-
1
-
-
79955705831
-
Radical prostatectomy versus watchful waiting in early prostate cancer
-
Bill-Axelson A., Holmberg L., Ruutu M., et al. Radical prostatectomy versus watchful waiting in early prostate cancer. N Engl J Med 2011, 364:1708-1717.
-
(2011)
N Engl J Med
, vol.364
, pp. 1708-1717
-
-
Bill-Axelson, A.1
Holmberg, L.2
Ruutu, M.3
-
2
-
-
60149089419
-
Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion
-
Harris W.P., Mostaghel E.A., Nelson P.S., Montgomery B. Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion. Nat Clin Pract Urol 2009, 6:76-85.
-
(2009)
Nat Clin Pract Urol
, vol.6
, pp. 76-85
-
-
Harris, W.P.1
Mostaghel, E.A.2
Nelson, P.S.3
Montgomery, B.4
-
3
-
-
0034806356
-
Trends and patterns of prostate cancer: what do they suggest
-
Hsing A.W., Devesa S.S. Trends and patterns of prostate cancer: what do they suggest. Epidemiol Rev 2001, 12:3-13.
-
(2001)
Epidemiol Rev
, vol.12
, pp. 3-13
-
-
Hsing, A.W.1
Devesa, S.S.2
-
4
-
-
34250736334
-
Extended 21-sample needle biopsy protocol for diagnosis of prostate cancer in 1000 consecutive patients
-
Guichard G., Larré S., Gallina A., et al. Extended 21-sample needle biopsy protocol for diagnosis of prostate cancer in 1000 consecutive patients. Eur Urol 2007, 52:430-435.
-
(2007)
Eur Urol
, vol.52
, pp. 430-435
-
-
Guichard, G.1
Larré, S.2
Gallina, A.3
-
5
-
-
84861714168
-
Prostate cancer screening, yes or no? The current controversy
-
Razi A. Prostate cancer screening, yes or no? The current controversy. Urol J 2009, 1:240-245.
-
(2009)
Urol J
, vol.1
, pp. 240-245
-
-
Razi, A.1
-
6
-
-
63249122661
-
Mortality results from a randomized prostate-cancer screening trial
-
Andriole G.L., Grubb R.L., Buys S.S., et al. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med 2009, 360:1310-1319.
-
(2009)
N Engl J Med
, vol.360
, pp. 1310-1319
-
-
Andriole, G.L.1
Grubb, R.L.2
Buys, S.S.3
-
7
-
-
49049102974
-
Benefits and harms of prostate-specific antigen screening for prostate cancer: an evidence update for the US Preventive Services Task Force
-
Lin K., Lipsitz R., Miller T., Janakiraman S. Benefits and harms of prostate-specific antigen screening for prostate cancer: an evidence update for the US Preventive Services Task Force. Ann Intern Med 2008, 149:192.
-
(2008)
Ann Intern Med
, vol.149
, pp. 192
-
-
Lin, K.1
Lipsitz, R.2
Miller, T.3
Janakiraman, S.4
-
8
-
-
35148817305
-
Androgen deprivation therapy in the treatment of advanced prostate cancer
-
Perlmutter M.A., Lepor H. Androgen deprivation therapy in the treatment of advanced prostate cancer. Rev Urol 2007, 9:S1-S8.
-
(2007)
Rev Urol
, vol.9
-
-
Perlmutter, M.A.1
Lepor, H.2
-
9
-
-
77954942975
-
Duration of first off-treatment interval is prognostic for time to castration resistance and death in men with biochemical relapse of prostate cancer treated on a prospective trial of intermittent androgen deprivation
-
Evan Y.Y., Gulati R., Telesca D., et al. Duration of first off-treatment interval is prognostic for time to castration resistance and death in men with biochemical relapse of prostate cancer treated on a prospective trial of intermittent androgen deprivation. J Clin Oncol 2010, 28:2668-2673.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2668-2673
-
-
Evan, Y.Y.1
Gulati, R.2
Telesca, D.3
-
10
-
-
20344408318
-
Future directions in the treatment of androgen-independent prostate cancer
-
Petrylak D.P. Future directions in the treatment of androgen-independent prostate cancer. Urology 2005, 65:8-12.
-
(2005)
Urology
, vol.65
, pp. 8-12
-
-
Petrylak, D.P.1
-
11
-
-
79961139550
-
TGF-beta/TGF-beta receptor system and its role in physiological and pathological conditions
-
Santibanez J.F., Quintanilla M., Bernabeu C. TGF-beta/TGF-beta receptor system and its role in physiological and pathological conditions. Clin Sci 2011, 121:233-251.
