Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells

Drug Metabolism and Disposition

Volumn 42, Issue 9, 2014, Pages 1556-1566

  Azzi, Pamela Bachour El ^a,b,c   Sharanek, Ahmad ^a,b   Abdel Razzak, Ziad ^c   Antherieu, Sebastien ^a,b,f   Al Attrache, Houssein ^a,b,c   Savary, Camille C ^a,b   Lepage, Sylvie ^d   Morel, Isabelle ^a,b,d   Labbe, Gilles ^e   Guguen Guillouzo, Christiane ^a,b   Guillouzo, André ^a,b  

^a Univ Rennes   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c LEBANESE UNIVERSITY   (Lebanon)

^d PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^e SANOFI   (France)

^f IMPECS IMPact de l Environnement Chimique sur la Santé humaine   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; BILE ACID; C REACTIVE PROTEIN; CHLORPROMAZINE; COTRANSPORTER; CYP1A2 PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 1A2; CYTOCHROME P450 3A; INTERLEUKIN DERIVATIVE; MESSENGER RNA; ORGANIC ANION TRANSPORTER; SODIUM-BILE ACID COTRANSPORTER; TAUROCHOLIC ACID;

CELL LINE; CHEMICALLY INDUCED; CHOLESTASIS; DOWN REGULATION; GENETICS; HUMAN; INFLAMMATION; METABOLISM; OXIDATIVE STRESS;

ACTINS; BILE ACIDS AND SALTS; C-REACTIVE PROTEIN; CELL LINE; CHLORPROMAZINE; CHOLESTASIS; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP3A; DOWN-REGULATION; HUMANS; INFLAMMATION; INTERLEUKINS; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; OXIDATIVE STRESS; RNA, MESSENGER; SYMPORTERS; TAUROCHOLIC ACID;

EID: 84906855709     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.114.058123     Document Type: Article

References (38)

