Obesity and insulin resistance-related changes in the expression of lipogenic and lipolytic genes in morbidly obese subjects

Obesity Surgery

Volumn 20, Issue 11, 2010, Pages 1559-1567

  Tinahones, F J ^a   Garrido Sanchez, L ^b   Miranda, M ^b   Garcia Almeida J M ^a   MacIas Gonzalez, M ^a,c   Ceperuelo, V ^b   Gluckmann, E ^a   Rivas Marin, J ^a   Vendrell, J ^b   Garcia Fuentes E ^a,c  

^a HOSPITAL UNIVERSITARIO VIRGEN DE LA VICTORIA   (Spain)

^b HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

^c Hospital University Carlos Haya de Málaga   (Spain)

Author keywords

Adipose tissue; Adipose triglyceride lipase; Insulin resistance; Obesity; Peroxisome proliferator activated receptor ; Phosphoenolpyruvate carboxykinase

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACYL COENZYME A; ADIPONECTIN; AQUAPORIN 7; CHOLESTEROL ACYLTRANSFERASE; FATTY ACID BINDING PROTEIN 4; GLYCEROL KINASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; LONG CHAIN FATTY ACID COENZYME A LIGASE; MESSENGER RNA; PERILIPIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); TRIACYLGLYCEROL LIPASE;

ADIPOSE TISSUE; ADULT; ARTICLE; BLOOD SAMPLING; BODY MASS; CARBOHYDRATE METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; HUMAN; INSULIN RESISTANCE; INTRAABDOMINAL FAT; MALE; MORBID OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUBCUTANEOUS FAT; UPREGULATION;

ADIPOSE TISSUE; ADULT; FEMALE; GENE EXPRESSION; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED; OBESITY, MORBID;

EID: 78449300149     PISSN: 09608923     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11695-010-0194-z     Document Type: Article

References (38)