-
(2011)
Clin Sci
, vol.121
, pp. 233-251
-
-
Santibanez, J.F.1
Quintanilla, M.2
Bernabeu, C.3
-
12
-
-
22544448149
-
Should activin C be more than a fading snapshot in the activin/TGF family album
-
Butler C., Gold E., Risbridger G. Should activin C be more than a fading snapshot in the activin/TGF family album. Cytokine Growth Factor Rev 2005, 16:377-385.
-
(2005)
Cytokine Growth Factor Rev
, vol.16
, pp. 377-385
-
-
Butler, C.1
Gold, E.2
Risbridger, G.3
-
13
-
-
0036965929
-
TGF- and the Smad signal transduction pathway
-
Mehra A., Wrana J.L. TGF- and the Smad signal transduction pathway. Biochem Cell Biol 2002, 80:605-622.
-
(2002)
Biochem Cell Biol
, vol.80
, pp. 605-622
-
-
Mehra, A.1
Wrana, J.L.2
-
14
-
-
0037040204
-
A nuclear antagonistic mechanism of inhibitory Smads in transforming growth factor-signaling
-
Bai S., Cao X. A nuclear antagonistic mechanism of inhibitory Smads in transforming growth factor-signaling. J Biol Chem 2002, 277:4176.
-
(2002)
J Biol Chem
, vol.277
, pp. 4176
-
-
Bai, S.1
Cao, X.2
-
15
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan D., Weinberg Robert A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg Robert, A.2
-
16
-
-
84861695148
-
Insensitivity to the growth inhibitory effects of activin A: an acquired capability in prostate cancer progression
-
Ottley E., Gold E. Insensitivity to the growth inhibitory effects of activin A: an acquired capability in prostate cancer progression. Cytokine Growth Factor Rev 2012, 23:119-125.
-
(2012)
Cytokine Growth Factor Rev
, vol.23
, pp. 119-125
-
-
Ottley, E.1
Gold, E.2
-
17
-
-
0035974474
-
The contribution of inhibins and activins to malignant prostate disease
-
Risbridger G., Mellor S., McPherson S., Schmitt J. The contribution of inhibins and activins to malignant prostate disease. Mol Cell Endocrinol 2001, 180:149-153.
-
(2001)
Mol Cell Endocrinol
, vol.180
, pp. 149-153
-
-
Risbridger, G.1
Mellor, S.2
McPherson, S.3
Schmitt, J.4
-
18
-
-
58249110402
-
Activin C antagonizes activin A in vitro and overexpression leads to pathologies in vivo
-
Gold E., Jetly N., O'Bryan M.K., et al. Activin C antagonizes activin A in vitro and overexpression leads to pathologies in vivo. Am J Pathol 2009, 174:184-195.
-
(2009)
Am J Pathol
, vol.174
, pp. 184-195
-
-
Gold, E.1
Jetly, N.2
O'Bryan, M.K.3
-
19
-
-
0030460696
-
Activin inhibition of prostate cancer cell growth: selective actions on androgen-responsive LNCaP cells
-
Dalkin A., Gilrain J., Bradshaw D., Myers C. Activin inhibition of prostate cancer cell growth: selective actions on androgen-responsive LNCaP cells. Endocrinology 1996, 137:5230-5235.
-
(1996)
Endocrinology
, vol.137
, pp. 5230-5235
-
-
Dalkin, A.1
Gilrain, J.2
Bradshaw, D.3
Myers, C.4
-
20
-
-
0030716244
-
Growth regulation of human prostate cancer cells by bone morphogenetic protein-2
-
Ide H., Yoshida T., Matsumoto N., et al. Growth regulation of human prostate cancer cells by bone morphogenetic protein-2. Cancer Res 1997, 57:5022-5027.
-
(1997)
Cancer Res
, vol.57
, pp. 5022-5027
-
-
Ide, H.1
Yoshida, T.2
Matsumoto, N.3
-
21
-
-
0033381357
-
The role for transforming growth factor-beta (TGF-beta) in human cancer
-
Gold L.I. The role for transforming growth factor-beta (TGF-beta) in human cancer. Crit Rev Oncog 1998, 10:303-360.
-
(1998)
Crit Rev Oncog
, vol.10
, pp. 303-360
-
-
Gold, L.I.1
-
22
-
-
0026689136
-
Transforming growth factor-beta
-
Massague J., Cheifetz S., Laiho M., Ralph D., Weis F., Zentella A. Transforming growth factor-beta. Cancer Surv 1991, 12:81-103.
