DNA delivery to ex vivo human liver segments

Gene Therapy

Volumn 19, Issue 5, 2012, Pages 504-512

  Herrero, M J ^a,b   Sabater, L ^c   Guenechea, G ^d   Sendra, L ^a   Montilla, A I ^a   Abargues, R ^e   Navarro, V ^b   Alino S F ^a,b  

^a UNIVERSITY OF VALENCIA   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

^c HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^d CIEMAT   (Spain)

^e UNIVERSITY OF VALENCIA   (Spain)

Author keywords

catheter; gene delivery; human; hydrodynamic; liver; naked DNA

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; GOLD NANOPARTICLE; PLASMID DNA; SODIUM CHLORIDE;

ARTICLE; CONTROLLED STUDY; EX VIVO STUDY; FLOW RATE; FLUORESCENCE ANALYSIS; GENE DOSAGE; GENE EXPRESSION PROFILING; HEPATIC VEIN; HUMAN; HUMAN TISSUE; HYDRODYNAMICS BASED TRANSFECTION; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CELL; LIVER RESECTION; MICROSCOPY; NONVIRAL GENE DELIVERY SYSTEM; PLASMID; PRIORITY JOURNAL; TISSUE SECTION; TRANSMISSION ELECTRON MICROSCOPY;

CATHETERIZATION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; HEPATIC VEINS; HUMANS; HYDRODYNAMICS; INJECTIONS, INTRAVENOUS; LIVER; PLASMIDS;

ANIMALIA; RODENTIA;

EID: 84862128812     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.144     Document Type: Article

References (23)

1. Liu F, Song YK, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Therapy 1999; 6: 1258-1266. (Pubitemid 29359019)
2. Aliño SF, Crespo A, Dasí F. Long-term therapeutic levels of human alpha-1-antitrypsin in plasma after hydrodynamic injection of nonviral DNA. Gene Therapy 2003; 10: 1672-1679. (Pubitemid 37069495)
3. Khorsandi SE, Bachellier P, Weber JC, Greget M, Jaeck D, Zacharoulis D et al. Minimally invasive and selective hydrodynamic gene therapy of liver segments in the pig and human. Cancer Gene Ther 2008; 15: 225-230. (Pubitemid 351367561)
4. Herrero MJ, Dasi F, Noguera I, Sanchez M, Moret I, Sanmartin I et al. Mouse and pig nonviral liver gene therapy: success and trials. Gene Ther Mol Biol 2005; 9: 169-180.
5. Aliñ o SF, Herrero MJ, Noguera I, Dasi F, Sanchez M. Pig liver gene therapy by noninvasive interventionist catheterism. Gene Therapy 2007; 14: 334-343.
6. Aliñ o SF, Herrero MJ, Bodi V, Noguera I, Mainar L, Dasi F et al. Naked DNA delivery to whole pig cardiac tissue by coronary sinus retrograde injection employing non-invasive catheterization. J Gene Med 2010; 12: 920-926.
7. Sawyer GJ, Zhang X, Fabre JW. Technical requirements for effective regional hydrodynamic gene delivery to the left lateral lobe of the rat liver. Gene Therapy 2010; 17: 560-564.
8. Crespo A, Peydro A, Dasi F, Benet M, Calvete JJ, Revert F et al. Hydrodynamic liver gene transfer mechanism involves transient sinusoidal blood stasis and massive endocytic vesicles. Gene Therapy 2005; 12: 927-935. (Pubitemid 40852211)
9. McTiernan CF, Mathier MA, Zhu X, Xiao X, Klein E, Swan CH et al. Myocarditis following adeno-associated viral gene expression of human soluble TNF receptor (TNFRII-Fc) in baboon hearts. Gene Therapy 2007; 14: 1613-1622. (Pubitemid 350143187)
10. Zhang G, Budker V, Wolf JA. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 1999; 10: 1735-1737. (Pubitemid 29328217)
11. Hoshino K, Kimura T, De Grand AM, Yoneyama R, Kawase Y, Houser S et al. Three catheter-based strategies for cardiac delivery of therapeutic gelatin microspheres. Gene Therapy 2006; 13: 1320-1327. (Pubitemid 44323688)
12. Suda T, Suda K, Liu D. Computer-assisted hydrodynamic gene delivery. Mol Ther 2008; 16: 1098-1104. (Pubitemid 351737075)
13. Fabre JW, Grehan A, Whiterhorne M, Sawyer GJ, Dong X, Salehi S et al. Hydrodynamic gene delivery to the pig liver via an isolated segment of the inferior vena cava. Gene Therapy 2008; 15: 452-462. (Pubitemid 351331003)
14. Kamimura K, Suda T, Xu W, Zhang G, Liu D. Image-guided, lobe-specific hydrodynamic gene delivery to swine liver. Mol Ther 2009; 17: 491-499.
15. Eastman SJ, Baskin KM, Hodges BL, Chu Q, Gates A, Dreusicke R et al. Development of catheter-based procedures for transducing the isolated rabbit liver with plasmid DNA. Hum Gene Ther 2002; 13: 2065-2077. (Pubitemid 35417351)
16. Gregory TR. Animal Genome Size Database (2010). http://www.genomesize.com (accessed on April 2010).
17. Sawyer GJ, Rela M, Davenport M, Whitehorne M, Zhang X, Fabre JW. Hydrodynamic gene delivery to the liver: theoretical and practical issues for clinical application. Curr Gene Ther 2009; 9: 128-135.
18. Fabre JW, Whitehorne M, Grehan A, Sawyer GF, Zhang X, Davenport M et al. Critical physiological and surgical considerations for hydrodynamic pressurisation of individual segments of the pig liver. Human Gene Ther 2010; 22: 879-887.
19. Zhang G, Gao X, Song YK, Volimer R, Stolz DB, Gasiorowski JZ et al. Hydroporation as the mechanism of hydrodynamic delivery. Gene Therapy 2004; 11: 675-682. (Pubitemid 38519275)
20. Sebestyén MG, Budker VG, Budker T, Subbotin VM, Zhang G, Monahan SD et al. Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules. J Gene Med 2006; 8: 852-873. (Pubitemid 44097141)
21. Suda T, Gao X, Stolz DB, Liu D. Structural impact of hydrodynamic injection on mouse liver. Gene Therapy 2007; 14: 129-137. (Pubitemid 46043818)
22. Si ZZ, Li JQ, Ai HA, He ZJ, Hu W, Li YN. Recombinant adenovirus vector Ad-hIL-10 protects grafts from cold ischemia-reperfusion injury following orthotopic liver transplantation in rats. Hepatobiliary Pancreat Dis Int 2010; 9: 144-148.
23. Kimling J, Maier M, Okenve B, Kotaidis V, Ballot H, Plech A. Turkevich method for gold nanoparticle synthesis revisited. J Phys Chem 2006; 110: 157-160.