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Volumn 92, Issue 11, 2014, Pages 1529-1548

GluN2B N-methyl-D-aspartic acid receptor subunit mediates atorvastatin-Induced neuroprotection after focal cerebral ischemia

Author keywords

Atorvastatin; BDNF; Cerebral ischemia; GluN2B; Neuroprotection; Synaptic plasticity

Indexed keywords

ATORVASTATIN; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; IFENPRODIL; MICROTUBULE ASSOCIATED PROTEIN 2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; POSTSYNAPTIC DENSITY PROTEIN 95; ANTITHROMBOCYTIC AGENT; HEPTANOIC ACID DERIVATIVE; HYPOCHOLESTEROLEMIC AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NERVE PROTEIN; NR2B NMDA RECEPTOR; PIPERIDINE DERIVATIVE; PYRROLE DERIVATIVE;

EID: 84906318037     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23426     Document Type: Article
Times cited : (31)

References (67)
  • 1
    • 16244397030 scopus 로고    scopus 로고
    • Early presynaptic and late postsynaptic components contribute independently to brain-derived neurotrophic factor-induced synaptic plasticity
    • Alder J, Thakker-Varia S, Crozier RA, Shaheen A, Plummer MR, Black IB. 2005. Early presynaptic and late postsynaptic components contribute independently to brain-derived neurotrophic factor-induced synaptic plasticity. J Neurosci 25:3080-3085.
    • (2005) J Neurosci , vol.25 , pp. 3080-3085
    • Alder, J.1    Thakker-Varia, S.2    Crozier, R.A.3    Shaheen, A.4    Plummer, M.R.5    Black, I.B.6
  • 2
    • 77953503045 scopus 로고    scopus 로고
    • Blockade of NR2A-containing NMDA receptors induces Tau phosphorylation in rat hippocampal slices
    • Allyson J, Dontigny E, Auberson Y, Cyr M, Massicotte G. 2010. Blockade of NR2A-containing NMDA receptors induces Tau phosphorylation in rat hippocampal slices. Neural Plast 2010:340168.
    • (2010) Neural Plast , vol.2010 , pp. 340168
    • Allyson, J.1    Dontigny, E.2    Auberson, Y.3    Cyr, M.4    Massicotte, G.5
  • 4
    • 26944487610 scopus 로고    scopus 로고
    • NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII
    • Barria A, Malinow R. 2005. NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII. Neuron 48:289-301.
    • (2005) Neuron , vol.48 , pp. 289-301
    • Barria, A.1    Malinow, R.2
  • 5
    • 0022483434 scopus 로고
    • Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination
    • Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H. 1986. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17:472-476.
    • (1986) Stroke , vol.17 , pp. 472-476
    • Bederson, J.B.1    Pitts, L.H.2    Tsuji, M.3    Nishimura, M.C.4    Davis, R.L.5    Bartkowski, H.6
  • 6
    • 0033519889 scopus 로고    scopus 로고
    • Middle cerebral artery occlusion in the mouse by intraluminal suture coated with poly-L-lysine: neurological and histological validation
    • Belayev L, Busto R, Zhao W, Fernandez G, Ginsberg MD. 1999. Middle cerebral artery occlusion in the mouse by intraluminal suture coated with poly-L-lysine: neurological and histological validation. Brain Res 833:181-190.
    • (1999) Brain Res , vol.833 , pp. 181-190
    • Belayev, L.1    Busto, R.2    Zhao, W.3    Fernandez, G.4    Ginsberg, M.D.5
  • 7
    • 0027476024 scopus 로고
    • A synaptic model of memory: long-term potentiation in the hippocampus
    • Bliss TV, Collingridge GL. 1993. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39.
    • (1993) Nature , vol.361 , pp. 31-39
    • Bliss, T.V.1    Collingridge, G.L.2
  • 9
    • 24144483438 scopus 로고    scopus 로고
    • BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis
    • Bramham CR, Messaoudi E. 2005. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol 76:99-125.
