Lorcaserin, a selective 5-HT2C receptor agonist, decreases alcohol intake in female alcohol preferring rats

Pharmacology Biochemistry and Behavior

Volumn 125, Issue , 2014, Pages 8-14

  Rezvani, Amir H ^a   Cauley, Marty C ^a   Levin, Edward D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alcoholism; Drinking; Ethanol; Locomotor activity; Serotonin receptors; Sucrose

Indexed keywords

LORCASERIN; SEROTONIN 2C AGONIST; SUCROSE; BENZAZEPINE DERIVATIVE; SEROTONIN 2 AGONIST; ALCOHOL; DRINKING WATER;

ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; FLUID INTAKE; LOCOMOTION; LOW DRUG DOSE; NONHUMAN; PRIORITY JOURNAL; RAT; REPEATED DRUG DOSE; SUGAR INTAKE; TASTE PREFERENCE; TREATMENT DURATION; ANIMAL; DOSE RESPONSE; DRINKING; DRINKING BEHAVIOR; DRUG EFFECTS; DRUG THERAPY; MOTOR ACTIVITY; ACUTE DRUG ADMINISTRATION; ADULT; ANIMAL BEHAVIOR; DRUG PREFERENCE;

ALCOHOL DRINKING; ANIMALS; BENZAZEPINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; FEMALE; MOTOR ACTIVITY; RATS; SEROTONIN 5-HT2 RECEPTOR AGONISTS;

EID: 84906705400     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2014.07.017     Document Type: Article

References (30)

