Effects of Rhodiola rosea L. extract on behavioural and physiological alterations induced by chronic mild stress in female rats

Journal of Psychopharmacology

Volumn 23, Issue 2, 2009, Pages 130-142

  Mattioli, L ^a   Funari, C ^a   Perfumi, M ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Adaptogens; Anhedonia; Antistress; CMS; Fluoxetine; Oestrous cycle; Rhodiola rosea

Indexed keywords

FLUOXETINE; RHODIOLA ROSEA EXTRACT; ROSAVIN; SALIDROSIDE; SUCROSE; UNCLASSIFIED DRUG; ANTIDEPRESSANT AGENT; PLANT EXTRACT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CHRONIC DRUG ADMINISTRATION; CHRONIC STRESS; CONTROLLED STUDY; ESTRUS CYCLE; EXPLORATORY BEHAVIOR; FEMALE; LOCOMOTION; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; RAT; WEIGHT GAIN; ANIMAL; CHEMISTRY; CHRONIC DISEASE; DOSE RESPONSE; DRUG EFFECT; MENTAL STRESS; METABOLISM; MOTOR ACTIVITY; PATHOPHYSIOLOGY; PHYTOTHERAPY; PLANT ROOT; RHODIOLA; WISTAR RAT;

ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; CHRONIC DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROUS CYCLE; EXPLORATORY BEHAVIOR; FEMALE; MOTOR ACTIVITY; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, WISTAR; RHODIOLA; STRESS, PSYCHOLOGICAL; SUCROSE; WEIGHT GAIN;

EID: 67650543082     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881108089872     Document Type: Article

References (57)

