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Volumn 135, Issue 9, 2014, Pages 2206-2214

Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer

Author keywords

claudin; gene expression profiling; non small cell lung cancer; targeted therapy; tissue microarray

Indexed keywords

CLAUDIN 18; CLAUDIN 6; EPIDERMAL GROWTH FACTOR RECEPTOR;

EID: 84906278734     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28857     Document Type: Article
Times cited : (87)

References (45)
  • 1
    • 84890571120 scopus 로고    scopus 로고
    • The receptor tyrosine kinase Axl in cancer: Biological functions and therapeutic implications
    • Paccez JD, Vogelsang M, Parker MI, et al. The receptor tyrosine kinase Axl in cancer: biological functions and therapeutic implications. Int J Cancer 2014; 134: 1024-33.
    • (2014) Int J Cancer , vol.134 , pp. 1024-1033
    • Paccez, J.D.1    Vogelsang, M.2    Parker, M.I.3
  • 2
    • 84866410479 scopus 로고    scopus 로고
    • Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing
    • Imielinski M, Berger AH, Hammerman PS, et al. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell 2012; 150: 1107-20.
    • (2012) Cell , vol.150 , pp. 1107-1120
    • Imielinski, M.1    Berger, A.H.2    Hammerman, P.S.3
  • 3
    • 80052252181 scopus 로고    scopus 로고
    • Novel therapeutic targets in non-small cell lung cancer
    • Janku F, Garrido-Laguna I, Petruzelka LB, et al. Novel therapeutic targets in non-small cell lung cancer. J Thorac Oncol 2011; 6: 1601-12.
    • (2011) J Thorac Oncol , vol.6 , pp. 1601-1612
    • Janku, F.1    Garrido-Laguna, I.2    Petruzelka, L.B.3
  • 4
    • 84876383602 scopus 로고    scopus 로고
    • A patient with lung adenocarcinoma and RET fusion treated with vandetanib
    • Gautschi O, Zander T, Keller FA, et al. A patient with lung adenocarcinoma and RET fusion treated with vandetanib. J Thorac Oncol 2013; 8: e43-4.
    • (2013) J Thorac Oncol , vol.8
    • Gautschi, O.1    Zander, T.2    Keller, F.A.3
  • 5
    • 83755188025 scopus 로고    scopus 로고
    • Targeted therapies for lung cancer: Clinical experience and novel agents
    • Larsen JE, Cascone T, Gerber DE, et al. Targeted therapies for lung cancer: clinical experience and novel agents. Cancer J 2011; 17: 512-27.
    • (2011) Cancer J , vol.17 , pp. 512-527
    • Larsen, J.E.1    Cascone, T.2    Gerber, D.E.3
  • 6
    • 84875950992 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitor-resistant disease
    • Ohashi K, Maruvka YE, Michor F, et al. Epidermal growth factor receptor tyrosine kinase inhibitor-resistant disease. J Clin Oncol 2013; 31: 1070-80.
    • (2013) J Clin Oncol , vol.31 , pp. 1070-1080
    • Ohashi, K.1    Maruvka, Y.E.2    Michor, F.3
  • 7
    • 84897461800 scopus 로고    scopus 로고
    • Safety, tolerability, and efficacy of the first-in-class antibody IMAB362 targeting claudin 18.2 in patients with metastatic gastroesophageal adenocarcinomas
    • Schuler MH, Zvirbule Z, Lordick F, et al. Safety, tolerability, and efficacy of the first-in-class antibody IMAB362 targeting claudin 18.2 in patients with metastatic gastroesophageal adenocarcinomas. ASCO Meeting Abstracts 2013; 31: 4080.
    • (2013) ASCO Meeting Abstracts , vol.31 , pp. 4080
    • Schuler, M.H.1    Zvirbule, Z.2    Lordick, F.3
  • 8
    • 79957464589 scopus 로고    scopus 로고
    • Claudins in lung diseases
    • Soini Y,. Claudins in lung diseases. Respir Res 2011; 12: 70.
