메뉴 건너뛰기




Volumn 34, Issue 9, 2014, Pages 1719-1727

Ocular pharmacology of topotecan and its activity in retinoblastoma

Author keywords

Camptothecins; Ocular pharmacokinetics; Retinoblastoma; Topotecan; Vitreous

Indexed keywords

CAMPTOTHECIN; CARBOPLATIN; MELPHALAN; TOPOTECAN; VINCRISTINE; ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE INHIBITOR;

EID: 84906937368     PISSN: 0275004X     EISSN: 15392864     Source Type: Journal    
DOI: 10.1097/IAE.0000000000000253     Document Type: Review
Times cited : (36)

References (61)
  • 1
    • 78149480585 scopus 로고    scopus 로고
    • Survival of retinoblastoma in less-developed countries impact of socioeconomic and health-related indicators
    • Canturk S, et al. Survival of retinoblastoma in less-developed countries impact of socioeconomic and health-related indicators. Br J Ophthalmol 2010;94:1432-1436.
    • (2010) Br J Ophthalmol , vol.94 , pp. 1432-1436
    • Canturk, S.1
  • 2
    • 0029958535 scopus 로고    scopus 로고
    • Results of combined chemotherapy and radiotherapy for advanced intraocular retinoblastoma
    • Kingston JE, et al. Results of combined chemotherapy and radiotherapy for advanced intraocular retinoblastoma. Arch Ophthalmol 1996;114:1339-1343.
    • (1996) Arch Ophthalmol , vol.114 , pp. 1339-1343
    • Kingston, J.E.1
  • 3
    • 77951298209 scopus 로고    scopus 로고
    • Retinoblastoma management: Advances in enucleation, intravenous chemoreduction, and intra-arterial chemotherapy
    • Shields CL, Shields JA. Retinoblastoma management: advances in enucleation, intravenous chemoreduction, and intra-arterial chemotherapy. Curr Opin Ophthalmol 2010;21:203-212.
    • (2010) Curr Opin Ophthalmol , vol.21 , pp. 203-212
    • Shields, C.L.1    Shields, J.A.2
  • 4
    • 61349184336 scopus 로고    scopus 로고
    • Chemoreduction for group e retinoblastoma: Comparison of chemoreduction alone versus chemoreduction plus low-dose external radiotherapy in 76 eyes
    • Shields CL, et al. Chemoreduction for group E retinoblastoma: comparison of chemoreduction alone versus chemoreduction plus low-dose external radiotherapy in 76 eyes. Ophthalmology 2009;116:544-551 e1.
    • (2009) Ophthalmology , vol.116
    • Shields, C.L.1
  • 5
    • 53149125658 scopus 로고    scopus 로고
    • Tandem high-dose chemotherapy and autologous stem cell rescue in children with bilateral advanced retinoblastoma
    • Lee SH, et al. Tandem high-dose chemotherapy and autologous stem cell rescue in children with bilateral advanced retinoblastoma. Bone Marrow Transplant 2008;42:385-391.
    • (2008) Bone Marrow Transplant , vol.42 , pp. 385-391
    • Lee, S.H.1
  • 6
    • 63949084823 scopus 로고    scopus 로고
    • Recent perspectives in ocular drug delivery
    • Gaudana R, et al. Recent perspectives in ocular drug delivery. Pharm Res 2009;26:1197-1216.
    • (2009) Pharm Res , vol.26 , pp. 1197-1216
    • Gaudana, R.1
  • 7
    • 0028905290 scopus 로고
    • Etoposide and carboplatin in extraocular retinoblastoma: A study by the Societe Francaise d'Oncologie Pediatrique
    • Doz F, et al. Etoposide and carboplatin in extraocular retinoblastoma: a study by the Societe Francaise d'Oncologie Pediatrique. J Clin Oncol 1995;13:902-909.
