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Volumn 5, Issue 8, 2014, Pages

Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; LEUPEPTIN; OXIDOPAMINE; PARKIN; PROTEASOME; PROTEIN BINDING; REPRESSOR PROTEIN; RTP801 PROTEIN, RAT; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE;

EID: 84906874980     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.333     Document Type: Article
Times cited : (39)

References (53)
  • 1
    • 0031658947 scopus 로고    scopus 로고
    • Medical treatment of Parkinson's disease
    • Fahn S. Medical treatment of Parkinson's disease. J Neurol 1998; 245(11 Suppl 3): P15-P24.
    • (1998) J Neurol , vol.245 , Issue.11 SUPPL. 3
    • Fahn, S.1
  • 2
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron 2003; 39: 889-909.
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 3
    • 44949116236 scopus 로고    scopus 로고
    • Invited article: Changing concepts in Parkinson disease: Moving beyond the decade of the brain
    • Marras C, Lang A. Invited article: changing concepts in Parkinson disease: moving beyond the decade of the brain. Neurology 2008; 70: 1996-2003.
    • (2008) Neurology , vol.70 , pp. 1996-2003
    • Marras, C.1    Lang, A.2
  • 4
    • 62449129138 scopus 로고    scopus 로고
    • Cell death pathways in Parkinson's disease: Proximal triggers, distal effectors, and final steps
    • Levy OA, Malagelada C, Greene LA. Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps. Apoptosis 2009; 14: 478-500.
    • (2009) Apoptosis , vol.14 , pp. 478-500
    • Levy, O.A.1    Malagelada, C.2    Greene, L.A.3
  • 5
    • 0032499264 scopus 로고    scopus 로고
    • Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
    • Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 1998; 392: 605-608.
    • (1998) Nature , vol.392 , pp. 605-608
    • Kitada, T.1    Asakawa, S.2    Hattori, N.3    Matsumine, H.4    Yamamura, Y.5    Minoshima, S.6
  • 6
    • 0033933048 scopus 로고    scopus 로고
    • Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
    • Shimura H, Hattori N, Kubo S, Mizuno Y, Asakawa S, Minoshima S et al. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet 2000; 25: 302-305.
    • (2000) Nat Genet , vol.25 , pp. 302-305
    • Shimura, H.1    Hattori, N.2    Kubo, S.3    Mizuno, Y.4    Asakawa, S.5    Minoshima, S.6
  • 7
    • 2542534741 scopus 로고    scopus 로고
    • S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function
    • Chung KK, Thomas B, Li X, Pletnikova O, Troncoso JC, Marsh L et al. S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science 2004; 304: 1328-1331.
    • (2004) Science , vol.304 , pp. 1328-1331
    • Chung, K.K.1    Thomas, B.2    Li, X.3    Pletnikova, O.4    Troncoso, J.C.5    Marsh, L.6
  • 8
    • 0344875488 scopus 로고    scopus 로고
    • Inactivation of parkin by oxidative stress and C-terminal truncations: A protective role of molecular chaperones
    • Winklhofer KF, Henn IH, Kay-Jackson PC, Heller U, Tatzelt J. Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones. J Biol Chem 2003; 278: 47199-47208.
    • (2003) J Biol Chem , vol.278 , pp. 47199-47208
    • Winklhofer, K.F.1    Henn, I.H.2    Kay-Jackson, P.C.3    Heller, U.4    Tatzelt, J.5
  • 11
    • 0037137702 scopus 로고    scopus 로고
    • Parkin protects against the toxicity associated with mutant alpha-synuclein: Proteasome dysfunction selectively affects catecholaminergic neurons
    • Petrucelli L, O'Farrell C, Lockhart PJ, Baptista M, Kehoe K, Vink L et al. Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons. Neuron 2002; 36: 1007-1019.
    • (2002) Neuron , vol.36 , pp. 1007-1019
    • Petrucelli, L.1    O'Farrell, C.2    Lockhart, P.J.3    Baptista, M.4    Kehoe, K.5    Vink, L.6
  • 12
    • 0037422010 scopus 로고    scopus 로고
    • Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity
    • Staropoli JF, McDermott C, Martinat C, Schulman B, Demireva E, Abeliovich A. Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity. Neuron 2003; 37: 735-749.