    • (2011) Respir Res , vol.12 , pp. 70
    • Soini, Y.1
  • 9
    • 84861966218 scopus 로고    scopus 로고
    • Claudins and other tight junction proteins
    • Gunzel D, Fromm M,. Claudins and other tight junction proteins. Comp Physiol 2012; 2: 1819-52.
    • (2012) Comp Physiol , vol.2 , pp. 1819-1852
    • Gunzel, D.1    Fromm, M.2
  • 10
    • 77951745982 scopus 로고    scopus 로고
    • Claudins: Unlocking the code to tight junction function during embryogenesis and in disease
    • Gupta IR, Ryan AK,. Claudins: unlocking the code to tight junction function during embryogenesis and in disease. Clin Genet 2010; 77: 314-25.
    • (2010) Clin Genet , vol.77 , pp. 314-325
    • Gupta, I.R.1    Ryan, A.K.2
  • 11
    • 59449083761 scopus 로고    scopus 로고
    • Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development
    • Sahin U, Koslowski M, Dhaene K, et al. Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development. Clin Cancer Res 2008; 14: 7624-34.
    • (2008) Clin Cancer Res , vol.14 , pp. 7624-7634
    • Sahin, U.1    Koslowski, M.2    Dhaene, K.3
  • 12
    • 33847127375 scopus 로고    scopus 로고
    • The claudin gene family: Expression in normal and neoplastic tissues
    • Hewitt KJ, Agarwal R, Morin PJ,. The claudin gene family: expression in normal and neoplastic tissues. BMC Cancer 2006; 6: 186.
    • (2006) BMC Cancer , vol.6 , pp. 186
    • Hewitt, K.J.1    Agarwal, R.2    Morin, P.J.3
  • 13
    • 84880044601 scopus 로고    scopus 로고
    • Tight junction proteins: From barrier to tumorigenesis
    • Runkle EA, Mu D,. Tight junction proteins: from barrier to tumorigenesis. Cancer Lett 2013; 337: 41-8.
    • (2013) Cancer Lett , vol.337 , pp. 41-48
    • Runkle, E.A.1    Mu, D.2
  • 14
    • 84887393202 scopus 로고    scopus 로고
    • The claudin family of proteins in human malignancy: A clinical perspective
    • Ding L, Lu Z, Lu Q, Chen YH,. The claudin family of proteins in human malignancy: a clinical perspective. Cancer Manag Res 2013; 5: 367-75.
    • (2013) Cancer Manag Res , vol.5 , pp. 367-375
    • Ding, L.1    Lu, Z.2    Lu, Q.3    Chen, Y.H.4
  • 15
    • 84858317599 scopus 로고    scopus 로고
    • Tight junctions in lung cancer and lung metastasis: A review
    • Soini Y,. Tight junctions in lung cancer and lung metastasis: a review. Int J Clin Exp Pathol 2012; 5: 126-36.
    • (2012) Int J Clin Exp Pathol , vol.5 , pp. 126-136
    • Soini, Y.1
  • 16
    • 84855554941 scopus 로고    scopus 로고
    • Claudins 10 and 18 are predominantly expressed in lung adenocarcinomas and in tumors of nonsmokers
    • Merikallio H, Paakko P, Harju T, et al. Claudins 10 and 18 are predominantly expressed in lung adenocarcinomas and in tumors of nonsmokers. Int J Clin Exp Pathol 2011; 4: 667-73.
    • (2011) Int J Clin Exp Pathol , vol.4 , pp. 667-673
    • Merikallio, H.1    Paakko, P.2    Harju, T.3
  • 17
    • 84861984275 scopus 로고    scopus 로고
    • Roles for claudins in alveolar epithelial barrier function
    • Overgaard CE, Mitchell LA, Koval M,. Roles for claudins in alveolar epithelial barrier function. Ann N Y Acad Sci 2012; 1257: 167-74.
    • (2012) Ann N y Acad Sci , vol.1257 , pp. 167-174
    • Overgaard, C.E.1    Mitchell, L.A.2    Koval, M.3
  • 18
    • 78649807643 scopus 로고    scopus 로고
    • Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells
    • LaFemina MJ, Rokkam D, Chandrasena A, et al. Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2010; 299: L724-34.