1. KL Wyne 2003 Free fatty acids and type 2 diabetes mellitus Am J Med 115 29S 36 1:CAS:528:DC%2BD2cXktlGktw%3D%3D 10.1016/j.amjmed.2003.09.004 14678863
2. KN Frayn 2003 The glucose-fatty acid cycle: a physiological perspective Biochem Soc Trans 31 1115 9 1:CAS:528:DC%2BD3sXps1yqurc%3D 10.1042/BST0311115 14641007
3. SJ Wang C Cornick J O'Dowd, et al. 2007 Improved glucose tolerance in acyl CoA:diacylglycerol acyltransferase 1-null mice is dependent on diet Lipids Health Dis 6 2 10.1186/1476-511X-6-2 17239230
4. S Wang KG Soni M Semache, et al. 2008 Lipolysis and the integrated physiology of lipid energy metabolism Mol Genet Metab 95 117 26 1:CAS:528:DC%2BD1cXht1Knt7%2FF 10.1016/j.ymgme.2008.06.012 18762440
5. R Zimmermann JG Strauss G Haemmerle, et al. 2004 Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase Science 306 1383 6 1:CAS:528:DC%2BD2cXpvVektLw%3D 10.1126/science.1100747 15550674
6. C Sztalryd G Xu H Dorward, et al. 2003 Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation J Cell Biol 161 1093 103 1:CAS:528:DC%2BD3sXkvFCmsr0%3D 10.1083/jcb.200210169 12810697
7. B Kalderon N Mayorek E Berry, et al. 2000 Fatty acid cycling in the fasting rat Am J Physiol Endocrinol Metab 279 E221 7 1:CAS:528: DC%2BD3cXltl2jsLo%3D 10893343
8. P Arner 1988 Control of lipolysis and its relevance to development of obesity in man Diab Metab Rev 4 507 15 1:STN:280:DyaL1M%2FptVyjsg%3D%3D 10.1002/dmr.5610040507
9. F Picard J Auwerx 2002 PPAR(gamma) and glucose homeostasis Annu Rev Nutr 22 167 97 1:CAS:528:DC%2BD38XmtF2htL4%3D 10.1146/annurev.nutr.22.010402.102808 12055342
10. RK Semple VK Chatterjee S O'Rahilly 2006 PPAR gamma and human metabolic disease J Clin Invest 116 581 9 1:CAS:528:DC%2BD28XitlGkt78%3D 10.1172/JCI28003 16511590
11. WT Festuccia M Laplante M Berthiaume, et al. 2006 PPARgamma agonism increases rat adipose tissue lipolysis, expression of glyceride lipases, and the response of lipolysis to hormonal control Diabetologia 49 2427 36 1:CAS:528:DC%2BD28XptF2kurw%3D 10.1007/s00125-006-0336-y 16906479
12. A Zieleniak M Wójcik LA Woźniak 2008 Structure and physiological functions of the human peroxisome proliferator-activated receptor gamma Arch Immunol Ther Exp (Warsz) 56 331 45 1:CAS:528:DC%2BD1cXhsVaiur3F 10.1007/s00005-008-0037-y
13. E García-Fuentes JM García-Almeida J García- Arnés, et al. 2006 Morbidly obese individuals with impaired fasting glucose have a specific pattern of insulin secretion and sensitivity: effect of weight loss after bariatric surgery Obes Surg 16 1179 88 10.1381/ 096089206778392383 16989702
14. F Soriguer S García-Serrano JM García-Almeida, et al. 2009 Changes in the serum composition of free-fatty acids during an intravenous glucose tolerance test Obesity (Silver Spring) 17 10 5 1:CAS:528: DC%2BD1MXhtVGjtQ%3D%3D 10.1038/oby.2008.475
15. L Garrido-Sánchez JM García-Almeida S García- Serrano, et al. 2008 Improved carbohydrate metabolism after bariatric surgery raises antioxidized LDL antibody levels in morbidly obese patients Diab Care 31 2258 64 10.2337/dc08-0930
16. U Kintscher RE Law 2005 PPARgamma-mediated insulin sensitization: the importance of fat versus muscle Am J Physiol Endocrinol Metab 288 E287 91 1:CAS:528:DC%2BD2MXhsVCktrw%3D 10.1152/ajpendo.00440.2004 15637349
17. E Garcia-Fuentes M Murri L Garrido-Sanchez, et al. 2010 PPARγ expression after a high-fat meal is associated with plasma superoxide dismutase activity in morbidly obese persons Obesity (Silver Spring) 18 952 8 1:CAS:528:DC%2BC3cXlt1ahtrc%3D 10.1038/oby.2009.314
18. M Macias-Gonzalez M Moreno-Santos JM Garcia-Almeida, et al. 2009 PPARγ2 protects against obesity by means of a mechanism that mediates insulin resistance Eur J Clin Invest 39 972 9 1:CAS:528:DC%2BD1MXhsVKhtb3F 10.1111/j.1365-2362.2009.02198.x 19645740
19. G Medina-Gomez SL Gray L Yetukuri, et al. 2007 PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism PLoS Genet 3 e64 10.1371/journal.pgen.0030064 17465682