    • (1995) J Clin Oncol , vol.13 , pp. 902-909
    • Doz, F.1
  • 8
    • 0033000684 scopus 로고    scopus 로고
    • Phase II window of idarubicin in children with extraocular retinoblastoma
    • Chantada GL, et al. Phase II window of idarubicin in children with extraocular retinoblastoma. J Clin Oncol 1999;17:1847-1850.
    • (1999) J Clin Oncol , vol.17 , pp. 1847-1850
    • Chantada, G.L.1
  • 9
    • 85081474871 scopus 로고    scopus 로고
    • Intra-arterial chemotherapy for retinoblastoma. Challenges of a Prospective Study
    • In press
    • Parareda A, et al. Intra-arterial chemotherapy for retinoblastoma. Challenges of a Prospective Study. Acta Ophthalmol 2013. In press.
    • (2013) Acta Ophthalmol
    • Parareda, A.1
  • 10
    • 0035575934 scopus 로고    scopus 로고
    • Histopathologic features of retinoblastoma and its relation with in vitro drug resistance measured by means of the MTT assay
    • Schouten-van Meeteren AY, et al. Histopathologic features of retinoblastoma and its relation with in vitro drug resistance measured by means of the MTT assay. Cancer 2001; 92: 2933-2940.
    • (2001) Cancer , vol.92 , pp. 2933-2940
    • Schouten-Van Meeteren, A.Y.1
  • 11
    • 10744229250 scopus 로고    scopus 로고
    • High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells
    • Barrie SE, et al. High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells. Anal Biochem 2003;320:66-74.
    • (2003) Anal Biochem , vol.320 , pp. 66-74
    • Barrie, S.E.1
  • 12
    • 67650311598 scopus 로고    scopus 로고
    • Characterization of the ATP-binding cassette transporter gene expression profile in Y79: A retinoblastoma cell line
    • Hendig D, et al. Characterization of the ATP-binding cassette transporter gene expression profile in Y79: a retinoblastoma cell line. Mol Cell Biochem 2009;328:85-92.
    • (2009) Mol Cell Biochem , vol.328 , pp. 85-92
    • Hendig, D.1
  • 13
    • 34648846580 scopus 로고    scopus 로고
    • Paclitaxel in the treatment of retinal tumors of LH beta-Tag murine transgenic model of retinoblastoma
    • Suarez F, et al. Paclitaxel in the treatment of retinal tumors of LH beta-Tag murine transgenic model of retinoblastoma. Invest Ophthalmol Vis Sci 2007;48:3437-3440.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 3437-3440
    • Suarez, F.1
  • 14
    • 84859941115 scopus 로고    scopus 로고
    • Retinoblastoma treatment: Utilization of the glycolytic inhibitor, 2-deoxy-2-fluoro-D-glucose (2-FG), to target the chemoresistant hypoxic regions in LH(BETA)T(AG) retinal tumors
    • Pina Y, et al. Retinoblastoma treatment: utilization of the glycolytic inhibitor, 2-deoxy-2-fluoro-D-glucose (2-FG), to target the chemoresistant hypoxic regions in LH(BETA)T(AG) retinal tumors. Invest Ophthalmol Vis Sci 2012;53:996-1002.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 996-1002
    • Pina, Y.1
  • 15
    • 27644469013 scopus 로고    scopus 로고
    • Use of preclinical models to improve treatment of retinoblastoma
    • Dyer MA, Rodriguez-Galindo C, Wilson MW. Use of preclinical models to improve treatment of retinoblastoma. PLos Med 2005;2:e332.
    • (2005) PLos Med , vol.2
    • Dyer, M.A.1    Rodriguez-Galindo, C.2    Wilson, M.W.3
  • 16
    • 0036300477 scopus 로고    scopus 로고
    • Factors predictive of recurrence of retinal tumors, vitreous seeds, and subretinal seeds following chemoreduction for retinoblastoma
    • Shields CL, et al. Factors predictive of recurrence of retinal tumors, vitreous seeds, and subretinal seeds following chemoreduction for retinoblastoma. Arch Ophthalmol 2002;120:460-464.
