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Journal of Experimental Medicine
Volumn 211, Issue 9, 2014, Pages 1833-1846
VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells
Author keywords

[No Author keywords available]
Indexed keywords

ALPHA4 INTEGRIN; CD146 ANTIGEN; NATALIZUMAB; P SELECTIN GLYCOPROTEIN LIGAND 1; P SELECTIN GLYCOPROTEIN LIGAND 1 RECEPTOR; RECEPTOR; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULAR CELL ADHESION MOLECULE 1 RECEPTOR; VERY LATE ACTIVATION ANTIGEN 4;
EID: 84906568560     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20140540     Document Type: Article
Times cited : (117)
References (45)
  • 1
    • 84886641249 scopus 로고    scopus 로고
    • Glial influence on the blood brain barrier
    • Alvarez, J.I., T. Katayama, and A. Prat. 2013. Glial influence on the blood brain barrier. Glia. 61:1939-1958.http://dx.doi.org/10.1002/glia.22575
    • (2013) Glia , vol.61 , pp. 1939-1958
    • Alvarez, J.I.1    Katayama, T.2    Prat, A.3
  • 2
    • 65249141706 scopus 로고    scopus 로고
    • Gaining entry to an uninflamed brain
    • Axtell, R.C., and L. Steinman. 2009. Gaining entry to an uninflamed brain. Nat. Immunol. 10:453-455. http://dx.doi.org/10.1038/ni0509-453
    • (2009) Nat. Immunol. , vol.10 , pp. 453-455
    • Axtell, R.C.1    Steinman, L.2
  • 3
    • 0034332965 scopus 로고    scopus 로고
    • CD4(+)CD45RO(+)CD49d(high) cells are involved in the pathogenesis of relapsing-remitting multiple sclerosis
    • Barrau, M.A., X. Montalban, I. Sáez-Torres, L. Brieva, N. Barberá and E.M. Martínez-Cáceres. 2000. CD4(+)CD45RO(+)CD49d(high) cells are involved in the pathogenesis of relapsing-remitting multiple sclerosis. J. Neuroimmunol. 111:215-223. http://dx.doi.org/10.1016/S0165-5728(00)00357-X
    • (2000) J. Neuroimmunol. , vol.111 , pp. 215-223
    • Barrau, M.A.1    Montalban, X.2    Sáez-Torres, I.3    Brieva, L.4    Barberá, N.5    Martínez-Cáceres, E.M.6
  • 4
    • 60549086393 scopus 로고    scopus 로고
    • Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity
    • Bauer, M., C. Brakebusch, C. Coisne, M. Sixt, H. Wekerle, B. Engelhardt, and R. Fässler. 2009. Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proc. Natl. Acad. Sci. USA. 106:1920-1925. http://dx.doi.org/10.1073/pnas.0808909106
    • (2009) Proc. Natl. Acad. Sci. USA. , vol.106 , pp. 1920-1925
    • Bauer, M.1    Brakebusch, C.2    Coisne, C.3    Sixt, M.4    Wekerle, H.5    Engelhardt, B.6    Fässler, R.7
  • 7
    • 0032536046 scopus 로고    scopus 로고
    • Chemokines and the arrest of lymphocytes rolling under flow conditions
    • Campbell, J.J., J. Hedrick, A. Zlotnik, M.A. Siani, D.A. Thompson, and E.C. Butcher. 1998. Chemokines and the arrest of lymphocytes rolling under flow conditions. Science. 279:381-384. http://dx.doi.org/10.1126/science.279.5349.381
    • (1998) Science , vol.279 , pp. 381-384
    • Campbell, J.J.1    Hedrick, J.2    Zlotnik, A.3    Siani, M.A.4    Thompson, D.A.5    Butcher, E.C.6
  • 8