-
(1991)
Cancer Surv
, vol.12
, pp. 81-103
-
-
Massague, J.1
Cheifetz, S.2
Laiho, M.3
Ralph, D.4
Weis, F.5
Zentella, A.6
-
23
-
-
84868615823
-
Differential role of Sloan-Kettering Institute (Ski) protein in nodal and transforming growth factor-beta (TGF-β)-induced Smad signaling in prostate cancer cells
-
Vo B.T., Cody B., Cao Y., Khan S.A. Differential role of Sloan-Kettering Institute (Ski) protein in nodal and transforming growth factor-beta (TGF-β)-induced Smad signaling in prostate cancer cells. Carcinogenesis 2012, 33:2054-2064.
-
(2012)
Carcinogenesis
, vol.33
, pp. 2054-2064
-
-
Vo, B.T.1
Cody, B.2
Cao, Y.3
Khan, S.A.4
-
25
-
-
84880921276
-
Adult-specific functions of animal microRNAs
-
Sun K., Lai E.C. Adult-specific functions of animal microRNAs. Nat Rev Genet 2013, 14:535-548.
-
(2013)
Nat Rev Genet
, vol.14
, pp. 535-548
-
-
Sun, K.1
Lai, E.C.2
-
28
-
-
0027751663
-
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
-
Lee R.C., Feinbaum R.L., Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993, 75:843-854.
-
(1993)
Cell
, vol.75
, pp. 843-854
-
-
Lee, R.C.1
Feinbaum, R.L.2
Ambros, V.3
-
29
-
-
0027730383
-
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
-
Wightman B., Ha I., Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 1993, 75:855-862.
-
(1993)
Cell
, vol.75
, pp. 855-862
-
-
Wightman, B.1
Ha, I.2
Ruvkun, G.3
-
30
-
-
0034708122
-
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
-
Reinhart B.J., Slack F.J., Basson M., et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 2000, 403:901-906.
-
(2000)
Nature
, vol.403
, pp. 901-906
-
-
Reinhart, B.J.1
Slack, F.J.2
Basson, M.3
-
31
-
-
79953249325
-
MicroRNA in prostate, bladder, and kidney cancer: a systematic review
-
Catto J.W.F., Alcaraz A., Bjartell A.S., et al. MicroRNA in prostate, bladder, and kidney cancer: a systematic review. Eur Urol 2011, 59:671-681.
-
(2011)
Eur Urol
, vol.59
, pp. 671-681
-
-
Catto, J.W.F.1
Alcaraz, A.2
Bjartell, A.S.3
-
32
-
-
18344369543
-
MicroRNA biogenesis: coordinated cropping and dicing
-
Kim V.N. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 2005, 6:376-385.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 376-385
-
-
Kim, V.N.1
-
33
-
-
34548607471
-
MicroRNA control of Nodal signalling
-
Martello G., Zacchigna L., Inui M., et al. MicroRNA control of Nodal signalling. Nature 2007, 449:183-188.
-
(2007)
Nature
, vol.449
, pp. 183-188
-
-
Martello, G.1
Zacchigna, L.2
Inui, M.3
-
34
-
-
84860488299
-
MiR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms
-
Senanayake U., Das S., Vesely P., et al. miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms. Carcinogenesis 2012, 33:1014-1021.
-
(2012)
Carcinogenesis
, vol.33
, pp. 1014-1021
-
-
Senanayake, U.1
Das, S.2
Vesely, P.3
-
35
-
-
38349146518
-
MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4
-
Wang Q., Huang Z., Xue H., et al. MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood 2008, 111:588-595.
-
(2008)
Blood
, vol.111
, pp. 588-595
-
-
Wang, Q.1
Huang, Z.2
Xue, H.3
-
36
-
-
84875170985
-
MicroRNA-181a Suppresses Mouse Granulosa Cell Proliferation by Targeting Activin Receptor IIA
-
Zhang Q., Sun H., Jiang Y., et al. MicroRNA-181a Suppresses Mouse Granulosa Cell Proliferation by Targeting Activin Receptor IIA. PloS ONE 2013, 8:e59667.
-
(2013)
PloS ONE
, vol.8
-
-
Zhang, Q.1
Sun, H.2
Jiang, Y.3
-
37
-
-
46449128469
-
SMAD proteins control DROSHA-mediated microRNA maturation
-
Davis B.N., Hilyard A.C., Lagna G., Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature 2008, 454:56-61.
