메뉴 건너뛰기




Volumn 92, Issue 1, 2014, Pages 49-60

MicroRNA and non-canonical TGF-β signalling: Implications for prostate cancer therapy

Author keywords

MicroRNA; Prostate cancer; Smad signalling; TGF superfamily

Indexed keywords

GROWTH FACTOR; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTATE SPECIFIC ANTIGEN; PROTEIN KINASE B; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; SIGNAL PEPTIDE;

EID: 84906938059     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2014.05.011     Document Type: Review
Times cited : (13)

References (92)
  • 1
    • 79955705831 scopus 로고    scopus 로고
    • Radical prostatectomy versus watchful waiting in early prostate cancer
    • Bill-Axelson A., Holmberg L., Ruutu M., et al. Radical prostatectomy versus watchful waiting in early prostate cancer. N Engl J Med 2011, 364:1708-1717.
    • (2011) N Engl J Med , vol.364 , pp. 1708-1717
    • Bill-Axelson, A.1    Holmberg, L.2    Ruutu, M.3
  • 2
    • 60149089419 scopus 로고    scopus 로고
    • Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion
    • Harris W.P., Mostaghel E.A., Nelson P.S., Montgomery B. Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion. Nat Clin Pract Urol 2009, 6:76-85.
    • (2009) Nat Clin Pract Urol , vol.6 , pp. 76-85
    • Harris, W.P.1    Mostaghel, E.A.2    Nelson, P.S.3    Montgomery, B.4
  • 3
    • 0034806356 scopus 로고    scopus 로고
    • Trends and patterns of prostate cancer: what do they suggest
    • Hsing A.W., Devesa S.S. Trends and patterns of prostate cancer: what do they suggest. Epidemiol Rev 2001, 12:3-13.
    • (2001) Epidemiol Rev , vol.12 , pp. 3-13
    • Hsing, A.W.1    Devesa, S.S.2
  • 4
    • 34250736334 scopus 로고    scopus 로고
    • Extended 21-sample needle biopsy protocol for diagnosis of prostate cancer in 1000 consecutive patients
    • Guichard G., Larré S., Gallina A., et al. Extended 21-sample needle biopsy protocol for diagnosis of prostate cancer in 1000 consecutive patients. Eur Urol 2007, 52:430-435.
    • (2007) Eur Urol , vol.52 , pp. 430-435
    • Guichard, G.1    Larré, S.2    Gallina, A.3
  • 5
    • 84861714168 scopus 로고    scopus 로고
    • Prostate cancer screening, yes or no? The current controversy
    • Razi A. Prostate cancer screening, yes or no? The current controversy. Urol J 2009, 1:240-245.
    • (2009) Urol J , vol.1 , pp. 240-245
    • Razi, A.1
  • 6
    • 63249122661 scopus 로고    scopus 로고
    • Mortality results from a randomized prostate-cancer screening trial
    • Andriole G.L., Grubb R.L., Buys S.S., et al. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med 2009, 360:1310-1319.
    • (2009) N Engl J Med , vol.360 , pp. 1310-1319
    • Andriole, G.L.1    Grubb, R.L.2    Buys, S.S.3
  • 7
    • 49049102974 scopus 로고    scopus 로고
    • Benefits and harms of prostate-specific antigen screening for prostate cancer: an evidence update for the US Preventive Services Task Force
    • Lin K., Lipsitz R., Miller T., Janakiraman S. Benefits and harms of prostate-specific antigen screening for prostate cancer: an evidence update for the US Preventive Services Task Force. Ann Intern Med 2008, 149:192.
    • (2008) Ann Intern Med , vol.149 , pp. 192
    • Lin, K.1    Lipsitz, R.2    Miller, T.3    Janakiraman, S.4
  • 8
    • 35148817305 scopus 로고    scopus 로고
    • Androgen deprivation therapy in the treatment of advanced prostate cancer
    • Perlmutter M.A., Lepor H. Androgen deprivation therapy in the treatment of advanced prostate cancer. Rev Urol 2007, 9:S1-S8.
    • (2007) Rev Urol , vol.9
    • Perlmutter, M.A.1    Lepor, H.2
  • 9
    • 77954942975 scopus 로고    scopus 로고
    • Duration of first off-treatment interval is prognostic for time to castration resistance and death in men with biochemical relapse of prostate cancer treated on a prospective trial of intermittent androgen deprivation
    • Evan Y.Y., Gulati R., Telesca D., et al. Duration of first off-treatment interval is prognostic for time to castration resistance and death in men with biochemical relapse of prostate cancer treated on a prospective trial of intermittent androgen deprivation. J Clin Oncol 2010, 28:2668-2673.
