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Volumn 22, Issue 9, 2014, Pages 2032-2038

Downregulation of lipogenesis and fatty acid oxidation in the subcutaneous adipose tissue of morbidly obese women

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; CD36 ANTIGEN; FAS ANTIGEN; FATTY ACID BINDING PROTEIN 4; INSULIN; INTERLEUKIN 6; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; FATTY ACIDS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84906935777     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20809     Document Type: Article
Times cited : (34)

References (40)
  • 1
    • 84878532462 scopus 로고    scopus 로고
    • Adipose tissue dysfunction contributes to obesity related metabolic diseases
    • Bluher M,. Adipose tissue dysfunction contributes to obesity related metabolic diseases. Best Pract Res Clin Endocrinol Metab 2013; 27: 163-177.
    • (2013) Best Pract Res Clin Endocrinol Metab , vol.27 , pp. 163-177
    • Bluher, M.1
  • 2
    • 0033821353 scopus 로고    scopus 로고
    • Pathophysiology of obesity
    • Lean ME,. Pathophysiology of obesity. Proc Nutr Soc 2000; 59: 331-336.
    • (2000) Proc Nutr Soc , vol.59 , pp. 331-336
    • Lean, M.E.1
  • 3
    • 33845914986 scopus 로고    scopus 로고
    • Mechanisms linking obesity with cardiovascular disease
    • Van Gaal LF, Mertens IL, De Block CE,. Mechanisms linking obesity with cardiovascular disease. Nature 2006; 444: 875-880.
    • (2006) Nature , vol.444 , pp. 875-880
    • Van Gaal, L.F.1    Mertens, I.L.2    De Block, C.E.3
  • 4
    • 68849132248 scopus 로고    scopus 로고
    • Adipose tissue dysfunction in obesity
    • Blüher M,. Adipose tissue dysfunction in obesity. Exp Clin Endocrinol Diabetes 2009; 117: 241-250.
    • (2009) Exp Clin Endocrinol Diabetes , vol.117 , pp. 241-250
    • Blüher, M.1
  • 5
    • 84867487909 scopus 로고    scopus 로고
    • Adiposopathy, diabetes mellitus, and primary prevention of atherosclerotic coronary artery disease: Treating «sick fat» through improving fat function with antidiabetes therapies
    • Bays HE,. Adiposopathy, diabetes mellitus, and primary prevention of atherosclerotic coronary artery disease: treating «sick fat» through improving fat function with antidiabetes therapies. Am J Cardiol 2012; 110: 4B-12B.
    • (2012) Am J Cardiol , vol.110
    • Bays, H.E.1
  • 6
    • 55249098186 scopus 로고    scopus 로고
    • White adipose tissue as endocrine organ and its role in obesity
    • Vázquez-Vela ME, Torres N, Tovar AR,. White adipose tissue as endocrine organ and its role in obesity. Arch Med Res 2008; 39: 715-728.
    • (2008) Arch Med Res , vol.39 , pp. 715-728
    • Vázquez-Vela, M.E.1    Torres, N.2    Tovar, A.R.3
  • 7
    • 0036228456 scopus 로고    scopus 로고
    • Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha
    • Sewter C, Berger D, Considine RV, et al. Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha. Diabetes 2002; 51: 1035-1041.
    • (2002) Diabetes , vol.51 , pp. 1035-1041
    • Sewter, C.1    Berger, D.2    Considine, R.V.3
  • 8
    • 34548190628 scopus 로고    scopus 로고
    • SREBP-1-independent regulation of lipogenic gene expression in adipocytes
    • Sekiya M, Yahagi N, Matsuzaka T, et al. SREBP-1-independent regulation of lipogenic gene expression in adipocytes. J Lipid Res 2007; 48: 1581-1591.
    • (2007) J Lipid Res , vol.48 , pp. 1581-1591
    • Sekiya, M.1    Yahagi, N.2    Matsuzaka, T.3
  • 9
    • 0036105148 scopus 로고    scopus 로고
    • Block the FAS, lose the fat
    • Mobbs CV, Makimura H,. Block the FAS, lose the fat. Nat Med 2002; 8: 335-336.