-
(2008)
Nature
, vol.454
, pp. 56-61
-
-
Davis, B.N.1
Hilyard, A.C.2
Lagna, G.3
Hata, A.4
-
38
-
-
77955484492
-
Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha
-
Davis B.N., Hilyard A.C., Nguyen P.H., Lagna G., Hata A. Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha. Mol Cell 2010, 39:373-384.
-
(2010)
Mol Cell
, vol.39
, pp. 373-384
-
-
Davis, B.N.1
Hilyard, A.C.2
Nguyen, P.H.3
Lagna, G.4
Hata, A.5
-
39
-
-
79952227351
-
Smad-mediated miRNA processing: a critical role for a conserved RNA sequence
-
Davis-Dusenbery B.N., Hata A. Smad-mediated miRNA processing: a critical role for a conserved RNA sequence. RNA Biol 2011, 8:71-76.
-
(2011)
RNA Biol
, vol.8
, pp. 71-76
-
-
Davis-Dusenbery, B.N.1
Hata, A.2
-
40
-
-
84862758071
-
Smad-mediated regulation of microRNA biosynthesis
-
Blahna M.T., Hata A. Smad-mediated regulation of microRNA biosynthesis. FEBS Lett 2012, 586:1906-1912.
-
(2012)
FEBS Lett
, vol.586
, pp. 1906-1912
-
-
Blahna, M.T.1
Hata, A.2
-
41
-
-
78650653944
-
MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-β
-
Louafi F., Martinez-Nunez R.T., Sanchez-Elsner T. MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-β. J Biol Chem 2010, 285:41328-41336.
-
(2010)
J Biol Chem
, vol.285
, pp. 41328-41336
-
-
Louafi, F.1
Martinez-Nunez, R.T.2
Sanchez-Elsner, T.3
-
42
-
-
84880826932
-
MicroRNA-224 targets SMAD family member 4 to promote cell proliferation and negatively influence patient survival
-
Wang Y., Ren J., Gao Y., et al. MicroRNA-224 targets SMAD family member 4 to promote cell proliferation and negatively influence patient survival. PloS ONE 2013, 8:e68744.
-
(2013)
PloS ONE
, vol.8
-
-
Wang, Y.1
Ren, J.2
Gao, Y.3
-
43
-
-
84872035173
-
Downregulation and prognostic performance of microRNA 224 expression in prostate cancer
-
Mavridis K., Stravodimos K., Scorilas A. Downregulation and prognostic performance of microRNA 224 expression in prostate cancer. Clin Chem 2013, 59:261-269.
-
(2013)
Clin Chem
, vol.59
, pp. 261-269
-
-
Mavridis, K.1
Stravodimos, K.2
Scorilas, A.3
-
44
-
-
77249164641
-
MicroRNA-224 is involved in transforming growth factor-β-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4
-
Yao G., Yin M., Lian J., et al. MicroRNA-224 is involved in transforming growth factor-β-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4. Mol Endocrinol 2010, 24:540-551.
-
(2010)
Mol Endocrinol
, vol.24
, pp. 540-551
-
-
Yao, G.1
Yin, M.2
Lian, J.3
-
45
-
-
84860919248
-
A microRNA signature differentiates between giant cell tumor derived neoplastic stromal cells and mesenchymal stem cells
-
Fellenberg J., Saehr H., Lehner B., Depeweg D. A microRNA signature differentiates between giant cell tumor derived neoplastic stromal cells and mesenchymal stem cells. Cancer Lett 2012, 321:162-168.
-
(2012)
Cancer Lett
, vol.321
, pp. 162-168
-
-
Fellenberg, J.1
Saehr, H.2
Lehner, B.3
Depeweg, D.4
-
46
-
-
77955373730
-
MiR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis
-
Liu G., Friggeri A., Yang Y., et al. miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med 2010, 207:1589-1597.
-
(2010)
J Exp Med
, vol.207
, pp. 1589-1597
-
-
Liu, G.1
Friggeri, A.2
Yang, Y.3
-
47
-
-
58149213801
-
Non-Smad pathways in TGF-β signaling
-
Zhang Y.E. Non-Smad pathways in TGF-β signaling. Cell Res 2008, 19:128-139.
-
(2008)
Cell Res
, vol.19
, pp. 128-139
-
-
Zhang, Y.E.1
-
49
-
-
84862705487
-
Crosstalk between TGF-β signaling and the microRNA machinery
-
Butz H., Rácz K., Hunyady L., Patócs A. Crosstalk between TGF-β signaling and the microRNA machinery. Trends Pharmacol Sci 2012, 33:382-393.
