MicroRNA-26a Inhibits Angiogenesis by Down-Regulating VEGFA through the PIK3C2α/Akt/HIF-1α Pathway in Hepatocellular Carcinoma

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Chai, Zong Tao ^a   Kong, Jian ^b   Zhu, Xiao Dong ^a   Zhang, Yuan Yuan ^a   Lu, Lu ^a   Zhou, Jia Min ^a   Wang, Long Rong ^a   Zhang, Ke Zhi ^a   Zhang, Qiang Bo ^a   Ao, Jian Yang ^b   Wang, Miao ^a   Wu, Wei Zhong ^a   Wang, Lu ^a   Tang, Zhao You ^a   Sun, Hui Chuan ^a  

^a FUDAN UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANGIOGENIC FACTOR; BEVACIZUMAB; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIFICIGUAT; LUCIFERASE; MICRORNA 26A; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN PIK3C2ALPHA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN A; HIF1A PROTEIN, HUMAN; MICRORNA; MIRN26A MICRORNA, HUMAN; PIK3C2A PROTEIN, HUMAN; VEGFA PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL MIGRATION; CELL STRAIN HEPG2; DOWN REGULATION; DOWNSTREAM PROCESSING; DRUG TARGETING; GENE DELIVERY SYSTEM; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; ANALYSIS OF VARIANCE; ANIMAL; CARCINOMA, HEPATOCELLULAR; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENETICS; HEPG2 CELL LINE; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; METABOLISM; NEOVASCULARIZATION, PATHOLOGIC; NUDE MOUSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; LUCIFERASES; MICE; MICE, NUDE; MICRORNAS; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHATIDYLINOSITOL 3-KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84886009612     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077957     Document Type: Article

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