Claudins in lung diseases

Respiratory Research

Volumn 12, Issue , 2011, Pages

  Soini, Ylermi ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CLAUDIN;

EMBRYO DEVELOPMENT; HUMAN; IMMUNOHISTOCHEMISTRY; INTERSTITIAL LUNG DISEASE; LUNG DEVELOPMENT; LUNG DISEASE; LUNG INJURY; LUNG TUMOR; MEMBRANE PERMEABILITY; MESOTHELIUM CELL; NONHUMAN; PLEURA MESOTHELIOMA; PNEUMONIA; PROTEIN EXPRESSION; REVIEW; TIGHT JUNCTION; CELL POLARITY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; LUNG; MALE; METABOLISM; PERMEABILITY; PRENATAL DEVELOPMENT; SIGNAL TRANSDUCTION;

CELL POLARITY; CLAUDINS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; LUNG; LUNG DISEASES; MALE; PERMEABILITY; SIGNAL TRANSDUCTION; TIGHT JUNCTIONS;

EID: 79957464589     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-12-70     Document Type: Review

References (114)

1. Krause G, Winkler L, Mueller SL, Haseloff RF, Piontek J, Blasig IE. Structure and function of claudins. Biochim Biophys Acta 2008, 1778:631-45. 10.1016/j.bbamem.2007.10.018, 18036336.
2. Mukherjee TM, Swift JG, Henderson DW. Freeze-fracture study of intercellular junctions in benign and malignant mesothelial cells in effusions and a comparison with those seen in pleural mesotheliomas (solid tumour). J Submicrosc Cytol Pathol 1988, 20:195-208.
3. Sawada N, Murata M, Kikuchi K, Osanai M, Tobioka H, Kojima T, Chiba H. Tight junctions and human diseases. Med Electron Microsc 2003, 36:147-56. 10.1007/s00795-003-0219-y, 14505058.
4. Landau D. Epithelial paracellular proteins in health and disease. Curr Opin Nephrol Hypertens 2006, 15:425-9. 10.1097/01.mnh.0000232883.43093.76, 16775457.
5. Xie J, Farage E, Sugimoto M, Anand-Apte B. A novel transgenic zebrafish model for blood-brain and blood-retinal barrier development. BMC Dev Biol 2010, 10:76. 10.1186/1471-213X-10-76, 2914679, 20653957.
6. Morrow CM, Tyagi G, Simon L, Carnes K, Murphy KM, Cooke PS, Hofmann MC, Hess RA. Claudin 5 expression in mouse seminiferous epithelium is dependent upon the transcription factor ets variant 5 and contributes to blood-testis barrier function. Biol Reprod 2009, 81:871-9. 10.1095/biolreprod.109.077040, 2770019, 19571261.
7. Matter K, Balda MS. Epithelial tight junctions, gene expression and nucleo-junctional interplay. J Cell Sci 2007, 120:1505-11. 10.1242/jcs.005975, 17452622.
8. Jeansonne B, Lu Q, Goodenough DA, Chen YH. Claudin-8 interacts with multi-PDZ domain protein 1 (MUPP1) and reduces paracellular conductance in epithelial cells. Cell Mol Biol 2003, 49:13-21.
9. Tsapara A, Matter K, Balda MS. The heat-shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB. Mol Biol Cell 2006, 17:1322-30. 1382320, 16407410.
10. Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol 1998, 141:1539-50. 10.1083/jcb.141.7.1539, 2132999, 9647647.
11. Mineta K, Yamamoto Y, Yamazaki Y, Tanaka H, Tada Y, Saito K, Tamura A, Igarashi M, Endo T, Takeuchi K, Tsukita S. Predicted expansion of the claudin multigene family. FEBS Lett 2011, 585:606-12. 10.1016/j.febslet.2011.01.028, 21276448.
12. Lal-Nag M, Morin PJ. The claudins. Genome Biol 2009, 10:235. 10.1186/gb-2009-10-8-235, 2745760, 19706201.
13. Günzel D, Yu AS. Function and regulation of claudins in the thick ascending limb of Henle. Pflugers Arch 2009, 458:77-88. 10.1007/s00424-008-0589-z, 2666100, 18795318.
14. Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG. Role of claudin interactions in airway tight junctional permeability. Am J Physiol Lung Cell Mol Physiol 2003, 285:L1166-78.
15. Mazzon E, Cuzzocrea S. Role of TNF-alpha in lung tight junction alteration in mouse model of acute lung inflammation. Respir Res 2007, 8:75. 10.1186/1465-9921-8-75, 2174464, 17971210.
16. Daugherty BL, Mateescu M, Patel AS, Wade K, Kimura S, Gonzales LW, Guttentag S, Ballard PL, Koval M. Developmental regulation of claudin localization by fetal alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2004, 287:L1266-73. 10.1152/ajplung.00423.2003, 15347569.
17. Kaarteenaho R, Merikallio H, Lehtonen S, Harju T, Soini Y. Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung. Respir Res 2010, 11:59. 10.1186/1465-9921-11-59, 2886022, 20478039.
18. Kaarteenaho-Wiik R, Soini Y. Claudin-1, -2, -3, -4, -5, and -7 in usual interstitial pneumonia and sarcoidosis. J Histochem Cytochem 2009, 57:187-95. 2664931, 18955738.
19. Telgenhoff D, Ramsay S, Hilz S, Slusarewicz P, Shroot B. Claudin 2 mRNA and protein are present in human keratinocytes and may be regulated by all-trans-retinoic acid. Skin Pharmacol Physiol 2008, 21:211-7. 10.1159/000135637, 18509255.
20. Fujita H, Sugimoto K, Inatomi S, Maeda T, Osanai M, Uchiyama Y, Yamamoto Y, Wada T, Kojima T, Yokozaki H, Yamashita T, Kato S, Sawada N, Chiba H. Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Mol Biol Cell 2008, 19:1912-21. 10.1091/mbc.E07-09-0973, 2366872, 18287530.
21. Aung PP, Mitani Y, Sanada Y, Nakayama H, Matsusaki K, Yasui W. Differential expression of claudin-2 in normal human tissues and gastrointestinal carcinomas. Virchows Arch 2006, 448:428-34. 10.1007/s00428-005-0120-2, 16328347.
22. Will C, Fromm M, Müller D. Claudin tight junction proteins: novel aspects in paracellular transport. Perit Dial Int 2008, 28:577-84.
23. Holmes JL, Van Itallie CM, Rasmussen JE, Anderson JM. Claudin profiling in the mouse during postnatal intestinal development and along the gastrointestinal tract reveals complex expression patterns. Gene Expr Patterns 2006, 6:581-8. 10.1016/j.modgep.2005.12.001, 16458081.
24. Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, Furuse M, Tsukita S. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. Cell Biol 2003, 161:653-60.
25. Chen SP, Zhou B, Willis BC, Sandoval AJ, Liebler JM, Kim KJ, Ann DK, Crandall ED, Borok Z. Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells. J Appl Physiol 2005, 98:322-8.
26. Wang F, Daugherty B, Keise LL, Wei Z, Foley JP, Savani RC, Koval M. Heterogeneity of claudin expression by alveolar epithelial cells. Am J Respir Cell Mol Biol 2003, 29:62-70. 10.1165/rcmb.2002-0180OC, 12600828.
27. Fernandez AL, Koval M, Fan X, Guidot DM. Chronic alcohol ingestion alters claudin expression in the alveolar epithelium of rats. Alcohol 2007, 41:371-9. 10.1016/j.alcohol.2007.04.010, 2048749, 17889313.
28. Meyer TN, Schwesinger C, Bush KT, Stuart RO, Rose DW, Shah MM, Vaughn DA, Steer DL, Nigam SK. Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney. Dev Biol 2004, 275:44-67. 10.1016/j.ydbio.2004.07.022, 15464572.
29. Bagnat M, Cheung ID, Mostov KE, Stainier DY. Genetic control of single lumen formation in the zebrafish gut. Nat Cell Biol 2007, 9:954-60. 10.1038/ncb1621, 17632505.