    • (2005) Prog Neurobiol , vol.76 , pp. 99-125
    • Bramham, C.R.1    Messaoudi, E.2
  • 11
    • 78049425264 scopus 로고    scopus 로고
    • p120 Catenin/alphaN-catenin are molecular targets in the neuroprotection and neuronal plasticity mediated by atorvastatin after focal cerebral ischemia
    • Cespedes-Rubio A, Jurado FW, Cardona-Gomez GP. 2010. p120 Catenin/alphaN-catenin are molecular targets in the neuroprotection and neuronal plasticity mediated by atorvastatin after focal cerebral ischemia. J Neurosci Res 88:3621-3634.
    • (2010) J Neurosci Res , vol.88 , pp. 3621-3634
    • Cespedes-Rubio, A.1    Jurado, F.W.2    Cardona-Gomez, G.P.3
  • 13
    • 14644444482 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice
    • Chen J, Zacharek A, Zhang C, Jiang H, Li Y, Roberts C, Lu M, Kapke A, Chopp M. 2005a. Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice. J Neurosci 25:2366-2375.
    • (2005) J Neurosci , vol.25 , pp. 2366-2375
    • Chen, J.1    Zacharek, A.2    Zhang, C.3    Jiang, H.4    Li, Y.5    Roberts, C.6    Lu, M.7    Kapke, A.8    Chopp, M.9
  • 15
    • 55749108180 scopus 로고    scopus 로고
    • Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance
    • Chen M, Lu TJ, Chen XJ, Zhou Y, Chen Q, Feng XY, Xu L, Duan WH, Xiong ZQ. 2008. Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance. Stroke 39:3042-3048.
    • (2008) Stroke , vol.39 , pp. 3042-3048
    • Chen, M.1    Lu, T.J.2    Chen, X.J.3    Zhou, Y.4    Chen, Q.5    Feng, X.Y.6    Xu, L.7    Duan, W.H.8    Xiong, Z.Q.9
  • 16
    • 0028799654 scopus 로고
    • Calcium: still center stage in hypoxic-ischemic neuronal death
    • Choi DW. 1995. Calcium: still center stage in hypoxic-ischemic neuronal death. Trends Neurosci 18:58-60.
    • (1995) Trends Neurosci , vol.18 , pp. 58-60
    • Choi, D.W.1
  • 18
    • 0036583275 scopus 로고    scopus 로고
    • A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat
    • Clayton DA, Mesches MH, Alvarez E, Bickford PC, Browning MD. 2002. A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat. J Neurosci 22:3628-3637.
    • (2002) J Neurosci , vol.22 , pp. 3628-3637
    • Clayton, D.A.1    Mesches, M.H.2    Alvarez, E.3    Bickford, P.C.4    Browning, M.D.5
  • 19
    • 0025275842 scopus 로고
    • Patterned activity, synaptic convergence, and the NMDA receptor in developing visual pathways
    • Constantine-Paton M, Cline HT, Debski E. 1990. Patterned activity, synaptic convergence, and the NMDA receptor in developing visual pathways. Annu Rev Neurosci 13:129-154.
    • (1990) Annu Rev Neurosci , vol.13 , pp. 129-154
    • Constantine-Paton, M.1    Cline, H.T.2    Debski, E.3
  • 20
    • 77952349119 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity
    • Cowansage KK, LeDoux JE, Monfils MH. 2010. Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity. Curr Mol Pharmacol 3:12-29.
    • (2010) Curr Mol Pharmacol , vol.3 , pp. 12-29
    • Cowansage, K.K.1    LeDoux, J.E.2    Monfils, M.H.3
  • 21
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: an integrated view
    • Dirnagl U, Iadecola C, Moskowitz MA. 1999. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22:391-397.
    • (1999) Trends Neurosci , vol.22 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 22
    • 42449118057 scopus 로고    scopus 로고
    • The evidence to date does not seem to be enough to alter clinical practice and we wait with interest more definitive information
    • Donnan GA. 2008. The evidence to date does not seem to be enough to alter clinical practice and we wait with interest more definitive information. Int J Stroke 3:77.
