Cerebrospinal fluid interleukin (IL)-6 in unipolar major depression

Journal of Affective Disorders

Volumn 79, Issue 1-3, 2004, Pages 285-289

  Carpenter, Linda L ^a   Heninger, George R ^b   Malison, Robert T ^b   Tyrka, Audrey R ^a   Price, Lawrence H ^a  

^a BUTLER HOSPITAL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cerebrospinal fluid; Cytokines; Depression; Interleukin 6; Mood disorder; Psychoneuroimmunology

Indexed keywords

INTERLEUKIN 6;

ADULT; AGED; ARTICLE; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID ANALYSIS; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME IMMUNOASSAY; FEMALE; HUMAN; LUMBAR PUNCTURE; MAJOR DEPRESSION; MALE; MENTAL PATIENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SAMPLE SIZE; STANDARD;

ADOLESCENT; ADULT; AGED; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER; FEMALE; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; SPINAL PUNCTURE;

EID: 1542719226     PISSN: 01650327     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0327(02)00460-3     Document Type: Article

References (26)

1. Brambilla F., Maggioni M. Blood levels of cytokines in elderly patients with major depressive disorder. Acta Psychiatr. Scand. 97:1998;309-313.
2. Connor T.J., Leonard B.E. Depression, stress and immunological activation: the role of cytokines in depressive disorders. Life Sci. 62:1998;583-606.
3. Frommberger U.H., Bauer J., Haselbauer P., Fraulin A., Riemann D., Berger M. Interleukin-6-(IL-6) plasma levels in depression and schizophrenia: comparison between the acute state and after remission. Eur. Arch. Psychiatry Clin. Neurosci. 247:1997;228-233.
4. Haack M., Hinze-Selch D., Fenzel T., Kraus T., Kuhn M., Schuld A., Pollmacher T. Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis. J. Psychiatr. Res. 33:1999;407-418.
5. Hopkins S.J., Rothwell N.J. Cytokines and the nervous system. I: Expression and recognition. Trends Neurosci. 18:1995;83-88.
6. Kagaya A., Kugaya A., Takebayashi M., Fukue-Saeki M., Saeki T., Yamawaki S., Uchitomi Y. Plasma concentrations of interleukin-1 β, interleukin-6, soluble interleukin-2 receptor and tumor necrosis factor α of depressed patients in Japan. Neuropsychobiology. 43:2001;59-62.
7. Kronfol Z., Remick D.G. Cytokines and the brain: implications for clinical psychiatry. Am. J. Psychiatry. 157:2000;683-694.
8. Kubera M., Kenis G., Bosmans E., Zieba A., Dudek D., Nowak G., Maes M. Plasma levels of interleukin-6, interleukin-10, and interleukin-1 receptor antagonist in depression: comparison between the acute state and after remission. Pol. J. Pharmacol. 52:2000;237-241.
9. Kudoh A., Katagai H., Takazawa T. Plasma inflammatory cytokine response to surgical trauma in chronic depressed patients. Cytokine. 13:2001;104-108.
10. Lanquillon S., Krieg J.C., Bening-Abu-Shach U., Vedder H. Cytokine production and treatment response in major depressive disorder. Neuropsychopharmacology. 22:2000;370-379.
11. Leonard B.E. Changes in the immune system in depression and dementia: causal or co-incidental effects? Int. J. Dev. Neurosci. 19:2001;305-312.
12. Leu S.J., Shiah I.S., Yatham L.N., Cheu Y.M., Lam R.W. Immune-inflammatory markers in patients with seasonal affective disorder: effects of light therapy. J. Affect. Disord. 63:2001;27-34.
13. Levine J., Barak Y., Chengappa K.N., Rapoport A., Rebey M., Barak V. Cerebrospinal cytokine levels in patients with acute depression. Neuropsychobiology. 40:1999;171-176.
14. Maes M., Bosmans E., Meltzer H.Y. Immunoendocrine aspects of major depression. Relationships between plasma interleukin-6 and soluble interleukin-2 receptor, prolactin and cortisol. Eur. Arch. Psychiatry Clin. Neurosci. 245:1995;172-178.
15. Maes M., Scharpe S., Meltzer H.Y., Bosmans E., Suy E., Calabrese J., Cosyns P. Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression. Psychiatry Res. 49:1993;11-27.
16. Maes M., Meltzer H.Y., Bosmans E., Bergmans R., Vandoolaeghe E., Ranjan R., Desnyder R. Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression. J. Affect. Disord. 34:1995;301-309.
17. Maier S.F., Watkins L.R. Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock. Brain Res. 695:1995;279-282.
18. Malek-Ahmadi P. Mood disorders associated with interferon treatment: theoretical and practical considerations. Ann. Pharmacother. 35:2001;489-495.
19. Musselman D.L., Miller A.H., Porter M.R., Manatunga A., Gao F., Penna S., Pearce B.D., Landry J., Glover S., McDaniel J.S., Nemeroff C.B. Higher than normal plasma interleukin-6 concentrations in cancer patients with depression: preliminary findings. Am. J. Psychiatry. 158:2001;1252-1257.
20. Price L.H., Rasmussen S.A. Stress and depression: is neuroimmunology the missing link? Harv. Rev. Psychiatry. 5:1997;108-112.
21. Schobitz B., De Kloet E.R., Holsboer F. Gene expression and function of interleukin 1, interleukin 6 and tumor necrosis factor in the brain. Prog. Neurobiol. 44:1994;397-432.
22. Schobitz B., de Kloet E.R., Sutanto W., Holsboer F. Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain. Eur. J. Neurosci. 5:1993;1426-1435.
23. Sluzewska A., Rybakowski J., Bosmans E., Sobieska M., Berghmans R., Maes M., Wiktorowicz K. Indicators of immune activation in major depression. Psychiatry Res. 64:1996;161-167.
24. Song C., Lin A., Bonaccorso S., Heide C., Verkerk R., Kenis G., Bosmans E., Scharpe S., Whelan A., Cosyns P., de Jongh R., Maes M. The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression. J. Affect. Disord. 49:1998;211-219.
25. Stubner S., Schon T., Padberg F., Teipel S.J., Schwarz M.J., Haslinger A., Buch K., Dukoff R., Lasser R., Muller N., Sunderland T., Rapoport S.I., Moller H.J., Hampel H. Interleukin-6 and the soluble IL-6 receptor are decreased in cerebrospinal fluid of geriatric patients with major depression: no alteration of soluble gp130. Neurosci. Lett. 259:1999;145-148.
26. van West D., Maes M. Activation of the inflammatory response system: a new look at the etiopathogenesis of major depression. Neuroendocrinol. Lett. 20:1999;11-17.