30. Tamura A, Kitano Y, Hata M, Katsuno T, Moriwaki K, Sasaki H, Hayashi H, Suzuki Y, Noda T, Furuse M, Tsukita S, Tsukita S. Megaintestine in claudin-15-deficient mice. Gastroenterology 2008, 134:523-34. 10.1053/j.gastro.2007.11.040, 18242218.
31. Gupta IR, Ryan AK. Claudins: unlocking the code to tight junction function during embryogenesis and in disease. Clin Genet 2010, 77:314-25. 10.1111/j.1399-0004.2010.01397.x, 20447145.
32. Kollmar R, Nakamura SK, Kappler JA, Hudspeth AJ. Expression and phylogeny of claudins in vertebrate primordia. Proc Natl Acad Sci USA 2001, 98:10196-201. 10.1073/pnas.171325898, 56938, 11517306.
33. Yamagishi M, Ito Y, Ariizumi T, Komazaki S, Danno H, Michiue T, Asashima M. Claudin5 genes encoding tight junction proteins are required for Xenopus heart formation. Dev Growth Differ 2010, 52:665-75. 10.1111/j.1440-169X.2010.01204.x, 20887567.
34. Zhang Z, Stiegler AL, Boggon TJ, Kobayashi S, Halmos B. EGFR-mutated lung cancer: a paradigm of molecular oncology. Oncotarget 2010, 1:497-514. 3001953, 21165163.
35. Butt AM, Jones HC, Abbott NJ. Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study. J Physiol 1990, 429:47-62. 1181686, 2277354.
36. Godfrey RW. Human airway epithelial tight junctions. Microsc Res Tech 1997, 38:488-99. 10.1002/(SICI)1097-0029(19970901)38:5<488::AID-JEMT5>3.0.CO;2-E, 9376652.
37. Coyne CB, Vanhook MK, Gambling TM, Carson JL, Boucher RC, Johnson LG. Regulation of airway tight junctions by proinflammatory cytokines. Mol Biol Cell 2002, 13:3218-34. 10.1091/mbc.E02-03-0134, 124154, 12221127.
38. Yoshino I, Kometani T, Shoji F, Osoegawa A, Ohba T, Kouso H, Takenaka T, Yohena T, Maehara Y. Induction of epithelial-mesenchymal transition-related genes by benzo[a]pyrene in lung cancer cells. Cancer 2007, 110:369-74. 10.1002/cncr.22728, 17559143.
39. Wei PL, Chang YJ, Ho YS, Lee CH, Yang YY, An J, Lin SY. Tobacco-specific carcinogen enhances colon cancer cell migration through alpha7-nicotinic acetylcholine receptor. Ann Surg 2009, 249:978-85. 10.1097/SLA.0b013e3181a6ce7e, 19474681.
40. Merikallio H, Kaarteenaho R, Pääkkö P, Lehtonen S, Hirvikoski P, Mäkitaro R, Harju T, Soini Y. Impact of smoking on the expression of claudins in lung carcinoma. Eur J Cancer 2010, 47:620-630.
41. Shaykhiev R, Otaki F, Bonsu P, Dang DT, Teater M, Strulovici-Barel Y, Salit J, Harvey BG, Crystal RG. Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo. Cell Mol Life Sci 2010, 68:877-892.
42. Gonzalez JE, DiGeronimo RJ, Arthur DE, King JM. Remodeling of the tight junction during recovery from exposure to hydrogen peroxide in kidney epithelial cells. Free Radic Biol Med 2009, 47:1561-9. 10.1016/j.freeradbiomed.2009.08.024, 2783357, 19733232.
43. Lipschutz JH, Li S, Arisco A, Balkovetz DF. Extracellular signal-regulated kinases 1/2 control claudin-2 expression in Madin-Darby canine kidney strain I and II cells. J Biol Chem 2005, 280:3780-8.
44. Rosenthal R, Milatz S, Krug SM, Oelrich B, Schulzke JD, Amasheh S, Günzel D, Fromm M. Claudin-2, a component of the tight junction, forms a paracellular water channel. J Cell Sci 2010, 123:1913-21. 10.1242/jcs.060665, 20460438.