-
(2012)
Trends Pharmacol Sci
, vol.33
, pp. 382-393
-
-
Butz, H.1
Rácz, K.2
Hunyady, L.3
Patócs, A.4
-
50
-
-
24944497786
-
Non-Smad TGF-β signals
-
Moustakas A., Heldin C-H. Non-Smad TGF-β signals. J Cell Sci 2005, 118:3573-3584.
-
(2005)
J Cell Sci
, vol.118
, pp. 3573-3584
-
-
Moustakas, A.1
Heldin, C.-H.2
-
51
-
-
84891064090
-
Dissecting major signaling pathways throughout the development of prostate cancer
-
da Silva H.B., Amaral E.P., Nolasco E.L., et al. Dissecting major signaling pathways throughout the development of prostate cancer. Prostate Cancer 2013, 2013:1-23.
-
(2013)
Prostate Cancer
, vol.2013
, pp. 1-23
-
-
da Silva, H.B.1
Amaral, E.P.2
Nolasco, E.L.3
-
52
-
-
77955489850
-
Smads stimulate mirna processing
-
Treiber T., Meister G. Smads stimulate mirna processing. Mol Cell 2010, 39:315-316.
-
(2010)
Mol Cell
, vol.39
, pp. 315-316
-
-
Treiber, T.1
Meister, G.2
-
53
-
-
70649086975
-
Control of microRNA biogenesis by TGFβ signaling pathway-a novel role of Smads in the nucleus
-
Hata A., Davis B.N. Control of microRNA biogenesis by TGFβ signaling pathway-a novel role of Smads in the nucleus. Cytokine Growth Factor Rev 2009, 20:517-521.
-
(2009)
Cytokine Growth Factor Rev
, vol.20
, pp. 517-521
-
-
Hata, A.1
Davis, B.N.2
-
54
-
-
33646399160
-
Targeting the ERK signaling pathway in cancer therapy
-
Kohno M., Pouyssegur J. Targeting the ERK signaling pathway in cancer therapy. Ann Med 2006, 38:200-211.
-
(2006)
Ann Med
, vol.38
, pp. 200-211
-
-
Kohno, M.1
Pouyssegur, J.2
-
55
-
-
0034618369
-
MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-XL, and Mcl-1 and promotes survival of human pancreatic cancer cells
-
Boucher M-J., Morisset J., Vachon P.H., Reed J.C., Lainé J., Rivard N. MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-XL, and Mcl-1 and promotes survival of human pancreatic cancer cells. J Cell Biochem 2000, 79:355-369.
-
(2000)
J Cell Biochem
, vol.79
, pp. 355-369
-
-
Boucher, M.-J.1
Morisset, J.2
Vachon, P.H.3
Reed, J.C.4
Lainé, J.5
Rivard, N.6
-
56
-
-
22244467085
-
Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner
-
Krysan K., Reckamp K.L., Dalwadi H., et al. Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner. Cancer Res 2005, 65:6275-6281.
-
(2005)
Cancer Res
, vol.65
, pp. 6275-6281
-
-
Krysan, K.1
Reckamp, K.L.2
Dalwadi, H.3
-
57
-
-
0032819983
-
Activation of extracellular signal-regulated kinase in human prostate cancer
-
Price D.T., Rocca G.D., Guo C., Ballo M.S., Schwinn D.A., Luttrell L.M. Activation of extracellular signal-regulated kinase in human prostate cancer. J Urol 1999, 162:1537-1542.
-
(1999)
J Urol
, vol.162
, pp. 1537-1542
-
-
Price, D.T.1
Rocca, G.D.2
Guo, C.3
Ballo, M.S.4
Schwinn, D.A.5
Luttrell, L.M.6
-
58
-
-
0142059045
-
ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cells
-
Zelivianski S., Spellman M., Kellerman M., et al. ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cells. Int J Cancer 2003, 107:478-485.
-
(2003)
Int J Cancer
, vol.107
, pp. 478-485
-
-
Zelivianski, S.1
Spellman, M.2
Kellerman, M.3
-
59
-
-
51349111250
-
Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model
-
Kinkade C.W., Castillo-Martin M., Puzio-Kuter A., et al. Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model. J Clin Investig 2008, 118:3051.
-
(2008)
J Clin Investig
, vol.118
, pp. 3051
-
-
Kinkade, C.W.1
Castillo-Martin, M.2
Puzio-Kuter, A.3
-
60
-
-
0033229853
-
Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17
-
Yoshida B.A., Dubauskas Z., Chekmareva M.A., Christiano T.R., Stadler W.M., Rinker-Schaeffer C.W. Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17. Cancer Res 1999, 59:5483-5487.
