Positive feedback loop of autocrine BDNF from microglia causes prolonged microglia activation

Cellular Physiology and Biochemistry

Volumn 34, Issue 3, 2014, Pages 715-723

  Zhang, Xin ^a   Zeng, Lulu ^a   Yu, Tingting ^a   Xu, Yongming ^a   Pu, Shaofeng ^a   Du, Dongping ^a   Jiang, Wei ^a  

^a SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

Author keywords

ATP; BDNF; Microglia; Pain

Indexed keywords

ADENOSINE TRIPHOSPHATE; BRAIN DERIVED NEUROTROPHIC FACTOR; CD11B ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CONTROLLED STUDY; IN VITRO STUDY; MICROGLIA; MICROGLIAL ACTIVATION; NONHUMAN; POSITIVE AUTOCRINE FEEDBACK LOOP; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN SYNTHESIS; UPREGULATION; ANIMAL; CELL LINE; FEEDBACK SYSTEM; METABOLISM; MOUSE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL LINE; FEEDBACK; IN VITRO TECHNIQUES; MICE; MICROGLIA;

EID: 84906590148     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000363036     Document Type: Article

References (27)

1. Sarzi-Puttini P, Vellucci R, Zuccaro SM, Cherubino P, Labianca R, Fornasari D: The appropriate treatment of chronic pain. Clin Drug Investig 2012;32:S21-33.
2. Eyo UB, Dailey ME: Microglia: key elements in neural development, plasticity and pathology. J Neuroimmune Pharmacol 2013;8:494-509.
3. Tsuda M, Masuda T, Tozaki-Saitoh H, Inoue K: Microglial regulation of neuropathic pain. J Pharmacol Sci 2013;121:89-94.
4. Ristoiu V: Contribution of macrophages to peripheral neuropathic pain pathogenesis. Life Sci 2013;93:870-881.
5. Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, Inoue K: P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 2003;424:778-783.
6. Winkelstein BA, DeLeo JA: Nerve root injury severity differentially modulates spinal glial activation in a rat lumbar radiculopathy model: considerations for persistent pain. Brain Res 2002;956:294-301.
7. Kunori S, Matsumura S, Okuda-Ashitaka E, Katano T, Audoly LP, Urade Y, Ito S: A novel role of prostaglandin E2 in neuropathic pain: blockade of microglial migration in the spinal cord. Glia 2011;59:208-218.
8. Inoue K, Koizumi S, Tsuda M, Shigemoto-Mogami Y: Signaling of ATP receptors in glia-neuron interaction and pain. Life Sci 2003;74:189-197.
9. Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, Gravel C, Salter MW, De Koninck Y: BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 2005;438:1017-1021.
10. Huang EJ, Reichardt LF: Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 2001;24:677-736.
11. Biggs JE, Lu VB, Stebbing MJ, Balasubramanyan S, Smith PA: Is BDNF sufficient for information transfer between microglia and dorsal horn neurons duringthe onset of central sensitization? Mol Pain 2010;6:44.
12. Trang T, Beggs S, Wan X, Salter MW: P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation. J Neurosci 2009;29:3518-3528.
13. Bardoni R, Ghirri A, Salio C, Prandini M, Merighi A: BDNF-mediated modulation of GABA and glycine release in dorsal horn lamina II from postnatal rats. Dev Neurobiol 2007;67:960-975.
14. Zhang X, Wang J, Zhou Q, Xu Y, Pu S, Wu J, Xue Y Tian Y Lu J, Jiang W DuD: Brain-derived neurotrophic factor-activated astrocytes produce mechanical allodynia in neuropathic pain. Neuroscience 2011;199:452-460.
15. Zhou LJ, Yang T, Wei X, Liu Y Xin WJ, Chen Y Pang RP, Zang Y Li YY, Liu XG: Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat. Brain Behav Immun 2011;25:322-334.
16. Woolf CJ: Central sensitization: implications forthe diagnosis and treatment of pain. Pain 2011;152:S2-15.
17. FigurovA, Pozzo-Miller LD, Olafsson P, Wang T, Lu B: Regulation of synaptic responses to high-frequency stimulationand LTP by neurotrophins inthe hippocampus. Nature 1996;381:706-709.
18. Chen W Walwyn W Ennes HS, Kim H, McRoberts JA, Marvizon JC: BDNF released during neuropathic pain potentiates NMDA receptors in primaryafferentterminals. Eur J Neurosci 2014;10.1111/ejn.l2516
19. Ciobanu C, Reid G, Babes A: Acute and chronic effects of neurotrophic factors BDNF and GDNF on responses mediated by thermo-sensitive TRP channels in cultured rat dorsal rootganglion neurons. Brain Res 2009;1284:54-67.
20. Cao XH, Chen SR, Li L, Pan HL: Nerve injury increases brain-derived neurotrophic factor levels to suppress BK channel activity in primary sensory neurons. J Neurochem 2012;121:944-953.
21. Zhang J, Geula C, Lu C, Koziel H, Hatcher LM, Roisen FJ: Neurotrophins regulate proliferation and survival of two microglial cell lines invitro. Exp Neurol 2003;183:469-481.
22. Mizoguchi Y MonjiA, Kato T, Seki Y Gotoh L, Horikawa H, Suzuki SO, Iwaki T, Yonaha M, Hashioka S, Kanba S: Brain-derived neurotrophic factor induces sustained elevation of intracellular Ca2+ in rodent microglia. J Immunol 2009;183:7778-7786.
23. Nakajima K, Kikuchi Y Ikoma E, Honda S, Ishikawa M, Liu Y Kohsaka S: Neurotrophins regulate the function ofcultured microglia. Glia 1998;24:272-289.
24. Lindholm D, Castren E, Hengerer B, Zafra F, Berninger B, Thoenen H: Differential Regulation of Nerve Growth Factor (NGF) Synthesis in Neurons and Astrocytes by Glucocorticoid Hormones. Eur J Neurosci 1992;4:404-410.
25. Rudge JS, Alderson RF, Pasnikowski E, McClain J, Ip NY, Lindsay RM: Expression of Ciliary Neurotrophic Factor and the Neurotrophins-Nerve Growth Factor, Brain-Derived Neurotrophic Factor and Neurotrophin 3-in Cultured Rat Hippocampal Astrocytes. Eur J Neurosci 1992;4:459-471.
26. Trang T, Beggs S, Salter MW: Brain-derived neurotrophic factor from microglia: a molecular substrate for neuropathic pain. Neuron Glia Biol 2011;7:99-108.
27. Kuno R, Wang J, Kawanokuchi J, Takeuchi H, Mizuno X Suzumura A: Autocrine activation of microglia by tumor necrosis factor-alpha. J Neuroimmunol 2005;162:89-96.