Effects of physical exercise on the P38MAPK/REDD1/14-3-3 pathways in the myocardium of diet-induced obesity rats

Hormone and Metabolic Research

Volumn 46, Issue 9, 2014, Pages 621-627

  Pieri, B L S ^a   Souza, D R ^a   Luciano, T F ^a   Marques, S O ^a   Pauli, J R ^b   Silva, A S R ^c   Ropelle, E R ^b   Pinho, R A ^a   Lira, F S ^d   De Souza, C T ^a  

^a UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

14 3 3 protein; mTOR phosphorylation; obesity; physical activity; REDD1

Indexed keywords

INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN 14 3 3; REGULATED IN DEVELOPMENT AND DNA DAMAGE RESPONSE 1; REGULATOR PROTEIN; S6 KINASE; UNCLASSIFIED DRUG; INSULIN; MTOR PROTEIN, RAT; REPRESSOR PROTEIN; RTP801 PROTEIN, RAT; TARGET OF RAPAMYCIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART; HEART MUSCLE; HISTOPATHOLOGY; INFANT; INSULIN RESISTANCE; LIPID DIET; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; TISSUE LEVEL; TREADMILL EXERCISE; WESTERN BLOTTING; ADVERSE EFFECTS; ANIMAL; GENETICS; HUMAN; KINESIOTHERAPY; METABOLISM; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; WISTAR RAT;

ANIMALIA; MAMMALIA; RATTUS; RATTUS NORVEGICUS;

14-3-3 PROTEINS; ANIMALS; DIET, HIGH-FAT; EXERCISE THERAPY; HUMANS; INSULIN; MALE; MUSCLE, SKELETAL; MYOCARDIUM; OBESITY; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, WISTAR; REPRESSOR PROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84906303522     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0034-1371824     Document Type: Article

References (27)

