Morphologic and molecular characterization of traditional serrated adenomas of the distal colon and rectum

American Journal of Surgical Pathology

Volumn 38, Issue 9, 2014, Pages 1290-1297

  Wiland, Homer O ^a   Shadrach, Bonnie ^a   Allende, Daniela ^a   Carver, Paula ^a   Goldblum, John R ^a   Liu, Xiuli ^a   Patil, Deepa T ^a   Rybicki, Lisa A ^a   Pai, Rish K ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANNEXIN; ANXA10 PROTEIN, HUMAN; B RAF KINASE; BRAF PROTEIN, HUMAN; GNAS PROTEIN, HUMAN; KRAS PROTEIN, HUMAN; ONCOPROTEIN; RAS PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; TUMOR MARKER;

ADENOMA; ADULT; AGED; ARTICLE; BIOPSY; CHEMISTRY; COLON POLYP; COLON TUMOR; COMPARATIVE STUDY; CPG ISLAND; DNA METHYLATION; FEMALE; GENETIC PREDISPOSITION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHENOTYPE; PROGNOSIS; RECTUM TUMOR; UNITED STATES; VERY ELDERLY;

ADENOMA; ADULT; AGED; AGED, 80 AND OVER; ANNEXINS; BIOPSY; COLONIC NEOPLASMS; COLONIC POLYPS; CPG ISLANDS; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTATION; OHIO; PHENOTYPE; PROGNOSIS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; RAS PROTEINS; RECTAL NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84906793935     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0000000000000253     Document Type: Article

References (24)

1. Leggett B, Whitehall V. Role of the serrated pathway in colorectal cancer pathogenesis. Gastroenterology. 2010;138:2088-2100.
2. Bettington M, Walker N, Clouston A, et al. The serrated pathway to colorectal carcinoma: current concepts and challenges. Histopathology. 2013;62:367-386.
3. Torlakovic E, Skovlund E, Snover DC, et al. Morphologic reappraisal of serrated colorectal polyps. Am J Surg Pathol. 2003; 27:65-81.
4. Longacre TA, Fenoglio-Preiser CM. Mixed hyperplastic adenomatous polyps/serrated adenomas. A distinct form of colorectal neoplasia. Am J Surg Pathol. 1990;14:524-537.
5. Snover DC, Ahnen DJ, Burt RW, et al. WHO Classification of Tumors of the Digestive System. International Agency for Research on Cancer; 2010:160-165.
6. Torlakovic EE, Gomez JD, Driman DK, et al. Sessile serrated adenoma (SSA) vs. traditional serrated adenoma (TSA). Am J Surg Pathol. 2008;32:21-29.
7. Jass JR, Baker K, Zlobec I, et al. Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a "fusion" pathway to colorectal cancer. Histopathology. 2006;49:121-131.
8. Yang S, Farraye FA, Mack C, et al. BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. Am J Surg Pathol. 2004;28:1452-1459.
9. Kim K-M, Lee EJ, Kim Y-H, et al. KRAS mutations in traditional serrated adenomas from Korea herald an aggressive phenotype. Am J Surg Pathol. 2010;34:667-675.
10. Kim M-J, Lee EJ, Suh JP, et al. Traditional serrated adenoma of the colorectum: clinicopathologic implications and endoscopic findings of the precursor lesions. Am J Clin Pathol. 2013;140:898-911.
11. Fu B, Yachida S, Morgan R, et al. Clinicopathologic and genetic characterization of traditional serrated adenomas of the colon. Am J Clin Pathol. 2012;138:356-366.
12. Yamada M, Sekine S, Ogawa R, et al. Frequent activating GNAS mutations in villous adenoma of the colorectum. J Pathol. 2012;228:113-118.
13. Gonzalo DH, Lai KK, Shadrach B, et al. Gene expression profiling of serrated polyps identifies Annexin A10 as a marker of a sessile serrated adenoma/polyp. J Pathol. 2013;230:420-429.
14. Nikiforova MN, Lynch RA, Biddinger PW, et al. RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma. J Clin Endocrinol Metab. 2003;88:2318-2326.
15. Pai RK, Mackinnon AC, Joseph L, et al. Identification of histologically distinct conventional adenomas that arise predominately in patients with sessile serrated adenomas. Am J Surg Pathol. 2010;34:355-363.
16. Weisenberger DJ, Siegmund KD, Campan M, et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet. 2006;38:787-793.
17. O'Brien MJ, Yang S, Mack C, et al. Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points. Am J Surg Pathol. 2006;30:1491-1501.
18. Lee EJ, Choi C, Park CK, et al. Tracing origin of serrated adenomas with BRAF and KRAS mutations. Virchows Arch. 2005;447:597-602.
19. Hinoue T, Weisenberger DJ, Lange CP, et al. Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Res. 2012;22:271-282.
20. Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature. 2012;487: 330-337.
21. Yagi K, Akagi K, Hayashi H, et al. Three DNA methylation epigenotypes in human colorectal cancer. Clin Cancer Res. 2010;16:21-33.
22. Ogino S, Kawasaki T, Kirkner GJ, et al. Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer. Gut. 2007;56:1564-1571.
23. Kawasaki T, Ohnishi M, Nosho K, et al. CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci. Mod Pathol. 2008;21:245-255.
24. Burnett-Hartman AN, Newcomb PA, Potter JD, et al. Genomic aberrations occurring in subsets of serrated colorectal lesions but not conventional adenomas. Cancer Res. 2013;73: 2863-2872.