    • (2010) J Clin Oncol , vol.28 , pp. 2668-2673
    • Evan, Y.Y.1    Gulati, R.2    Telesca, D.3
  • 10
    • 20344408318 scopus 로고    scopus 로고
    • Future directions in the treatment of androgen-independent prostate cancer
    • Petrylak D.P. Future directions in the treatment of androgen-independent prostate cancer. Urology 2005, 65:8-12.
    • (2005) Urology , vol.65 , pp. 8-12
    • Petrylak, D.P.1
  • 11
    • 79961139550 scopus 로고    scopus 로고
    • TGF-beta/TGF-beta receptor system and its role in physiological and pathological conditions
    • Santibanez J.F., Quintanilla M., Bernabeu C. TGF-beta/TGF-beta receptor system and its role in physiological and pathological conditions. Clin Sci 2011, 121:233-251.
    • (2011) Clin Sci , vol.121 , pp. 233-251
    • Santibanez, J.F.1    Quintanilla, M.2    Bernabeu, C.3
  • 12
    • 22544448149 scopus 로고    scopus 로고
    • Should activin C be more than a fading snapshot in the activin/TGF family album
    • Butler C., Gold E., Risbridger G. Should activin C be more than a fading snapshot in the activin/TGF family album. Cytokine Growth Factor Rev 2005, 16:377-385.
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 377-385
    • Butler, C.1    Gold, E.2    Risbridger, G.3
  • 13
    • 0036965929 scopus 로고    scopus 로고
    • TGF- and the Smad signal transduction pathway
    • Mehra A., Wrana J.L. TGF- and the Smad signal transduction pathway. Biochem Cell Biol 2002, 80:605-622.
    • (2002) Biochem Cell Biol , vol.80 , pp. 605-622
    • Mehra, A.1    Wrana, J.L.2
  • 14
    • 0037040204 scopus 로고    scopus 로고
    • A nuclear antagonistic mechanism of inhibitory Smads in transforming growth factor-signaling
    • Bai S., Cao X. A nuclear antagonistic mechanism of inhibitory Smads in transforming growth factor-signaling. J Biol Chem 2002, 277:4176.
    • (2002) J Biol Chem , vol.277 , pp. 4176
    • Bai, S.1    Cao, X.2
  • 15
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg Robert A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg Robert, A.2
  • 16
    • 84861695148 scopus 로고    scopus 로고
    • Insensitivity to the growth inhibitory effects of activin A: an acquired capability in prostate cancer progression
    • Ottley E., Gold E. Insensitivity to the growth inhibitory effects of activin A: an acquired capability in prostate cancer progression. Cytokine Growth Factor Rev 2012, 23:119-125.
    • (2012) Cytokine Growth Factor Rev , vol.23 , pp. 119-125
    • Ottley, E.1    Gold, E.2
  • 17
    • 0035974474 scopus 로고    scopus 로고
    • The contribution of inhibins and activins to malignant prostate disease
    • Risbridger G., Mellor S., McPherson S., Schmitt J. The contribution of inhibins and activins to malignant prostate disease. Mol Cell Endocrinol 2001, 180:149-153.
    • (2001) Mol Cell Endocrinol , vol.180 , pp. 149-153
    • Risbridger, G.1    Mellor, S.2    McPherson, S.3    Schmitt, J.4
  • 18
    • 58249110402 scopus 로고    scopus 로고
    • Activin C antagonizes activin A in vitro and overexpression leads to pathologies in vivo
    • Gold E., Jetly N., O'Bryan M.K., et al. Activin C antagonizes activin A in vitro and overexpression leads to pathologies in vivo. Am J Pathol 2009, 174:184-195.
    • (2009) Am J Pathol , vol.174 , pp. 184-195
    • Gold, E.1    Jetly, N.2    O'Bryan, M.K.3
  • 19
    • 0030460696 scopus 로고    scopus 로고
    • Activin inhibition of prostate cancer cell growth: selective actions on androgen-responsive LNCaP cells
    • Dalkin A., Gilrain J., Bradshaw D., Myers C. Activin inhibition of prostate cancer cell growth: selective actions on androgen-responsive LNCaP cells. Endocrinology 1996, 137:5230-5235.
    • (1996) Endocrinology , vol.137 , pp. 5230-5235
    • Dalkin, A.1    Gilrain, J.2    Bradshaw, D.3    Myers, C.4
  • 20
    • 0030716244 scopus 로고    scopus 로고
    • Growth regulation of human prostate cancer cells by bone morphogenetic protein-2
    • Ide H., Yoshida T., Matsumoto N., et al. Growth regulation of human prostate cancer cells by bone morphogenetic protein-2. Cancer Res 1997, 57:5022-5027.