    • (2003) Neuron , vol.37 , pp. 735-749
    • Staropoli, J.F.1    McDermott, C.2    Martinat, C.3    Schulman, B.4    Demireva, E.5    Abeliovich, A.6
  • 13
    • 34548741834 scopus 로고    scopus 로고
    • RAAV-mediated nigral human parkin over-expression partially amelioratesmotor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease
    • Manfredsson FP, Burger C, Sullivan LF, Muzyczka N, Lewin AS, Mandel RJ. rAAV-mediated nigral human parkin over-expression partially amelioratesmotor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease. Exp Neurol 2007; 207: 289-301.
    • (2007) Exp Neurol , vol.207 , pp. 289-301
    • Manfredsson, F.P.1    Burger, C.2    Sullivan, L.F.3    Muzyczka, N.4    Lewin, A.S.5    Mandel, R.J.6
  • 14
  • 16
    • 0036863624 scopus 로고    scopus 로고
    • REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species
    • Ellisen LW, Ramsayer KD, Johannessen CM, Yang A, Beppu H, Minda K et al. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell 2002; 10: 995-1005.
    • (2002) Mol Cell , vol.10 , pp. 995-1005
    • Ellisen, L.W.1    Ramsayer, K.D.2    Johannessen, C.M.3    Yang, A.4    Beppu, H.5    Minda, K.6
  • 17
    • 0036118562 scopus 로고    scopus 로고
    • Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis
    • Shoshani T, Faerman A, Mett I, Zelin E, Tenne T, Gorodin S et al. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol Cell Biol 2002; 22: 2283-2293.
    • (2002) Mol Cell Biol , vol.22 , pp. 2283-2293
    • Shoshani, T.1    Faerman, A.2    Mett, I.3    Zelin, E.4    Tenne, T.5    Gorodin, S.6
  • 18
    • 11844287697 scopus 로고    scopus 로고
    • Analysis of gene expression changes in a cellular model of Parkinson disease
    • Ryu EJ, Angelastro JM, Greene LA. Analysis of gene expression changes in a cellular model of Parkinson disease. Neurobiol Dis 2005; 18: 54-74.
    • (2005) Neurobiol Dis , vol.18 , pp. 54-74
    • Ryu, E.J.1    Angelastro, J.M.2    Greene, L.A.3
  • 19
    • 33749166640 scopus 로고    scopus 로고
    • RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation
    • Malagelada C, Ryu EJ, Biswas SC, Jackson-Lewis V, Greene LA. RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation. J Neurosci 2006; 26: 9996-10005.
    • (2006) J Neurosci , vol.26 , pp. 9996-10005
    • Malagelada, C.1    Ryu, E.J.2    Biswas, S.C.3    Jackson-Lewis, V.4    Greene, L.A.5
  • 20
    • 58149395816 scopus 로고    scopus 로고
    • RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation
    • Malagelada C, Jin ZH, Greene LA. RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation. J Neurosci 2008; 28: 14363-14371.
    • (2008) J Neurosci , vol.28 , pp. 14363-14371
    • Malagelada, C.1    Zh, J.2    Greene, L.A.3
  • 21
    • 68249104457 scopus 로고    scopus 로고
    • REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase
    • Katiyar S, Liu E, Knutzen CA, Lang ES, Lombardo CR, Sankar S et al. REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase. EMBO Rep 2009; 10: 866-872.
    • (2009) EMBO Rep , vol.10 , pp. 866-872
    • Katiyar, S.1    Liu, E.2    Knutzen, C.A.3    Lang, E.S.4    Lombardo, C.R.5    Sankar, S.6
  • 22
    • 41249094257 scopus 로고    scopus 로고
    • Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis
    • Kimball SR, Do AN, Kutzler L, Cavener DR, Jefferson LS. Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. J Biol Chem 2008; 283: 3465-3475.
    • (2008) J Biol Chem , vol.283 , pp. 3465-3475
    • Kimball, S.R.1    Do, A.N.2    Kutzler, L.3    Cavener, D.R.4    Jefferson, L.S.5
  • 23
    • 75749127850 scopus 로고    scopus 로고
    • Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease
    • Malagelada C, Jin ZH, Jackson-Lewis V, Przedborski S, Greene LA. Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease. J Neurosci 2010; 30: 1166-1175.
    • (2010) J Neurosci , vol.30 , pp. 1166-1175
    • Malagelada, C.1    Zh, J.2    Jackson-Lewis, V.3    Przedborski, S.4    Greene, L.A.5
  • 25
    • 0034680913 scopus 로고    scopus 로고
    • Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity
    • Imai Y, Soda M, Takahashi R. Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. J Biol Chem 2000; 275: 35661-35664.