1. R.L. Bell, H.J.K. Sable, G. Colombo, P. Hyytia, Z.A. Rodd, and L. Lumeng Animal models of medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity Pharmacol Biochem Behav 103 2012 119 155
2. S. Borg, H. Kvande, P. Liljeberg, D. Mossberg, and P. Valverious 5-Hydroxyindoleacetic acid in cerebrospinal fluid in alcoholic patients under different clinical conditions Alcohol 2 1985 415 418 (Pubitemid 15242723)
3. 2c receptors Brain Res 865 2000 85 90 (Pubitemid 30256209)
4. V. Di Matteo, M. Cacchio, C. Di Giulio, and E. Esposito Role of serotonin2C receptors in the control of brain dopaminergic function Pharmacol Biochem Behav 71 2002 727 734 (Pubitemid 34219223)
5. M.L. Fils-Aime, M.J. Eckardt, D.T. George, G.L. Brown, I. Mefford, and M. Linnoila Early-onset alcoholics have lower cerebrospinal fluid 5-hydroxyindoleacetic acid levels than late-onset alcoholics Arch Gen Psychiatry 53 1996 211 216
6. M.A. Gongwer, J.M. Murphy, W.J. McBride, L. Lumeng, and T.K. Li Regional brain contents of serotonin, dopamine and their metabolites in the selectively bred high- and low-alcohol drinking lines of rats Alcohol 6 1989 317 320
7. A.J. Grottick, P.J. Fletcher, and G.A. Higgins Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior J Pharmacol Exp Ther 295 2000 1183 1191
8. A.J. Grottick, W.A. Corrigall, and G.A. Higgins Activation of 5-HT2C receptors reduces the locomotor and rewarding effects of nicotine Psychopharmacology (Berl) 157 2001 292 298 (Pubitemid 32905571)
9. A. Heinz, K. Mann, D.R. Weinberger, and D. Goldman Serotonergic dysfunction, negative mood states, and response to alcohol Alcohol Clin Exp Res 25 2001 487 495 (Pubitemid 32323414)
10. G.A. Higgins, and P.J. Fletcher Serotonin and drug reward: focus on 5-HT2c receptors Eur J Pharmacol 480 2003 151 162 (Pubitemid 37410367)
11. G.A. Higgins, L.B. Silenieks, A. Roβmann, Z. Rizos, K. Noble, and A.D. Soko et al. The 5-HT2C receptor agonist lorcaserin reduces nicotine self-administration, discrimination, and reinstatement: relationship to feeding behavior and impulse control Neuropsychopharmacology 37 2012 1177 1191
12. J.D. Higley, J. Suomi, and M. Linnoila A nonhuman primate model of type II excessive alcohol drinking consumption. Part 1. Low cerebrospinal fluid 5-hydroxyindolacetic acid concentration and diminished social competence correlate with excessive alcohol consumption Alcohol Clin Exp Res 20 1996 629 642
13. H.R. Kranzler, J.A. Burleson, F.K. Del Broca, M.J. Bohn, J. Brown, and N. Libowitz Placebo-controlled trial of fluoxetine as an adjunct to relapse prevention in alcoholics Am J Psychiatry 152 1995 391 397
14. Ed Levin, J.E. Johnson, S. Slade, C. Wells, M. Cauley, and A. Petro et al. Lorcaserin, a 5-HT2c agonist, decreases nicotine self-administration in female rat J Pharmacol Exp Ther 338 2011 890 896
15. S. Maurel, J. De Vry, R. De Beun, and R. Schreiber 5HT2a and 5-HT2c/5-HT1b receptors are differentially involved in alcohol preference and consummatory behavior in cAA rats Pharm Biochem Behav 62 1999 89 96 (Pubitemid 29017760)
16. W.J. McBride, J.M. Murphy, L. Lumeng, and T.K. Li Serotonin, dopamine and GABA involvement in alcohol drinking of selectively-bred rats Alcohol 7 1990 199 205 (Pubitemid 20268902)
17. T.F. Meert, and P.A.J. Janssen Ritanserin, a new therapeutic approach for drug abuse. Part 1: Effects on alcohol Drug Dev Res 24 1991 235 249
18. J. Murphy, W.J. McBride, L. Lumeng, and T.K. Li Alcohol preference and regional brain monoamine contents of N/Nih heterogenous stock rats Alcohol Drug Res 7 1987 33 39 (Pubitemid 17188020)
19. J. Murphy, W.J. McBride, L. Lumeng, and T.K. Li Contents of monoamines in forebrain regions of alcohol-preferring (p) and -nonpreferring (NP) lines of rats Pharmacol Biochem Behav 26 1987 389 392 (Pubitemid 17038124)
20. C.A. Naranjo, E.M. Seller, and M.O. Lawrin Modulation of ethanol intake by serotonin uptake inhibitors J Clin Psychiatry 47 1986 16 22 (Pubitemid 16121467)
21. D.H. Overstreet, A.H. Rezvani, O. Pucilowsky, and D.S. Janowsky 5-HT receptors: implications for the neuropharmacology of alcohol and alcoholism Alcohol Alcohol Suppl 2 1994 207 212
22. A.H. Rezvani, and D.R. Grady Suppression of alcohol consumption by fenfluramine in Fawn-Hooded rats with serotonin dysfunction Pharmacol Biochem Behav 48 1994 105 110 (Pubitemid 24135162)
23. A.H. Rezvani, D.H. Overstreet, and D.S. Janowsky Genetic serotonin deficiency and alcohol preference in the Fawn-Hooded rats Alcohol Alcohol 25 1990 573 575
24. A.H. Rezvani, D.H. Overstreet, and A. Parsian The Fawn-Hooded (FH/Wjd) rat: a genetic animal model of comorbid depression and alcoholism Psychiatr Genet 12 2002 1 16 (Pubitemid 34274489)
25. A.H. Rezvani, S. Slade, C. Wells, A. Petro, L. Lumeng, and T.K. Li et al. Effects of sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor desensitizing agent on both alcohol and nicotine self-administration in selectively-bred alcohol preferring rats Psychopharmacology (Berl) 211 2010 161 174
26. A.H. Rezvani, H.G. Sexton, J. Johnson, C. Wells, K. Gordon, and E.D. Levin Effects of caffeine on alcohol consumption and nicotine self-administration in rats Alcohol Clin Exp Res 37 2013 1609 1617
27. R.J. Thielen, E.A. Engleman, Z.A. Rodd, J.M. Murphy, L. Lumeng, and T.K. Li et al. Ethanol drinking and deprivation alter dopaminergic and serotonergic function in the nucleus accumbens of alcohol-preferring rats J Pharmacol Exp Ther 309 2004 216 225 (Pubitemid 38393133)
28. W.J1. Thomsen, A.J. Grottick, F. Menzaghi, H. Reyes-Saldana, S. Espitia, and D. Yuskin et al. Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization J Pharmacol Exp Ther 325 2008 577 587 (Pubitemid 351574813)
29. D.M. Tomkins, N. Joharchi, M. Tampakeras, J.R. Martin, J. Wichman, and G.A. Higgins An investigation of the role of 5-HT2c receptors in modifying ethanol self-administration behavior Pharm Biochem Behav 71 2002 735 744 (Pubitemid 34219224)
30. D.L. William, and H.Y. Meltzer Serotonin 5-HT2c agonists selectively inhibits morphine-induced dopamine efflux in the nucleus accumbens Brain Res. 781 1998 291 299 (Pubitemid 28082874)