Mitogen-Activated protein kinase phosphatase 3 (mkp-3)- Deficient mice are resistant to diet-induced obesity

Diabetes

Volumn 63, Issue 9, 2014, Pages 2924-2934

  Feng, Bin ^a   Jiao, Ping ^a,b   Helou, Ynes ^c   Li, Yujie ^a   He, Qin ^a   Walters, Matthew S ^d   Salomon, Arthur ^a,e   Xu, Haiyan ^a  

^a BROWN UNIVERSITY   (United States)

^b JILIN UNIVERSITY   (China)

^c BROWN UNIVERSITY   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DUAL SPECIFICITY PHOSPHATASE 6; GLUCOSE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; SERINE; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET; ENERGY EXPENDITURE; ENZYME ACTIVITY; ENZYME DEFICIENCY; FATTY LIVER; FEMALE; GLUCOSE TRANSPORT; INSULIN SENSITIVITY; LIPID DIET; LIPID METABOLISM; LIVER; LIVER CELL; MALE; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEOMICS; WEIGHT GAIN;

ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; DIET, HIGH-FAT; DUAL SPECIFICITY PHOSPHATASE 6; FEMALE; HISTONE DEACETYLASES; LIVER; MALE; MICE; OBESITY; SIGNAL TRANSDUCTION; TRIGLYCERIDES; WEIGHT GAIN;

EID: 84906699251     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0066     Document Type: Article

References (31)

1. Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol 2008;8:923-934
2. Lomonaco R, Sunny NE, Bril F, Cusi K. Nonalcoholic fatty liver disease: current issues and novel treatment approaches. Drugs 2013;73:1-14
3. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001;414:799-806
4. Myers MG Jr, White MF. Insulin signal transduction and the IRS proteins. Annu Rev Pharmacol Toxicol 1996;36:615-658.
5. Holman GD, Kasuga M. From receptor to transporter: insulin signalling to glucose transport. Diabetologia 1997;40:991-1003
6. Rhodes CJ. Type 2 diabetes-A matter of beta-cell life and death? Science 2005;307:380-384
7. Pilkis SJ, Granner DK. Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Physiol 1992;54:885-909
8. Muoio DM, Newgard CB. Obesity-related derangements in metabolic regulation. Annu Rev Biochem 2006;75:367-401
9. Xu H, Yang Q, Shen M, et al. Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells. J Biol Chem 2005;280:36013-36018
10. Wu Z, Jiao P, Huang X, et al. MAPK phosphatase-3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice. J Clin Invest 2010;120:3901-3911
11. Orlicky DJ, DeGregori J, Schaack J. Construction of stable coxsackievirus and adenovirus receptor-expressing 3T3-L1 cells. J Lipid Res 2001;42:910-915
12. Jiao P, Chen Q, Shah S, et al. Obesity-related upregulation of monocyte chemotactic factors in adipocytes: involvement of nuclear factor-kappaB and c-Jun NH2-terminal kinase pathways. Diabetes 2009;58:104-115
13. Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 2003;100:9440-9445
14. Maillet M, Purcell NH, Sargent MA, York AJ, Bueno OF, Molkentin JD. DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility. J Biol Chem 2008;283:31246-31255
15. Montgomery RL, Davis CA, Potthoff MJ, et al. Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev 2007;21:1790-1802
16. Montgomery RL, Hsieh J, Barbosa AC, Richardson JA, Olson EN. Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development. Proc Natl Acad Sci U S A 2009;106:7876-7881
17. Yamaguchi T, Cubizolles F, Zhang Y, et al. Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression. Genes Dev 2010;24:455-469
18. LeBoeuf M, Terrell A, Trivedi S, et al. Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell 2010;19: 807-818
19. Karlsson M, Mathers J, Dickinson RJ, Mandl M, Keyse SM. Both nuclearcytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal. J Biol Chem 2004;279:41882-41891
20. Kim JY, Shen S, Dietz K, et al. HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage. Nat Neurosci 2010;13:180-189
21. Bakin RE, Jung MO. HDAC2 cytoplasmic sequestration potentiates keratinocyte terminal differentiation. Open Cell Dev Biol J 2008;1:1-9
22. Camps M, Nichols A, Arkinstall S. Dual specificity phosphatases: A gene family for control of MAP kinase function. FASEB J 2000;14:6-16
23. Dickinson RJ, Keyse SM. Diverse physiological functions for dual-specificity MAP kinase phosphatases. J Cell Sci 2006;119:4607-4615
24. Zhao Y, Zhang ZY. The mechanism of dephosphorylation of extracellular signal-regulated kinase 2 by mitogen-Activated protein kinase phosphatase J Biol Chem 2001;276:32382-32391
25. Jiao P, Feng B, Li Y, He Q, Xu H. Hepatic ERK activity plays a role in energy metabolism. Mol Cell Endocrinol 2013;375:157-166
26. Jiao P, Feng B, Xu H. Mapping MKP-3/FOXO1 interaction and evaluating the effect on gluconeogenesis. PLoS One 2012;7:e41168
27. Segré CV, Chiocca S. Regulating the regulators: the post-translational code of class I HDAC1 and HDAC2. J Biomed Biotechnol 2011;2011:690848
28. Grunstein M. Histone acetylation in chromatin structure and transcription. Nature 1997;389:349-352
29. Ye J. Improving insulin sensitivity with HDAC inhibitor. Diabetes 2013;62: 685-687
30. Pflum MK, Tong JK, Lane WS, Schreiber SL. Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation. J Biol Chem 2001;276:47733-47741
31. Knutson SK, Chyla BJ, Amann JM, Bhaskara S, Huppert SS, Hiebert SW. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J 2008;27:1017-1028