Development of topotecan loaded lipid nanoparticles for chemical stabilization and prolonged release

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 79, Issue 1, 2011, Pages 189-196

  Souza, L G ^a   Silva, E J ^a   Martins, A L L ^a   Mota, M F ^a   Braga, R C ^a   Lima, E M ^a   Valadares, M C ^a   Taveira, S F ^a   Marreto, R N ^a  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

Author keywords

Chemical degradation; Lipid matrix; Mass spectrometry; Microemulsion; Nanoparticles; Topotecan

Indexed keywords

DRUG CARRIER; NANOSTRUCTURED LIPID CARRIER; SOLID LIPID NANOPARTICLE; TOPOTECAN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG RELEASE; DRUG STABILITY; FREEZE DRYING; MICROEMULSION; NANOENCAPSULATION; ZETA POTENTIAL;

CELL SURVIVAL; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; EMULSIONS; FREEZE DRYING; HUMANS; K562 CELLS; LIPIDS; NANOPARTICLES; NANOSTRUCTURES; PARTICLE SIZE; SOLUBILITY; SURFACE PROPERTIES; TEMPERATURE; TOPOISOMERASE I INHIBITORS; TOPOTECAN; TRYPAN BLUE;

EID: 80052273857     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.02.012     Document Type: Article

References (37)