    • (2000) J Biol Chem , vol.275 , pp. 35661-35664
    • Imai, Y.1    Soda, M.2    Takahashi, R.3
  • 26
    • 70449519412 scopus 로고    scopus 로고
    • Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease
    • da Costa CA, Sunyach C, Giaime E, West A, Corti O, Brice A et al. Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease. Nat Cell Biol 2009; 11: 1370-1375.
    • (2009) Nat Cell Biol , vol.11 , pp. 1370-1375
    • Da Costa, C.A.1    Sunyach, C.2    Giaime, E.3    West, A.4    Corti, O.5    Brice, A.6
  • 28
    • 34249946941 scopus 로고    scopus 로고
    • Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage
    • Stichel CC, Zhu XR, Bader V, Linnartz B, Schmidt S, Lubbert H. Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage. Hum Mol Genet 2007; 16: 2377-2393.
    • (2007) Hum Mol Genet , vol.16 , pp. 2377-2393
    • Stichel, C.C.1    Zhu, X.R.2    Bader, V.3    Linnartz, B.4    Schmidt, S.5    Lubbert, H.6
  • 30
    • 28844439032 scopus 로고    scopus 로고
    • Proteomic analysis of parkin knockout mice: Alterations in energy metabolism, protein handling and synaptic function
    • Periquet M, Corti O, Jacquier S, Brice A. Proteomic analysis of parkin knockout mice: alterations in energy metabolism, protein handling and synaptic function. J Neurochem 2005; 95: 1259-1276.
    • (2005) J Neurochem , vol.95 , pp. 1259-1276
    • Periquet, M.1    Corti, O.2    Jacquier, S.3    Brice, A.4
  • 31
    • 0038373385 scopus 로고    scopus 로고
    • Dexamethasoneinduced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals
    • Wang Z, Malone MH, Thomenius MJ, Zhong F, Xu F, Distelhorst CW. Dexamethasoneinduced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals. J Biol Chem 2003; 278: 27053-27058.
    • (2003) J Biol Chem , vol.278 , pp. 27053-27058
    • Wang, Z.1    Malone, M.H.2    Thomenius, M.J.3    Zhong, F.4    Xu, F.5    Distelhorst, C.W.6
  • 32
    • 84874861183 scopus 로고    scopus 로고
    • The cerebellum in Parkinson's disease
    • Wu T, Hallett M. The cerebellum in Parkinson's disease. Brain 2013; 136(Pt 3): 696-709.
    • (2013) Brain , vol.136 , Issue.PART 3 , pp. 696-709
    • Wu, T.1    Hallett, M.2
  • 33
    • 84873287971 scopus 로고    scopus 로고
    • ATF4 protects against neuronal death in cellular PD models by maintaining levels of parkin
    • Sun X, Liu J, Crary J.F, Malagelada C, Sulzer D, Greene L.A, Levy O.A. ATF4 protects against neuronal death in cellular PD models by maintaining levels of parkin. J Neurosci 2013; 33: 2398-2407.
    • (2013) J Neurosci , vol.33 , pp. 2398-2407
    • Sun, X.1    Liu, J.2    Crary, J.F.3    Malagelada, C.4    Sulzer, D.5    Greene, L.A.6    Levy, O.A.7
  • 35
    • 84857254436 scopus 로고    scopus 로고
    • Alpha-synuclein's degradation in vivo: Opening a new (cranial) window on the roles of degradation pathways in Parkinson disease
    • Ebrahimi-Fakhari D, McLean PJ, Unni VK. Alpha-synuclein's degradation in vivo: opening a new (cranial) window on the roles of degradation pathways in Parkinson disease. Autophagy 2012; 8: 281-283.
    • (2012) Autophagy , vol.8 , pp. 281-283
    • Ebrahimi-Fakhari, D.1    McLean, P.J.2    Unni, V.K.3
  • 36
    • 84867204635 scopus 로고    scopus 로고
    • Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis
    • Zhao Y, Xiong X, Jia L, Sun Y. Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death Dis 2012; 3: e386.
    • (2012) Cell Death Dis , vol.3
    • Zhao, Y.1    Xiong, X.2    Jia, L.3    Sun, Y.4
  • 37
    • 77953424577 scopus 로고    scopus 로고
    • The role of parkin in familial and sporadic Parkinson's disease
    • Dawson TM, Dawson VL. The role of parkin in familial and sporadic Parkinson's disease. Mov Disord 2010; 25(Suppl 1): S32-S39.