    • (2010) Am J Physiol Lung Cell Mol Physiol , vol.299
    • Lafemina, M.J.1    Rokkam, D.2    Chandrasena, A.3
  • 19
    • 84873697794 scopus 로고    scopus 로고
    • Claudin heterogeneity and control of lung tight junctions
    • Koval M,. Claudin heterogeneity and control of lung tight junctions. Ann Review Physiol 2013; 75: 551-67.
    • (2013) Ann Review Physiol , vol.75 , pp. 551-567
    • Koval, M.1
  • 20
    • 79957638275 scopus 로고    scopus 로고
    • Claudin-18 gene structure, regulation, and expression is evolutionary conserved in mammals
    • Tureci O, Koslowski M, Helftenbein G, et al. Claudin-18 gene structure, regulation, and expression is evolutionary conserved in mammals. Gene 2011; 481: 83-92.
    • (2011) Gene , vol.481 , pp. 83-92
    • Tureci, O.1    Koslowski, M.2    Helftenbein, G.3
  • 21
    • 49249128970 scopus 로고    scopus 로고
    • Immunohistochemical staining of Reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma
    • Sentani K, Oue N, Tashiro T, et al. Immunohistochemical staining of Reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma. Am J Surg Pathol 2008; 32: 1182-9.
    • (2008) Am J Surg Pathol , vol.32 , pp. 1182-1189
    • Sentani, K.1    Oue, N.2    Tashiro, T.3
  • 22
    • 38649104848 scopus 로고    scopus 로고
    • New markers of pancreatic cancer identified through differential gene expression analyses: Claudin 18 and annexin A8
    • Karanjawala ZE, Illei PB, Ashfaq R, et al. New markers of pancreatic cancer identified through differential gene expression analyses: claudin 18 and annexin A8. Am J Surg Pathol 2008; 32: 188-96.
    • (2008) Am J Surg Pathol , vol.32 , pp. 188-196
    • Karanjawala, Z.E.1    Illei, P.B.2    Ashfaq, R.3
  • 23
    • 80054835640 scopus 로고    scopus 로고
    • Claudin-18 is an early-stage marker of pancreatic carcinogenesis
    • Tanaka M, Shibahara J, Fukushima N, et al. Claudin-18 is an early-stage marker of pancreatic carcinogenesis. J Histochem Cytochem 2011; 59: 942-52.
    • (2011) J Histochem Cytochem , vol.59 , pp. 942-952
    • Tanaka, M.1    Shibahara, J.2    Fukushima, N.3
  • 24
    • 84860769540 scopus 로고    scopus 로고
    • Expression of claudins 7 and 18 in pancreatic ductal adenocarcinoma: Association with features of differentiation
    • Soini Y, Takasawa A, Eskelinen M, et al. Expression of claudins 7 and 18 in pancreatic ductal adenocarcinoma: association with features of differentiation. J Clin Pathol 2012; 65: 431-6.
    • (2012) J Clin Pathol , vol.65 , pp. 431-436
    • Soini, Y.1    Takasawa, A.2    Eskelinen, M.3
  • 25
    • 79960022337 scopus 로고    scopus 로고
    • Claudin-18 in biliary neoplasms. Its significance in the classification of intrahepatic cholangiocarcinoma
    • Shinozaki A, Shibahara J, Noda N, et al. Claudin-18 in biliary neoplasms. Its significance in the classification of intrahepatic cholangiocarcinoma. Virchows Archiv 2011; 459: 73-80.
    • (2011) Virchows Archiv , vol.459 , pp. 73-80
    • Shinozaki, A.1    Shibahara, J.2    Noda, N.3
  • 26
    • 0034787457 scopus 로고    scopus 로고
    • Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing
    • Niimi T, Nagashima K, Ward JM, et al. claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing. Mol Cell Biol 2001; 21: 7380-90.
    • (2001) Mol Cell Biol , vol.21 , pp. 7380-7390
    • Niimi, T.1    Nagashima, K.2    Ward, J.M.3
  • 27
    • 84887990527 scopus 로고    scopus 로고
    • Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms
    • Woll S, Schlitter AM, Dhaene K, et al. Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms. Int J Cancer 2014; 134: 731-9.
