Topotecan hydrochloride effects on retinal vessels in newborn rats

Histology and Histopathology

Volumn 27, Issue 4, 2012, Pages 497-506

  Pescosolido, Nicola ^a   Pascarella, Antonia ^b   Scarsella, Gianfranco ^b   Tafani, Marco ^a   Stefanini, Stefania ^b   Nebbioso, Marcella ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Angiogenesis modulation; Confocal microscopy; Peribulbar injection; Retinal fluorangiography; Topoisomerase inhibitor

Indexed keywords

DNA TOPOISOMERASE INHIBITOR; TOPOTECAN;

ANGIOGENESIS; ANIMAL; ARTICLE; DISEASE MODEL; DRUG EFFECT; FEMALE; FLUORESCENCE ANGIOGRAPHY; GROWTH, DEVELOPMENT AND AGING; INTRAVENOUS DRUG ADMINISTRATION; LONGEVITY; MALE; METHODOLOGY; NEWBORN; PATHOLOGY; PHYSIOLOGY; RAT; RETINA; RETINA ARTERY; SUBCUTANEOUS DRUG ADMINISTRATION; WISTAR RAT;

ANIMALS; ANIMALS, NEWBORN; DISEASE MODELS, ANIMAL; FEMALE; FLUORESCEIN ANGIOGRAPHY; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; LONGEVITY; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, WISTAR; RETINA; RETINAL ARTERY; TOPOISOMERASE I INHIBITORS; TOPOTECAN;

ANIMALIA; RATTUS; RODENTIA;

EID: 84857716538     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Carcaboso A.M., Bramuglia G.F., Chantada G.L., Fandiño A.C., Chiappetta D.A., de Davila M.T., Rubio M.C. and Abramson D.H. (2007). Topotecan vitreous levels after periocular or intravenous delivery in rabbits: an alternative for retinoblastoma chemotherapy. Invest. Ophthalmol. Vis. Sci. 48, 3761-3767.
2. Carcaboso A.M., Chiappetta D.A., Opezzo J.A., Höcht C., Fandiño A.C., Croxatto J.O., Rubio M.C., Sosnik A., Abramson D.H., Bramuglia G.F. and Chantada G.L. (2010). Episcleral implants for topotecan delivery to the posterior segment of the eye. Invest. Ophthalmol. Vis. Sci. 51, 2126-2134.
3. Carmeliet P. (2003). Angiogenesis in health and disease. Nat. Med. 9, 653-660.
4. Claxton S. and Fruttiger M. (2003). Role of arteries in oxygen induced vasobliteration. Exp. Eye. Res. 77, 305-311.
5. El-Gizawy S.A. and Hedaya M.A. (1999). Comparative brain tissue distribution of camptothecin and topotecan in the rat. Cancer Chemother. Pharmacol. 43, 364-370.
6. Gariano R.F. and Gardner T.W. (2005). Retinal angiogenesis in development and disease. Nature 438, 960-966.
7. Gerhardt H., Golding M., Fruttiger M., Ruhrberg C., Lundkvist A., Abramsson A., Jeltsch M., Mitchell C., Alitalo K., Shima D. and Betsholtz C. (2003). VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J. Cell Biol. 161, 1163-1177.
8. Lu X., Le Noble F., Yuan L., Jiang Q., De Lafarge B., Sugiyama D., Breant C., Claes F., De Smet F., Thomas J.L., Autiero M., Carmeliet P., Tessier-Lavigne M. and Eichmann A. (2004). The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 432, 179-186.
9. Magliozzi R., Nardacci R., Scarsella G., Di Carlo V. and Stefanini S. (2003). Effects of the plasticiser DEHP on lung of newborn rats: catalase immunocytochemistry and morphometric analysis. Histochem. Cell. Biol. 120, 41-49.
10. Nakashio A., Fujta N. and Tsuruo T. (2002). Topotecan inhibits VEGF and bFGF-induced vascular endothelial cell migration via downregulation of the Pl3K-Akt signalling pathway. Int. J. Cancer 98, 36-41.
11. O'Leary J., Shapiro R., Ren C., Chuang N., Cohen H. and Potmesil M. (1999). Antiangiogenic effects of camptothecin analogues 9-amino-20(S)-camptothecin, Topotecan, and CPT-11 studied in the mouse cornea model. Chem. Cancer Res. 5, 181-187.
12. Pommier Y. (2006). Topoisomerase I inhibitors: camptothecin and beyond. Nat. Rev. Cancer 6, 789-802.
13. Puppo M., Battaglia F., Ottaviano C., Delfino S., Ribatti D., Varesio L. and Bosco M.C. (2008). Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and-2alpha. Mol. Cancer. Ther. 7, 1974-1984.
14. Rapisarda A., Uranchimeg B., Scudiero D.A., Selby M., Sausville E.A., Shoemaker R.H. and Melillo G. (2002). Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res. 62, 4316-4324.
15. Rapisarda A., Uranchimeg B., Sordet O., Pommier Y., Shoemaker R.H. and Melillo G. (2004). Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. Cancer. Res. 64, 1475-1482.
16. Risau W. (1997). Mechanisms of angiogenesis. Nature 386, 671-674.
17. Rosicarelli B. and Stefanini S. (2009). DEHP effects on histology and cell proliferation in lung of newborn rats. Histochem. Cell. Biol. 131, 491-500.
18. Rossant J. and Howard L. (2002). Signaling pathways in vascular development. Annu. Rev. Cell. Dev. Biol. 18, 541-573.
19. Staker B.L., Hjerrild K., Feese M.D., Behnke C.A., Burgin A.B. Jr and Stewart L. (2002). The mechanism of topoisomerase I poisoning by a camptothecin analog. Proc. Natl. Acad. Sci. USA 99. 15387-15392.
20. Streltsov S., Ermishov M., Mochalov K., Sukhanova A., Nechipurenko Y., Grokhovsky S., Zhuze A. and Pluot M. (2003). Interaction of clinically important human DNA topoisomerase I poison, Topotecan, with double-strended DNA. Biopolymers 72, 442-454.
21. Tsui J.Y., Dalgard C., Van Quill K.R., Lee L., Grossniklaus H.E., Edelhauser H.F. and O'Brien J.M. (2008). Subconjunctival Topotecan in fibrin sealant in the treatment of transgenic murine retinoblastoma. Invest. Ophthalmol. Vis. Sci. 49, 490-496.
22. Uemura A., Ogawa M., Hirashima M., Fujiwara T., Koyama S., Takagi H., Honda Y., Wiegand S.J., Yancopoulos G.D. and Nishikawa S. (2002). Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells. J. Clin. Invest. 110, 1619-1628.
23. Uemura A., Kusuhara S., Katsuta H. and Nishikawa S. (2006). Angiogenesis in the mouse retina: A model system for experimental manipulation. Exp. Cell. Res. 312, 676-683.
24. Yancopoulos G.D., Davis S., Gale N.W., Rudge J.S., Wiegand S.J. and Holash J. (2000). Vascular-specific growth factors and blood vessel formation. Nature 407, 242-248.
25. Zei D., Pascarella A., Barrese C., Pantalone S. and Stefanini S. (2009). DEHP effects on retinal vessels in newborn rats: a qualitative and quantitative analysis. Histochem. Cell. Biol. 132, 567-575.