Low RNA translation activit limits the efficacy of hydrodynamic gene transfer to pig liver in vivo

Journal of Gene Medicine

Volumn 16, Issue 7-8, 2014, Pages 179-192

  Sendra, Luis ^a   Carreño, Omar ^b   Miguel, Antonio ^a   Montalvá, Eva ^b   Herrero, María José ^a,c   Orbis, Francisco ^b   Noguera, Inmaculada ^d   Barettino, Domingo ^e   López Andújar, Rafael ^b   Aliño, Salvador F ^a,b,c  

^a UNIVERSITY OF VALENCIA   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

^c INSTITUTO DE INVESTIGACIÓN SANITARIA DEL HOSPITAL CLÍNICO SAN CARLOS IDISSC   (Spain)

^d UNIVERSITY OF VALENCIA   (Spain)

^e INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

Author keywords

Gene therapy; Hydrodynamic; Liver; Nanoparticle; Nonviral; Pig

Indexed keywords

DNA; ENHANCED GREEN FLUORESCENT PROTEIN; GOLD NANOPARTICLE; MESSENGER RNA; PROTEIN; GOLD; GREEN FLUORESCENT PROTEIN; METAL NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTEROGRADE INJECTION; ARTICLE; COMPARATIVE STUDY; DNA CONFORMATION; ELECTRON MICROSCOPY; FEMALE; GENE DOSAGE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HYDRODYNAMICS BASED TRANSFECTION; IN VIVO STUDY; LIVER; LIVER CELL; LIVER TOXICITY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROGRADE INJECTION; RNA TRANSLATION; SAFETY; SURGICAL TECHNIQUE; SWINE; ANIMAL; BIOSYNTHESIS; CELL MEMBRANE PERMEABILITY; CHEMISTRY; CYTOLOGY; GENETIC TRANSFECTION; GENETICS; METABOLISM; PARTICLE SIZE; PLASMID; PROCEDURES; PROTEIN SYNTHESIS; ULTRASTRUCTURE;

ANIMALS; CELL MEMBRANE PERMEABILITY; FEMALE; GOLD; GREEN FLUORESCENT PROTEINS; HEPATOCYTES; LIVER; METAL NANOPARTICLES; PARTICLE SIZE; PLASMIDS; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; SUS SCROFA; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 84906515260     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.2777     Document Type: Article

References (42)