    • (2002) Arch Ophthalmol , vol.120 , pp. 460-464
    • Shields, C.L.1
  • 17
    • 67650996035 scopus 로고    scopus 로고
    • Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid
    • Shen J, et al. Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid. Cancer Res 2009;69:5885-5892.
    • (2009) Cancer Res , vol.69 , pp. 5885-5892
    • Shen, J.1
  • 18
    • 18744402164 scopus 로고    scopus 로고
    • Phase i clinical trial of intrathecal topotecan in patients with neoplastic meningitis
    • Blaney SM, et al. Phase I clinical trial of intrathecal topotecan in patients with neoplastic meningitis. J Clin Oncol 2003;21:143-147.
    • (2003) J Clin Oncol , vol.21 , pp. 143-147
    • Blaney, S.M.1
  • 19
    • 70350676961 scopus 로고    scopus 로고
    • Retinoblastoma CSF metastasis cured by multimodality chemotherapy without radiation
    • Dimaras H, et al. Retinoblastoma CSF metastasis cured by multimodality chemotherapy without radiation. Ophthalmic Genet 2009;30:121-126.
    • (2009) Ophthalmic Genet , vol.30 , pp. 121-126
    • Dimaras, H.1
  • 20
    • 0031759531 scopus 로고    scopus 로고
    • Topotecan in pediatric patients with recurrent and progressive solid tumors: A Pediatric Oncology Group Phase II Study
    • Nitschke R, et al. Topotecan in pediatric patients with recurrent and progressive solid tumors: a Pediatric Oncology Group Phase II Study. J Pediatr Hematol Oncol 1998;20:315-318.
    • (1998) J Pediatr Hematol Oncol , vol.20 , pp. 315-318
    • Nitschke, R.1
  • 21
    • 0033391318 scopus 로고    scopus 로고
    • Phase i study of topotecan administered as a 21-day continous infusion in children with recurrent solid tumors: A report from the Children's Cancer Group
    • Frangoul H, et al. Phase I study of topotecan administered as a 21-day continous infusion in children with recurrent solid tumors: a report from the Children's Cancer Group. Clin Cancer Res 1999;5:3956-3962.
    • (1999) Clin Cancer Res , vol.5 , pp. 3956-3962
    • Frangoul, H.1
  • 22
    • 1942518815 scopus 로고    scopus 로고
    • Activity of topotecan in retinoblastoma
    • Chantada GL, et al. Activity of topotecan in retinoblastoma. Ophthalmic Genet 2004;25:37-43.
    • (2004) Ophthalmic Genet , vol.25 , pp. 37-43
    • Chantada, G.L.1
  • 23
    • 27144450572 scopus 로고    scopus 로고
    • Topotecan combination chemotherapy in two new rodent models of retinoblastoma
    • Laurie NA, et al. Topotecan combination chemotherapy in two new rodent models of retinoblastoma. Clin Cancer Res 2005; 11:7569-7578.
    • (2005) Clin Cancer Res , vol.11 , pp. 7569-7578
    • Laurie, N.A.1
  • 24
    • 0036140067 scopus 로고    scopus 로고
    • Phase i study of combination topotecan and carboplatin in pediatric solid tumors
    • Athale UH, et al. Phase I study of combination topotecan and carboplatin in pediatric solid tumors. J Clin Oncol 2002;20:88-95.
    • (2002) J Clin Oncol , vol.20 , pp. 88-95
    • Athale, U.H.1
  • 25
    • 78650972381 scopus 로고    scopus 로고
    • Subconjunctival carboplatin and systemic topotecan treatment in preclinical models of retinoblastoma
    • Nemeth KM, et al. Subconjunctival carboplatin and systemic topotecan treatment in preclinical models of retinoblastoma. Cancer 2011;117:421-434.
