011 379 446
24. K. Sand-Jensen, and T.S. Jespersen Tolerance of the widespread cyanobacterium Nostoc commune to extreme temperature variations (-269 to 105°C), pH and salt stress Oecologia 169 2012 331 339
25. P.A. Scherle, E.A. Jones, M.F. Favata, A.J. Daulerio, M.B. Covington, S.A. Nurnberg, R.L. Magolda, and J.M. Trzaskos Inhibition of MAP kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes J. Immunol. 161 1998 5681 5686 (Pubitemid 28519136)
26. A. Schildberger, E. Rossmanith, T. Eichhorn, K. Strassl, and V. Weber Monocytes, peripheral blood mononuclear cells, and THP-1 cells exhibit different cytokine expression patterns following stimulation with lipopolysaccharide Mediators Inflamm. 2013 2013 697972
27. L. Shi, R. Kishore, M.R. McMullen, and L.E. Nagy Lipopolysaccharide stimulation of ERK1/2 increases TNF-alpha production via Egr-1 Am. J. Physiol. Cell Physiol. 282 2002 C1205 C1211
28. F.R. Smiderle, A.C. Ruthes, J. van Arkel, W. Chanput, M. Iacomini, H.J. Wichers, and L.J. Van Griensven Polysaccharides from Agaricus bisporus and Agaricus brasiliensis show similarities in their structures and their immunomodulatory effects on human monocytic THP-1 cells BMC Complement. Altern. Med. 11 2011 58
29. N.-Y. Su, T.-C. Peng, P.-S. Tsai, and C.-J. Huang Phosphoinositide 3-kinase/Akt pathway is involved in mediating the anti-inflammation effects of magnesium sulfate J. Surg. Res. 185 2013 726 732
30. R. Tamai, S. Sugawara, O. Takeuchi, S. Akira, and H. Takada Synergistic effects of lipopolysaccharide and interferon-gamma in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14, Toll-like receptor 4, MD-2 and MyD88 expression J. Endotoxin Res. 9 2003 145 153 (Pubitemid 36722594)
31. T.D. Troutman, J.F. Bazan, and C. Pasare Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K Cell Cycle 11 2012 3559 3567
32. H.B. Wang, S.J. Wu, and D. Liu Preparation of polysaccharides from cyanobacteria Nostoc commune and their antioxidant activities Carbohydr. Polym. 99 2014 553 555
33. Yimin, and M. Kohanawa A regulatory effect of the balance between TNF-alpha and IL-6 in the granulomatous and inflammatory response to Rhodococcus aurantiacus infection in mice J. Immunol. 177 2006 642 650 (Pubitemid 43939178)