    • (1997) Cancer Res , vol.57 , pp. 5022-5027
    • Ide, H.1    Yoshida, T.2    Matsumoto, N.3
  • 21
    • 0033381357 scopus 로고    scopus 로고
    • The role for transforming growth factor-beta (TGF-beta) in human cancer
    • Gold L.I. The role for transforming growth factor-beta (TGF-beta) in human cancer. Crit Rev Oncog 1998, 10:303-360.
    • (1998) Crit Rev Oncog , vol.10 , pp. 303-360
    • Gold, L.I.1
  • 23
    • 84868615823 scopus 로고    scopus 로고
    • Differential role of Sloan-Kettering Institute (Ski) protein in nodal and transforming growth factor-beta (TGF-β)-induced Smad signaling in prostate cancer cells
    • Vo B.T., Cody B., Cao Y., Khan S.A. Differential role of Sloan-Kettering Institute (Ski) protein in nodal and transforming growth factor-beta (TGF-β)-induced Smad signaling in prostate cancer cells. Carcinogenesis 2012, 33:2054-2064.
    • (2012) Carcinogenesis , vol.33 , pp. 2054-2064
    • Vo, B.T.1    Cody, B.2    Cao, Y.3    Khan, S.A.4
  • 25
    • 84880921276 scopus 로고    scopus 로고
    • Adult-specific functions of animal microRNAs
    • Sun K., Lai E.C. Adult-specific functions of animal microRNAs. Nat Rev Genet 2013, 14:535-548.
    • (2013) Nat Rev Genet , vol.14 , pp. 535-548
    • Sun, K.1    Lai, E.C.2
  • 27
    • 84858056340 scopus 로고    scopus 로고
    • Recent updates on the role of microRNAs in prostate cancer
    • Hassan O., Ahmad A., Sethi S., Sarkar F.H. Recent updates on the role of microRNAs in prostate cancer. J Hematol Oncol 2012, 2012.
    • (2012) J Hematol Oncol , pp. 2012
    • Hassan, O.1    Ahmad, A.2    Sethi, S.3    Sarkar, F.H.4
  • 28
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee R.C., Feinbaum R.L., Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993, 75:843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 29
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    • Wightman B., Ha I., Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 1993, 75:855-862.
    • (1993) Cell , vol.75 , pp. 855-862
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 30
    • 0034708122 scopus 로고    scopus 로고
    • The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    • Reinhart B.J., Slack F.J., Basson M., et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 2000, 403:901-906.
    • (2000) Nature , vol.403 , pp. 901-906
    • Reinhart, B.J.1    Slack, F.J.2    Basson, M.3
  • 31
    • 79953249325 scopus 로고    scopus 로고
    • MicroRNA in prostate, bladder, and kidney cancer: a systematic review
    • Catto J.W.F., Alcaraz A., Bjartell A.S., et al. MicroRNA in prostate, bladder, and kidney cancer: a systematic review. Eur Urol 2011, 59:671-681.
    • (2011) Eur Urol , vol.59 , pp. 671-681
    • Catto, J.W.F.1    Alcaraz, A.2    Bjartell, A.S.3
  • 32
    • 18344369543 scopus 로고    scopus 로고
    • MicroRNA biogenesis: coordinated cropping and dicing
    • Kim V.N. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 2005, 6:376-385.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 376-385
    • Kim, V.N.1
  • 33
    • 34548607471 scopus 로고    scopus 로고
    • MicroRNA control of Nodal signalling
    • Martello G., Zacchigna L., Inui M., et al. MicroRNA control of Nodal signalling. Nature 2007, 449:183-188.
    • (2007) Nature , vol.449 , pp. 183-188
    • Martello, G.1    Zacchigna, L.2    Inui, M.3
  • 34
    • 84860488299 scopus 로고    scopus 로고
    • MiR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms
    • Senanayake U., Das S., Vesely P., et al. miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms. Carcinogenesis 2012, 33:1014-1021.
    • (2012) Carcinogenesis , vol.33 , pp. 1014-1021
    • Senanayake, U.1    Das, S.2    Vesely, P.3
  • 35
    • 38349146518 scopus 로고    scopus 로고
    • MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4
    • Wang Q., Huang Z., Xue H., et al. MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood 2008, 111:588-595.
    • (2008) Blood , vol.111 , pp. 588-595
    • Wang, Q.1    Huang, Z.2    Xue, H.3
  • 36
    • 84875170985 scopus 로고    scopus 로고
    • MicroRNA-181a Suppresses Mouse Granulosa Cell Proliferation by Targeting Activin Receptor IIA
    • Zhang Q., Sun H., Jiang Y., et al. MicroRNA-181a Suppresses Mouse Granulosa Cell Proliferation by Targeting Activin Receptor IIA. PloS ONE 2013, 8:e59667.
