Pro-angiogenic effects of Carthami Flos whole extract in human microvascular endothelial cells in vitro and in zebrafish in vivo

Phytomedicine

Volumn 21, Issue 11, 2014, Pages 1256-1263

  Zhou, Xuelin ^a   Siu, Wing Sum ^a   Fung, Chak Hei ^a   Cheng, Ling ^a   Wong, Chun Wai ^a   Zhang, Cheng ^a   Liu, Cheuk Lun ^a   Kwok, Hin Fai ^a   Lau, Ching Po ^a   Wat, Elaine ^a   Lau, Clara Bik San ^a   Leung, Ping Chung ^a   Ko, Chun Hay ^a   Hung, Leung Kim ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Carthami Flos; Gene expression; Human microvascular endothelial cells; Pro angiogenesis; Zebrafish

Indexed keywords

ALCOHOL; BETA CATENIN; BETA3 INTEGRIN; CARDIOVASCULAR AGENT; CARTHAMI FLOS EXTRACT; CD31 ANTIGEN; CELL ADHESION MOLECULE; CONNECTIVE TISSUE GROWTH FACTOR; EPHRIN B2; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 2; GELATINASE A; GELATINASE B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NEUROPILIN 2; PLANT EXTRACT; PLASMINOGEN ACTIVATOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; SCATTER FACTOR RECEPTOR; SOMATOMEDIN C; SPHINGOSINE 1 PHOSPHATE RECEPTOR; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UNCLASSIFIED DRUG; UROKINASE; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; WATER; ANGIOGENIC FACTOR; HERBACEOUS AGENT;

ANGIOGENESIS; ARTICLE; CAPILLARY ENDOTHELIAL CELL; CARTHAMI FLOS; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CHINESE HERB; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MONITORING; MTT ASSAY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SOLVENT EXTRACTION; UPREGULATION; WOUND HEALING; ZEBRA FISH; ANIMAL; ANIMAL EMBRYO; CARTHAMUS; CELL CULTURE; CELL MOTION; CHEMISTRY; DRUG EFFECTS; EMBRYOLOGY; TRANSGENIC ANIMAL;

ANGIOGENESIS INDUCING AGENTS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CARTHAMUS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DRUGS, CHINESE HERBAL; EMBRYO, NONMAMMALIAN; ENDOTHELIAL CELLS; HUMANS; PLANT EXTRACTS; ZEBRAFISH;

EID: 84906726351     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.06.010     Document Type: Article

References (44)