    • (2010) Mov Disord , vol.25 , Issue.SUPPL. 1
    • Dawson, T.M.1    Dawson, V.L.2
  • 40
    • 67649479622 scopus 로고    scopus 로고
    • Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice
    • Kitada T, Pisani A, Karouani M, Haburcak M, Martella G, Tscherter A et al. Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice. J Neurochem 2009; 110: 613-621.
    • (2009) J Neurochem , vol.110 , pp. 613-621
    • Kitada, T.1    Pisani, A.2    Karouani, M.3    Haburcak, M.4    Martella, G.5    Tscherter, A.6
  • 41
    • 2442481789 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative damage in parkin-deficient mice
    • Palacino JJ, Sagi D, Goldberg MS, Krauss S, Motz C, Wacker M et al. Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J Biol Chem 2004; 279: 18614-18622.
    • (2004) J Biol Chem , vol.279 , pp. 18614-18622
    • Palacino, J.J.1    Sagi, D.2    Goldberg, M.S.3    Krauss, S.4    Motz, C.5    Wacker, M.6
  • 42
    • 0141891953 scopus 로고    scopus 로고
    • Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons
    • Goldberg MS, Fleming SM, Palacino JJ, Cepeda C, Lam HA, Bhatnagar A et al. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J Biol Chem 2003; 278: 43628-43635.
    • (2003) J Biol Chem , vol.278 , pp. 43628-43635
    • Goldberg, M.S.1    Fleming, S.M.2    Palacino, J.J.3    Cepeda, C.4    Lam, H.A.5    Bhatnagar, A.6
  • 43
    • 13844253723 scopus 로고    scopus 로고
    • Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonismlinked gene DJ-1
    • Goldberg MS, Pisani A, Haburcak M, Vortherms TA, Kitada T, Costa C et al. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonismlinked gene DJ-1. Neuron 2005; 45: 489-496.
    • (2005) Neuron , vol.45 , pp. 489-496
    • Goldberg, M.S.1    Pisani, A.2    Haburcak, M.3    Vortherms, T.A.4    Kitada, T.5    Costa, C.6
  • 44
  • 46
    • 10644281090 scopus 로고    scopus 로고
    • Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease
    • Lo Bianco C, Schneider BL, Bauer M, Sajadi A, Brice A, Iwatsubo T et al. Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease. Proc Natl Acad Sci USA 2004; 101: 17510-17515.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 17510-17515
    • Lo Bianco, C.1    Schneider, B.L.2    Bauer, M.3    Sajadi, A.4    Brice, A.5    Iwatsubo, T.6
  • 47
    • 84863393846 scopus 로고    scopus 로고
    • Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells
    • Jiang H, Ren Y, Yuen EY, Zhong P, Ghaedi M, Hu Z et al. Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. Nature Commun 2012; 3: 668.
    • (2012) Nature Commun , vol.3 , pp. 668
    • Jiang, H.1    Ren, Y.2    Yuen, E.Y.3    Zhong, P.4    Ghaedi, M.5    Hu, Z.6
  • 48
  • 50
    • 84864855385 scopus 로고    scopus 로고
    • Phase 1 dose-escalation study of a siRNA targeting the RTP801 gene in age-related macular degeneration patients
    • Nguyen QD, Schachar RA, Nduaka CI, Sperling M, Basile AS, Klamerus KJ et al. Phase 1 dose-escalation study of a siRNA targeting the RTP801 gene in age-related macular degeneration patients. Eye 2012; 26: 1099-1105.
    • (2012) Eye , vol.26 , pp. 1099-1105
    • Nguyen, Q.D.1    Schachar, R.A.2    Nduaka, C.I.3    Sperling, M.4    Basile, A.S.5    Klamerus, K.J.6
  • 52
    • 0345704610 scopus 로고
    • Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
    • Greene LA, Tischler AS. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 1976; 73: 2424-2428.
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 2424-2428
    • Greene, L.A.1    Tischler, A.S.2
  • 53
    • 0037114971 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease
    • Ryu EJ, Harding HP, Angelastro JM, Vitolo OV, Ron D, Greene LA. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci 2002; 22: 10690-10698.
    • (2002) J Neurosci , vol.22 , pp. 10690-10698
    • Ryu, E.J.1    Harding, H.P.2    Angelastro, J.M.3    Vitolo, O.V.4    Ron, D.5    Greene, L.A.6


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