    • (2013) PloS ONE , vol.8
    • Zhang, Q.1    Sun, H.2    Jiang, Y.3
  • 37
    • 46449128469 scopus 로고    scopus 로고
    • SMAD proteins control DROSHA-mediated microRNA maturation
    • Davis B.N., Hilyard A.C., Lagna G., Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature 2008, 454:56-61.
    • (2008) Nature , vol.454 , pp. 56-61
    • Davis, B.N.1    Hilyard, A.C.2    Lagna, G.3    Hata, A.4
  • 38
    • 77955484492 scopus 로고    scopus 로고
    • Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha
    • Davis B.N., Hilyard A.C., Nguyen P.H., Lagna G., Hata A. Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha. Mol Cell 2010, 39:373-384.
    • (2010) Mol Cell , vol.39 , pp. 373-384
    • Davis, B.N.1    Hilyard, A.C.2    Nguyen, P.H.3    Lagna, G.4    Hata, A.5
  • 39
    • 79952227351 scopus 로고    scopus 로고
    • Smad-mediated miRNA processing: a critical role for a conserved RNA sequence
    • Davis-Dusenbery B.N., Hata A. Smad-mediated miRNA processing: a critical role for a conserved RNA sequence. RNA Biol 2011, 8:71-76.
    • (2011) RNA Biol , vol.8 , pp. 71-76
    • Davis-Dusenbery, B.N.1    Hata, A.2
  • 40
    • 84862758071 scopus 로고    scopus 로고
    • Smad-mediated regulation of microRNA biosynthesis
    • Blahna M.T., Hata A. Smad-mediated regulation of microRNA biosynthesis. FEBS Lett 2012, 586:1906-1912.
    • (2012) FEBS Lett , vol.586 , pp. 1906-1912
    • Blahna, M.T.1    Hata, A.2
  • 41
    • 78650653944 scopus 로고    scopus 로고
    • MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-β
    • Louafi F., Martinez-Nunez R.T., Sanchez-Elsner T. MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-β. J Biol Chem 2010, 285:41328-41336.
    • (2010) J Biol Chem , vol.285 , pp. 41328-41336
    • Louafi, F.1    Martinez-Nunez, R.T.2    Sanchez-Elsner, T.3
  • 42
    • 84880826932 scopus 로고    scopus 로고
    • MicroRNA-224 targets SMAD family member 4 to promote cell proliferation and negatively influence patient survival
    • Wang Y., Ren J., Gao Y., et al. MicroRNA-224 targets SMAD family member 4 to promote cell proliferation and negatively influence patient survival. PloS ONE 2013, 8:e68744.
    • (2013) PloS ONE , vol.8
    • Wang, Y.1    Ren, J.2    Gao, Y.3
  • 43
    • 84872035173 scopus 로고    scopus 로고
    • Downregulation and prognostic performance of microRNA 224 expression in prostate cancer
    • Mavridis K., Stravodimos K., Scorilas A. Downregulation and prognostic performance of microRNA 224 expression in prostate cancer. Clin Chem 2013, 59:261-269.
    • (2013) Clin Chem , vol.59 , pp. 261-269
    • Mavridis, K.1    Stravodimos, K.2    Scorilas, A.3
  • 44
    • 77249164641 scopus 로고    scopus 로고
    • MicroRNA-224 is involved in transforming growth factor-β-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4
    • Yao G., Yin M., Lian J., et al. MicroRNA-224 is involved in transforming growth factor-β-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4. Mol Endocrinol 2010, 24:540-551.
    • (2010) Mol Endocrinol , vol.24 , pp. 540-551
    • Yao, G.1    Yin, M.2    Lian, J.3
  • 45
    • 84860919248 scopus 로고    scopus 로고
    • A microRNA signature differentiates between giant cell tumor derived neoplastic stromal cells and mesenchymal stem cells
    • Fellenberg J., Saehr H., Lehner B., Depeweg D. A microRNA signature differentiates between giant cell tumor derived neoplastic stromal cells and mesenchymal stem cells. Cancer Lett 2012, 321:162-168.
    • (2012) Cancer Lett , vol.321 , pp. 162-168
    • Fellenberg, J.1    Saehr, H.2    Lehner, B.3    Depeweg, D.4
  • 46
    • 77955373730 scopus 로고    scopus 로고
    • MiR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis
    • Liu G., Friggeri A., Yang Y., et al. miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med 2010, 207:1589-1597.