1. Abidov M, Crendal F, Grachev S, Seifulla R, Ziegenfuss T, (2003) Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles. Bull Exp Biol Med 136: 585 - 587.
2. American Psychiatric Association (1994) DSM IV - Diagnostic and Statistical Manual of Psychiatric Disorders, fourth ed. Washington: American Psychiatric Association.
3. Baker SL, Kentner AC, Konkle AT, Santa-Maria Barbagallo L, Bielajew C, (2006) Behavioral and physiological effects of chronic mild stress in female rats. Physiol Behav 87: 314 - 322.
4. Bekris S, Antoniou K, Daskas S, Papadopoulou-Daifoti Z, (2005) Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains. Behav Brain Res 161: 45 - 59.
5. Brown RP, Gerbarg PL, Ramazanov Z, (2002) Rhodiola rosea. A phytomedicinal overview. Herbal Gram 56: 40 - 52.
6. Dalla C, Antoniou K, Drossopoulou G, Xagoraris M, Kokras N, Sfikakis A, (2005) Chronic mild stress impact: are females more vulnerable? Neuroscience 135: 703 - 714.
7. Dallman MF, Pecoraro N, Akana SF, La Fleur SE, Gomez F, Houshyar H, (2003) Chronic stress and obesity: a new view of ?comfort food'. Proc Natl Acad Sci USA 100: 11696 - 11701.
8. Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H, (2000) Rhodiola rosea in stress induced fatigue - a double blind cross-over study of a standardized extract SHR-5 with a repeated lowdose regimen on the mental performance of healthy physicians during night duty. Phytomedicine 7: 365 - 371.
9. Di Chiara G, Loddo P, Tanda G, (1999) Reciprocal changes in prefrontal and limbic dopamine responsiveness to aversive and rewarding stimuli after chronic mild stress: implications for the psychobiology of depression. Biol Psychiatry 46: 1624 - 1633.
10. Faraday MM, (2002) Rat sex and strain differences in responses to stress. Physiol Behav 75: 507 - 522.
11. Genazzani AR, Petraglia F, DeRamundo BM, (1991) Neuroendocrine correlates of stress-related amenorrhea. Ann N Y Acad Sci 626: 125 - 129.
12. German C, Ramazanov Z, Bernard Suarez M, (1999) Artic Root (Rodiola rosea). the powerful ginseng alternative. New York: Kensington Publishing Corp.
13. Gobshtis N, Ben-Shabat S, Fride E, (2007) Antidepressant-induced undesirable weight gain: prevention with rimonabant without interference with behavioral effectiveness. Eur J Pharmacol 554: 155 - 163.
14. Graeff FG, Guimaraes FS, De Andrade TG, Deakin JF, (1996) Role of 5-HT in stress, anxiety, and depression. Pharmacol Biochem Behav 54: 129 - 141.
15. Grippo AJ, Beltz TG, Weiss RM, Johnson AK, (2006) The effects of chronic fluoxetine treatment on chronic mild stress-induced cardiovascular changes and anhedonia. Biol Psychiatry 59: 309 - 316.
16. Grippo AJ, Sullivan NR, Damjanoska KJ, Crane JW, Carrasco GA, Shi J, (2005) Chronic mild stress induces behavioral and physiological changes, and may alter serotonin 1A receptor function, in male and cycling female rats. Psychopharmacology (Berl) 179: 769 - 780.
17. Halbreich U, (2003) The etiology, biology, and evolving pathology of premenstrual syndromes. Psychoneuroendocrinology 28 (Suppl. 3). 55 - 99.
18. Harro J, Haidkind R, Harro M, Modiri AR, Gillberg PG, Pahkla R, (1999) Chronic mild unpredictable stress after noradrenergic denervation: attenuation of behavioural and biochemical effects of DSP-4 treatment. Eur Neuropsychopharmacol 10: 5 - 16.
19. Harvey BH, Bouwer CD, (2000) Neuropharmacology of paradoxic weight gain with selective serotonin reuptake inhibitors. Clin Neuropharmacol 23: 90 - 97.
20. Kelly GS, (2001) Rhodiola rosea: a possible plant adaptogen. Altern Med Rev 6: 293 - 302.
21. Kendler KS, (1998) Gender differences in the genetic epidemiology of major depression. J Gend Specif Med 1: 28 - 31.
22. Kendler KS, Thornton LM, Gardner CO, (2000) Stressful life events and previous episodes in the etiology of major depression in women: and evaluation of the ?kindling? hypothesis. Am J Psychiatry 157: 1243 - 1251.
23. Kennett GA, Chaouloff F, Marcou M, Curzon G, (1986) Female rats are more vulnerable than males in an animal model of depression: the possible role of serotonin. Brain Res 382: 416 - 421.
24. Kessing LV, (2007) Epidemiology of subtypes of depression. Acta Psychiatr Scand Suppl 433: 85 - 89.
25. Kioukia-Fougia N, Antoniou K, Bekris S, Liapi C, Christofidis I, Papadopoulou-Daifoti Z, (2002) The effects of stress exposure on the hypothalamic-pituitary-adrenal axis, thymus, thyroid hormones and glucose levels. Prog Neuropsychopharmacol Biol Psychiatry 26: 823 - 830.
26. Knobil E, (1990) The GnRH pulse generator. Am J Obstet Gynecol 163: 1721 - 1727.
27. Konkle AT, Baker SL, Kentner AC, Barbagallo LS, Merali Z, Bielajew C, (2003) Evaluation of the effects of chronic mild stressors on hedonic and physiological responses: sex and strain compared. Brain Res 992: 227 - 238.
28. Koob GF, Heinrichs SC, (1999) A role for corticotropin realising factor and urocortin in behavioral responses to stressors. Brain Res 848: 141 - 152.
29. Kurkin VA, Zapesochnaya GG, (1986) Chemical composition and pharmacological properties of Rhodiola rosea. Khim Pharm Zurnal 20: 1231 - 1244.