    • (2014) Int J Cancer , vol.134 , pp. 731-739
    • Woll, S.1    Schlitter, A.M.2    Dhaene, K.3
  • 28
    • 0034796342 scopus 로고    scopus 로고
    • Claudin-6: A novel tight junction molecule is developmentally regulated in mouse embryonic epithelium
    • Turksen K, Troy TC,. Claudin-6: a novel tight junction molecule is developmentally regulated in mouse embryonic epithelium. Dev Dyn 2001; 222: 292-300.
    • (2001) Dev Dyn , vol.222 , pp. 292-300
    • Turksen, K.1    Troy, T.C.2
  • 29
    • 84870386216 scopus 로고    scopus 로고
    • Distinct expression pattern of claudin-6, a primitive phenotypic tight junction molecule, in germ cell tumours and visceral carcinomas
    • Ushiku T, Shinozaki-Ushiku A, Maeda D, et al. Distinct expression pattern of claudin-6, a primitive phenotypic tight junction molecule, in germ cell tumours and visceral carcinomas. Histopathology 2012; 61: 1043-56.
    • (2012) Histopathology , vol.61 , pp. 1043-1056
    • Ushiku, T.1    Shinozaki-Ushiku, A.2    Maeda, D.3
  • 30
    • 77950188724 scopus 로고    scopus 로고
    • Distribution and expression pattern of claudins 6, 7, and 9 in diffuse- and intestinal-type gastric adenocarcinomas
    • Rendon-Huerta E, Teresa F, Teresa GM, et al. Distribution and expression pattern of claudins 6, 7, and 9 in diffuse- and intestinal-type gastric adenocarcinomas. J Gastrointestinal Cancer 2010; 41: 52-9.
    • (2010) J Gastrointestinal Cancer , vol.41 , pp. 52-59
    • Rendon-Huerta, E.1    Teresa, F.2    Teresa, G.M.3
  • 31
    • 78650486487 scopus 로고    scopus 로고
    • Claudin-6, 7, or 9 overexpression in the human gastric adenocarcinoma cell line AGS increases its invasiveness, migration, and proliferation rate
    • Zavala-Zendejas VE, Torres-Martinez AC, Salas-Morales B, et al. Claudin-6, 7, or 9 overexpression in the human gastric adenocarcinoma cell line AGS increases its invasiveness, migration, and proliferation rate. Cancer Invest 2011; 29: 1-11.
    • (2011) Cancer Invest , vol.29 , pp. 1-11
    • Zavala-Zendejas, V.E.1    Torres-Martinez, A.C.2    Salas-Morales, B.3
  • 32
    • 84879905939 scopus 로고    scopus 로고
    • Immunologic and chemical targeting of the tight-junction protein Claudin-6 eliminates tumorigenic human pluripotent stem cells
    • Ben-David U, Nudel N, Benvenisty N,. Immunologic and chemical targeting of the tight-junction protein Claudin-6 eliminates tumorigenic human pluripotent stem cells. Nature Commun 2013; 4: 1992.
    • (2013) Nature Commun , vol.4 , pp. 1992
    • Ben-David, U.1    Nudel, N.2    Benvenisty, N.3
  • 33
    • 80054924102 scopus 로고    scopus 로고
    • Gene copy number aberrations are associated with survival in histologic subgroups of non-small cell lung cancer
    • Micke P, Edlund K, Holmberg L, et al. Gene copy number aberrations are associated with survival in histologic subgroups of non-small cell lung cancer. J Thorac Oncol 2011; 6: 1833-40.
    • (2011) J Thorac Oncol , vol.6 , pp. 1833-1840
    • Micke, P.1    Edlund, K.2    Holmberg, L.3
  • 34
    • 84871959921 scopus 로고    scopus 로고
    • Biomarker discovery in non-small cell lung cancer: Integrating gene expression profiling, meta-analysis, and tissue microarray validation
    • Botling J, Edlund K, Lohr M, et al. Biomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis, and tissue microarray validation. Clin Cancer Res 2013; 19: 194-204.