    • (2010) J Exp Med , vol.207 , pp. 1589-1597
    • Liu, G.1    Friggeri, A.2    Yang, Y.3
  • 47
    • 58149213801 scopus 로고    scopus 로고
    • Non-Smad pathways in TGF-β signaling
    • Zhang Y.E. Non-Smad pathways in TGF-β signaling. Cell Res 2008, 19:128-139.
    • (2008) Cell Res , vol.19 , pp. 128-139
    • Zhang, Y.E.1
  • 49
    • 84862705487 scopus 로고    scopus 로고
    • Crosstalk between TGF-β signaling and the microRNA machinery
    • Butz H., Rácz K., Hunyady L., Patócs A. Crosstalk between TGF-β signaling and the microRNA machinery. Trends Pharmacol Sci 2012, 33:382-393.
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 382-393
    • Butz, H.1    Rácz, K.2    Hunyady, L.3    Patócs, A.4
  • 50
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-β signals
    • Moustakas A., Heldin C-H. Non-Smad TGF-β signals. J Cell Sci 2005, 118:3573-3584.
    • (2005) J Cell Sci , vol.118 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.-H.2
  • 51
    • 84891064090 scopus 로고    scopus 로고
    • Dissecting major signaling pathways throughout the development of prostate cancer
    • da Silva H.B., Amaral E.P., Nolasco E.L., et al. Dissecting major signaling pathways throughout the development of prostate cancer. Prostate Cancer 2013, 2013:1-23.
    • (2013) Prostate Cancer , vol.2013 , pp. 1-23
    • da Silva, H.B.1    Amaral, E.P.2    Nolasco, E.L.3
  • 52
    • 77955489850 scopus 로고    scopus 로고
    • Smads stimulate mirna processing
    • Treiber T., Meister G. Smads stimulate mirna processing. Mol Cell 2010, 39:315-316.
    • (2010) Mol Cell , vol.39 , pp. 315-316
    • Treiber, T.1    Meister, G.2
  • 53
    • 70649086975 scopus 로고    scopus 로고
    • Control of microRNA biogenesis by TGFβ signaling pathway-a novel role of Smads in the nucleus
    • Hata A., Davis B.N. Control of microRNA biogenesis by TGFβ signaling pathway-a novel role of Smads in the nucleus. Cytokine Growth Factor Rev 2009, 20:517-521.
    • (2009) Cytokine Growth Factor Rev , vol.20 , pp. 517-521
    • Hata, A.1    Davis, B.N.2
  • 54
    • 33646399160 scopus 로고    scopus 로고
    • Targeting the ERK signaling pathway in cancer therapy
    • Kohno M., Pouyssegur J. Targeting the ERK signaling pathway in cancer therapy. Ann Med 2006, 38:200-211.
    • (2006) Ann Med , vol.38 , pp. 200-211
    • Kohno, M.1    Pouyssegur, J.2
  • 55
    • 0034618369 scopus 로고    scopus 로고
    • MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-XL, and Mcl-1 and promotes survival of human pancreatic cancer cells
    • Boucher M-J., Morisset J., Vachon P.H., Reed J.C., Lainé J., Rivard N. MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-XL, and Mcl-1 and promotes survival of human pancreatic cancer cells. J Cell Biochem 2000, 79:355-369.
    • (2000) J Cell Biochem , vol.79 , pp. 355-369
    • Boucher, M.-J.1    Morisset, J.2    Vachon, P.H.3    Reed, J.C.4    Lainé, J.5    Rivard, N.6
  • 56
    • 22244467085 scopus 로고    scopus 로고
    • Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner
    • Krysan K., Reckamp K.L., Dalwadi H., et al. Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner. Cancer Res 2005, 65:6275-6281.
    • (2005) Cancer Res , vol.65 , pp. 6275-6281
    • Krysan, K.1    Reckamp, K.L.2    Dalwadi, H.3
  • 57
    • 0032819983 scopus 로고    scopus 로고
    • Activation of extracellular signal-regulated kinase in human prostate cancer
    • Price D.T., Rocca G.D., Guo C., Ballo M.S., Schwinn D.A., Luttrell L.M. Activation of extracellular signal-regulated kinase in human prostate cancer. J Urol 1999, 162:1537-1542.
    • (1999) J Urol , vol.162 , pp. 1537-1542
    • Price, D.T.1    Rocca, G.D.2    Guo, C.3    Ballo, M.S.4    Schwinn, D.A.5    Luttrell, L.M.6
  • 58
    • 0142059045 scopus 로고    scopus 로고
    • ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cells
    • Zelivianski S., Spellman M., Kellerman M., et al. ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cells. Int J Cancer 2003, 107:478-485.
    • (2003) Int J Cancer , vol.107 , pp. 478-485
    • Zelivianski, S.1    Spellman, M.2    Kellerman, M.3
  • 59
    • 51349111250 scopus 로고    scopus 로고
    • Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model
    • Kinkade C.W., Castillo-Martin M., Puzio-Kuter A., et al. Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model. J Clin Investig 2008, 118:3051.