1. E. Borges, Y. Jan, and E. Ruoslahti Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain J. Biol. Chem. 275 51 2000 39867 39873 (Pubitemid 32064606)
2. Z.T. Chai, J. Kong, X.D. Zhu, Y.Y. Zhang, L. Lu, J.M. Zhou, L.R. Wang, K.Z. Zhang, Q.B. Zhang, J.Y. Ao, M. Wang, W.Z. Wu, L. Wang, Z.Y. Tang, and H.C. Sun MicroRNA-26a inhibits angiogenesis by down-regulating VEGFA through the PIK3C2alpha/Akt/HIF-1alpha pathway in hepatocellular carcinoma PLoS ONE 8 10 2013 e77957
3. J.Y. Chan, J.C. Koon, X. Liu, M. Detmar, B. Yu, S.K. Kong, and K.P. Fung Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo J. Ethnopharmacol. 137 1 2011 64 69
4. S.M. Chim, J. Tickner, S.T. Chow, V. Kuek, B. Guo, G. Zhang, V. Rosen, W. Erber, and J. Xu Angiogenic factors in bone local environment Cytokine Growth Factor Rev. 24 3 2013 297 310
5. Y.H. Choi, J.S. Do, H.J. Seo, J.K. Hwang, J.H. Kim, E.J. Song, and S.Y. Nam Oral administration of aqueous extract of Carthami Flos induces macrophage activation and preferentially potentiates type 1 helper T-cell response in vivo Immunopharmacol. Immunotoxicol. 29 2 2007 187 200
6. L. Fan, H.Y. Zhao, M. Xu, L. Zhou, H. Guo, J. Han, B.R. Wang, and D.A. Guo Qualitative evaluation and quantitative determination of 10 major active components in Carthamus tinctorius L. by high-performance liquid chromatography coupled with diode array detector J. Chromatogr. A 1216 11 2009 2063 2070
7. B. Favier, A. Alam, P. Barron, J. Bonnin, P. Laboudie, P. Fons, M. Mandron, J.P. Herault, G. Neufeld, P. Savi, J.M. Herbert, and F. Bono Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration Blood 108 4 2006 1243 1250 (Pubitemid 44232021)
8. U. Fiedler, T. Krissl, S. Koidl, C. Weiss, T. Koblizek, U. Deutsch, G. Martiny-Baron, D. Marme, and H.G. Augustin Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats J. Biol. Chem. 278 3 2003 1721 1727 (Pubitemid 36801406)
9. J. Folkman Angiogenesis in cancer, vascular, rheumatoid and other disease Nat. Med. 1 1 1995 27 31
10. J. Fu, X. Li, H. Lu, and Y. Liang Analysis of volatile components in herbal pair Semen Persicae-Flos Carthami by GC-MS and chemometric resolution J. Sep. Sci. 35 21 2012 2940 2948
11. D. Gao, J. Song, J. Hu, J. Lin, L. Zheng, J. Cai, J. Du, and K. Chen Angiogenesis promoting effects of Chinese herbal medicine for activating blood circulation to remove stasis on chick embryo chorio-allantoic membrane Zhongguo Zhong Xi Yi Jie He Za Zhi 25 10 2005 912 915
12. T. Geback, M.M. Schulz, P. Koumoutsakos, and M. Detmar TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays Biotechniques 46 4 2009 265 274
13. M. Guo, J.W. Breslin, M.H. Wu, C.J. Gottardi, and S.Y. Yuan VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability Am. J. Physiol. Cell Physiol. 294 4 2008 C977 C984
14. E. Hadjipanayi, and A.F. Schilling Hypoxia-based strategies for angiogenic induction: the dawn of a new era for ischemia therapy and tissue regeneration Organogenesis 9 4 2013 261 272
15. S.Y. Han, H.X. Li, X. Ma, K. Zhang, Z.Z. Ma, Y. Jiang, and P.F. Tu Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of Panax notoginseng and Carthamus tinctorius in rats J. Ethnopharmacol. 145 3 2013 722 727
16. E.B. Jude, I. Eleftheriadou, and N. Tentolouris Peripheral arterial disease in diabetes -A review Diabet. Med. 27 1 2010 4 14
17. I. Kim, H.G. Kim, J.N. So, J.H. Kim, H.J. Kwak, and G.Y. Koh Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3′-Kinase/Akt signal transduction pathway Circ. Res. 86 1 2000 24 29 (Pubitemid 30044164)
18. R.I. Kirk, M.R. Sanderson, and K.M. Lerea Threonine phosphorylation of the beta(3) integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding J. Biol. Chem. 275 40 2000 30901 30906
19. T. Korff, G. Dandekar, D. Pfaff, T. Fuller, W. Goettsch, H. Morawietz, F. Schaffner, and H.G. Augustin Endothelial ephrinB2 is controlled by microenvironmental determinants and associates context-dependently with CD31 Arterioscler. Thromb. Vasc. Biol. 26 3 2006 468 474
20. M.J. Lee, S. Thangada, J.H. Paik, G.P. Sapkota, N. Ancellin, S.S. Chae, M. Wu, M. Morales-Ruiz, W.C. Sessa, D.R. Alessi, and T. Hla Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis Mol. Cell 8 3 2001 693 704 (Pubitemid 32946945)
21. J. Lilien, and J. Balsamo The regulation of cadherin-mediated adhesion by tyrosine phosphorylation/dephosphorylation of beta-catenin Curr. Opin. Cell Biol. 17 5 2005 459 465 (Pubitemid 41267159)
22. C.M. Lin, J.H. Chiu, I.H. Wu, B.W. Wang, C.M. Pan, and Y.H. Chen Ferulic acid augments angiogenesis via VEGF, PDGF and HIF-1 alpha J. Nutr. Biochem. 21 7 2010 627 633
23. R.M. Littleton, and J.R. Hove Zebrafish: a non traditional model of traditional medicine J. Ethnopharmacol. 145 3 2013 677 685