    • (2011) Cancer , vol.117 , pp. 421-434
    • Nemeth, K.M.1
  • 26
    • 84868200289 scopus 로고    scopus 로고
    • Topotecan and vincristine combination is effective against advanced bilateral intraocular retinoblastoma and has manageable toxicity
    • Qaddoumi I, et al. Topotecan and vincristine combination is effective against advanced bilateral intraocular retinoblastoma and has manageable toxicity. Cancer 2012;118:5663-5670.
    • (2012) Cancer , vol.118 , pp. 5663-5670
    • Qaddoumi, I.1
  • 27
    • 40749102939 scopus 로고    scopus 로고
    • Using pharmacokinetic and pharmacodynamic modeling and simulation to evaluate importance of schedule in topotecan therapy for pediatric neuroblastoma
    • Panetta JC, et al. Using pharmacokinetic and pharmacodynamic modeling and simulation to evaluate importance of schedule in topotecan therapy for pediatric neuroblastoma. Clin Cancer Res 2008;14:318-325.
    • (2008) Clin Cancer Res , vol.14 , pp. 318-325
    • Panetta, J.C.1
  • 28
    • 0037316914 scopus 로고    scopus 로고
    • A pilot study of protracted topotecan dosing using a pharmacokinetically guided dosing approach in children with solid tumors
    • Santana VM, et al. A pilot study of protracted topotecan dosing using a pharmacokinetically guided dosing approach in children with solid tumors. Clin Cancer Res 2003;9:633-640.
    • (2003) Clin Cancer Res , vol.9 , pp. 633-640
    • Santana, V.M.1
  • 29
    • 84874971861 scopus 로고    scopus 로고
    • Intra-arterial chemotherapy is more effective than sequential periocular and intravenous chemotherapy as salvage treatment for relapsed retinoblastoma
    • Schaiquevich P, et al. Intra-arterial chemotherapy is more effective than sequential periocular and intravenous chemotherapy as salvage treatment for relapsed retinoblastoma. Pediatr Blood Cancer 2013;60:766-770.
    • (2013) Pediatr Blood Cancer , vol.60 , pp. 766-770
    • Schaiquevich, P.1
  • 30
    • 84882594794 scopus 로고    scopus 로고
    • Carboplatin +/-topotecan ophthalmic artery chemosurgery for intraocular retinoblastoma
    • Francis JH, et al. Carboplatin +/-topotecan ophthalmic artery chemosurgery for intraocular retinoblastoma. PLoS One 2013; 8:e72441.
    • (2013) PLoS One , vol.8
    • Francis, J.H.1
  • 31
    • 79958694863 scopus 로고    scopus 로고
    • Intra-arterial chemotherapy for the management of retinoblastoma: Four-year experience
    • Gobin YP, et al. Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience. Arch Ophthalmol 2011;129:732-737.
    • (2011) Arch Ophthalmol , vol.129 , pp. 732-737
    • Gobin, Y.P.1
  • 32
    • 84866274933 scopus 로고    scopus 로고
    • Pharmacokinetic analysis of melphalan after superselective ophthalmic artery infusion in preclinical models and retinoblastoma patients
    • Schaiquevich P, et al. Pharmacokinetic analysis of melphalan after superselective ophthalmic artery infusion in preclinical models and retinoblastoma patients. Invest Ophthalmol Vis Sci 2012;53:4205-4212.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 4205-4212
    • Schaiquevich, P.1
  • 33
    • 79958811171 scopus 로고    scopus 로고
    • Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3a
    • Brennan RC, et al. Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3a. Cancer Res 2011;71: 4205-4213.
    • (2011) Cancer Res , vol.71 , pp. 4205-4213
    • Brennan, R.C.1
  • 34
    • 84857716538 scopus 로고    scopus 로고
    • Topotecan hydrochloride effects on retinal vessels in newborn rats
    • Pescosolido N, et al. Topotecan hydrochloride effects on retinal vessels in newborn rats. Histol Histopathol 2012;27:497-506.