    • (2002) Nat Med , vol.8 , pp. 335-336
    • Mobbs, C.V.1    Makimura, H.2
  • 10
    • 0034733730 scopus 로고    scopus 로고
    • Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
    • Loftus TM, Jaworsky DE, Frehywot GL, et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 2000; 288: 2379-2381.
    • (2000) Science , vol.288 , pp. 2379-2381
    • Loftus, T.M.1    Jaworsky, D.E.2    Frehywot, G.L.3
  • 11
    • 3042698325 scopus 로고    scopus 로고
    • A novel missense substitution (Val1483Ile) in the fatty acid synthase gene (FAS) is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians
    • Kovacs P, Harper I, Hanson RL, et al. A novel missense substitution (Val1483Ile) in the fatty acid synthase gene (FAS) is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians. Diabetes 2004; 53: 1915-1919.
    • (2004) Diabetes , vol.53 , pp. 1915-1919
    • Kovacs, P.1    Harper, I.2    Hanson, R.L.3
  • 12
    • 79955721912 scopus 로고    scopus 로고
    • Expression profile in omental and subcutaneous adipose tissue from lean and obese subjects. Repression of lipolytic and lipogenic genes
    • del Pozo CH, Calvo RM, Vesperinas-Garcia G, et al. Expression profile in omental and subcutaneous adipose tissue from lean and obese subjects. Repression of lipolytic and lipogenic genes. Obes Surg 2011; 21: 633-643.
    • (2011) Obes Surg , vol.21 , pp. 633-643
    • Del Pozo, C.H.1    Calvo, R.M.2    Vesperinas-Garcia, G.3
  • 13
    • 84865422248 scopus 로고    scopus 로고
    • From excess adiposity to insulin resistance: The role of free fatty acids
    • Capurso C, and, Capurso A,. From excess adiposity to insulin resistance: the role of free fatty acids. Vascul Pharmacol 2012; 57: 91-97.
    • (2012) Vascul Pharmacol , vol.57 , pp. 91-97
    • Capurso, C.1    Capurso, A.2
  • 14
    • 77953612080 scopus 로고    scopus 로고
    • Gluteofemoral body fat as a determinant of metabolic health
    • Manolopoulos KN, Karpe F, Frayn KN,. Gluteofemoral body fat as a determinant of metabolic health. Int J Obes (Lond) 2010; 34: 949-959.
    • (2010) Int J Obes (Lond) , vol.34 , pp. 949-959
    • Manolopoulos, K.N.1    Karpe, F.2    Frayn, K.N.3
  • 15
    • 0036079637 scopus 로고    scopus 로고
    • Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity
    • Diraison F, Dusserre E, Vidal H, Sothier M, Beylot M,. Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity. Am J Physiol Endocrinol Metab 2002; 282: E46-E51.
    • (2002) Am J Physiol Endocrinol Metab , vol.282
    • Diraison, F.1    Dusserre, E.2    Vidal, H.3    Sothier, M.4    Beylot, M.5
  • 16
    • 0345529871 scopus 로고    scopus 로고
    • Comparison of the expression and activity of the lipogenic pathway in human and rat adipose tissue
    • Letexier D, Pinteur C, Large V, Frering V, Beylot M,. Comparison of the expression and activity of the lipogenic pathway in human and rat adipose tissue. J Lipid Res 2003; 44: 2127-2134.
    • (2003) J Lipid Res , vol.44 , pp. 2127-2134
    • Letexier, D.1    Pinteur, C.2    Large, V.3    Frering, V.4    Beylot, M.5
  • 17
    • 6344226251 scopus 로고    scopus 로고
    • Effect of carbohydrate overfeeding on whole body macronutrient metabolism and expression of lipogenic enzymes in adipose tissue of lean and overweight humans
    • Minehira K, Vega N, Vidal H, Acheson K, Tappy L,. Effect of carbohydrate overfeeding on whole body macronutrient metabolism and expression of lipogenic enzymes in adipose tissue of lean and overweight humans. Int J Obes Relat Metab Disord 2004; 28: 1291-1298.