1. C.J.H. Gerrits, H. Burris, J.H.M. Schellens, A.S.T. Planting, M.E.L. Van Den Burg, G.I. Rodrigez, V. Van Beurden, W.J. Loos, I. Hudson, S. Fields, J. Verweij, and D.D. Von Hoff Five days of oral topotecan (Hycamtin®), a phase I and pharmacological study in adult patients with solid tumours Eur. J. Cancer 34 1998 1030 1035 (Pubitemid 28308343)
2. A. Hatefi, and B. Amsden Camptothecin delivery methods Pharm. Res. 19 2002 1389 1399 (Pubitemid 35266542)
3. J.F. Pizzolato, and L.B. Saltz The camptothecins Lancet 361 2003 2235 2242 (Pubitemid 36782561)
4. P. Tardi, E. Choice, D. Masin, T. Redelmeier, M. Bally, and T.D. Madden Liposomal encapsulation of topotecan enhances anticancer efficacy in murine and human xenograft models Cancer Res. 60 2000 3389 3393 (Pubitemid 30482152)
5. J. Fassberg, and V.J. Stella A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues J. Pharm. Sci. 81 1992 676 684 (Pubitemid 23006796)
6. T.G. Burke, A.K. Mishra, M.C. Wani, and M.E. Wall Lipid bilayer partitioning and stability of camptothecin drugs Biochemistry 32 1993 5352 5364 (Pubitemid 23167976)
7. T.G. Burke, and X. Gao Stabilization of topotecan in low pH liposomes composed of distearoylphosphatidylcholine J. Pharm. Sci. 83 1994 967 969 (Pubitemid 24228546)
8. D. Subramanian, and M.T. Muller Liposomal encapsulation increases the activity of the topoisomerase I inhibitor topotecan Oncol. Res. 7 1995 461 469 (Pubitemid 26005411)
9. J.J. Liu, R.L. Hong, W.F. Cheng, K. Hong, F.H. Chang, and Y.L. Tseng Simple efficient liposomal encapsulation of topotecan by ammonium sulfate gradient: stability, pharmacokinetic and therapeutic evaluation Anti-cancer Drugs 13 2002 709 717
10. Y.-L. Hao, Y.-L. Deng, Y. Chen, K.-Z. Wang, A.-J. Hao, and Y. Zhang In vitro cytotoxicity, in vivo biodistribution and anti-tumour effect of PEGylated liposomal topotecan J. Pharm. Pharmacol. 57 2005 1279 1287 (Pubitemid 41545893)
11. A.M. Vali, T. Toliyat, B. Shafaghi, and S. Dadashzadeh Preparation, optimization, and characterization of topotecan loaded PEGylated liposomes using factorial design Drug Dev. Ind. Pharm. 34 2008 10 23 (Pubitemid 351156969)
12. D.C. Drumond, C.O. Noble, Z. Guo, M.E. Hayes, C. Connolly-Ingram, B.S. Gabriel, B. Hann, B. Liu, J.W. Park, K. Hong, C.C. Benz, J.D. Marks, and D.B. Kirpotin Development of a highly stable and targetable nanoliposomal formulation of topotecan J. Control. Release 141 2010 13 21
13. H.L. Wong, R. Bendayan, A.M. Rauth, Y. Li, and X.Y. Wu Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles Adv. Drug Deliv. Rev. 59 2007 491 504 (Pubitemid 47259227)
14. R.H. Müller, K. Mader, and S. Gohla Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art Eur. J. Pharm. Biopharm. 50 2000 161 177 (Pubitemid 30326695)
15. W. Mehnert, and K. Mader Solid lipid nanoparticles: production, characterization and applications Adv. Drug Deliv. Rev. 47 2001 165 196 (Pubitemid 32324113)
16. K. Vivek, H. Reddy, and S.R.R. Murthy Investigations of the effect of the lipid matrix on drug entrapment, in vitro release, and physical stability of olanzapine-loaded solid lipid nanoparticles AAPS Pharm. Sci. Tech. 8 2007 E1 E9
17. M.R. Gasco, Method of producing solid lipid microspheres having narrow size distribution, US Patent 5250,236, 1993.
18. M. Muchow, P. Maincent, and R.H. Muller Lipid nanoparticles with a solid matrix (SLN, NLC, LDC) for oral drug delivery Drug Dev. Ind. Pharm. 34 2008 1394 1405
19. R.H. Muller, M. Radtke, and S.A. Wissing Nanostructured lipid matrices for improved encapsulation of drugs Int. J. Pharm. 242 2002 121 128
20. S. Yang, J. Zhu, Y. Lu, B. Liang, and C. Yang Body distribution of camptothecin solid lipid nanoparticles after oral administration Pharm. Res. 16 1999 751 757 (Pubitemid 29227107)
21. Z.-R. Huang, S.-C. Hua, Y.-L. Yang, and J.-Y. Fang Development and evaluation of lipid nanoparticles for camptothecin delivery: a comparison of solid lipid nanoparticles, nanostructured lipid carriers, and lipid emulsion Acta Pharmacol. Sin. 29 2008 1094 1102
22. J. Liu, T. Gong, C. Wang, Z. Zhong, and Z. Zhang Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholine-based mixed micelles: preparation and characterization Int. J. Pharm. 340 2007 153 162 (Pubitemid 47044961)
23. H. Yuan, S.-P. Jiang, Y.-Z. Du, J. Miao, X.-G. Zhang, and F.-Q. Fu-Qiang Hu Strategic approaches for improving entrapment of hydrophilic peptide drugs by lipid nanoparticles Colloids Surf. B: Biointerfaces 70 2009 248 253
24. F. Marquele-Oliveira, D.C.A. Santana, S.F. Taveira, D.M. Vermeulen, A.R.M. Oliveira, R.S. Silva, and R.F.V. Lopez Development of nitrosyl ruthenium complex-loaded lipid carriers for topical administration: improvement in skin stability and nitric oxide release by visible light irradiation J. Pharm. Biomed. Anal. 53 2010 843 851
25. D.L. Warner, and T.G. Burke Simple and versatile high-performance liquid chromatographic method for the simultaneous quantitation of the lactone and carboxylate forms of camptothecin anticancer drugs J. Chromatogr. B 691 1997 161 171 (Pubitemid 27168851)
26. International Conference of Harmonization, Q2 (R1) Validation of Analytical Procedures: Text and Methodology, 2005.
27. X. Li, W.L. Lu, G.W. Liang, G.R. Ruan, H.Y. Hong, C. Long, Y.T. Zhang, Y. Liu, J.C. Wang, X. Zhang, and Q. Zhang Effect of stealthy liposomal topotecano plus amlodipine on the multidrug-resistant leukaemia cells in vitro and xenograft in mice Eur. J. Clin. Investig. 36 2006 409 418 (Pubitemid 43742699)
28. J. You, F. Wan, F. Cui, Y. Sun, Y.-Z. Du, and F.Q. Hu Preparation and characteristic of vinorelbine bitartrate-loaded solid lipid nanoparticles Int. J. Pharm. 434 2007 270 276 (Pubitemid 47321031)
29. X.-Y. Ying, Y.-Z. Du, W.-W. Chen, H. Yuan, and F.-Q. Hu Preparation and characterization of modified lipid nanoparticles for doxorubicin controlled release Pharmazie 63 2008 862 878
30. K. Ruckmani, M. Sivakumar, and P.A. Ganeshkumar Methotrexate loaded solid lipid nanoparticles (SLN) for effective treatment of carcinoma J. Nanosci. Nanotechnol. 6 2006 1 5
31. A.S. Kearney, K. Patel, and N.R. Palepu Preformulation studies to aid in the development of a ready-to-use injectable solution of the antitumor agent, topotecan Int. J. Pharm. 127 1996 229 237 (Pubitemid 26091008)
32. H.P. Benton, D.M. Wong, S.A. Trauger, and G. Siuzdak XCMS2: processing tandem mass spectrometry data for metabolite identification and structural characterization Anal. Chem. 80 2008 6382 6389
33. C.A. Smith, E.J. Want, G. O'Maille, R. Abagyan, and G. Siuzdak XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification Anal. Chem. 78 2006 779 787 (Pubitemid 43228585)
34. E. Marengo, R. Cavalli, O. Caputo, L. Rodriguez, and M.R. Gasco Scale-up of preparation process of solid lipid nanospheres, Part I Int. J. Pharm. 205 2000 3 13
35. S.A. Abraham, K. Edwards, G. Karlsson, N. Hudon, L.D. Mayer, and M.B. Bally An evaluation of transmembrane ion gradient-mediated encapsulation of topotecan with liposomes J. Control. Release 96 2004 449 461 (Pubitemid 38553923)
36. A. Laloo, P. Chao, P. Hu, S. Stein, and P.J. Sinko Pharmacokinetic and pharmacodynamic evaluation of a novel in situ forming poly(ethylene glycol)-based hydrogel for the controlled delivery of the camptothecins J. Control. Release 112 2006 333 342 (Pubitemid 43737145)
37. B.E. Davies, E.A. Minthorn, M.J. Dennis, H. Rosing, and J.H. Beijnen The pharmacokinetics of topotecano and its carboxylate form following separate intravenous administration to the dog Pharm. Res. 14 1997 1461 1465 (Pubitemid 27481080)