    • (2008) J Clin Investig , vol.118 , pp. 3051
    • Kinkade, C.W.1    Castillo-Martin, M.2    Puzio-Kuter, A.3
  • 60
    • 0033229853 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17
    • Yoshida B.A., Dubauskas Z., Chekmareva M.A., Christiano T.R., Stadler W.M., Rinker-Schaeffer C.W. Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17. Cancer Res 1999, 59:5483-5487.
    • (1999) Cancer Res , vol.59 , pp. 5483-5487
    • Yoshida, B.A.1    Dubauskas, Z.2    Chekmareva, M.A.3    Christiano, T.R.4    Stadler, W.M.5    Rinker-Schaeffer, C.W.6
  • 61
    • 24944439828 scopus 로고    scopus 로고
    • Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3
    • Matsuura I., Wang G., He D., Liu F. Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3. Biochemistry 2005, 44:12546-12553.
    • (2005) Biochemistry , vol.44 , pp. 12546-12553
    • Matsuura, I.1    Wang, G.2    He, D.3    Liu, F.4
  • 62
    • 0033106484 scopus 로고    scopus 로고
    • A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras
    • Kretzschmar M., Doody J., Timokhina I., Massagué J. A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras. Genes Dev 1999, 13:804-816.
    • (1999) Genes Dev , vol.13 , pp. 804-816
    • Kretzschmar, M.1    Doody, J.2    Timokhina, I.3    Massagué, J.4
  • 63
    • 70449571904 scopus 로고    scopus 로고
    • MiR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice
    • Clapé C., Fritz V., Henriquet C., et al. miR-143 interferes with ERK5 signaling, and abrogates prostate cancer progression in mice. PloS ONE 2009, 4:e7542.
    • (2009) PloS ONE , vol.4
    • Clapé, C.1    Fritz, V.2    Henriquet, C.3
  • 64
    • 79951673289 scopus 로고    scopus 로고
    • ERK5 signalling in prostate cancer promotes an invasive phenotype
    • Ramsay A., McCracken S., Soofi M., et al. ERK5 signalling in prostate cancer promotes an invasive phenotype. Br J Cancer 2011, 104:664-672.
    • (2011) Br J Cancer , vol.104 , pp. 664-672
    • Ramsay, A.1    McCracken, S.2    Soofi, M.3
  • 65
    • 34247627509 scopus 로고    scopus 로고
    • Mitogenic growth signalling, DNA replication licensing, and survival are linked in prostate cancer
    • Dudderidge T., McCracken S., Loddo M., et al. Mitogenic growth signalling, DNA replication licensing, and survival are linked in prostate cancer. Br J Cancer 2007, 96:1384-1393.
    • (2007) Br J Cancer , vol.96 , pp. 1384-1393
    • Dudderidge, T.1    McCracken, S.2    Loddo, M.3
  • 66
    • 84872557347 scopus 로고    scopus 로고
    • Mir143 expression inversely correlates with nuclear ERK5 immunoreactivity in clinical prostate cancer
    • Ahmad I., Singh L., Yang Z., et al. Mir143 expression inversely correlates with nuclear ERK5 immunoreactivity in clinical prostate cancer. Br J Cancer 2013, 108:149-154.
    • (2013) Br J Cancer , vol.108 , pp. 149-154
    • Ahmad, I.1    Singh, L.2    Yang, Z.3
  • 68
    • 60149087720 scopus 로고    scopus 로고
    • MicroRNA profile analysis of human prostate cancers
    • Tong A., Fulgham P., Jay C., et al. MicroRNA profile analysis of human prostate cancers. Cancer Gene Ther 2009, 16:206-216.
    • (2009) Cancer Gene Ther , vol.16 , pp. 206-216
    • Tong, A.1    Fulgham, P.2    Jay, C.3
  • 69
    • 84864647706 scopus 로고    scopus 로고
    • Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling
    • Hough C., Radu M., Doré J.J. Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling. PLoS ONE 2012, 7:e42513.
    • (2012) PLoS ONE , vol.7
    • Hough, C.1    Radu, M.2    Doré, J.J.3
  • 70
    • 79953696225 scopus 로고    scopus 로고
    • MiR-143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS
    • Xu B., Niu X., Zhang X., et al. miR-143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS. Mol Cell Biochem 2011, 350:207-213.
    • (2011) Mol Cell Biochem , vol.350 , pp. 207-213
    • Xu, B.1    Niu, X.2    Zhang, X.3
  • 71
    • 5444248307 scopus 로고    scopus 로고
    • Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac
    • De Wever O., Nguyen Q-D., Van Hoorde L., et al. Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac. FASEB J 2004, 18:1016-1018.
