Coevolutionary information, protein folding landscapes, and the thermodynamics of natural selection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 34, 2014, Pages 12408-12413

  Morcos, Faruck ^a   Schafer, Nicholas P ^a   Cheng, Ryan R ^a   Onuchic, José N ^a   Wolynes, Peter G ^a  

^a RICE UNIVERSITY   (United States)

Author keywords

Elastic effects; Energy landscape theory; Funneled landscapes; Information theory; Selection temperature

Indexed keywords

DEOXYCORTICOSTERONE ACETATE; PROTEIN TYROSINE PHOSPHATASE; REPRESSOR PROTEIN; REPRESSOR PROTEIN C1, BACTERIOPHAGE; VIRUS PROTEIN;

AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; ARTICLE; ASSOCIATIVE MEMORY; COEVOLUTION; ENERGY; ENERGY TRANSFER; ENTROPY; LANDSCAPE; MOLECULAR EVOLUTION; NATURAL SELECTION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT; TEMPERATURE; THERMODYNAMICS; BIOPHYSICS; CHEMICAL STRUCTURE; CHEMISTRY; GENETIC SELECTION; GENETICS; INFORMATION SCIENCE; PROTEIN CONFORMATION; STATISTICAL MODEL;

BIOPHYSICAL PHENOMENA; EVOLUTION, MOLECULAR; INFORMATION THEORY; MODELS, MOLECULAR; MODELS, STATISTICAL; PROTEIN CONFORMATION; PROTEIN FOLDING; REPRESSOR PROTEINS; SELECTION, GENETIC; SEQUENCE ALIGNMENT; THERMODYNAMICS; VIRAL PROTEINS;

EID: 84906706579     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1413575111     Document Type: Article

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