    • (2004) Int J Obes Relat Metab Disord , vol.28 , pp. 1291-1298
    • Minehira, K.1    Vega, N.2    Vidal, H.3    Acheson, K.4    Tappy, L.5
  • 18
    • 39749194050 scopus 로고    scopus 로고
    • The effect of dietary carbohydrate on genes for fatty acid synthase and inflammatory cytokines in adipose tissues from lean and obese subjects
    • Hudgins LC, Baday A, Hellerstein MK, et al. The effect of dietary carbohydrate on genes for fatty acid synthase and inflammatory cytokines in adipose tissues from lean and obese subjects. J Nutr Biochem 2008; 19: 237-245.
    • (2008) J Nutr Biochem , vol.19 , pp. 237-245
    • Hudgins, L.C.1    Baday, A.2    Hellerstein, M.K.3
  • 19
    • 33845564887 scopus 로고    scopus 로고
    • The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: Effects of obesity, insulin resistance, and TZD treatment
    • Ranganathan G, Unal R, Pokrovskaya I, et al. The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment. J Lipid Res 2006; 47: 2444-2450.
    • (2006) J Lipid Res , vol.47 , pp. 2444-2450
    • Ranganathan, G.1    Unal, R.2    Pokrovskaya, I.3
  • 20
    • 78449300149 scopus 로고    scopus 로고
    • Obesity and insulin resistance-related changes in the expression of lipogenic and lipolytic genes in morbidly obese subjects
    • Tinahones FJ, Garrido-Sanchez L, Miranda M, et al. Obesity and insulin resistance-related changes in the expression of lipogenic and lipolytic genes in morbidly obese subjects. Obes Surg 2010; 20: 1559-1567.
    • (2010) Obes Surg , vol.20 , pp. 1559-1567
    • Tinahones, F.J.1    Garrido-Sanchez, L.2    Miranda, M.3
  • 21
    • 84892659350 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus
    • American Diabetes Association.
    • American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2014; S1: S81-S90.
    • (2014) Diabetes Care , vol.1 S
  • 22
    • 84876296264 scopus 로고    scopus 로고
    • Retinol binding protein-4 circulating levels were higher in nonalcoholic fatty liver disease vs. Histologically normal liver from morbidly obese women
    • Terra X, Auguet T, Broch M, et al. Retinol binding protein-4 circulating levels were higher in nonalcoholic fatty liver disease vs. histologically normal liver from morbidly obese women. Obesity 2013; 21: 170-177.
    • (2013) Obesity , vol.21 , pp. 170-177
    • Terra, X.1    Auguet, T.2    Broch, M.3
  • 23
    • 73949146174 scopus 로고    scopus 로고
    • The gene expression of the main lipogenic enzymes is downregulated in visceral adipose tissue of obese subjects
    • Ortega FJ, Mayas D, Moreno-Navarrete JM, et al. The gene expression of the main lipogenic enzymes is downregulated in visceral adipose tissue of obese subjects. Obesity (Silver Spring) 2010; 18: 13-20.
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 13-20
    • Ortega, F.J.1    Mayas, D.2    Moreno-Navarrete, J.M.3
  • 26
    • 13244279594 scopus 로고    scopus 로고
    • Regional differences of insulin action in adipose tissue: Insights from in vivo and in vitro studies
    • Giorgino F, Laviola L, Eriksson JW,. Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies. Acta Physiol Scand 2005; 183: 13-30.
    • (2005) Acta Physiol Scand , vol.183 , pp. 13-30
    • Giorgino, F.1    Laviola, L.2    Eriksson, J.W.3
  • 27
    • 78650680276 scopus 로고    scopus 로고
    • Comparison of the relative contributions of intra-abdominal and liver fat to components of the metabolic syndrome
    • Kotronen A, Yki-Jarvinen H, Sevastianova K, et al. Comparison of the relative contributions of intra-abdominal and liver fat to components of the metabolic syndrome. Obesity 2011; 19: 23-28.