-
(1999)
Cancer Res
, vol.59
, pp. 5483-5487
-
-
Yoshida, B.A.1
Dubauskas, Z.2
Chekmareva, M.A.3
Christiano, T.R.4
Stadler, W.M.5
Rinker-Schaeffer, C.W.6
-
61
-
-
24944439828
-
Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3
-
Matsuura I., Wang G., He D., Liu F. Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3. Biochemistry 2005, 44:12546-12553.
-
(2005)
Biochemistry
, vol.44
, pp. 12546-12553
-
-
Matsuura, I.1
Wang, G.2
He, D.3
Liu, F.4
-
62
-
-
0033106484
-
A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras
-
Kretzschmar M., Doody J., Timokhina I., Massagué J. A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras. Genes Dev 1999, 13:804-816.
-
(1999)
Genes Dev
, vol.13
, pp. 804-816
-
-
Kretzschmar, M.1
Doody, J.2
Timokhina, I.3
Massagué, J.4
-
63
-
-
70449571904
-
MiR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice
-
Clapé C., Fritz V., Henriquet C., et al. miR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice. PloS ONE 2009, 4:e7542.
-
(2009)
PloS ONE
, vol.4
-
-
Clapé, C.1
Fritz, V.2
Henriquet, C.3
-
64
-
-
79951673289
-
ERK5 signalling in prostate cancer promotes an invasive phenotype
-
Ramsay A., McCracken S., Soofi M., et al. ERK5 signalling in prostate cancer promotes an invasive phenotype. Br J Cancer 2011, 104:664-672.
-
(2011)
Br J Cancer
, vol.104
, pp. 664-672
-
-
Ramsay, A.1
McCracken, S.2
Soofi, M.3
-
65
-
-
34247627509
-
Mitogenic growth signalling, DNA replication licensing, and survival are linked in prostate cancer
-
Dudderidge T., McCracken S., Loddo M., et al. Mitogenic growth signalling, DNA replication licensing, and survival are linked in prostate cancer. Br J Cancer 2007, 96:1384-1393.
-
(2007)
Br J Cancer
, vol.96
, pp. 1384-1393
-
-
Dudderidge, T.1
McCracken, S.2
Loddo, M.3
-
66
-
-
84872557347
-
Mir143 expression inversely correlates with nuclear ERK5 immunoreactivity in clinical prostate cancer
-
Ahmad I., Singh L., Yang Z., et al. Mir143 expression inversely correlates with nuclear ERK5 immunoreactivity in clinical prostate cancer. Br J Cancer 2013, 108:149-154.
-
(2013)
Br J Cancer
, vol.108
, pp. 149-154
-
-
Ahmad, I.1
Singh, L.2
Yang, Z.3
-
67
-
-
34447132924
-
MicroRNA expression profiling in prostate cancer
-
Porkka K.P., Pfeiffer M.J., Waltering K.K., Vessella R.L., Tammela T.L.J., Visakorpi T. MicroRNA expression profiling in prostate cancer. Cancer Res 2007, 67:6130.
-
(2007)
Cancer Res
, vol.67
, pp. 6130
-
-
Porkka, K.P.1
Pfeiffer, M.J.2
Waltering, K.K.3
Vessella, R.L.4
Tammela, T.L.J.5
Visakorpi, T.6
-
68
-
-
60149087720
-
MicroRNA profile analysis of human prostate cancers
-
Tong A., Fulgham P., Jay C., et al. MicroRNA profile analysis of human prostate cancers. Cancer Gene Ther 2009, 16:206-216.
-
(2009)
Cancer Gene Ther
, vol.16
, pp. 206-216
-
-
Tong, A.1
Fulgham, P.2
Jay, C.3
-
69
-
-
84864647706
-
Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling
-
Hough C., Radu M., Doré J.J. Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling. PLoS ONE 2012, 7:e42513.
-
(2012)
PLoS ONE
, vol.7
-
-
Hough, C.1
Radu, M.2
Doré, J.J.3
-
70
-
-
79953696225
-
MiR-143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS
-
Xu B., Niu X., Zhang X., et al. miR-143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS. Mol Cell Biochem 2011, 350:207-213.
-
(2011)
Mol Cell Biochem
, vol.350
, pp. 207-213
-
-
Xu, B.1
Niu, X.2
Zhang, X.3
-
71
-
-
5444248307
-
Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac
-
De Wever O., Nguyen Q-D., Van Hoorde L., et al. Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac. FASEB J 2004, 18:1016-1018.