    • (2008) Int J Stroke , vol.3 , pp. 77
    • Donnan, G.A.1
  • 25
    • 0344519489 scopus 로고    scopus 로고
    • Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice
    • Fukaya M, Kato A, Lovett C, Tonegawa S, Watanabe M. 2003. Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc Natl Acad Sci U S A 100:4855-4860.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4855-4860
    • Fukaya, M.1    Kato, A.2    Lovett, C.3    Tonegawa, S.4    Watanabe, M.5
  • 26
    • 27144500256 scopus 로고    scopus 로고
    • Transcription of the NR1 subunit of the N-methyl-D-aspartate receptor is downregulated by excitotoxic stimulation and cerebral ischemia
    • Gascon S, Deogracias R, Sobrado M, Roda JM, Renart J, Rodriguez-Pena A, Diaz-Guerra M. 2005. Transcription of the NR1 subunit of the N-methyl-D-aspartate receptor is downregulated by excitotoxic stimulation and cerebral ischemia. J Biol Chem 280:35018-35027.
    • (2005) J Biol Chem , vol.280 , pp. 35018-35027
    • Gascon, S.1    Deogracias, R.2    Sobrado, M.3    Roda, J.M.4    Renart, J.5    Rodriguez-Pena, A.6    Diaz-Guerra, M.7
  • 27
    • 37249023297 scopus 로고    scopus 로고
    • Excitotoxicity and focal cerebral ischemia induce truncation of the NR2A and NR2B subunits of the NMDA receptor and cleavage of the scaffolding protein PSD-95
    • Gascon S, Sobrado M, Roda JM, Rodriguez-Pena A, Diaz-Guerra M. 2008. Excitotoxicity and focal cerebral ischemia induce truncation of the NR2A and NR2B subunits of the NMDA receptor and cleavage of the scaffolding protein PSD-95. Mol Psychiatry 13:99-114.
    • (2008) Mol Psychiatry , vol.13 , pp. 99-114
    • Gascon, S.1    Sobrado, M.2    Roda, J.M.3    Rodriguez-Pena, A.4    Diaz-Guerra, M.5
  • 28
    • 34248577303 scopus 로고    scopus 로고
    • A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain
    • Ge S, Yang CH, Hsu KS, Ming GL, Song H. 2007. A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Neuron 54:559-566.
    • (2007) Neuron , vol.54 , pp. 559-566
    • Ge, S.1    Yang, C.H.2    Hsu, K.S.3    Ming, G.L.4    Song, H.5
  • 29
    • 58149463218 scopus 로고    scopus 로고
    • Surface trafficking of N-methyl-D-aspartate receptors: physiological and pathological perspectives
    • Groc L, Bard L, Choquet D. 2009. Surface trafficking of N-methyl-D-aspartate receptors: physiological and pathological perspectives. Neuroscience 158:4-18.
    • (2009) Neuroscience , vol.158 , pp. 4-18
    • Groc, L.1    Bard, L.2    Choquet, D.3
  • 30
    • 77955369320 scopus 로고    scopus 로고
    • Postnatal BDNF expression profiles in prefrontal cortex and hippocampus of a rat schizophrenia model induced by MK-801 administration
    • Guo C, Yang Y, Su Y, Si T. 2010. Postnatal BDNF expression profiles in prefrontal cortex and hippocampus of a rat schizophrenia model induced by MK-801 administration. J Biomed Biotechnol 2010:783297.
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 783297
    • Guo, C.1    Yang, Y.2    Su, Y.3    Si, T.4
  • 31
    • 0036241207 scopus 로고    scopus 로고
    • Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
    • Hardingham GE, Fukunaga Y, Bading H. 2002. Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 5:405-414.
    • (2002) Nat Neurosci , vol.5 , pp. 405-414
    • Hardingham, G.E.1    Fukunaga, Y.2    Bading, H.3
  • 32
    • 0041488911 scopus 로고    scopus 로고
    • Trk receptors: roles in neuronal signal transduction
    • Huang EJ, Reichardt LF. 2003. Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem 72:609-642.
