Perceptions of genetic testing for personalized nutrition: A randomized trial of DNA-based dietary advice

Journal of Nutrigenetics and Nutrigenomics

Volumn 7, Issue 2, 2014, Pages 94-104

  Nielsen, Daiva E ^a   Shih, Sarah ^a   El Sohemy, Ahmed ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Genetic testing; Nutrigenetics; Nutrigenomics; Perceptions; Personalized nutrition

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; DIET THERAPY; DIETITIAN; DOUBLE BLIND PROCEDURE; FEMALE; GENETIC ANALYSIS; GENETIC SCREENING; HEALTH CARE PERSONNEL; HUMAN; HUMAN EXPERIMENT; LIKERT SCALE; MALE; NORMAL HUMAN; NUTRIGENOMICS; NUTRITION; PERSONALIZED NUTRITION; PHYSICIAN; RANDOMIZED CONTROLLED TRIAL; YOUNG ADULT; ALLELE; ATTITUDE TO HEALTH; DIET; INTERVENTION STUDY; NUTRITIONAL ASSESSMENT; NUTRITIONAL STATUS; PERSONALIZED MEDICINE;

DNA;

ADULT; ALLELES; ATTITUDE TO HEALTH; DIET; DNA; DOUBLE-BLIND METHOD; FEMALE; GENETIC TESTING; HEALTH KNOWLEDGE, ATTITUDES, PRACTICE; HUMANS; INDIVIDUALIZED MEDICINE; INTERVENTION STUDIES; MALE; NUTRITION ASSESSMENT; NUTRITIONAL STATUS; YOUNG ADULT;

EID: 84906574661     PISSN: 16616499     EISSN: 16616758     Source Type: Journal    
DOI: 10.1159/000365508     Document Type: Article

References (43)