    • 70350718157 scopus 로고    scopus 로고
    • Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the bloodbrain barrier in vivo in an animal model of multiple sclerosis
    • Coisne, C., W. Mao, and B. Engelhardt. 2009. Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the bloodbrain barrier in vivo in an animal model of multiple sclerosis. J. Immunol. 182:5909-5913. http://dx.doi.org/10.4049/jimmunol.0803418
    • (2009) J. Immunol. , vol.182 , pp. 5909-5913
    • Coisne, C.1    Mao, W.2    Engelhardt, B.3
  • 9
  • 10
    • 33745038011 scopus 로고    scopus 로고
    • CLEAR Multinational Study Group. CLinical experience acquired with the efalizumab (Raptiva) (CLEAR) trial in patients with moderate-to-severe plaque psoriasis: results from a phase III international randomized, placebo-controlled trial
    • Dubertret, L., W. Sterry, J.D. Bos, S. Chimenti, S. Shumack, C.G. Larsen, N.H. Shear, and K.A. Papp. CLEAR Multinational Study Group. 2006. CLinical experience acquired with the efalizumab (Raptiva) (CLEAR) trial in patients with moderate-to-severe plaque psoriasis: results from a phase III international randomized, placebo-controlled trial. Br. J. Dermatol. 155:170-181. http://dx.doi.org/10.1111/j.1365-2133.2006.07344.x
    • (2006) Br. J. Dermatol. , vol.155 , pp. 170-181
    • Dubertret, L.1    Sterry, W.2    Bos, J.D.3    Chimenti, S.4    Shumack, S.5    Larsen, C.G.6    Shear, N.H.7    Papp, K.A.8
  • 11
    • 84869885852 scopus 로고    scopus 로고
    • Capture, crawl, cross: the T cell code to breach the blood-brain barriers
    • Engelhardt, B., and R.M. Ransohoff. 2012. Capture, crawl, cross: the T cell code to breach the blood-brain barriers. Trends Immunol. 33:579-589. http://dx.doi.org/10.1016/j.it.2012.07.004
    • (2012) Trends Immunol , vol.33 , pp. 579-589
    • Engelhardt, B.1    Ransohoff, R.M.2
  • 12
    • 73449115641 scopus 로고    scopus 로고
    • The blood-brain and the bloodcerebrospinal fluid barriers: function and dysfunction
    • Engelhardt, B., and L. Sorokin. 2009. The blood-brain and the bloodcerebrospinal fluid barriers: function and dysfunction. Semin. Immunopathol. 31:497-511. http://dx.doi.org/10.1007/s00281-009-0177-0
    • (2009) Semin. Immunopathol. , vol.31 , pp. 497-511
    • Engelhardt, B.1    Sorokin, L.2
  • 14
    • 84855218290 scopus 로고    scopus 로고
    • Autoimmune disease in the brain-how to spot the culprits and how to keep them in check
    • Flüel, A., C. Schler, F. Lüder, and F. Odoardi. 2011. Autoimmune disease in the brain-how to spot the culprits and how to keep them in check. J. Neurol. Sci. 311:S3-S11.
    • (2011) J. Neurol. Sci. , vol.311
    • Flüel, A.1    Schler, C.2    Lüder, F.3    Odoardi, F.4
  • 15
    • 0026022298 scopus 로고
    • Muromonab CD-3: a review of its pharmacology, pharmacokinetics, and clinical use in transplantation
    • Hooks, M.A., C.S. Wade, and W.J. Millikan Jr. 1991. Muromonab CD-3: a review of its pharmacology, pharmacokinetics, and clinical use in transplantation. Pharmacotherapy. 11:26-37.