24. C.L. Liu, F. Kwok, L. Cheng, E. Ko, E. Wong, T. Ho, P.C. Leung, K.P. Fung, and C.B.S. Lau Molecular mechanisms of angiogenesis effect of active sub-fraction from root of Rehmannia glutinosa by zebrafish sprout angiogenesis-guided fractionation J. Ethnopharmacol. 151 1 2013 565 575
25. J. Liu, T.C. Jin, S. Chang, A. Czajka-Jakubowska, and B.H. Clarkson Adhesion and growth of dental pulp stem cells on enamel-like fluorapatite surfaces J. Biomed. Mater. Res. A 96 3 2011 528 534
26. L. Liu, J.A. Duan, Y. Tang, J. Guo, N. Yang, H. Ma, and X. Shi Taoren-Honghua herb pair and its main components promoting blood circulation through influencing on hemorheology, plasma coagulation and platelet aggregation J. Ethnopharmacol. 139 2 2012 381 387
27. Y. Lu, Y.L. Hu, X.F. Kong, and D.Y. Wang Selection of component drug in activating blood flow and removing blood stasis of Chinese herbal medicinal formula for dairy cow mastitis by hemorheological method J. Ethnopharmacol. 116 2 2008 313 317
28. V. Miragliotta, Z. Ipina, J. Lefebvre-Lavoie, J.G. Lussier, and C.L. Theoret Equine CTNNB1 and PECAM1 nucleotide structure and expression analyses in an experimental model of normal and pathological wound repair BMC Physiol. 2008 81
29. L.H. Peng, C.H. Ko, S.W. Siu, C.M. Koon, G.L. Yue, W.H. Cheng, T.W. Lau, Q.B. Han, K.M. Ng, K.P. Fung, C.B.S. Lau, and P.C. Leung In vitro & in vivo assessment of a herbal formula used topically for bone fracture treatment J. Ethnopharmacol. 131 2 2010 282 289
30. S.M. Piecewicz, A. Pandey, B. Roy, S.H. Xiang, B.R. Zetter, and S. Sengupta Insulin-like growth factors promote vasculogenesis in embryonic stem cells PLoS ONE 7 2 2012 e32191
31. A. Redlitz, G. Daum, and E.H. Sage Angiostatin diminishes activation of the mitogen-activated protein kinases ERK-1 and ERK-2 in human dermal microvascular endothelial cells J. Vasc. Res. 36 1 1999 28 34 (Pubitemid 29106804)
32. A.H. Rosendahl, and G. Forsberg IGF-I and IGFBP-3 augment transforming growth factor-beta actions in human renal carcinoma cells Kidney Int. 70 9 2006 1584 1590 (Pubitemid 44606993)
33. H.M. Rosenfeldt, J.P. Hobson, S. Milstien, and S. Spiegel The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility Biochem. Soc. Trans. 29 Pt 6 2001 836 839 (Pubitemid 33131790)
34. D.W. Seo, H. Li, L. Guedez, P.T. Wingfield, T. Diaz, R. Salloum, B.Y. Wei, and W.G. Stetler-Stevenson TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism Cell 114 2 2003 171 180 (Pubitemid 36936911)
35. S. Silletti, T. Kessler, J. Goldberg, D.L. Boger, and D.A. Cheresh Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo Proc. Natl. Acad. Sci. USA 98 1 2001 119 124 (Pubitemid 32095873)
36. Y.L. Siow, P.C. Choy, and W.M.O.K. Leung Effect of Flos carthami on stress-activated protein kinase activity in the isolated reperfused rat heart Mol. Cell. Biochem. 207 1-2 2000 41 47 (Pubitemid 30406450)
37. M. Sun, J.J. Zhang, J.Z. Shan, H. Zhang, C.Y. Jin, S. Xu, and Y.L. Wang Clinical observation of Danhong Injection (herbal TCM product from Radix Salviae miltiorrhizae and Flos Carthami tinctorii) in the treatment of traumatic intracranial hematoma Phytomedicine 16 8 2009 683 689
38. C. Suri, P.F. Jones, S. Patan, S. Bartunkova, P.C. Maisonpierre, S. Davis, T.N. Sato, and G.D. Yancopoulos Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis Cell 87 7 1996 1171 1180 (Pubitemid 27010101)
39. K. Suzuma, K. Naruse, I. Suzuma, N. Takahara, K. Ueki, L.P. Aiello, and G.L. King Vascular endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal vascular cells J. Biol. Chem. 275 52 2000 40725 40731 (Pubitemid 32054890)
40. Y.C. Tian, and A.O. Phillips Interaction between the transforming growth factor-beta type II receptor/Smad pathway and beta-catenin during transforming growth factor-beta 1-mediated adherens junction disassembly Am. J. Pathol. 160 5 2002 1619 1628 (Pubitemid 34525642)
41. Y.C. Tien, J.Y. Lin, C.H. Lai, C.H. Kuo, W.Y. Lin, C.H. Tsai, F.J. Tsai, Y.C. Cheng, W.H. Peng, and C.Y. Huang Carthamus tinctorius L. prevents LPS-induced TNFalpha signaling activation and cell apoptosis through JNK1/2-NFkappaB pathway inhibition in H9c2 cardiomyoblast cells J. Ethnopharmacol. 130 3 2010 505 513
42. F. Yang, D.W. Strand, and D.R. Rowley Fibroblast growth factor-2 mediates transforming growth factor-beta action in prostate cancer reactive stroma Oncogene 27 4 2008 450 459
43. P.Y. Yue, D.Y. Wong, W.Y. Ha, M.C. Fung, N.K. Mak, H.W. Yeung, H.W. Leung, K. Chan, L. Liu, T.P. Fan, and R.N. Wong Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg(1) in vivo and in vitro Angiogenesis 8 3 2005 205 216 (Pubitemid 41759145)
44. Y. Zhao, C.E. Lyons Jr., A. Xiao, D.J. Templeton, Q.A. Sang, K. Brew, and I.M. Hussaini Urokinase directly activates matrix metalloproteinases-9: a potential role in glioblastoma invasion Biochem. Biophys. Res. Commun. 369 4 2008 1215 1220