Natural products as potential human ether-a-Go-Go-related gene channel inhibitors - Outcomes from a screening of widely used herbal medicines and edible plants

Planta Medica

Volumn 80, Issue 12, 2014, Pages 1045-1050

  Schramm, Anja ^a   Jähne, Evelyn A ^a   Baburin, Igor ^b   Hering, Steffen ^b   Hamburger, Matthias ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

alkaloids; dietary plants; herbal drugs; hERG channel inhibition; HPLC based activity profiling; Xenopus oocyte assay

Indexed keywords

ACETIC ACID ETHYL ESTER; BERBERINE; BLACK PEPPER EXTRACT; CINNAMOMUM ZEYLANICUM EXTRACT; CISAPRIDE; COPTIS CHINENSIS EXTRACT; GUARANA EXTRACT; HERBACEOUS AGENT; METHANOL; MYRISTICA FRAGRANS EXTRACT; PIPERINE; PLANT EXTRACT; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG; TANNIN DERIVATIVE; UNCLASSIFIED DRUG; ALKALOID; BIOLOGICAL PRODUCT;

ANIMAL CELL; ARTICLE; BLACK PEPPER; CINNAMOMUM ZEYLANICUM; CONTROLLED STUDY; COPTIS CHINENSIS; DRUG ISOLATION; DRUG SCREENING; EDIBLE PLANT; GENE; GENOTOXICITY; GUARANA; HERBAL MEDICINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IC 50; MEDICINAL PLANT; MICROELECTRODE; NONHUMAN; NUTMEG; OOCYTE; POTASSIUM CHANNEL HERG GENE; VOLTAGE CLAMP TECHNIQUE; XENOPUS LAEVIS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; CHEMISTRY; CONGENITAL MALFORMATION; HEART ARRHYTHMIA; HEART MUSCLE CONDUCTION SYSTEM; XENOPUS;

ALKALOIDS; ANIMALS; ARRHYTHMIAS, CARDIAC; BIOLOGICAL PRODUCTS; ETHER-A-GO-GO POTASSIUM CHANNELS; HEART CONDUCTION SYSTEM; HERBAL MEDICINE; HUMANS; OOCYTES; PLANT EXTRACTS; PLANTS, EDIBLE; PLANTS, MEDICINAL; POTASSIUM CHANNEL BLOCKERS; TANNINS; XENOPUS;

EID: 84906938513     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0034-1382907     Document Type: Article

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