Molecular cytotoxic mechanisms of chlorpromazine in isolated rat hepatocytes

Canadian Journal of Physiology and Pharmacology

Volumn 91, Issue 1, 2013, Pages 56-63

  MacAllister, Stephanie L ^a   Young, Cheryl ^a   Guzdek, Anna ^a   Zhidkov, Nickholas ^a   O'Brien, Peter J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Chlorpromazine; Cytochrome P450; Glutathione; Inflammation; Mitochondrial membrane potential; Oxidative stress

Indexed keywords

BORNEOL; CHLORPROMAZINE; CYTOCHROME P450 1A2; CYTOCHROME P450 2D1; GLUCURONIDE; GLUTATHIONE; PEROXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ANIMAL CELL; ARTICLE; CELL ISOLATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DETOXIFICATION; ENZYME ACTIVATION; ENZYME INHIBITION; GLUCURONIDATION; INFLAMMATION; LIVER CELL; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT;

ALCOHOL OXIDOREDUCTASES; ANIMALS; ANTIPSYCHOTIC AGENTS; CELL SURVIVAL; CELLS, CULTURED; CHLORPROMAZINE; CYTOCHROMES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HEPATOCYTES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; METABOLIC DETOXICATION, DRUG; MITOCHONDRIA, LIVER; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84873595224     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2012-0223     Document Type: Article

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