    • (1991) Pharmacotherapy , vol.11 , pp. 26-37
    • Hooks, M.A.1    Wade, C.S.2    Millikan Jr., W.J.3
  • 16
    • 70149099765 scopus 로고    scopus 로고
    • Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosis
    • Huang, Y.-H., A.L. Zozulya, C. Weidenfeller, I. Metz, D. Buck, K.V. Toyka, W. Brük, and H. Wiendl. 2009. Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosis. Ann. Neurol. 66:171-183. http://dx.doi.org/10.1002/ana.21705
    • (2009) Ann. Neurol. , vol.66 , pp. 171-183
    • Huang, Y.-H.1    Zozulya, A.L.2    Weidenfeller, C.3    Metz, I.4    Buck, D.5    Toyka, K.V.6    Brük, W.7    Wiendl, H.8
  • 18
    • 33646468932 scopus 로고    scopus 로고
    • Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis
    • Kerfoot, S.M., M.U. Norman, B.M. Lapointe, C.S. Bonder, L. Zbytnuik, and P. Kubes. 2006. Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis. J. Immunol. 176:6225-6234. http://dx.doi.org/10.4049/jimmunol.176.10.6225
    • (2006) J. Immunol. , vol.176 , pp. 6225-6234
    • Kerfoot, S.M.1    Norman, M.U.2    Lapointe, B.M.3    Bonder, C.S.4    Zbytnuik, L.5    Kubes, P.6
  • 20
    • 67650032747 scopus 로고    scopus 로고
    • Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells
    • Kivisk, P., B.C. Healy, V. Viglietta, F.J. Quintana, M.A. Hootstein, H.L. Weiner, and S.J. Khoury. 2009. Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells. Neurology. 72:1922-1930. http://dx.doi.org/10.1212/WNL.0b013e3181a8266f
    • (2009) Neurology , vol.72 , pp. 1922-1930
    • Kivisk, P.1    Healy, B.C.2    Viglietta, V.3    Quintana, F.J.4    Hootstein, M.A.5    Weiner, H.L.6    Khoury, S.J.7
  • 21
    • 81755179424 scopus 로고    scopus 로고
    • How do immune cells overcome the blood-brain barrier in multiple sclerosis
    • Larochelle, C., J.I. Alvarez, and A. Prat. 2011. How do immune cells overcome the blood-brain barrier in multiple sclerosis FEBS Lett. 585:3770-3780. http://dx.doi.org/10.1016/j.febslet.2011.04.066
    • (2011) FEBS Lett , vol.585 , pp. 3770-3780
    • Larochelle, C.1    Alvarez, J.I.2    Prat, A.3
  • 22
    • 84867735795 scopus 로고    scopus 로고
    • Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system
    • Larochelle, C., R. Cayrol, H. Kebir, J.I. Alvarez, M.-A. Luyer, I. Ifergan,. Viel, L. Bourbonnie, D. Beauseigle, S. Terouz, et al. 2012. Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system. Brain. 135: 2906-2924. http://dx.doi.org/10.1093/brain/aws212
    • (2012) Brain , vol.135 , pp. 2906-2924
    • Larochelle, C.1    Cayrol, R.2    Kebir, H.3    Alvarez, J.I.4    Luyer, M.-A.5    Ifergan, I.6    Viel, É.7    Bourbonnie, L.8    Beauseigle, D.9    Terouz, S.10
  • 23
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination
    • Lucchinetti, C., W. Brück, J. Parisi, B. Scheithauer, M. Rodriguez, and H. Lassmann. 2000. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann. Neurol. 47:707-717. http://dx.doi.org/10.1002/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO;2-Q
    • (2000) Ann. Neurol. , vol.47 , pp. 707-717
    • Lucchinetti, C.1    Brück, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 24
    • 84896716343 scopus 로고    scopus 로고
    • Post-natalizumab clinical and radiological findings in a cohort of multiple sclerosis patients: 12-month follow-up
    • Melis, M., E. Cocco, J. Frau, L. Lorefice, G. Fenu, G. Coghe, M. Mura, and M.G. Marrosu. 2013. Post-natalizumab clinical and radiological findings in a cohort of multiple sclerosis patients: 12-month follow-up. Neurol. Sci. 35:401-408.