    • (2003) Annu Rev Biochem , vol.72 , pp. 609-642
    • Huang, E.J.1    Reichardt, L.F.2
  • 33
    • 33947597084 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics
    • Jope RS, Yuskaitis CJ, Beurel E. 2007. Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem Res 32:577-595.
    • (2007) Neurochem Res , vol.32 , pp. 577-595
    • Jope, R.S.1    Yuskaitis, C.J.2    Beurel, E.3
  • 34
    • 0034044227 scopus 로고    scopus 로고
    • Neurotrophin signal transduction in the nervous system
    • Kaplan DR, Miller FD. 2000. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 10:381-391.
    • (2000) Curr Opin Neurobiol , vol.10 , pp. 381-391
    • Kaplan, D.R.1    Miller, F.D.2
  • 35
    • 79951570562 scopus 로고    scopus 로고
    • The effects of voluntary, involuntary, and forced exercises on brain-derived neurotrophic factor and motor function recovery: a rat brain ischemia model
    • Ke Z, Yip SP, Li L, Zheng XX, Tong KY. 2011. The effects of voluntary, involuntary, and forced exercises on brain-derived neurotrophic factor and motor function recovery: a rat brain ischemia model. PLoS One 6:e16643.
    • (2011) PLoS One , vol.6
    • Ke, Z.1    Yip, S.P.2    Li, L.3    Zheng, X.X.4    Tong, K.Y.5
  • 37
    • 0032579763 scopus 로고    scopus 로고
    • BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities
    • Lin SY, Wu K, Levine ES, Mount HT, Suen PC, Black IB. 1998. BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities. Brain Res Mol Brain Res 55:20-27.
    • (1998) Brain Res Mol Brain Res , vol.55 , pp. 20-27
    • Lin, S.Y.1    Wu, K.2    Levine, E.S.3    Mount, H.T.4    Suen, P.C.5    Black, I.B.6
  • 38
    • 37049030994 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity
    • Lipsky RH, Marini AM. 2007. Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Ann N Y Acad Sci 1122:130-143.
    • (2007) Ann N Y Acad Sci , vol.1122 , pp. 130-143
    • Lipsky, R.H.1    Marini, A.M.2
  • 39
    • 0028762647 scopus 로고
    • Excitatory amino acids as a final common pathway for neurologic disorders
    • Lipton SA, Rosenberg PA. 1994. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 330:613-622.
    • (1994) N Engl J Med , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 41
    • 84984763363 scopus 로고    scopus 로고
    • Mechanisms, challenges and opportunities in stroke
    • Lo EH, Dalkara T, Moskowitz MA. 2003. Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci 4:399-415.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 399-415
    • Lo, E.H.1    Dalkara, T.2    Moskowitz, M.A.3
  • 42
    • 70450260698 scopus 로고    scopus 로고
    • Decrease of Tau hyperphosphorylation by 17beta estradiol requires sphingosine kinase in a glutamate toxicity model
    • Lopez-Tobon A, Cepeda-Prado E, Cardona-Gomez GP. 2009. Decrease of Tau hyperphosphorylation by 17beta estradiol requires sphingosine kinase in a glutamate toxicity model. Neurochem Res 34:2206-2214.
    • (2009) Neurochem Res , vol.34 , pp. 2206-2214
    • Lopez-Tobon, A.1    Cepeda-Prado, E.2    Cardona-Gomez, G.P.3
  • 43
    • 0037385008 scopus 로고    scopus 로고
    • PSD-95 regulates NMDA receptors in developing cerebellar granule neurons of the rat
    • Losi G, Prybylowski K, Fu Z, Luo J, Wenthold RJ, Vicini S. 2003. PSD-95 regulates NMDA receptors in developing cerebellar granule neurons of the rat. J Physiol 548:21-29.