30. Li JM, Kong LD, Wang YM, Cheng CH, Zhang WY, Tan WZ, (2003) Behavioral and biochemical studies on chronic mild stress models in rats treated with a Chinese traditional prescription Banxia-houpu decoction. Life Sci 74: 55 - 73.
31. Linh PT, Kim YH, Hong SP, Jian JJ, Kang JS, (2000) Quantitative determination of salidroside and tyrosol from the underground part of Rhodiola rosea by high performance liquid chromatography. Arch Pharm Res 23: 349 - 352.
32. Long JA, Evans HM, (1922) The oestrous cycle in the rat and its associated phenomena. In: AO Leuschner, (ed). Memoirs of the University of California. Berkeley, CA: University of California Press, pp. 1 - 148.
33. Maina G, Albert U, Salvi V, Bogetto F, (2004) Weight gain during long-term treatment of obsessive-compulsive disorder: a prospective comparison between serotonin reuptake inhibitors. J Clin Psychiatry 65: 1365 - 1371.
34. Matthews K, Forbes N, Reid IC, (1995) Sucrose consumption as an hedonic measure following chronic unpredictable mild stress. Physiol Behav 57: 241 - 248.
35. Mattioli L; ,Perfumi M; , (2007) Rhodiola rosea L. extract reduces stress- and CRF-induced anorexia in rats. J Psychopharmacol 21: 742-750.
36. Mitchell PB, Parker GB, Gladstone GL, Wilhelm K, Austin MP, (2003) Severity of stressful life events in first and subsequent episodes of depression: the relevance of depressive subtype. J Affect Disord 73: 245 - 252.
37. Monleon S, D'Aquila P, Parra A, Simon VM, Brain PF, Willner P, (1995) Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine. Psychopharmacology 117: 453 - 457.
38. Moreau J-L, Jenck F, Martin JR, Mortas P, Haefely WE, (1992) Antidepressant treatment prevents chronic unpredictable mild stress-induced anhedonia as assessed by ventral tegmentum self-stimulation behavior in rats. Eur Neuropsychopharmacol 2: 43 - 49.
39. Muscat R, Willner P, (1992) Suppression of sucrose drinking by chronic mild unpredictable stress: a methodological analysis. Neurosci Biobehav Rev 16: 507 - 517.
40. Panossian A, (2003) Adaptogens: tonic herbs for fatigue and stress. Alt Comp Ther 9: 327 - 332.
41. Panossian A, Wagner H, (2005) Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. Phytother Res 19: 819 - 838.
42. Papp M, Nalepa I, Antkiewicz-Michaluk L, Sanchez C, (2002) Behavioural and biochemical studies of citalopram and WAY 100635 in rat chronic mild stress model. Pharmacol Biochem Behav 72: 465 - 474.
43. Perfumi M, Mattioli L, (2007) Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice. Phytother Res 21: 37 - 43.
44. Ressler KJ, Nemeroff CB, (2000) Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress Anxiety 12 (Suppl. 1). 2 - 19.
45. Rygula R, Abumaria N, Domenici E, Hiemke C, Fuchs E, (2006) Effects of fluoxetine on behavioral deficits evoked by chronic social stress in rats. Behav Brain Res 174: 188 - 192.
46. Shevtsov VA, Zholus BI, Shervarly VI, Vol'skij VB, Korovin YP, Khristich MP, (2003) A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 10: 95 - 105.
47. Solberg LC, Horton TH, Turek FW, (1999) Circadian rhythms and depression: effects of exercise in an animal model. Am J Physiol Regul Integr Comp Physiol 276: R152 - R161.
48. Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV, (2000) A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine 7: 85 - 89.
49. Wagner H, Norr H, Winterhoff H, (1994) Plant adaptogens. Phytomedicine 1: 63 - 76.
50. Wang S, You XT, Wang FP, (1992) HPLC determination of salidroside in the roots of Rhodiola genus plants. Yao Xue Xue Pao 27: 849 - 852.
51. Willner P, (1997) Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology (Berl) 134: 319 - 329.
52. Willner P, Muscat R, Papp M, (1992) Chronic mild stress-induced anhedonia: a realistic animal model of depression. Neurosci Biobehav Rev 16: 525 - 534.
53. Willner P, Towell A, Sampson D, Sophokleous S, Muscat R, (1987) Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl) 93: 358 - 364.
54. Xia X, Pan Y, Zhang WY, Cheng G, Kong LD, (2006) Ethanolic extracts from Curcuma longa attenuates behavioral, immune, and neuroendocrine alterations in a rat chronic mild stress model. Biol Pharm Bull 29: 938 - 944.
55. Yoshikawa M, Shimada H, Shimoda H, Murakami N, Yamahara J, Matsuda H, (1996) Bioactive constituents of Chinese natural medicines. II. Rhodiolae radix. (1). Chemical structures and antiallergic activity of rhodiocyanosides A and B from the underground part of Rhodiola quadrifida (Pall.) Fisch. Et Mey (Crassulaceae). Chem Pharm Bull (Tokyo) 44: 2086 - 2091.
56. Zhou W, Cunningham KA, Thomas ML, (2002) Estrogen regulation of gene expression in the brain: a possible mechanism altering the response to psychostimulants in female rats. Brain Res Mol Brain Res 100: 75 - 83.
57. Zhu BW, Sun YM, Yun X, Han S, Piao ML, Murata Y, (2003) Reduction of noise-stress-induced physiological damage by radices of Astragali and Rhodiolae: glycogen, lactic acid and cholesterol contents in liver of the rat. Biosci Biotechnol Biochem 67: 1930 - 1936.