20. HC Chen SJ Stone P Zhou, et al. 2002 Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue Diabetes 51 3189 95 1:CAS:528:DC%2BD38Xos1aht7c%3D 10.2337/diabetes.51.11.3189 12401709
21. CL Yen SJ Stone S Koliwad, et al. 2008 Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis J Lipid Res 49 2283 301 1:CAS:528:DC%2BD1cXht12it7rI 10.1194/jlr.R800018-JLR200 18757836
22. Y Zang T Wang W Xie, et al. 2005 Regulation of acetyl CoA carboxylase and carnitine palmitoyl transferase-1 in rat adipocytes Obes Res 13 1530 9 1:CAS:528:DC%2BD2MXhtFyhtLbO 10.1038/oby.2005.188 16222055
23. RW Brownsey AN Boone JE Elliott, et al. 2006 Regulation of acetyl-CoA carboxylase Biochem Soc Trans 34 223 7 1:CAS:528:DC%2BD28Xis1ersrs%3D 10.1042/BST20060223 16545081
24. FJ Ortega D Mayas JM Moreno-Navarrete, et al. 2010 The gene expression of the main lipogenic enzymes is downregulated in visceral adipose tissue of obese subjects Obesity (Silver Spring) 18 13 20 1:CAS:528:DC%2BD1MXhs1Sqt7rL 10.1038/oby.2009.202
25. K Kishida H Kuriyama T Funahashi, et al. 2000 Aquaporin adipose, a putative glycerol channel in adipocytes J Biol Chem 275 20896 902 1:CAS:528:DC%2BD3cXkvVyhtLc%3D 10.1074/jbc.M001119200 10777495
26. V Catalán J Gómez-Ambrosi C Pastor, et al. 2008 Influence of morbid obesity and insulin resistance on gene expression levels of AQP7 in visceral adipose tissue and AQP9 in liver Obes Surg 18 695 701 10.1007/s11695-008-9453-7 18401671
27. V Ceperuelo-Mallafré M Miranda MR Chacón, et al. 2007 Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes J Clin Endocrinol Metab 92 3640 5 10.1210/jc.2007-0531 17566090
28. P Arner 2005 Human fat cell lipolysis: biochemistry, regulation and clinical role Best Pract Res Clin Endocrinol Metab 19 471 82 1:CAS:528:DC%2BD2MXht1GhsLjN 10.1016/j.beem.2005.07.004 16311212
29. A Mairal D Langin P Arner, et al. 2006 Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity Diabetologia 49 1629 36 1:CAS:528:DC%2BD28Xlt1Ojurk%3D 10.1007/s00125-006-0272-x 16752181
30. Y Tang H Osawa H Onuma, et al. 1999 Improvement in insulin resistance and the restoration of reduced phosphodiesterase 3B gene expression by pioglitazone in adipose tissue of obese diabetic KKAy mice Diabetes 48 1830 5 1:CAS:528:DyaK1MXmtVaitbw%3D 10.2337/diabetes.48.9.1830 10480615
31. M Flechtner-Mors CP Jenkinson A Alt, et al. 2005 Studies of phosphodiesterase effects on adipose tissue metabolism in obese subjects by the microdialysis technique J Physiol Pharmacol 56 355 68 1:CAS:528: DC%2BD2MXhtFGlsbvN 16204759
32. J Tordjman G Chauvet J Quette, et al. 2003 Thiazolidinediones block fatty acid release by inducing glyceroneogenesis in fat cells J Biol Chem 278 18785 90 1:CAS:528:DC%2BD3sXjvVSlur8%3D 10.1074/jbc.M206999200 12644461
33. K Sasaki TP Cripe SR Koch, et al. 1984 Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin J Biol Chem 259 15242 51 1:CAS:528:DyaL2cXmt1eitbg%3D 6096365
34. JK Sethi AJ Vidal-Puig 2007 Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation J Lipid Res 48 1253 62 1:CAS:528:DC%2BD2sXmtFGmt78%3D 10.1194/jlr.R700005-JLR200 17374880
35. A Misra NK Vikram 2003 Clinical and pathophysiological consequences of abdominal adiposity and abdominal adipose tissue depots Nutrition 19 457 66 10.1016/S0899-9007(02)01003-1 12714101
36. MM Ibrahim 2009 Subcutaneous and visceral adipose tissue: structural and functional differences Obes Rev 11 11 8 10.1111/j.1467-789X.2009.00623.x 19656312
37. TM Larsen S Toubro A Astrup 2003 PPARgamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy? Int J Obes Relat Metab Disord 27 147 61 1:CAS:528:DC%2BD3sXhtFGhsrc%3D 10.1038/sj.ijo.802223 12586994
38. V Large P Arner 1998 Regulation of lipolysis in humans. Pathophysiological modulation in obesity, diabetes, and hyperlipidaemia Diab Metab 24 409 18 1:CAS:528:DyaK1MXlsVersg%3D%3D