    • (2003) J Physiol , vol.548 , pp. 21-29
    • Losi, G.1    Prybylowski, K.2    Fu, Z.3    Luo, J.4    Wenthold, R.J.5    Vicini, S.6
  • 44
    • 23044488902 scopus 로고    scopus 로고
    • The yin and yang of neurotrophin action
    • Lu B, Pang PT, Woo NH. 2005. The yin and yang of neurotrophin action. Nat Rev Neurosci 6:603-614.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 603-614
    • Lu, B.1    Pang, P.T.2    Woo, N.H.3
  • 45
    • 34547098112 scopus 로고    scopus 로고
    • Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury
    • Lu D, Qu C, Goussev A, Jiang H, Lu C, Schallert T, Mahmood A, Chen J, Li Y, Chopp M. 2007. Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury. J Neurotrauma 24:1132-1146.
    • (2007) J Neurotrauma , vol.24 , pp. 1132-1146
    • Lu, D.1    Qu, C.2    Goussev, A.3    Jiang, H.4    Lu, C.5    Schallert, T.6    Mahmood, A.7    Chen, J.8    Li, Y.9    Chopp, M.10
  • 46
    • 39849083186 scopus 로고    scopus 로고
    • BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?
    • Lu Y, Christian K, Lu B. 2008. BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiol Learn Mem 89:312-323.
    • (2008) Neurobiol Learn Mem , vol.89 , pp. 312-323
    • Lu, Y.1    Christian, K.2    Lu, B.3
  • 47
    • 38549181783 scopus 로고    scopus 로고
    • Kalirin-7 is an essential component of both shaft and spine excitatory synapses in hippocampal interneurons
    • Ma XM, Wang Y, Ferraro F, Mains RE, Eipper BA. 2008. Kalirin-7 is an essential component of both shaft and spine excitatory synapses in hippocampal interneurons. J Neurosci 28:711-724.
    • (2008) J Neurosci , vol.28 , pp. 711-724
    • Ma, X.M.1    Wang, Y.2    Ferraro, F.3    Mains, R.E.4    Eipper, B.A.5
  • 48
    • 0742270492 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons
    • Morabito MA, Sheng M, Tsai LH. 2004. Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons. J Neurosci 24:865-876.
    • (2004) J Neurosci , vol.24 , pp. 865-876
    • Morabito, M.A.1    Sheng, M.2    Tsai, L.H.3
  • 49
    • 0021173996 scopus 로고
    • Developments of a water-maze procedure for studying spatial learning in the rat
    • Morris R. 1984. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11:47-60.
    • (1984) J Neurosci Methods , vol.11 , pp. 47-60
    • Morris, R.1
  • 50
    • 0035876476 scopus 로고    scopus 로고
    • Glutamate release and neuronal damage in ischemia
    • Nishizawa Y. 2001. Glutamate release and neuronal damage in ischemia. Life Sci 69:369-381.
    • (2001) Life Sci , vol.69 , pp. 369-381
    • Nishizawa, Y.1
  • 51
    • 84864439799 scopus 로고    scopus 로고
    • Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
    • Pazos MR, Cinquina V, Gomez A, Layunta R, Santos M, Fernandez-Ruiz J, Martinez-Orgado J. 2012. Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function. Neuropharmacology 63:776-783.
    • (2012) Neuropharmacology , vol.63 , pp. 776-783
    • Pazos, M.R.1    Cinquina, V.2    Gomez, A.3    Layunta, R.4    Santos, M.5    Fernandez-Ruiz, J.6    Martinez-Orgado, J.7
  • 52
    • 65249126363 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats
    • Ploughman M, Windle V, MacLellan CL, White N, Dore JJ, Corbett D. 2009. Brain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats. Stroke 40:1490-1495.