1. Abdel-Razzak Z, Loyer P, Fautrel A, Gautier JC, Corcos L, Turlin B, Beaune P, and Guillouzo A (1993) Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol Pharmacol 44:707-715. (Pubitemid 23317282)
2. Aitken AE, Richardson TA, and Morgan ET (2006) Regulation of drug-metabolizing enzymes and transporters in inflammation. Annu Rev Pharmacol Toxicol 46:123-149. (Pubitemid 43271186)
3. Aninat C, Piton A, Glaise D, Le Charpentier T, Langouët S, Morel F, Guguen-Guillouzo C, and Guillouzo A (2006) Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab Dispos 34:75-83. (Pubitemid 43042648)
4. Aninat C, Seguin P, Descheemaeker PN, Morel F, Malledant Y, and Guillouzo A (2008) Catecholamines induce an inflammatory response in human hepatocytes. Crit Care Med 36:848-854.
5. Anthérieu S, Bachour-El Azzi P, Dumont J, Abdel-Razzak Z, Guguen-Guillouzo C, Fromenty B, Robin MA, and Guillouzo A (2013) Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells. Hepatology 57:1518-1529.
6. Barton CC, Ganey PE, and Roth RA (2000) Lipopolysaccharide augments aflatoxin B(1)-induced liver injury through neutrophil-dependent and -independent mechanisms. Toxicol Sci 58:208-215.
7. Breuker C, Moreau A, Lakhal L, Tamasi V, Parmentier Y, Meyer U, Maurel P, Lumbroso S, Vilarem MJ, and Pascussi JM (2010) Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3). Endocrinology 151:1653-1661.
8. Buchweitz JP, Ganey PE, Bursian SJ, and Roth RA (2002) Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy? J Pharmacol Exp Ther 300:460-467.
9. Cerec V, Glaise D, Garnier D, Morosan S, Turlin B, Drenou B, Gripon P, Kremsdorf D, Guguen-Guillouzo C, and Corlu A (2007) Transdifferentiation of hepatocyte-like cells from the human hepatoma HepaRG cell line through bipotent progenitor. Hepatology 45:957-967. (Pubitemid 46631564)
10. Diao L, Li N, Brayman TG, Hotz KJ, and Lai Y (2010) Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-alpha, IL-6, and IL-1beta. J Biol Chem 285:31185-31192.
11. Elferink MG, Olinga P, Draaisma AL, Merema MT, Faber KN, Slooff MJ, Meijer DK, and Groothuis GM (2004) LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process. Am J Physiol Gastrointest Liver Physiol 287:G1008 -G1016.
12. Fujimura H, Dekura E, Kurabe M, Shimazu N, Koitabashi M, and Toriumi W (2007) Cell-based fluorescence assay for evaluation of new-drugs potential for phospholipidosis in an early stage of drug development. Exp Toxicol Pathol 58:375-382. (Pubitemid 47058266)
13. Gandhi A, Guo T, and Ghose R (2010) Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-alpha) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes. J Toxicol Sci 35:163-173.
14. Gerets HH, Tilmant K, Gerin B, Chanteux H, Depelchin BO, Dhalluin S, and Atienzar FA (2012) Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol 28:69-87.
15. Greer ML, Barber J, Eakins J, and Kenna JG (2010) Cell based approaches for evaluation of drug-induced liver injury. Toxicology 268:125-131.
16. Gripon P, Rumin S, Urban S, Le Seyec J, Glaise D, Cannie I, Guyomard C, Lucas J, Trepo C, and Guguen-Guillouzo C (2002) Infection of a human hepatoma cell line by hepatitis B virus. Proc Natl Acad Sci USA 99:15655-15660. (Pubitemid 35403987)
17. Hollister LE (1957) Allergy to chlorpromazine manifested by jaundice. Am J Med 23:870-879.
18. Le Vee M, Gripon P, Stieger B, and Fardel O (2008) Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta. Drug Metab Dispos 36:217-222. (Pubitemid 351185762)
19. Le Vee M, Lecureur V, Stieger B, and Fardel O (2009) Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-alpha or interleukin-6. Drug Metab Dispos 37:685-693.
20. MacAllister SL, Young C, Guzdek A, Zhidkov N, and O'Brien PJ (2013) Molecular cytotoxic mechanisms of chlorpromazine in isolated rat hepatocytes. Can J Physiol Pharmacol 91:56-63.
21. Marion TL, Perry CH, St Claire RL, 3rd, and Brouwer KL (2012) Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes. Toxicol Appl Pharmacol 261:1-9.
22. Meng Q (2010) Three-dimensional culture of hepatocytes for prediction of drug-induced hepatotoxicity. Expert Opin Drug Metab Toxicol 6:733-746.
23. Mullock BM, Hall DE, Shaw LJ, and Hinton RH (1983) Immune responses to chlorpromazine in rats. Detection and relation to hepatotoxicity. Biochem Pharmacol 32:2733-2738. (Pubitemid 13009425)
24. Ni Y, Lempp FA, Mehrle S, Nkongolo S, Kaufman C, Falth M, Stindt J, Koniger C, Nassal M, and Kubitz R, et al. (2014) Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes. Gastroenterology 146: 1070 -1083.
25. Pernelle K, Le Guevel R, Glaise D, Stasio CG, Le Charpentier T, Bouaita B, Corlu A, and Guguen-Guillouzo C (2011) Automated detection of hepatotoxic compounds in human hepatocytes using HepaRG cells and image-based analysis of mitochondrial dysfunction with JC-1 dye. Toxicol Appl Pharmacol 254:256-266.
26. Regal RE, Billi JE, and Glazer HM (1987) Phenothiazine-induced cholestatic jaundice. Clin Pharm 6:787-794. (Pubitemid 17153596)
27. Roth RA, Harkema JR, Pestka JP, and Ganey PE (1997) Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents? Toxicol Appl Pharmacol 147:300-311. (Pubitemid 28062747)
28. Shaw PJ, Hopfensperger MJ, Ganey PE, and Roth RA (2007) Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. Toxicol Sci 100:259-266. (Pubitemid 47617822)
29. Velayudham LS and Farrell GC (2003) Drug-induced cholestasis. Expert Opin Drug Saf 2:287-304.
30. Wagner M, Zollner G, and Trauner M (2009) New molecular insights into the mechanisms of cholestasis. J Hepatol 51:565-580.
31. Waring JF, Liguori MJ, Luyendyk JP, Maddox JF, Ganey PE, Stachlewitz RF, North C, Blomme EA, and Roth RA (2006) Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils. J Pharmacol Exp Ther 316:1080-1087. (Pubitemid 43345281)
32. Wójcikowski J, Boksa J, and Daniel WA (2010) Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver - a comparison with other phenothiazines. Biochem Pharmacol 80:1252-1259.
33. Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, Huang Y, Qi Y, Peng B, and Wang H, et al. (2012) Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. eLife 1:e00049.
34. Yee SB, Kinser S, Hill DA, Barton CC, Hotchkiss JA, Harkema JR, Ganey PE, and Roth RA (2000) Synergistic hepatotoxicity from coexposure to bacterial endotoxin and the pyrrolizidine alkaloid monocrotaline. Toxicol Appl Pharmacol 166:173-185. (Pubitemid 30640628)
35. Zamek-Gliszczynski MJ, Xiong H, Patel NJ, Turncliff RZ, Pollack GM, and Brouwer KL (2003) Pharmacokinetics of 5 (and 6)-carboxy-2′,7′- dichlorofluorescein and its diacetate promoiety in the liver. J Pharmacol Exp Ther 304:801-809. (Pubitemid 36152359)
36. Zimmermann HW, Seidler S, Gassler N, Nattermann J, Luedde T, Trautwein C, and Tacke F (2011) Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis. PLoS ONE 6:e21381.
37. Zollner G, Fickert P, Zenz R, Fuchsbichler A, Stumptner C, Kenner L, Ferenci P, Stauber RE, Krejs GJ, and Denk H, et al. (2001) Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases. Hepatology 33:633-646. (Pubitemid 32185226)
38. Zollner G, Marschall HU, Wagner M, and Trauner M (2006) Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations. Mol Pharm 3:231-251. (Pubitemid 44021431)