    • (2012) Histol Histopathol , vol.27 , pp. 497-506
    • Pescosolido, N.1
  • 35
    • 78650463600 scopus 로고    scopus 로고
    • Camptothecin induces apoptosis of human retinoblastoma cells via activation of FOXO1
    • Han S, Wei W. Camptothecin induces apoptosis of human retinoblastoma cells via activation of FOXO1. Curr Eye Res 2011;36:71-77.
    • (2011) Curr Eye Res , vol.36 , pp. 71-77
    • Han, S.1    Wei, W.2
  • 36
    • 0031802434 scopus 로고    scopus 로고
    • Induction of apoptosis in human retinoblastoma cells by topoisomerase inhibitors
    • Giuliano M, et al. Induction of apoptosis in human retinoblastoma cells by topoisomerase inhibitors. Invest Ophthalmol Vis Sci 1998;39:1300-1311.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 1300-1311
    • Giuliano, M.1
  • 37
    • 84890074282 scopus 로고    scopus 로고
    • In vitro moxifloxacin drug interaction with chemotherapeutics: Implications for retinoblastoma management
    • Barot M, et al. In vitro moxifloxacin drug interaction with chemotherapeutics: implications for retinoblastoma management. Exp Eye Res 2014;118:61-71.
    • (2014) Exp Eye Res , vol.118 , pp. 61-71
    • Barot, M.1
  • 38
    • 77953261239 scopus 로고    scopus 로고
    • Intensive multimodality therapy for patients with stage 4a metastatic retinoblastoma
    • Dunkel IJ, et al. Intensive multimodality therapy for patients with stage 4a metastatic retinoblastoma. Pediatr Blood Cancer 2010;55:55-59.
    • (2010) Pediatr Blood Cancer , vol.55 , pp. 55-59
    • Dunkel, I.J.1
  • 39
    • 0029912057 scopus 로고    scopus 로고
    • Penetration of chemotherapy into vitreous is increased by cryotherapy and cyclosporine in rabbits
    • Wilson TW, et al. Penetration of chemotherapy into vitreous is increased by cryotherapy and cyclosporine in rabbits. Arch Ophthalmol 1996;114:1390-1395.
    • (1996) Arch Ophthalmol , vol.114 , pp. 1390-1395
    • Wilson, T.W.1
  • 40
    • 85047174354 scopus 로고    scopus 로고
    • Periocular chemotherapy for retinoblastoma: Success with problems
    • author reply 129
    • Abramson DH. Periocular chemotherapy for retinoblastoma: success with problems Arch Ophthalmol 2005;123:128-129; author reply 129.
    • (2005) Arch Ophthalmol , vol.123 , pp. 128-129
    • Abramson, D.H.1
  • 41
    • 0032449410 scopus 로고    scopus 로고
    • Intraocular concentrations of chemotherapeutic agents after systemic or local administration
    • Mendelsohn ME, et al. Intraocular concentrations of chemotherapeutic agents after systemic or local administration. Arch Ophthalmol 1998;116:1209-1212.
