Tracing origin of serrated adenomas with BRAF and KRAS mutations

Virchows Archiv

Volumn 447, Issue 3, 2005, Pages 597-602

  Lee, Eui Jin ^a   Choi, Chan ^b   Park, Cheol Keun ^c   Maeng, Leeso ^a   Lee, Jehoon ^a   Lee, Anhi ^a   Kim, Kyoung Mee ^a  

^a The Catholic University of Korea   (South Korea)

^b Chonnam National University   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

BRAF; KRAS; Mutations; Serrated adenomas

Indexed keywords

B RAF KINASE; KRAS PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLON; COLON ADENOMA; COLON POLYP; CONTROLLED STUDY; EXON; FEMALE; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; MALE; POLYMERASE CHAIN REACTION; POLYP; PRIORITY JOURNAL;

ADENOMA; BASE SEQUENCE; COLORECTAL NEOPLASMS; DNA MUTATIONAL ANALYSIS; FEMALE; HUMANS; MALE; MIDDLE AGED; MUTATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF;

EID: 24744446040     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-005-1226-2     Document Type: Article

References (27)

1. Ajioka Y, Watanabe H, Jass JR, Yokota Y, Kobayashi M, Nishikura K (1998) Infrequent K-ras codon 12 mutation in serrated adenomas of human colorectum. Gut 42:680-684
2. Bariol C, Hawkins NJ, Turner JJ, Meagher AP, Williams DB, Ward RL (2004) Histopathological and clinical evaluation of serrated adenomas of the colon and rectum. Mod Pathol 16:417-423
3. Chan TL, Zhao W, Leung SY, Yuen ST (2003) BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas. Cancer Res 63:4878-4881
4. Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA (2002) Mutations of the BRAF gene in human cancer. Nature 417:949-954
5. Dong SM, Lee EJ, Jeon ES, Park CK, Kim KM (2004) Progressive methylation during the serrated neoplasia pathway of the colorectum. Mod Pathol [Epub ahead of print]
6. Fukushima T, Suzuki S, Mashiko M, Ohtake T, Endo Y, Takebayashi Y, Sekikawa K, Hagiwara K, Takenoshita S (2003) BRAF mutations in papillary carcinomas of the thyroid. Oncogene 322:6455-6457
7. Hawkins NJ, Bariol C, Ward RL (2002) The serrated neoplasia pathway. Pathology 34:548-555
8. Higashidani Y, Tamura S, Morita T, Tadokoro T, Yokoyama Y, Miyazaki J, Yang Y, Takeuchi S, Taguchi H, Onishi S (2003) Analysis of K-ras codon 12 mutation in flat and nodular variants of serrated adenoma in the colon. Dis Colon Rectum 46:327-332
9. Iino H, Jass JR, Simms LA, Young J, Leggett B, Ajioka Y, Watanabe H (1999) DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer? J Clin Pathol 52:5-9
10. Jass JR (1999) Serrated adenoma and colorectal cancer. J Pathol 187:499-502
11. Jass JR, Young J, Leggett BA (2000) Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum. Histopathology 37:295-301
12. Jass JR (2001) Serrated route to colorectal cancer: back street or super highway? J Pathol 193:283-285
13. Jass JR (2002) Progress in gastrointestinal pathology in the genetic era. Pathology 34:493
14. Kambara T, Simms LA, Whitehall VL, Spring KJ, Wynter CV, Walsh MD, Barker MA, Arnold S, McGivern A, Matsubara N, Tanaka N, Higuchi T, Young J, Jass JR, Leggett BA (2004) BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut 53(8):1137-1144
15. Koinuma K, Shitoh K, Miyakura Y, Furukawa T, Yamashita Y, Ota J, Ohki R, Choi YL, Wada T, Konishi F, Nagai H, Mano H (2004) Mutations of BRAF are associated with extensive hMLH1 promoter methylation in sporadic colorectal carcinomas. Int J Cancer 108:237-242
16. O'Brien MJ, Yang S, Clebanoff JL, Mulcahy E, Farraye FA, Amorosino M, Swan N (2004) Hyperplastic (serrated) polyps of the colorectum: relationship of CpG island methylator phenotype and K-ras mutation to location and histologic subtype. Am J Surg Pathol 28:423-434
17. Oliveira C, Pinto M, Duval A, Brennetot C, Domingo E, Espin E, Armengol M, Yamamoto H, Hamelin R, Seruca R, Schwartz S Jr (2003) BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency. Oncogene 22:9192-9196
18. Otori K, Oda Y, Sugiyama K, Hasebe T, Mukai K, Fujii T, Tajiri H, Yoshida S, Fukushima S, Esumi H (1997) High frequency of K-ras mutations in human colorectal hyperplastic polyps. Gut 40:660-663
19. Rashid A, Houlihan PS, Booker S, Petersen GM, Giardiello FM, Hamilton SR (2000) Phenotypic and molecular characteristics of hyperplastic polyposis. Gastroenterology 119:323-332
20. Russell SE, McCluggage WG (2004) A multistep model for ovarian tumorigenesis: the value of mutation analysis in the KRAS and BRAF genes. J Pathol 203:617-619
21. Sieben NL, Macropoulos P, Roemen GM, Kolkman-Uljee SM, Jan Fleuren G, Houmadi R, Diss T, Warren B, Al Adnani M, De Goeij AP, Krausz T, Flanagan AM (2004) In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours. J Pathol 202:336-340
22. Singer G, Oldt R III, Cohen Y, Wang BG, Sidransky D, Kurman RJ, Shih I-M (2003) Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. J Natl Cancer Inst 395:484-486
23. Sommerer F, Vieth M, Markwarth A, Rohrich K, Vomschloss S, May A, Ell C, Stolte M, Hengge UR, Wittekind C, Tannapfel A (2004) Mutations of BRAF and KRAS2 in the development of Barrett's adenocarcinoma. Oncogene 23:554-558
24. Torlakovic E, Skovlund E, Snover DC, Torlakovic G, Nesland JM (2003) Morphologic reappraisal of serrated colorectal polyps. Am J Surg Pathol 27:65-81
25. Wang L, Cunningham JM, Winters JL, Guenther JC, French AJ, Boardman LA, Burgart LJ, McDonnell SK, Schaid DJ, Thibodeau SN (2003) BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair. Cancer Res 63:5209-5212
26. Yang S, Farraye FA, Mack C, Posnik O, O'Brien MJ (2004) BRAF and KRAS mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. Am J Surg Pathol 28(11):1452-1459
27. Yuen ST, Davies H, Chan TL, Ho JW, Bignell GR, Cox C, Stephens P, Edkins S, Tsui WW, Chan AS, Futreal PA, Stratton MR, Wooster R, Leung SY (2002) Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia. Cancer Res 62:6451-6455