1. Sterling R: The on-line promotion and sale of nutrigenomic services. Genet Med 2008; 10: 784-796.
2. Coghlan A: 23andMe ordered to stop selling $99 genetic test. New Scientist, 2013. http://www.newscientist.com/article/dn24656-23andme-ordered-to-stop-selling-99-genetic-test.html (accessed April 23, 2014).
3. O'Connor L: 23andMe faces $5 million lawsuit days after being banned by FDA. The Huffington Post, December 4, 2013. http://www.huffingtonpost.com/2013/12/04/23andme-lawsuit-n-4387699.html (accessed April 23, 2014).
4. Human Genetics Commission: A common framework of principles for direct-to-consumer genetic testing services. 2010. http://www.cellmark.co.uk/pdfs/HGCprinciples.pdf (accessed April 23, 2014).
5. Wagner JK: Understanding FDA regulation of DTC genetic tests within the context of administrative law. Am J Hum Genet 2010; 87: 451-456.
6. Borry P, van Hellemondt RE, Sprumont D, Jales CF, Rial-Sebbag E, Spranger TM, Curren L, Kaye J, Nys H, Howard H: Legislation on direct-to-consumer genetic testing in seven European countries. Eur J Hum Genet 2012; 20: 715-721.
7. Cherkas LF, Harris JM, Levinson E, Spector TD, Prainsack B: A survey of UK public interest in internet-based personal genome testing. PLoS One 2010; 5:e13473.
8. Goddard KA, Duquette D, Zlot A, Johnson J, Annis-Emeott A, Lee PW, Bland MP, Edwards KL, Oehlke K, Giles RT, Rafferty A, Cook ML, Khoury MJ: Public awareness and use of direct-to-consumer genetic tests: results from 3 state population-based surveys, 2006. Am J Public Health 2009; 99: 442-445.
9. Kolor K, Duquette D, Zlot A, Foland J, Anderson B, Giles R, Wrathall J, Khoury MJ: Public awareness and use of direct-to-consumer personal genomic tests from four state population-based surveys, and implications for clinical and public health practice. Genet Med 2012; 14: 860-867.
10. Stewart-Knox BJ, Bunting BP, Gilpin S, Parr HJ, Pinhao S, Strain JJ, de Almeida MD, Gibney M: Attitudes toward genetic testing and personalised nutrition in a representative sample of European consumers. Br J Nutr 2009; 101: 982-989.
11. Ronteltap A, van Trijp JC, Renes RJ: Consumer acceptance of nutrigenomics-based personalised nutrition. Br J Nutr 2009; 101: 132-144.
12. Roosen J, Bruhn M, Mecking RA, Drescher LS: Consumer demand for personalized nutrition and functional food. Int J Vitam Nutr Res 2008; 78: 269-274.
13. Goddard KA, Moore C, Ottman D, Szegda KL, Bradley L, Khoury MJ: Awareness and use of direct-to-consumer nutrigenomic tests, United States, 2006. Genet Med 2007; 9: 510-517.
14. Stenne R, Hurlimann T, Godard B: Benefits associated with nutrigenomics research and their reporting in the scientific literature: researchers' perspectives. Account Res 2013; 20: 167-183.
15. Nielsen DE, El-Sohemy A: A randomized trial of genetic information for personalized nutrition. Genes Nutr 2012; 7: 559-566.
16. Nawrot P, Jordan S, Eastwood J, Rotstein J, Hugenholtz A, Feeley M: Effects of caffeine on human health. Food Addit Contam 2003; 20: 1-30.
17. Otten JJ, Hellwig JP, Meyers LD (eds): Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Washington, National Academies Press, 2006.
18. Nishida C, Uauy R, Kumanyika S, Shetty P: The joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutr 2004; 7: 245-250.
19. Cornelis MC, El-Sohemy A, Kabagambe EK, Campos H: Coffee, cyp1a2 genotype, and risk of myocardial infarction. JAMA 2006; 295: 1135-1141.
20. Palatini P, Ceolotto G, Ragazzo F, Dorigatti F, Saladini F, Papparella I, Mos L, Zanata G, Santonastaso M: CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension. J Hypertens 2009; 27: 1594-1601.
21. Cahill LE, Fontaine-Bisson B, El-Sohemy A: Functional genetic variants of glutathione S-transferase protect against serum ascorbic acid deficiency. Am J Clin Nutr 2009; 90: 1411-1417.
22. Giner V, Poch E, Bragulat E, Oriola J, Gonzalez D, Coca A, De La Sierra A: Renin-angiotensin system genetic polymorphisms and salt sensitivity in essential hypertension. Hypertension 2000; 35: 512-517.
23. Poch E, Gonzalez D, Giner V, Bragulat E, Coca A, de La Sierra A: Molecular basis of salt sensitivity in human hypertension. Evaluation of renin-angiotensin-aldosterone system gene polymorphisms. Hypertension 2001; 38: 1204-1209.
24. Narum SR: Beyond Bonferroni. Less conservative analyses for conservation genetics. Conserv Genet 2006; 7: 783-787.
25. Rosenstock IM, Strecher VJ, Becker MH: Social learning theory and the health belief model. Health Educ Q 1988; 15: 175-183.
26. Maher B: Nature readers flirt with personal genomics. Nature 2011; 478: 19.
27. Kaufman DJ, Bollinger JM, Dvoskin RL, Scott JA: Risky business: risk perception and the use of medical services among customers of DTC personal genetic testing. J Genet Couns 2012; 21: 413-422.
28. Almeling R, Gadarian SK: Public opinion on policy issues in genetics and genomics. Genet Med 2014; 16: 491- 494.
29. Morin K: Knowledge and attitudes of Canadian consumers and health care professionals regarding nutritional genomics. OMICS 2009; 13: 37-41.
30. Ferguson LR, Barnett MPG: Research in nutrigenomics and potential applications to practice. Nutr Diet 2012; 69: 198-202.
31. Weir M, Morin K, Ries N, Castle D: Canadian health care professionals' knowledge, attitudes and perceptions of nutritional genomics. Br J Nutr 2010; 104: 1112-1119.
32. Birmingham WC, Agarwal N, Kohlmann W, Aspinwall LG, Wang M, Bishoff J, Dechet C, Kinney AY: Patient and provider attitudes toward genomic testing for prostate cancer susceptibility: A mixed method study. BMC Health Serv Res 2013; 13: 279.
33. Cormier H, Tremblay BL, Paradis AM, Garneau V, Desroches S, Robitaille J, Vohl MC: Nutrigenomics - perspectives from registered dietitians: A report from the Quebec-wide e-consultation on nutrigenomics among registered dietitians. J Hum Nutr Diet 2014; 27: 391-400.
34. Harris A, Kelly SE, Wyatt S: Counseling customers: emerging roles for genetic counselors in the direct-toconsumer genetic testing market. J Genet Couns 2013; 22: 277-288.
35. Salari K, Karczewski KJ, Hudgins L, Ormond KE: Evidence that personal genome testing enhances student learning in a course on genomics and personalized medicine. PLoS One 2013; 8:e68853.
36. McBride CM, Bryan AD, Bray MS, Swan GE, Green ED: Health behavior change: can genomics improve behavioral adherence? Am J Public Health 2012; 102: 401-405.
37. Bloss CS, Schork NJ, Topol EJ: Effect of direct-to-consumer genomewide profiling to assess disease risk. N Engl J Med 2011; 364: 524-534.
38. Bloss CS, Wineinger NE, Darst BF, Schork NJ, Topol EJ: Impact of direct-to-consumer genomic testing at long term follow-up. J Med Genet 2013; 50: 393-400.
39. Hurlimann T, Menuz V, Graham J, Robitaille J, Vohl MC, Godard B: Risks of nutrigenomics and nutrigenetics? What the scientists say. Genes Nutr 2014; 9: 370.
40. Grant RW, O'Brien KE, Waxler JL, Vassy JL, Delahanty LM, Bissett LG, Green RC, Stember KG, Guiducci C, Park ER, Florez JC, Meigs JB: Personalized genetic risk counseling to motivate diabetes prevention: A randomized trial. Diabetes Care 2013; 36: 13-19.
41. Arkadianos I, Valdes AM, Marinos E, Florou A, Gill RD, Grimaldi KA: Improved weight management using genetic information to personalize a calorie controlled diet. Nutr J 2007; 6: 29.
42. Chao S, Roberts JS, Marteau TM, Silliman R, Cupples LA, Green RC: Health behavior changes after genetic risk assessment for Alzheimer disease: The reveal study. Alzheimer Dis Assoc Disord 2008; 22: 94-97.
43. Gollust SE, Gordon ES, Zayac C, Griffin G, Christman MF, Pyeritz RE, Wawak L, Bernhardt BA: Motivations and perceptions of early adopters of personalized genomics: perspectives from research participants. Public Health Genomics 2012; 15: 22-30.