    • (2013) Clin Cancer Res , vol.19 , pp. 194-204
    • Botling, J.1    Edlund, K.2    Lohr, M.3
  • 35
    • 84867063079 scopus 로고    scopus 로고
    • CD99 is a novel prognostic stromal marker in non-small cell lung cancer
    • Edlund K, Lindskog C, Saito A, et al. CD99 is a novel prognostic stromal marker in non-small cell lung cancer. Int J Cancer 2012; 131: 2264-73.
    • (2012) Int J Cancer , vol.131 , pp. 2264-2273
    • Edlund, K.1    Lindskog, C.2    Saito, A.3
  • 36
    • 84871920961 scopus 로고    scopus 로고
    • Consistent mutation status within histologically heterogeneous lung cancer lesions
    • Mattsson JS, Imgenberg-Kreuz J, Edlund K, et al. Consistent mutation status within histologically heterogeneous lung cancer lesions. Histopathology 2012; 61: 744-8.
    • (2012) Histopathology , vol.61 , pp. 744-748
    • Mattsson, J.S.1    Imgenberg-Kreuz, J.2    Edlund, K.3
  • 37
    • 84876724283 scopus 로고    scopus 로고
    • The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer
    • Lohr M, Edlund K, Botling J, et al. The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer. Cancer Lett 2013; 333: 222-8.
    • (2013) Cancer Lett , vol.333 , pp. 222-228
    • Lohr, M.1    Edlund, K.2    Botling, J.3
  • 38
    • 84879924535 scopus 로고    scopus 로고
    • The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer
    • Thornton M, Aslam MA, Tweedle EM, et al. The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer. Int J Cancer 2013; 133: 1408-18.
    • (2013) Int J Cancer , vol.133 , pp. 1408-1418
    • Thornton, M.1    Aslam, M.A.2    Tweedle, E.M.3
  • 39
    • 33845439074 scopus 로고    scopus 로고
    • Outlier sums for differential gene expression analysis
    • Tibshirani R, Hastie T,. Outlier sums for differential gene expression analysis. Biostatistics 2007; 8: 2-8.
    • (2007) Biostatistics , vol.8 , pp. 2-8
    • Tibshirani, R.1    Hastie, T.2
  • 41
    • 79951575639 scopus 로고    scopus 로고
    • Predicted expansion of the claudin multigene family
    • Mineta K, Yamamoto Y, Yamazaki Y, et al. Predicted expansion of the claudin multigene family. FEBS Lett 2011; 585: 606-12.
    • (2011) FEBS Lett , vol.585 , pp. 606-612
    • Mineta, K.1    Yamamoto, Y.2    Yamazaki, Y.3
  • 42
    • 67349129369 scopus 로고    scopus 로고
    • Diagnostic utility of expression of claudins in non-small cell lung cancer: Different expression profiles in squamous cell carcinomas and adenocarcinomas
    • Jung JH, Jung CK, Choi HJ, et al. Diagnostic utility of expression of claudins in non-small cell lung cancer: different expression profiles in squamous cell carcinomas and adenocarcinomas. Pathol Res Pract 2009; 205: 409-16.
    • (2009) Pathol Res Pract , vol.205 , pp. 409-416
    • Jung, J.H.1    Jung, C.K.2    Choi, H.J.3
  • 43
    • 34447265054 scopus 로고    scopus 로고
    • Distinct claudin expression profile in histologic subtypes of lung cancer
    • Moldvay J, Jackel M, Paska C, et al. Distinct claudin expression profile in histologic subtypes of lung cancer. Lung Cancer 2007; 57: 159-67.
    • (2007) Lung Cancer , vol.57 , pp. 159-167
    • Moldvay, J.1    Jackel, M.2    Paska, C.3
  • 44
    • 77956863080 scopus 로고    scopus 로고
    • Immunohistochemical analysis of colorectal cancer with gastric phenotype: Claudin-18 is associated with poor prognosis
    • Matsuda M, Sentani K, Noguchi T, et al. Immunohistochemical analysis of colorectal cancer with gastric phenotype: claudin-18 is associated with poor prognosis. Pathol Int 2010; 60: 673-80.
    • (2010) Pathol Int , vol.60 , pp. 673-680
    • Matsuda, M.1    Sentani, K.2    Noguchi, T.3
  • 45


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