-
(2004)
FASEB J
, vol.18
, pp. 1016-1018
-
-
De Wever, O.1
Nguyen, Q.-D.2
Van Hoorde, L.3
-
72
-
-
19944432271
-
Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo
-
Pillé J-Y., Denoyelle C., Varet J., et al. Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo. Mol Ther 2005, 11:267-274.
-
(2005)
Mol Ther
, vol.11
, pp. 267-274
-
-
Pillé, J.-Y.1
Denoyelle, C.2
Varet, J.3
-
73
-
-
3242699514
-
Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer
-
Kamai T., Yamanishi T., Shirataki H., et al. Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer. Clin Cancer Res 2004, 10:4799-4805.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 4799-4805
-
-
Kamai, T.1
Yamanishi, T.2
Shirataki, H.3
-
74
-
-
0037444376
-
Requirement of RhoA activity for increased nuclear factor (B activity and PC-3 human prostate cancer cell invasion
-
Hodge J.C., Bub J., Kaul S., Kajdacsy-Balla A., Lindholm P.F. Requirement of RhoA activity for increased nuclear factor (B activity and PC-3 human prostate cancer cell invasion. Cancer Res 2003, 63:1359-1364.
-
(2003)
Cancer Res
, vol.63
, pp. 1359-1364
-
-
Hodge, J.C.1
Bub, J.2
Kaul, S.3
Kajdacsy-Balla, A.4
Lindholm, P.F.5
-
75
-
-
28844433954
-
Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells
-
Lee J., Lee I., Park C., Kang W.K. Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells. Biochem Biophys Res Commun 2006, 339:748-754.
-
(2006)
Biochem Biophys Res Commun
, vol.339
, pp. 748-754
-
-
Lee, J.1
Lee, I.2
Park, C.3
Kang, W.K.4
-
76
-
-
0036569943
-
RhoA-dependent murine prostate cancer cell proliferation and apoptosis role of protein kinase Cζ
-
Ghosh P.M., Bedolla R., Mikhailova M., Kreisberg J.I. RhoA-dependent murine prostate cancer cell proliferation and apoptosis role of protein kinase Cζ. Cancer Res 2002, 62:2630-2636.
-
(2002)
Cancer Res
, vol.62
, pp. 2630-2636
-
-
Ghosh, P.M.1
Bedolla, R.2
Mikhailova, M.3
Kreisberg, J.I.4
-
77
-
-
0043172396
-
Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis
-
Grünert S., Jechlinger M., Beug H. Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nat Rev Mol Cell Biol 2003, 4:657-665.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 657-665
-
-
Grünert, S.1
Jechlinger, M.2
Beug, H.3
-
78
-
-
55849123946
-
MicroRNA-155 is regulated by the transforming growth factor β/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA
-
Kong W., Yang H., He L., et al. MicroRNA-155 is regulated by the transforming growth factor β/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol 2008, 28:6773-6784.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 6773-6784
-
-
Kong, W.1
Yang, H.2
He, L.3
-
79
-
-
2342436038
-
Smad7 is required for TGF-β-induced activation of the small GTPase Cdc42
-
Edlund S., Landström M., Heldin C-H., Aspenström P. Smad7 is required for TGF-β-induced activation of the small GTPase Cdc42. J Cell Sci 2004, 117:1835-1847.
-
(2004)
J Cell Sci
, vol.117
, pp. 1835-1847
-
-
Edlund, S.1
Landström, M.2
Heldin, C.-H.3
Aspenström, P.4
-
80
-
-
65349132693
-
EMT, the cytoskeleton, and cancer cell invasion
-
Yilmaz M., Christofori G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev 2009, 28:15-33.
-
(2009)
Cancer Metastasis Rev
, vol.28
, pp. 15-33
-
-
Yilmaz, M.1
Christofori, G.2
-
81
-
-
0034708373
-
Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells
-
Somlyo A.V., Bradshaw D., Ramos S., Murphy C., Myers C.E., Somlyo A.P. Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells. Biochem Biophys Res Commun 2000, 269:652-659.