    • (2004) FASEB J , vol.18 , pp. 1016-1018
    • De Wever, O.1    Nguyen, Q.-D.2    Van Hoorde, L.3
  • 72
    • 19944432271 scopus 로고    scopus 로고
    • Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo
    • Pillé J-Y., Denoyelle C., Varet J., et al. Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo. Mol Ther 2005, 11:267-274.
    • (2005) Mol Ther , vol.11 , pp. 267-274
    • Pillé, J.-Y.1    Denoyelle, C.2    Varet, J.3
  • 73
    • 3242699514 scopus 로고    scopus 로고
    • Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer
    • Kamai T., Yamanishi T., Shirataki H., et al. Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer. Clin Cancer Res 2004, 10:4799-4805.
    • (2004) Clin Cancer Res , vol.10 , pp. 4799-4805
    • Kamai, T.1    Yamanishi, T.2    Shirataki, H.3
  • 74
    • 0037444376 scopus 로고    scopus 로고
    • Requirement of RhoA activity for increased nuclear factor (B activity and PC-3 human prostate cancer cell invasion
    • Hodge J.C., Bub J., Kaul S., Kajdacsy-Balla A., Lindholm P.F. Requirement of RhoA activity for increased nuclear factor (B activity and PC-3 human prostate cancer cell invasion. Cancer Res 2003, 63:1359-1364.
    • (2003) Cancer Res , vol.63 , pp. 1359-1364
    • Hodge, J.C.1    Bub, J.2    Kaul, S.3    Kajdacsy-Balla, A.4    Lindholm, P.F.5
  • 75
    • 28844433954 scopus 로고    scopus 로고
    • Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells
    • Lee J., Lee I., Park C., Kang W.K. Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells. Biochem Biophys Res Commun 2006, 339:748-754.
    • (2006) Biochem Biophys Res Commun , vol.339 , pp. 748-754
    • Lee, J.1    Lee, I.2    Park, C.3    Kang, W.K.4
  • 76
    • 0036569943 scopus 로고    scopus 로고
    • RhoA-dependent murine prostate cancer cell proliferation and apoptosis role of protein kinase Cζ
    • Ghosh P.M., Bedolla R., Mikhailova M., Kreisberg J.I. RhoA-dependent murine prostate cancer cell proliferation and apoptosis role of protein kinase Cζ. Cancer Res 2002, 62:2630-2636.
    • (2002) Cancer Res , vol.62 , pp. 2630-2636
    • Ghosh, P.M.1    Bedolla, R.2    Mikhailova, M.3    Kreisberg, J.I.4
  • 77
    • 0043172396 scopus 로고    scopus 로고
    • Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis
    • Grünert S., Jechlinger M., Beug H. Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nat Rev Mol Cell Biol 2003, 4:657-665.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 657-665
    • Grünert, S.1    Jechlinger, M.2    Beug, H.3
  • 78
    • 55849123946 scopus 로고    scopus 로고
    • MicroRNA-155 is regulated by the transforming growth factor β/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA
    • Kong W., Yang H., He L., et al. MicroRNA-155 is regulated by the transforming growth factor β/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol 2008, 28:6773-6784.
    • (2008) Mol Cell Biol , vol.28 , pp. 6773-6784
    • Kong, W.1    Yang, H.2    He, L.3
  • 79
    • 2342436038 scopus 로고    scopus 로고
    • Smad7 is required for TGF-β-induced activation of the small GTPase Cdc42
    • Edlund S., Landström M., Heldin C-H., Aspenström P. Smad7 is required for TGF-β-induced activation of the small GTPase Cdc42. J Cell Sci 2004, 117:1835-1847.
    • (2004) J Cell Sci , vol.117 , pp. 1835-1847
    • Edlund, S.1    Landström, M.2    Heldin, C.-H.3    Aspenström, P.4
  • 80
    • 65349132693 scopus 로고    scopus 로고
    • EMT, the cytoskeleton, and cancer cell invasion
    • Yilmaz M., Christofori G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev 2009, 28:15-33.
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 15-33
    • Yilmaz, M.1    Christofori, G.2
  • 82
    • 19944427667 scopus 로고    scopus 로고
    • Antibody-based profiling of the phosphoinositide 3-kinase pathway in clinical prostate cancer
    • Thomas G.V., Horvath S., Smith B.L., et al. Antibody-based profiling of the phosphoinositide 3-kinase pathway in clinical prostate cancer. Clin Cancer Res 2004, 10:8351-8356.