1. Budker V, Zhang G, Knechtle S, Wolff JA. Naked DNA delivered intraportally expresses efficiently in hepatocytes. Gene Ther 1996; 3: 593-598.
2. Zhang G, Vargo D, Budker V, Armstrong N, Knechtle S, Wolff JA. Expression of naked plasmid DNA injected into the afferent and efferent vessels of rodent and dog livers. Hum Gene Ther 1997; 8: 1763-1772.
3. Liu F, Song Y, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 1999; 6: 1258-1266.
4. Zhang G, Budker V, Wolff JA. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 1999; 10: 1735-1737.
5. Crespo A, Peydro A, Dasi F, et al. Hydrodynamic liver gene transfer mechanism involves transient sinusoidal blood stasis and massive hepatocyte endocytic vesicles. Gene Ther 2005; 12: 927-935.
6. Kay MA, Glorioso JC, Naldini L. Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nat Med 2001; 7: 33-40.
7. Zhang G, Gao X, Song YK, et al. Hydroporation as the mechanism of hydrodynamic delivery. Gene Ther 2004; 11: 675-682.
8. Herrero MJ, Dasi F, Noguera I, et al. Mouse and pig nonviral liver gene therapy: success and trials. Gene Ther Mol Biol 2005; 9: 169-180.
9. Suda T, Gao X, Stolz DB, Liu D. Structural impact of hydrodynamic injection on mouse liver. Gene Ther 2007; 14: 129-137.
10. Sawyer GJ, Dong X, Whitehorne M, et al. Cardiovascular function following acute volume overload for hydrodynamic gene delivery to the liver. Gene Ther 2007; 14: 1208-1217.
11. Sawyer GJ, Rela M, Davenport M, Whitehorne M, Zhang X, Fabre JW. Hydrodynamic gene delivery to the liver: theoretical and practical issues for clinical application. Curr Gene Ther 2009; 9: 128-35.
12. Zhang X, Collins L, Sawyer GJ, Dong X, Qiu Y, Fabre JW. In vivo gene delivery via portal vein and bile duct to individual lobes of the rat liver using a polylysine-based nonviral DNA vector in combination with chloroquine. Hum Gene Ther 2001; 12: 2179-2190.
13. Eastman SJ, Baskin KM, Hodges BL, et al. Development of catheter-based procedures for transducing the isolated rabbit liver with plasmid DNA. Hum Gene Ther 2002; 13: 2065-2077.
14. Aliño SF, Herrero MJ, Noguera I, Dasí F, Sánchez M. Pig liver gene therapy by noninvasive interventionist catheterizm. Gene Ther 2007; 14: 334-343.
15. Fabre JW, Whitehorne M, Grehan A, Sawyer GJ, Zhang X, Davenport M, Rela M. Critical, physiological and surgical considerations for hydrodynamic pressurization of individual segments of the pig liver. Hum Gene Ther 2011; 22: 879-87.
16. Kamimura K, Suda T, Xu W, Zhang G, Liu D. Image-guided, lobe-specific hydrodynamic gene delivery to swine liver. Mol Ther 2009; 17: 491-499.
17. Yoshino H, Hashizume K, Kobayashi E. Naked plasmid DNA transfer to the porcine liver using rapid injection with large volume. Gene Ther 2006; 13: 1696-1702.
18. Sawyer GJ, Zhang X, Fabre JW. Technical requirements for effective regional hydrodynamic gene delivery to the left lateral lobe of the rat liver. Gene Ther 2010; 17: 560-564.
19. Fabre JW, Grehan A, Whiterhorne M, et al. Hydrodynamic gene delivery to the pig liver via an isolated segment of the inferior vena cava. Gene Ther 2008; 15: 452-462.
20. Carreño O, Sendra L, Montalvá E, et al. A surgical model for isolating the pig liver in vivo for gene therapy. Eur Surg Res 2013; 51: 47-57.
21. Sebestyén MG, Budker VG, Budker T, et al. Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules. J Gene Med 2006; 8: 852-873.
22. Herrero MJ, Sabater L, Guenechea G, et al. DNA delivery to 'ex vivo' human liver segments. Gene Ther 2012; 19: 504-512.
23. NCBI Genome Database. http://www.ncbi.nlm.nih.gov/genome/84. (accessed on December 2012).
24. Alberts B, Johnson A, Lewis J, et al. (eds). From DNA to RNA. In Molecular Biology of the Cell (4th edn). Garland Science: New York, NY, 2002.
25. Brown TA. Transcriptomes and genomes. In Genomes (2nd edn). Wiley-Liss: Oxford, 2002.
26. Beck M, Schmidt A, Malmstroem J, et al. The quantitative proteome of a human cell lines. Mol Syst Biol 2011; 7: 549-556.
27. Masiá S, Alvarez S, de Lera AR, Barettino D. Rapid, nongenomic actions of retinoic acid on phosphatidylinositol-3-kinase signaling pathway mediated by the retinoic acid receptor. Mol Endocrinol 2007; 21: 2391-2402.
28. Kimling J, Maier M, Okenve B, Kotaidis V, Ballot H, Plech A. Turkevich method for gold nanoparticle synthesis revisited. J Phys Chem 2006; 110: 157-160.
29. de Groot GH, Reuvers CB, Schalm SW, et al. A reproducible model of acute hepatic failure by transient ischemia in the pig. J Surg Res 1987; 42: 92-100.
30. Lee KU, Zheng LX, Cho YB, et al. An experimental animal model of fulminant hepatic failure in pigs. J Korean Med Sci 2005; 20: 427-32.
31. Li S. Electroporation gene therapy. Preface. Meth Mol Biol 2008; 423: v-vii.
32. Heller LC, Heller R. Electroporation gene therapy preclinical and clinical trials for melanoma. Curr Gene Ther 2010; 10: 312-317.
33. Aliño SF, Herrero MJ, Bodí V, et al. Naked DNA delivery to whole pig cardiac tissue by coronary sinus retrograde injection employing non-invasive catheterization. J Gene Med 2010; 12: 920-926.
34. Aliño SF, Escrig E, Revert FM, Guillem VM, Crespo A. Pharmacodynamic approach to study the gene transfer process employing non-viral vectors. Biochem Pharmacol 2000; 60: 1845-1853.
35. Rácz Z, Godó M, Révész C, Hamar P. Immune activation and target organ damage are consequences of hydrodynamic treatment but not delivery of naked siRNAs in mice. Nucleic Acid Ther 2011; 21: 215-224.
36. Herrero MJ, Monleon D, Morales JM, Mata M, Serna E, Aliño SF. Microarray analysis of gene expression changes in mouse liver induced by hydrodynamic DNA injection. Curr Top Gen 2010; 4: 43-54.
37. Herrero MJ, Monleon D, Morales JM, Mata M, Serna E, Aliño SF. Analysis of metabolic and gene expression changes after hydrodynamic DNA injection into mouse liver. Biol Pharm Bull 2011; 34: 167-172.
38. Balagopal V, Parker R. Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs. Curr Opin Cell Biol 2009; 21: 403-408.
39. Harding HP, Calfon M, Urano F, Novoa I, Ron D. Transcriptional and translational control in the Mammalian unfolded protein response. Ann Rev Cell Dev Biol 2002; 18: 575-599.
40. Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science 2011; 334: 1081-1086.
41. Cargnello M, Tcherkezian J, Dorn JF, et al. Phosphorylation of the eukaryotic translation initiation factor 4E-transporter (4E-T) by c-Jun N-terminal kinase promotes stress-dependent P-body assembly. Mol Cell Biol 2012; 32: 4572-4584.
42. Lodish H, Berk A, Zipursky SL, et al. Chapter 3. Protein structure and function. In Molecular Cell Biology (4th edn). WH Freeman: New York, 2000.