    • (2013) Neurol. Sci. , vol.35 , pp. 401-408
    • Melis, M.1    Cocco, E.2    Frau, J.3    Lorefice, L.4    Fenu, G.5    Coghe, G.6    Mura, M.7    Marrosu, M.G.8
  • 25
    • 0037083641 scopus 로고    scopus 로고
    • Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors
    • Piccio, L., B. Rossi, E. Scarpini, C. Laudanna, C. Giagulli, A.C. Issekutz, D. Vestweber, E.C. Butcher, and G. Constantin. 2002. Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors. J. Immunol. 168:1940-1949. http://dx.doi.org/10.4049/jimmunol.168.4.1940
    • (2002) J. Immunol. , vol.168 , pp. 1940-1949
    • Piccio, L.1    Rossi, B.2    Scarpini, E.3    Laudanna, C.4    Giagulli, C.5    Issekutz, A.C.6    Vestweber, D.7    Butcher, E.C.8    Constantin, G.9
  • 28
    • 0033540112 scopus 로고    scopus 로고
    • Expression of laminin alpha1, alpha2, alpha4, and alpha5 chains, fibronectin, and tenascin-C in skeletal muscle of dystrophic 129ReJ dy/dy mice
    • Ringelmann, B., C. Rer, R. Hallmann, M. Maley, M. Davies, M. Grounds, and L. Sorokin. 1999. Expression of laminin alpha1, alpha2, alpha4, and alpha5 chains, fibronectin, and tenascin-C in skeletal muscle of dystrophic 129ReJ dy/dy mice. Exp. Cell Res. 246:165-182. http://dx.doi.org/10.1006/excr.1998.4244
    • (1999) Exp. Cell Res. , vol.246 , pp. 165-182
    • Ringelmann, B.1    Rer, C.2    Hallmann, R.3    Maley, M.4    Davies, M.5    Grounds, M.6    Sorokin, L.7
  • 29
    • 84855475637 scopus 로고    scopus 로고
    • Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE
    • Rothhammer, V., S. Heink, F. Petermann, R. Srivastava, M.C. Claussen, B. Hemmer, and T. Korn. 2011. Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE. J. Exp. Med. 208:2465-2476. http://dx.doi.org/10.1084/jem.20110434
    • (2011) J Exp. Med. , vol.208 , pp. 2465-2476
    • Rothhammer, V.1    Heink, S.2    Petermann, F.3    Srivastava, R.4    Claussen, M.C.5    Hemmer, B.6    Korn, T.7
  • 31
    • 84858405029 scopus 로고    scopus 로고
    • Efficacy of anti-interleukin-2 receptor antibody (daclizumab) in reducing the incidence of acute rejection after renal transplantation
    • Saghafi, H., K. Rahbar, A. Nobakht Haghighi, M. Qoreishi, and F. Safdari. 2012. Efficacy of anti-interleukin-2 receptor antibody (daclizumab) in reducing the incidence of acute rejection after renal transplantation. Nephrourol Mon. 4:475-477. http://dx.doi.org/10.5812/numonthly.1806
    • (2012) Nephrourol Mon , vol.4 , pp. 475-477
    • Saghafi, H.1    Rahbar, K.2    Nobakht Haghighi, A.3    Qoreishi, M.4    Safdari, F.5
  • 32
    • 78649600894 scopus 로고    scopus 로고
    • Regulatory T cells exhibit enhanced migratory characteristics, a feature impaired in patients with multiple sclerosis
    • Schneider-Hohendorf, T., M.-P. Stenner, C. Weidenfeller, A.L. Zozulya, O.J. Simon, N. Schwab, and H. Wiendl. 2010. Regulatory T cells exhibit enhanced migratory characteristics, a feature impaired in patients with multiple sclerosis. Eur. J. Immunol. 40:3581-3590. http://dx.doi.org/10.1002/eji.201040558
    • (2010) Eur. J. Immunol. , vol.40 , pp. 3581-3590
    • Schneider-Hohendorf, T.1    Stenner, M.-P.2    Weidenfeller, C.3    Zozulya, A.L.4    Simon, O.J.5    Schwab, N.6    Wiendl, H.7
  • 33
    • 77954521172 scopus 로고    scopus 로고
    • An imbalance of two functionally and phenotypically different subsets of plasmacytoid dendritic cells characterizes the dysfunctional immune regulation in multiple sclerosis