    • (1998) Arch Ophthalmol , vol.116 , pp. 1209-1212
    • Mendelsohn, M.E.1
  • 42
    • 34447556254 scopus 로고    scopus 로고
    • Topotecan vitreous levels after periocular or intravenous delivery in rabbits: An alternative for retinoblastoma chemotherapy
    • Carcaboso AM, et al. Topotecan vitreous levels after periocular or intravenous delivery in rabbits: an alternative for retinoblastoma chemotherapy. Invest Ophthalmol Vis Sci 2007;48:3761-3767.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 3761-3767
    • Carcaboso, A.M.1
  • 43
    • 64049093382 scopus 로고    scopus 로고
    • A phase i study of periocular topotecan in children with intraocular retinoblastoma
    • Chantada GL, et al. A phase I study of periocular topotecan in children with intraocular retinoblastoma. Invest Ophthalmol Vis Sci 2009;50:1492-1496.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 1492-1496
    • Chantada, G.L.1
  • 45
    • 77951218267 scopus 로고    scopus 로고
    • Episcleral implants for topotecan delivery to the posterior segment of the eye
    • Carcaboso AM, et al. Episcleral implants for topotecan delivery to the posterior segment of the eye. Invest Ophthalmol Vis Sci 2010;51:2126-2134.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 2126-2134
    • Carcaboso, A.M.1
  • 46
    • 40649113410 scopus 로고    scopus 로고
    • Subconjunctival topotecan in fibrin sealant in the treatment of transgenic murine retinoblastoma
    • Tsui JY, et al. Subconjunctival topotecan in fibrin sealant in the treatment of transgenic murine retinoblastoma. Invest Ophthalmol Vis Sci 2008;49:490-496.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 490-496
    • Tsui, J.Y.1
  • 47
    • 20144377752 scopus 로고    scopus 로고
    • Subconjunctival carboplatin in fibrin sealant in the treatment of transgenic murine retinoblastoma
    • Van Quill KR, et al. Subconjunctival carboplatin in fibrin sealant in the treatment of transgenic murine retinoblastoma. Ophthalmology 2005;112:1151-1158.
    • (2005) Ophthalmology , vol.112 , pp. 1151-1158
    • Van Quill, K.R.1
  • 48
    • 77952419959 scopus 로고    scopus 로고
    • Fibrin sealant: Past, present, and future: A brief review
    • Spotnitz WD. Fibrin sealant: past, present, and future: a brief review. World J Surg 2010;34:632-634.
    • (2010) World J Surg , vol.34 , pp. 632-634
    • Spotnitz, W.D.1
  • 49
    • 79958762360 scopus 로고    scopus 로고
    • Periocular topotecan for intraocular retinoblastoma
    • Mallipatna AC, et al. Periocular topotecan for intraocular retinoblastoma. Arch Ophthalmol 2011;129:738-745.
    • (2011) Arch Ophthalmol , vol.129 , pp. 738-745
    • Mallipatna, A.C.1
  • 50
    • 84896796725 scopus 로고    scopus 로고
    • No ocular motility complications after subtenon topotecan with fibrin sealant for retinoblastoma
    • Yousef YA, et al. No ocular motility complications after subtenon topotecan with fibrin sealant for retinoblastoma. Can J Ophthalmol 2013;48:524-528.
    • (2013) Can J Ophthalmol , vol.48 , pp. 524-528
    • Yousef, Y.A.1
  • 51
    • 84864831608 scopus 로고    scopus 로고
    • Intravitreal chemotherapy for vitreous disease in retinoblastoma revisited: From prohibition to conditional indications
    • Munier FL, et al. Intravitreal chemotherapy for vitreous disease in retinoblastoma revisited: from prohibition to conditional indications. Br J Ophthalmol 2012;96:1078-1083.
    • (2012) Br J Ophthalmol , vol.96 , pp. 1078-1083
    • Munier, F.L.1
  • 52
    • 79955022978 scopus 로고    scopus 로고
    • Ophthalmic drug delivery systems for the treatment of retinal diseases: Basic research to clinical applications
    • Edelhauser HF, et al. Ophthalmic drug delivery systems for the treatment of retinal diseases: basic research to clinical applications. Invest Ophthalmol Vis Sci 2010;51:5403-5420.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 5403-5420
    • Edelhauser, H.F.1
  • 53
    • 77953361130 scopus 로고    scopus 로고
    • Pharmacokinetic analysis of topotecan after intra-vitreal injection. Implications for retinoblastoma treatment
    • Buitrago E, et al. Pharmacokinetic analysis of topotecan after intra-vitreal injection. Implications for retinoblastoma treatment. Exp Eye Res 2010;91:9-14.