1. Adams K. F., Schatzkin A., Harris T. B., Mouw T., Ballard-Barbash R., Hollenbeck A., Leitzmann M. F. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med: 2006; 355 763778
2. Lakka T. A., Lakka H. M., Salonen R., Kaplan G. A., Salonen J. T. Abdominal obesity is associated with accelerated progression of carotid atherosclerosis in men. Atherosclerosis: 2001; 154 497 504
3. Kenchaiah S., Evans J. C., Levy D., Wilson P. W., Benjamin E. J., Larson M. G., Kannel W. B., Vasan R. S. Obesity and the risk of heart failure. N Engl J Med: 2002; 347 305 313
4. Olefsky J. M., Glass C. K. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol: 2010; 72 219 246
5. Golbidi S., Laher I. Exercise and the cardiovascular system. Cardiol Res Pract: 2012; 2012 210852
6. Rolfe M., McLeod L. E., Pratt P. F., Proud C. G. Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2). Biochem J: 2005; 388 973 984
7. Yang Q., Guan K. L. Expanding mTOR signaling. Cell Res: 2007; 17 666 681
8. Vega-Rubin-de-Celis S., Abdallah Z., Kinch L., Grishin N. V., Brugarolas J., Zhang X. Structural analysis and functional implications of the negative mTORC1 regulator REDD1. Biochemistry: 2010; 49 2491 2501
9. Hernández G., Lal H., Fidalgo M., Guerrero A., Zalvide J., Force T., Pombo C. M. A novel cardioprotective p38-MAPK/mTOR pathway. Exp Cell Res: 2011; 317 2938 2949
10. Kleppe R., Martinez A., Doskeland S. O., Haavik J. The 14-3-3 proteins in regulation of cellular metabolism. Semin Cell Dev Biol: 2011; 22 713 719
11. Autieri M. V., Haines D. S., Romanic A. M., Ohlstein E. H. Expression of 14-3-3 gamma in injured arteries and growth factor- and cytokine-stimulated human vascular smooth muscle cells. Cell Growth Differ: 1996; 7 1453 1460
12. Chen H. P., He M., Xu Y. L., Huang Q. R., Zeng G. H., Liu D., Liao Z. P. Anoxic preconditioning up-regulates 14-3-3 protein expression in neonatal rat cardiomyocytes through extracellular signal-regulated protein kinase 1/2. Life Sci: 2007; 81 372 379
13. He M., Zhang J., Shao L., Huang Q., Chen J., Chen H., Chen X., Liu D., Luo Z. Upregulation of 14-3-3 isoforms in acute rat myocardial injuries induced by burn and lipopolysaccharide. Clin Exp Pharmacol Physiol: 2006; 33 374 380
14. DeYoung M. P., Horak P., Sofer A., Sgroi D., Ellisen L. W. Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev: 2008; 22 239 251
15. Igarashi M., Yamaguchi H., Hirata A., Daimon M., Tominaga M., Kato T. Insulin activates p38 mitogen-activated protein (MAP) kinase via a MAP kinase kinase (MKK) 3/MKK 6 pathway in vascular smooth muscle cells. Eur J Clin Invest: 2000; 30 668 677
16. Da Silva A. S., Pauli J. R., Ropelle E. R., Oliveira A. G., Cintra D. E., de Souza C. T., Velloso L. A., Carvalheira J. B., Saad M. J. Exercise intensity, inflammatory signaling, and insulin resistance in obese rats. Med Sci Sports Exerc: 2010; 42 2180 2188
17. Marinho R., Ropelle E. R., Cintra D. E., De Souza C. T., Da Silva A. S., Bertoli F. C., Colantonio E., D'Almeida V., Pauli J. R. Endurance exercise training increases APPL1 expression and improves insulin signaling in the hepatic tissue of diet-induced obese mice, independently of weight loss. J Cell Physiol: 2012; 227 2917 2926
18. de Moura L. P., Souza Pauli L. S., Cintra D. E., De Souza C. T., da Silva A. S., Marinho R., de Melo M. A., Ropelle E. R., Pauli J. R. Acute exercise decreases PTP-1B protein level and improves insulin signaling in the liver of old rats. Immun Ageing: 2013; 10 8
19. Medeiros C., Frederico M. J., da Luz G., Pauli J. R., Silva A. S., Pinho R. A., Velloso L. A., Ropelle E. R., De Souza C. T. Exercise training reduces insulin resistance and upregulates the mTOR/p70S6k pathway in cardiac muscle of diet-induced obesity rats. J Cell Physiol: 2011; 226 666 674
20. De Souza C. T., Araujo E. P., Bordin S., Ashimine R., Zollner R. L., Boschero A. C., Saad M. J., Velloso L. A. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology: 2005; 146 4189 4191
21. Barbosa V. A., Luciano T. F., Vitto M. F., Cesconetto P. A., Marques S. O., Souza D. R., Bom K., Pimentel G. D., Katashima C. K., Ropelle E. R., Pinho R. A., De Souza C. T. Exercise training plays cardioprotection through the oxidative stress reduction in obese rats submitted to myocardial infarction. Int J Cardiol: 2012; 157 422 424
22. Da Luz G., Frederico M. J., da Silva S., Vitto M. F., Cesconetto P. A., de Pinho R. A., Pauli J. R., Silva A. S., Cintra D. E., Ropelle E. R., De Souza C. T. Endurance exercise training ameliorates insulin resistance and reticulum stress in adipose and hepatic tissue in obese rats. Eur J Appl Physiol: 2011; 111 2015 2023
23. Pauli R. J., Cintra D. E., De Souza C. T., Ropelle E. R. New mechanisms by which physical exercise improves insulin resistance in the skeletal muscle. Arq Bras Endocrinol Metab: 2009; 53 399 408
24. Bodine S. C. mTOR signaling and the molecular adaptation to resistance exercise. Med Sci Sports Exerc: 2006; 38 1950 1957
25. Nojima H., Tokunaga C., Eguchi S., Oshiro N., Hidayat S., Yoshino K., Hara K., Tanaka N., Avruch J., Yonezawa K. The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J Biol Chem: 2003; 278 15461 15464
26. Cully M., Genevet A., Warne P., Treins C., Liu T., Bastien J., Baum B., Tapon N., Leevers S. J., Downward J. A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. Mol Cell Biol: 2010; 30 481 495
27. Nellist M., Goedbloed M. A., Halley D. J. Regulation of tuberous sclerosis complex (TSC) function by 14-3-3 proteins. Biochem Soc Trans: 2003; 31 587 591