    • Schwab, N., A.L. Zozulya, B.C. Kieseier, K.V. Toyka, and H. Wiendl. 2010. An imbalance of two functionally and phenotypically different subsets of plasmacytoid dendritic cells characterizes the dysfunctional immune regulation in multiple sclerosis. J. Immunol. 184:5368-5374. http://dx.doi.org/10.4049/jimmunol.0903662
    • (2010) J. Immunol. , vol.184 , pp. 5368-5374
    • Schwab, N.1    Zozulya, A.L.2    Kieseier, B.C.3    Toyka, K.V.4    Wiendl, H.5
  • 36
    • 84896903104 scopus 로고    scopus 로고
    • Immunology of relapse and remission in multiple sclerosis
    • Steinman, L. 2014. Immunology of relapse and remission in multiple sclerosis. Annu. Rev. Immunol. 32:257-281. http://dx.doi.org/10.1146/annurevimmunol-032713-120227
    • (2014) Annu. Rev. Immunol. , vol.32 , pp. 257-281
    • Steinman, L.1
  • 38
    • 70350539771 scopus 로고    scopus 로고
    • Iatrogenic immunosuppression with biologics in MS: expecting the unexpected
    • Stüve, O., and H. Wiendl. 2009. Iatrogenic immunosuppression with biologics in MS: expecting the unexpected Neurology. 73:1346-1347. http://dx.doi.org/10.1212/WNL.0b013e3181beed38
    • (2009) Neurology , vol.73 , pp. 1346-1347
    • Stüve, O.1    Wiendl, H.2
  • 41
    • 84864431745 scopus 로고    scopus 로고
    • Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter
    • Varrin-Doyer, M., C.M. Spencer, U. Schulze-Topphoff, P.A. Nelson, R.M. Stroud, B.A.C. Cree, and S.S. Zamvil. 2012. Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter. Ann. Neurol. 72:53-64. http://dx.doi.org/10.1002/ana.23651
    • (2012) Ann. Neurol. , vol.72 , pp. 53-64
    • Varrin-Doyer, M.1    Spencer, C.M.2    Schulze-Topphoff, U.3    Nelson, P.A.4    Stroud, R.M.5    Cree, B.A.C.6    Zamvil, S.S.7
  • 42
    • 84873087237 scopus 로고    scopus 로고
    • CD146, a multi-functional molecule beyond adhesion
    • Wang, Z., and X. Yan. 2013. CD146, a multi-functional molecule beyond adhesion. Cancer Lett. 330:150-162. http://dx.doi.org/10.1016/j.canlet.2012.11.049
    • (2013) Cancer Lett , vol.330 , pp. 150-162
    • Wang, Z.1    Yan, X.2
  • 43
    • 77951837763 scopus 로고    scopus 로고
    • Trafficking of immune cells in the central nervous system
    • Wilson, E.H., W. Weninger, and C.A. Hunter. 2010. Trafficking of immune cells in the central nervous system. J. Clin. Invest. 120:1368-1379. http://dx.doi.org/10.1172/JCI41911
    • (2010) J. Clin. Invest. , vol.120 , pp. 1368-1379
    • Wilson, E.H.1    Weninger, W.2    Hunter, C.A.3
  • 44
    • 0026506799 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin
    • Yednock, T.A., C. Cannon, L.C. Fritz, F. Sanchez-Madrid, L. Steinman, and N. Karin. 1992. Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature. 356:63-66. http://dx.doi.org/10.1038/356063a0
    • (1992) Nature , vol.356 , pp. 63-66
    • Yednock, T.A.1    Cannon, C.2    Fritz, L.C.3    Sanchez-Madrid, F.4    Steinman, L.5    Karin, N.6
  • 45
    • 34250180872 scopus 로고    scopus 로고
    • Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1
    • Zarbock, A., C.A. Lowell, and K. Ley. 2007. Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1. Immunity. 26:773-783. http://dx.doi.org/10.1016/j.immuni.2007.04.011
    • (2007) Immunity , vol.26 , pp. 773-783
    • Zarbock, A.1    Lowell, C.A.2    Ley, K.3

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