    • (2011) Obesity , vol.19 , pp. 23-28
    • Kotronen, A.1    Yki-Jarvinen, H.2    Sevastianova, K.3
  • 28
    • 0344375097 scopus 로고    scopus 로고
    • Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma
    • Savage DB, Tan GD, Acerini CL, et al. Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma. Diabetes 2003; 52: 910-917.
    • (2003) Diabetes , vol.52 , pp. 910-917
    • Savage, D.B.1    Tan, G.D.2    Acerini, C.L.3
  • 29
    • 72449185147 scopus 로고    scopus 로고
    • Efficacy of leptin therapy in the different forms of human lipodystrophy
    • Chong AY, Lupsa BC, Cochran EK, Gorden P,. Efficacy of leptin therapy in the different forms of human lipodystrophy. Diabetologia 2010; 53: 27-35.
    • (2010) Diabetologia , vol.53 , pp. 27-35
    • Chong, A.Y.1    Lupsa, B.C.2    Cochran, E.K.3    Gorden, P.4
  • 32
    • 54749114466 scopus 로고    scopus 로고
    • It's not how fat you are, it's what you do with it that counts
    • Virtue S, Vidal-Puig A,. It's not how fat you are, it's what you do with it that counts. PLoS Biol 2008; 6: e237.
    • (2008) PLoS Biol , vol.6
    • Virtue, S.1    Vidal-Puig, A.2
  • 34
    • 0346250163 scopus 로고    scopus 로고
    • Adipose tissue, insulin action and vascular disease: Inflammatory signals
    • (Suppl).
    • Yudkin JS,. Adipose tissue, insulin action and vascular disease: inflammatory signals. Int J Obes Relat Metab Disord 2003; 27 (Suppl 3): S25-S28.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , Issue.3
    • Yudkin, J.S.1
  • 35
    • 0035666553 scopus 로고    scopus 로고
    • Is obesity an inflammatory condition?
    • Das UN,. Is obesity an inflammatory condition? Nutrition 2001; 17: 953-966.
    • (2001) Nutrition , vol.17 , pp. 953-966
    • Das, U.N.1
  • 36
    • 0034769377 scopus 로고    scopus 로고
    • The relation of body fat mass and distribution to markers of chronic inflammation
    • Festa A, D'Agostino R Jr, Williams K, et al. The relation of body fat mass and distribution to markers of chronic inflammation. Int J Obes Relat Metab Disord 2001; 25: 1407-1415.
    • (2001) Int J Obes Relat Metab Disord , vol.25 , pp. 1407-1415
    • Festa, A.1    D'Agostino, Jr.R.2    Williams, K.3
  • 37
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS,. Inflammation and metabolic disorders. Nature 2006; 444: 860.
    • (2006) Nature , vol.444 , pp. 860
    • Hotamisligil, G.S.1
  • 38
    • 6944237757 scopus 로고    scopus 로고
    • Adipokines: Inflammation and the pleiotropic role of white adipose tissue
    • Trayhurn P, Wood IS,. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004; 92: 347-355.
    • (2004) Br J Nutr , vol.92 , pp. 347-355
    • Trayhurn, P.1    Wood, I.S.2
  • 40
    • 85008978659 scopus 로고    scopus 로고
    • Subcutaneous adipose tissue transplantation in diet-induced obese mice attenuates metabolic dysregulation while removal exacerbates it
    • Foster MT, Softic S, Caldwell J, Kohli R, deKloet AD, Seeley RJ,. Subcutaneous adipose tissue transplantation in diet-induced obese mice attenuates metabolic dysregulation while removal exacerbates it. Physiol Rep 2013; 1: e00015.
    • (2013) Physiol Rep , vol.1
    • Foster, M.T.1    Softic, S.2    Caldwell, J.3    Kohli, R.4    Dekloet, A.D.5    Seeley, R.J.6


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