    • (2010) Exp Eye Res , vol.91 , pp. 9-14
    • Buitrago, E.1
  • 54
    • 84872028310 scopus 로고    scopus 로고
    • Topotecan vitreous and plasma levels and retinal toxicity after transcorneal intravitreal delivery in healthy albino rabbits: Alternative retinoblastoma treatment
    • Darsova D, et al. Topotecan vitreous and plasma levels and retinal toxicity after transcorneal intravitreal delivery in healthy albino rabbits: alternative retinoblastoma treatment. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2012; 156:318-323.
    • (2012) Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub , vol.156 , pp. 318-323
    • Darsova, D.1
  • 55
    • 84873303364 scopus 로고    scopus 로고
    • Ocular and systemic toxicity of intravitreal topotecan in rabbits for potential treatment of retinoblastoma
    • Buitrago E, et al. Ocular and systemic toxicity of intravitreal topotecan in rabbits for potential treatment of retinoblastoma. Exp Eye Res 2013;108:103-109.
    • (2013) Exp Eye Res , vol.108 , pp. 103-109
    • Buitrago, E.1
  • 56
    • 80052273857 scopus 로고    scopus 로고
    • Development of topotecan loaded lipid nanoparticles for chemical stabilization and prolonged release
    • Souza LG, et al. Development of topotecan loaded lipid nanoparticles for chemical stabilization and prolonged release. Eur J Pharm Biopharm 2011;79:189-196.
    • (2011) Eur J Pharm Biopharm , vol.79 , pp. 189-196
    • Souza, L.G.1
  • 57
    • 84861586236 scopus 로고    scopus 로고
    • Multifunctionalized mesoporous silica nanoparticles for the in vitro treatment of retinoblastoma: Drug delivery, one and two-photon photodynamic therapy
    • Gary-Bobo M, et al. Multifunctionalized mesoporous silica nanoparticles for the in vitro treatment of retinoblastoma: drug delivery, one and two-photon photodynamic therapy. Int J Pharm 2012;432:99-104.
    • (2012) Int J Pharm , vol.432 , pp. 99-104
    • Gary-Bobo, M.1
  • 58
    • 84856591867 scopus 로고    scopus 로고
    • Pharmacokinetic analysis of topotecan after superselective ophthalmic artery infusion and periocular administration in a porcine model
    • Schaiquevich P, et al. Pharmacokinetic analysis of topotecan after superselective ophthalmic artery infusion and periocular administration in a porcine model. Retina 2012;32: 387-395.
    • (2012) Retina , vol.32 , pp. 387-395
    • Schaiquevich, P.1
  • 59
    • 84906934832 scopus 로고    scopus 로고
    • Electroretinogram monitoring of dosedependent toxicity after ophthalmic artery chemosurgery in retinoblastoma eyes: Six year review
    • Francis JH, et al. Electroretinogram monitoring of dosedependent toxicity after ophthalmic artery chemosurgery in retinoblastoma eyes: six year review. PLoS One 2014;9: e84247.
    • (2014) PLoS One , vol.9
    • Francis, J.H.1
  • 60
    • 84880259768 scopus 로고    scopus 로고
    • Superselective intraophthalmic artery chemotherapy in a nonhuman primate model: Histopathologic findings
    • Tse BC, et al. Superselective intraophthalmic artery chemotherapy in a nonhuman primate model: histopathologic findings. JAMA Ophthalmol 2013;131:903-911.
    • (2013) JAMA Ophthalmol , vol.131 , pp. 903-911
    • Tse, B.C.1
  • 61
    • 85081464286 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of intra-arterial melphalan and topotecan combination in patients with retinoblastoma
    • In press
    • Taich P, et al. Clinical pharmacokinetics of intra-arterial melphalan and topotecan combination in patients with retinoblastoma. Ophthalmology 2013. In press.
    • (2013) Ophthalmology
    • Taich, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.