    • (2009) Stroke , vol.40 , pp. 1490-1495
    • Ploughman, M.1    Windle, V.2    MacLellan, C.L.3    White, N.4    Dore, J.J.5    Corbett, D.6
  • 53
    • 41149132355 scopus 로고    scopus 로고
    • Simvastatin reduces the association of NMDA receptors to lipid rafts: a cholesterol-mediated effect in neuroprotection
    • Ponce J, de la Ossa NP, Hurtado O, Millan M, Arenillas JF, Davalos A, Gasull T. 2008. Simvastatin reduces the association of NMDA receptors to lipid rafts: a cholesterol-mediated effect in neuroprotection. Stroke 39:1269-1275.
    • (2008) Stroke , vol.39 , pp. 1269-1275
    • Ponce, J.1    de la Ossa, N.P.2    Hurtado, O.3    Millan, M.4    Arenillas, J.F.5    Davalos, A.6    Gasull, T.7
  • 54
    • 70349090181 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor controls activity-dependent maturation of CA1 synapses by downregulating tonic activation of presynaptic kainate receptors
    • Sallert M, Rantamaki T, Vesikansa A, Anthoni H, Harju K, Yli-Kauhaluoma J, Taira T, Castren E, Lauri SE. 2009. Brain-derived neurotrophic factor controls activity-dependent maturation of CA1 synapses by downregulating tonic activation of presynaptic kainate receptors. J Neurosci 29:11294-11303.
    • (2009) J Neurosci , vol.29 , pp. 11294-11303
    • Sallert, M.1    Rantamaki, T.2    Vesikansa, A.3    Anthoni, H.4    Harju, K.5    Yli-Kauhaluoma, J.6    Taira, T.7    Castren, E.8    Lauri, S.E.9
  • 55
    • 84855966123 scopus 로고    scopus 로고
    • NMDA-induced ERK signalling is mediated by NR2B subunit in rat cortical neurons and switches from positive to negative depending on stage of development
    • Sava A, Formaggio E, Carignani C, Andreetta F, Bettini E, Griffante C. 2012. NMDA-induced ERK signalling is mediated by NR2B subunit in rat cortical neurons and switches from positive to negative depending on stage of development. Neuropharmacology 62:925-932.
    • (2012) Neuropharmacology , vol.62 , pp. 925-932
    • Sava, A.1    Formaggio, E.2    Carignani, C.3    Andreetta, F.4    Bettini, E.5    Griffante, C.6
  • 56
    • 33746238490 scopus 로고    scopus 로고
    • BDNF increases release probability and the size of a rapidly recycling vesicle pool within rat hippocampal excitatory synapses
    • Tyler WJ, Zhang XL, Hartman K, Winterer J, Muller W, Stanton PK, Pozzo-Miller L. 2006. BDNF increases release probability and the size of a rapidly recycling vesicle pool within rat hippocampal excitatory synapses. J Physiol 574:787-803.
    • (2006) J Physiol , vol.574 , pp. 787-803
    • Tyler, W.J.1    Zhang, X.L.2    Hartman, K.3    Winterer, J.4    Muller, W.5    Stanton, P.K.6    Pozzo-Miller, L.7
  • 57
    • 9644270414 scopus 로고    scopus 로고
    • Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
    • Vaynman S, Ying Z, Gomez-Pinilla F. 2004. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 20:2580-2590.
    • (2004) Eur J Neurosci , vol.20 , pp. 2580-2590
    • Vaynman, S.1    Ying, Z.2    Gomez-Pinilla, F.3
  • 58
    • 38049034068 scopus 로고    scopus 로고
    • Pleiotropic effects of statin therapy: molecular mechanisms and clinical results
    • Wang CY, Liu PY, Liao JK. 2008. Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. Trends Mol Med 14:37-44.
    • (2008) Trends Mol Med , vol.14 , pp. 37-44
    • Wang, C.Y.1    Liu, P.Y.2    Liao, J.K.3
  • 59
    • 84906310112 scopus 로고    scopus 로고
    • WHO. Global status report on noncommunicable diseases. World Health Organization 2011.
    • WHO. 2010. Global status report on noncommunicable diseases. World Health Organization 2011.
