Minimalistic sample preparation strategies for LC-MS quantification of large molecule biopharmaceuticals: A case study highlighting alpha-1 antitrypsin protein

Bioanalysis

Volumn 6, Issue 13, 2014, Pages 1813-1825

  Wright, Katherine ^a   Dufield, Dawn ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; ALPHA 1 ANTITRYPSIN CONCENTRATE; REAGENT; PEPTIDE; TRYPSIN;

ACCURACY; ANTIBODY AFFINITY; ARTICLE; CONTROLLED STUDY; DILUTION; HUMAN; INTERFEROMETRY; LIQUID CHROMATOGRAPHY; LUNG LAVAGE; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROCESS OPTIMIZATION; PROTEIN BLOOD LEVEL; SENSITIVITY ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOAFFINITY CHROMATOGRAPHY; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; NANOTECHNOLOGY; TANDEM MASS SPECTROMETRY;

ALPHA 1-ANTITRYPSIN; AMINO ACID SEQUENCE; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; IMMUNOCHROMATOGRAPHY; MICE; MOLECULAR SEQUENCE DATA; NANOTECHNOLOGY; PEPTIDES; TANDEM MASS SPECTROMETRY; TRYPSIN;

EID: 84906683431     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.14.146     Document Type: Article

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