Ibuprofen sodium dihydrate, an ibuprofen formulation with improved absorption characteristics, provides faster and greater pain relief than ibuprofen acid

International Journal of Clinical Pharmacology and Therapeutics

Volumn 45, Issue 2, 2007, Pages 89-97

  Schleier, P ^a   Prochnau, A ^a   Schmidt Westhausen, A M ^b   Peters, H ^b   Becker, J ^c   Latz, T ^c   Jackowski, J ^d   Peters, E U ^d   Romanos, G E ^e   Zahn, B ^e   Ludemann J ^f   Maares, J ^g   Petersen, Birte ^f  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^d UNIVERSITY OF WITTEN HERDECKE   (Germany)

^e GOETHE UNIVERSITY   (Germany)

^f Bayer Consumer Care AG   (Switzerland)

^g NONE   (Germany)

Author keywords

Clinical trial; Dental pain; Ibuprofen; Onset

Indexed keywords

IBUPROFEN; IBUPROFEN DERIVATIVE; IBUPROFEN SODIUM; SARIDON; UNCLASSIFIED DRUG;

ADULT; ANALGESIA; ARTICLE; CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG EFFICACY; DRUG ERUPTION; DRUG FORMULATION; DRUG SAFETY; DRUG TOLERABILITY; EDEMA; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PAIN ASSESSMENT; RATING SCALE; SINGLE DRUG DOSE; TOOTH EXTRACTION; TOOTH PAIN;

EID: 33847374772     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP45089     Document Type: Article

References (13)

1. Averbuch M, Katzper M. Baseline pain and response to analgesic medications in the postsurgery dental pain model. J Clin Pharmacol. 2000; 40: 133-137.
2. Black P, Max MM, Desjardins P, Norwood T, Ardia A, Pallotta T. A randomized, double-blind, placebo-controlled comparison of the analgesic efficacy, onset of action, anf tolerability of ibuprofen arginate and ibuprofen in postoperative dental pain. Clin Ther. 2002; 24: 1072-1089.
3. CHMP. Note for guidance on clinical investigation of medicinal products for treatment of nociceptive pain. CPMP/EWP/612/00; 2002.
4. Hersch EV, Moore PA, Ross GL. Over-the-counter analgesics and antipyretics: a critical assessment. Clin Ther. 2000; 22: 500-548.
5. Klueglich M, Ring A, Scheurer S, Trommeshauser D, Schuijt C, Liepold B, Berndl G. Ibuprofen extrudate, a novel, rapidly dissolving ibuprofen formulation: relative bioavailability compared to ibuprofen lysinate and regular ibuprofen, and food effect on all formulations. J Clin Pharmacol. 2005; 45: 1055-1061.
6. Martinez MN, Amidon GL. A mechanistic approach to understanding the factors affecting drug absorption: a review of fundamentals. J Clin Pharmacol. 2002; 42: 620-643.
7. McQuay HJ, Edwards JE, Moore RA. Evaluating analgesia: the challenges. Am J Ther. 2002; 9: 179-187.
8. Melisch DR, Jasper RD, Brown P. Korn SH, McCarrol K, Murakami AA. Comparative study of ibuprofen lysine and acetaminophen in patients with postoperative dental pain. Clin Ther 1. 1995; 7: 852-860.
9. Melisch DR, Ardia A, Palotta T. A controlled comparative study of ibuprofen arginate versus conventional ibuprofen in the treatment of postoperative dental pain. J Clin Pharmacol. 2002; 42: 904-911.
10. Moore N, Van Ganse E, Le Parc J-M, Wall R, Schneid H, Farhan M, Verrière F, Pelen F. The PAIN study: paracetamol, aspirin and ibuprofen new tolerability study. Clin Drug Invest. 1999; 18: 89-98.
11. Nelson SL, Brahim JS, Korn SH, Greene SS, Suchower LJ. Comparison of single-dose ibuprofen lysine, acetylsalicylic acid, and placebo for moderate to severe postoperative dental pain. Clin Ther. 1994; 16: 458-465.
12. Schachtel BP, Meskin NA, Sanner RN. How fast is over-the-counter pain relief? Clin Pharmacol Ther. 2005; 77: PII-4; https://secure.ascpt.org/ annual/2005/2005MeetingAbstracts.pdf.
13. Soergel F, Fuhr U, Minic M, Siegmund M, Maares J, Jetter A, Kinzig-Schippers M, Thomalik-Schane D, Szymanski J, Goeser T, Scheidel B, Lehmacher W. Pharmacokinetics of ibuprofen sodium dihydrate and gastrointestinal tolerability of short-term treatment with a novel, rapidly absorbed formulation. Int J Clin Pharmacol Ther. 2005; 43: 140-149.