    • (2004) Clin Cancer Res , vol.10 , pp. 8351-8356
    • Thomas, G.V.1    Horvath, S.2    Smith, B.L.3
  • 83
    • 5144228549 scopus 로고    scopus 로고
    • High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence
    • Ayala G., Thompson T., Yang G., et al. High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence. Clin Cancer Res 2004, 10:6572-6578.
    • (2004) Clin Cancer Res , vol.10 , pp. 6572-6578
    • Ayala, G.1    Thompson, T.2    Yang, G.3
  • 84
    • 70349459742 scopus 로고    scopus 로고
    • MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation
    • Lee K-H., Chen Y-L., Yeh S., et al. MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation. Oncogene 2009, 28:3360-3370.
    • (2009) Oncogene , vol.28 , pp. 3360-3370
    • Lee, K.-H.1    Chen, Y.-L.2    Yeh, S.3
  • 85
    • 25444520537 scopus 로고    scopus 로고
    • MiR-15 and miR-16 induce apoptosis by targeting BCL2
    • Cimmino A., Calin G.A., Fabbri M., et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 2005, 102:13944-13949.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 13944-13949
    • Cimmino, A.1    Calin, G.A.2    Fabbri, M.3
  • 86
    • 51049123624 scopus 로고    scopus 로고
    • Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer
    • Ambs S., Prueitt R.L., Yi M., et al. Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer Res 2008, 68:6162-6170.
    • (2008) Cancer Res , vol.68 , pp. 6162-6170
    • Ambs, S.1    Prueitt, R.L.2    Yi, M.3
  • 87
    • 84984585952 scopus 로고    scopus 로고
    • Synergistic interactions between sorafenib and bortezomib in hepatocellular carcinoma involve PP2A-dependent Akt inactivation
    • Chen K-F., Yu H-C., Liu T-H., Lee S-S., Chen P-J., Cheng A-L. Synergistic interactions between sorafenib and bortezomib in hepatocellular carcinoma involve PP2A-dependent Akt inactivation. J Hepatol 2010, 52:88-95.
    • (2010) J Hepatol , vol.52 , pp. 88-95
    • Chen, K.-F.1    Yu, H.-C.2    Liu, T.-H.3    Lee, S.-S.4    Chen, P.-J.5    Cheng, A.-L.6
  • 88
    • 27844601539 scopus 로고    scopus 로고
    • Regulation of the Akt kinase by interacting proteins
    • Du K., Tsichlis P.N. Regulation of the Akt kinase by interacting proteins. Oncogene 2005, 24:7401-7409.
    • (2005) Oncogene , vol.24 , pp. 7401-7409
    • Du, K.1    Tsichlis, P.N.2
  • 89
    • 79955519053 scopus 로고    scopus 로고
    • Overexpression of miR-200c induces chemoresistance in esophageal cancers mediated through activation of the Akt signaling pathway
    • Hamano R., Miyata H., Yamasaki M., et al. Overexpression of miR-200c induces chemoresistance in esophageal cancers mediated through activation of the Akt signaling pathway. Clin Cancer Res 2011, 17:3029-3038.
    • (2011) Clin Cancer Res , vol.17 , pp. 3029-3038
    • Hamano, R.1    Miyata, H.2    Yamasaki, M.3
  • 90
    • 80054774985 scopus 로고    scopus 로고
    • Epigenetic silencing of microRNA-375 regulates PDK1 expression in esophageal cancer
    • Li X., Lin R., Li J. Epigenetic silencing of microRNA-375 regulates PDK1 expression in esophageal cancer. Dig Dis Sci 2011, 56:2849-2856.
    • (2011) Dig Dis Sci , vol.56 , pp. 2849-2856
    • Li, X.1    Lin, R.2    Li, J.3
  • 91
    • 84868474396 scopus 로고    scopus 로고
    • MicroRNA-350 induces pathological heart hypertrophy by repressing both p38 and JNK pathways
    • Ge Y., Pan S., Guan D., et al. MicroRNA-350 induces pathological heart hypertrophy by repressing both p38 and JNK pathways. Biochim Biophys Acta 2012, 1-10.
    • (2012) Biochim Biophys Acta , pp. 1-10
    • Ge, Y.1    Pan, S.2    Guan, D.3
  • 92
    • 84874547217 scopus 로고    scopus 로고
    • MicroRNA-204-5p regulates epithelial-to-mesenchymal transition during human posterior capsule opacification by targeting SMAD4
    • Wang Y., Li W., Zang X., et al. MicroRNA-204-5p regulates epithelial-to-mesenchymal transition during human posterior capsule opacification by targeting SMAD4. Invest Ophthalmol Vis Sci 2013, 54:323-332.
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , pp. 323-332
    • Wang, Y.1    Li, W.2    Zang, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.