-
(2000)
Biochem Biophys Res Commun
, vol.269
, pp. 652-659
-
-
Somlyo, A.V.1
Bradshaw, D.2
Ramos, S.3
Murphy, C.4
Myers, C.E.5
Somlyo, A.P.6
-
82
-
-
19944427667
-
Antibody-based profiling of the phosphoinositide 3-kinase pathway in clinical prostate cancer
-
Thomas G.V., Horvath S., Smith B.L., et al. Antibody-based profiling of the phosphoinositide 3-kinase pathway in clinical prostate cancer. Clin Cancer Res 2004, 10:8351-8356.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8351-8356
-
-
Thomas, G.V.1
Horvath, S.2
Smith, B.L.3
-
83
-
-
5144228549
-
High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence
-
Ayala G., Thompson T., Yang G., et al. High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence. Clin Cancer Res 2004, 10:6572-6578.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6572-6578
-
-
Ayala, G.1
Thompson, T.2
Yang, G.3
-
84
-
-
70349459742
-
MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation
-
Lee K-H., Chen Y-L., Yeh S., et al. MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation. Oncogene 2009, 28:3360-3370.
-
(2009)
Oncogene
, vol.28
, pp. 3360-3370
-
-
Lee, K.-H.1
Chen, Y.-L.2
Yeh, S.3
-
85
-
-
25444520537
-
MiR-15 and miR-16 induce apoptosis by targeting BCL2
-
Cimmino A., Calin G.A., Fabbri M., et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 2005, 102:13944-13949.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 13944-13949
-
-
Cimmino, A.1
Calin, G.A.2
Fabbri, M.3
-
86
-
-
51049123624
-
Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer
-
Ambs S., Prueitt R.L., Yi M., et al. Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer Res 2008, 68:6162-6170.
-
(2008)
Cancer Res
, vol.68
, pp. 6162-6170
-
-
Ambs, S.1
Prueitt, R.L.2
Yi, M.3
-
87
-
-
84984585952
-
Synergistic interactions between sorafenib and bortezomib in hepatocellular carcinoma involve PP2A-dependent Akt inactivation
-
Chen K-F., Yu H-C., Liu T-H., Lee S-S., Chen P-J., Cheng A-L. Synergistic interactions between sorafenib and bortezomib in hepatocellular carcinoma involve PP2A-dependent Akt inactivation. J Hepatol 2010, 52:88-95.
-
(2010)
J Hepatol
, vol.52
, pp. 88-95
-
-
Chen, K.-F.1
Yu, H.-C.2
Liu, T.-H.3
Lee, S.-S.4
Chen, P.-J.5
Cheng, A.-L.6
-
88
-
-
27844601539
-
Regulation of the Akt kinase by interacting proteins
-
Du K., Tsichlis P.N. Regulation of the Akt kinase by interacting proteins. Oncogene 2005, 24:7401-7409.
-
(2005)
Oncogene
, vol.24
, pp. 7401-7409
-
-
Du, K.1
Tsichlis, P.N.2
-
89
-
-
79955519053
-
Overexpression of miR-200c induces chemoresistance in esophageal cancers mediated through activation of the Akt signaling pathway
-
Hamano R., Miyata H., Yamasaki M., et al. Overexpression of miR-200c induces chemoresistance in esophageal cancers mediated through activation of the Akt signaling pathway. Clin Cancer Res 2011, 17:3029-3038.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 3029-3038
-
-
Hamano, R.1
Miyata, H.2
Yamasaki, M.3
-
90
-
-
80054774985
-
Epigenetic silencing of microRNA-375 regulates PDK1 expression in esophageal cancer
-
Li X., Lin R., Li J. Epigenetic silencing of microRNA-375 regulates PDK1 expression in esophageal cancer. Dig Dis Sci 2011, 56:2849-2856.
-
(2011)
Dig Dis Sci
, vol.56
, pp. 2849-2856
-
-
Li, X.1
Lin, R.2
Li, J.3
-
91
-
-
84868474396
-
MicroRNA-350 induces pathological heart hypertrophy by repressing both p38 and JNK pathways
-
Ge Y., Pan S., Guan D., et al. MicroRNA-350 induces pathological heart hypertrophy by repressing both p38 and JNK pathways. Biochim Biophys Acta 2012, 1-10.
-
(2012)
Biochim Biophys Acta
, pp. 1-10
-
-
Ge, Y.1
Pan, S.2
Guan, D.3
-
92
-
-
84874547217
-
MicroRNA-204-5p regulates epithelial-to-mesenchymal transition during human posterior capsule opacification by targeting SMAD4
-
Wang Y., Li W., Zang X., et al. MicroRNA-204-5p regulates epithelial-to-mesenchymal transition during human posterior capsule opacification by targeting SMAD4. Invest Ophthalmol Vis Sci 2013, 54:323-332.
-
(2013)
Invest Ophthalmol Vis Sci
, vol.54
, pp. 323-332
-
-
Wang, Y.1
Li, W.2
Zang, X.3
|