    • (2010)
  • 60
    • 7444271017 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor acutely enhances tyrosine phosphorylation of the AMPA receptor subunit GluR1 via NMDA receptor-dependent mechanisms
    • Wu K, Len GW, McAuliffe G, Ma C, Tai JP, Xu F, Black IB. 2004. Brain-derived neurotrophic factor acutely enhances tyrosine phosphorylation of the AMPA receptor subunit GluR1 via NMDA receptor-dependent mechanisms. Brain Res Mol Brain Res 130:178-186.
    • (2004) Brain Res Mol Brain Res , vol.130 , pp. 178-186
    • Wu, K.1    Len, G.W.2    McAuliffe, G.3    Ma, C.4    Tai, J.P.5    Xu, F.6    Black, I.B.7
  • 61
    • 33846502748 scopus 로고    scopus 로고
    • Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity
    • Xu W, Wong TP, Chery N, Gaertner T, Wang YT, Baudry M. 2007. Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity. Neuron 53:399-412.
    • (2007) Neuron , vol.53 , pp. 399-412
    • Xu, W.1    Wong, T.P.2    Chery, N.3    Gaertner, T.4    Wang, Y.T.5    Baudry, M.6
  • 63
    • 47949102102 scopus 로고    scopus 로고
    • Postsynaptic density-95 (PSD-95) and calcineurin control the sensitivity of N-methyl-D-aspartate receptors to calpain cleavage in cortical neurons
    • Yuen EY, Ren Y, Yan Z. 2008. Postsynaptic density-95 (PSD-95) and calcineurin control the sensitivity of N-methyl-D-aspartate receptors to calpain cleavage in cortical neurons. Mol Pharmacol 74:360-370.
    • (2008) Mol Pharmacol , vol.74 , pp. 360-370
    • Yuen, E.Y.1    Ren, Y.2    Yan, Z.3
  • 64
    • 0346749450 scopus 로고    scopus 로고
    • 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity
    • Zacco A, Togo J, Spence K, Ellis A, Lloyd D, Furlong S, Piser T. 2003. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. J Neurosci 23:11104-11111.
    • (2003) J Neurosci , vol.23 , pp. 11104-11111
    • Zacco, A.1    Togo, J.2    Spence, K.3    Ellis, A.4    Lloyd, D.5    Furlong, S.6    Piser, T.7
  • 65
    • 25144490621 scopus 로고    scopus 로고
    • Neurogenesis in the adult ischemic brain: generation, migration, survival, and restorative therapy
    • Zhang RL, Zhang ZG, Chopp M. 2005. Neurogenesis in the adult ischemic brain: generation, migration, survival, and restorative therapy. Neuroscientist 11:408-416.
    • (2005) Neuroscientist , vol.11 , pp. 408-416
    • Zhang, R.L.1    Zhang, Z.G.2    Chopp, M.3
  • 66
    • 38349009068 scopus 로고    scopus 로고
    • Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors
    • Zhang S, Edelmann L, Liu J, Crandall JE, Morabito MA. 2008. Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors. J Neurosci 28:415-424.
    • (2008) J Neurosci , vol.28 , pp. 415-424
    • Zhang, S.1    Edelmann, L.2    Liu, J.3    Crandall, J.E.4    Morabito, M.A.5
  • 67
    • 17744370770 scopus 로고    scopus 로고
    • N-methyl-D-aspartate and TrkB receptors protect neurons against glutamate excitotoxicity through an extracellular signal-regulated kinase pathway
    • Zhu D, Wu X, Strauss KI, Lipsky RH, Qureshi Z, Terhakopian A, Novelli A, Banaudha K, Marini AM. 2005. N-methyl-D-aspartate and TrkB receptors protect neurons against glutamate excitotoxicity through an extracellular signal-regulated kinase pathway. J Neurosci Res 80:104-113.
    • (2005) J Neurosci Res , vol.80 , pp. 104-113
    • Zhu, D.1    Wu, X.2    Strauss, K.I.3    Lipsky, R.H.4    Qureshi, Z.5    Terhakopian, A.6    Novelli, A.7    Banaudha, K.8    Marini, A.M.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.