High-sensitivity LC-MS/MS quantification of peptides and proteins in complex biological samples: The impact of enzymatic digestion and internal standard selection on method performance

Analytical Chemistry

Volumn 85, Issue 20, 2013, Pages 9528-9535

  Bronsema, Kees J ^a,b   Bischoff, Rainer ^a   Van De Merbel, Nico C ^a,b  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b PRA Health Sciences   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY AND PRECISION; BIOLOGICAL SAMPLES; ENZYMATIC DIGESTIONS; INTERNAL STANDARDIZATION; LOWER LIMIT OF QUANTIFICATIONS; PROTEIN QUANTIFICATION; SELECTED REACTION MONITORING; SOLID-PHASE EXTRACTION;

INTERFERENCE SUPPRESSION; ISOTOPES; MASS SPECTROMETRY;

PEPTIDES;

CALCITONIN; PEPTIDE FRAGMENT; TRYPSIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BLOOD; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; LIQUID CHROMATOGRAPHY; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN DEGRADATION; SALMON; STANDARD; TANDEM MASS SPECTROMETRY;

AMINO ACID SEQUENCE; ANIMALS; CALCITONIN; CHROMATOGRAPHY, LIQUID; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEOLYSIS; REFERENCE STANDARDS; SALMON; TANDEM MASS SPECTROMETRY; TRYPSIN;

EID: 84886929028     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac4015116     Document Type: Article

References (28)

1. Brownridge, P.; Beynon, R. J. Methods 2011, 54, 351-60
2. Arsene, C. G.; Ohlendorf, R.; Burkitt, W.; Pritchard, C.; Henrion, A.; O'Connor, G.; Bunk, D. M.; Güttler, B. Anal. Chem. 2008, 80, 4154-60
3. Proc, J. L.; Kuzyk, M. A.; Hardie, D. B.; Yang, J.; Smith, D. S.; Jackson, A. M.; Parker, C. E.; Borchers, C. H. J. Protein Res. 2010, 9, 5422-37
4. Lesur, A.; Varesio, E.; Hopfgartner, G. J. Chromatogr., A 2010, 1217, 57-64
5. Vesper, H. W.; Mi, L.; Enada, A.; Myers, G. L. Rapid Commun. Mass Spectrom. 2005, 19, 2865-70
6. Ji, C.; Sadagopan, N.; Zhang, Y.; Lepsy, C. Anal. Chem. 2009, 81, 9321-8
7. Yuan, L.; Arnold, M. E.; Aubry, A.-F.; Ji, Q. C. Bioanalysis 2012, 4, 2887-96
8. Kushnir, M. M.; Rockwood, A. L.; Roberts, W. L.; Abraham, D.; Hoofnagle, A. N.; Meikle, A. W. Clin. Chem. 2013, 59, 982-90
9. Xu, Y.; Mehl, J. T.; Bakhtiar, R.; Woolf, E. J. Anal. Chem. 2010, 82, 6877-86
10. Yang, Z.; Hayes, M.; Fang, X.; Daley, M. P.; Ettenberg, S.; Tse, F. L. S. Anal. Chem. 2007, 79, 9294-301
11. Domanski, D.; Percy, A. J.; Yang, J.; Chambers, A. G.; Hill, J. S.; Freue, G. V. C.; Borchers, C. H. Proteomics 2012, 12, 1222-43
12. Bronsema, K. J.; Bischoff, R.; van de Merbel, N. C. J. Chromatogr., B 2012, 893-894, 1-14
13. Seegmiller, J. C.; Barnidge, D. R.; Burns, B. E.; Larson, T. S.; Lieske, J. C.; Kumar, R. Clin. Chem. 2009, 55, 1100-7
14. Halquist, M. S.; Karnes, H. T. J. Chromatogr., B 2011, 879, 789-98
15. Aguiar, M.; Masse, R.; Gibbs, B. F. Anal. Biochem. 2006, 354, 175-81
16. Hagman, C.; Ricke, D.; Ewert, S.; Bek, S.; Falchetto, R.; Bitsch, F. Anal. Chem. 2008, 80, 1290-6
17. Ocaña, M. F.; Neubert, H. Anal. Biochem. 2010, 399, 202-10
18. Barnidge, D. R.; Hall, G. D.; Stocker, J. L.; Muddiman, D. C. J. Proteome Res. 2004, 3, 658-61
19. Jiang, H.; Ramos, A. a; Yao, X. Anal. Chem. 2010, 82, 336-42
20. Murphy, R. C.; Clay, K. L. Biomed. Mass Spectrom. 1979, 6, 309-14
21. Brun, V.; Masselon, C.; Garin, J.; Dupuis, A. J. Proteomics 2009, 72, 740-9
22. Lanckmans, K.; Sarre, S.; Smolders, I.; Michotte, Y. Rapid Commun. Mass Spectrom. 2007, 21, 1187-95
23. Stokvis, E.; Rosing, H.; López-Lázaro, L.; Schellens, J. H. M.; Beijnen, J. H. Biomed. Chromatogr. 2004, 18, 400-2
24. Brun, V.; Dupuis, A.; Adrait, A.; Marcellin, M.; Thomas, D.; Court, M.; Vandenesch, F.; Garin, J. Mol. Cell. Proteomics 2007, 6, 2139-49
25. Swaney, D. L.; Wenger, C. D.; Coon, J. J. J. Proteome Res. 2010, 9, 1323-9
26. Duncan, M. Int. J. Pharm. 1995, 120, 179-188
27. Kulevich, S. E.; Frey, B. L.; Kreitinger, G.; Smith, L. M. Anal. Chem. 2010, 82, 10135-42
28. Wang, S.; Bobst, C. E.; Kaltashov, I. A. Anal. Chem. 2011, 83, 7227-32