Development of nanocrystal formulation of meloxicam with improved dissolution and pharmacokinetic behaviors

International Journal of Pharmaceutics

Volumn 474, Issue 1-2, 2014, Pages 151-156

  Ochi, Masanori ^a   Kawachi, Takaki ^a   Toita, Eri ^a   Hashimoto, Issei ^a   Yuminoki, Kayo ^a   Onoue, Satomi ^b   Hashimoto, Naofumi ^a  

^a SETSUNAN UNIVERSITY   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Dissolution; Meloxicam; Nanocrystals; Pharmacokinetic; Stabilization; Supersaturation

Indexed keywords

ACRYLIC ACID COPOLYMER; EUDRAGIT; HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; MELOXICAM; METHACRYLIC ACID METHYL ESTER; NANOCRYSTAL; POLYVINYL ALCOHOL; POVIDONE; COPOLYMER; HYDROXYPROPYLCELLULOSE; POLYMER; NANOPARTICLE; THIAZINE DERIVATIVE; THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHEMICAL PROCEDURES; CONTROLLED STUDY; CRYSTALLIZATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; FREEZE DRYING; GROWTH INHIBITION; HIGH THROUGHPUT SCREENING; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; WET MILLING; X RAY POWDER DIFFRACTION; BIOAVAILABILITY; DRUG FORMULATION; LASER DIFFRACTION; ANIMAL; CHEMISTRY; MEDICINAL CHEMISTRY; ORAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT; SURFACE PROPERTY;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; MALE; NANOPARTICLES; PARTICLE SIZE; POVIDONE; RATS; RATS, SPRAGUE-DAWLEY; SURFACE PROPERTIES; THIAZINES; THIAZOLES;

EID: 84906667698     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.08.022     Document Type: Article

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