45. Caraballo JC, Yshii C, Westphal W, Moninger T, Comellas AP. Ambient particulate matter affects occludin distribution and increases alveolar transepithelial electrical conductance. Respirology 2011, 16:340-349. 10.1111/j.1440-1843.2010.01910.x, 21122029.
46. Crosby LM, Waters CM. Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol 2010, 298:L715-31. 10.1152/ajplung.00361.2009, 2886606, 20363851.
47. Capaldo CT, Nusrat A. Cytokine regulation of tight junctions. Biochim Biophys Acta 2009, 1788:864-71. 10.1016/j.bbamem.2008.08.027, 2699410, 18952050.
48. Bottoms SE, Howell JE, Reinhardt AK, Evans IC, McAnulty RJ. TGF-Beta isoform specific regulation of airway inflammation and remodelling in a murine model of asthma. PLoS One 2010, 5:9674.
49. Morty RE, Königshoff M, Eickelberg O. Transforming growth factor-beta signaling across ages: from distorted lung development to chronic obstructive pulmonary disease. Proc Am Thorac Soc 2009, 6:607-13. 10.1513/pats.200908-087RM, 19934357.
50. Górska K, Maskey-Warzechowska M, Krenke R. Airway inflammation in chronic obstructive pulmonary disease. Curr Opin Pulm Med 2010, 16:89-96. 10.1097/MCP.0b013e3283341ba0, 19904205.
51. Yeo NK, Jang YJ. Rhinovirus infection-induced alteration of tight junction and adherens junction components in human nasal epithelial cells. Laryngoscope 2010, 120:346-52.
52. Nazli A, Chan O, Dobson-Belaire WN, Ouellet M, Tremblay MJ, Gray-Owen SD, Arsenault AL, Kaushic C. Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation. PLoS Pathog 2010, 6:e1000852. 10.1371/journal.ppat.1000852, 2851733, 20386714.
53. Nava P, López S, Arias CF, Islas S, González-Mariscal L. The rotavirus surface protein VP8 modulates the gate and fence function of tight junctions in epithelial cells. J Cell Sci 2004, 117:5509-19. 10.1242/jcs.01425, 15494377.
54. Hering NA, Richter JF, Krug SM, Günzel D, Fromm A, Bohn E, Rosenthal R, Bücker R, Fromm M, Troeger H, Schulzke JD. Yersinia enterocolitica induces epithelial barrier dysfunction through regional tight junction changes in colonic HT-29/B6 cell monolayers. Lab Invest 2011, 91:310-324. 10.1038/labinvest.2010.180, 20956974.
55. Strauman MC, Harper JM, Harrington SM, Boll EJ, Nataro JP. Enteroaggregative Escherichia coli disrupts epithelial cell tight junctions. Infect Immun 2010, 78:4958-64. 10.1128/IAI.00580-10, 2976312, 20823198.
56. Lapointe TK, O'Connor PM, Jones NL, Menard D, Buret AG. Interleukin-1 receptor phosphorylation activates Rho kinase to disrupt human gastric tight junctional claudin-4 during Helicobacter pylori infection. Cell Microbiol 2010, 12:692-703. 10.1111/j.1462-5822.2010.01429.x, 20070312.
57. Evans MJ, von Hahn T, Tscherne DM, Syder AJ, Panis M, Wölk B, Hatziioannou T, McKeating JA, Bieniasz PD, Rice CM. Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. Nature 2007, 446:801-5. 10.1038/nature05654, 17325668.
58. Meertens L, Bertaux C, Cukierman L, Cormier E, Lavillette D, Cosset FL, Dragic T. The tight junction proteins claudin-1, -6, and -9 are entry cofactors for hepatitis C virus. J Virol 2008, 82:3555-60. 10.1128/JVI.01977-07, 2268462, 18234789.
59. Gao F, Duan X, Lu X, Liu Y, Zheng L, Ding Z, Li J. Novel binding between pre-membrane protein and claudin-1 is required for efficient dengue virus entry. Biochem Biophys Res Commun 2010, 391:952-7. 10.1016/j.bbrc.2009.11.172, 19962368.
60. Van Itallie CM, Betts L, Smedley JG, McClane BA, Anderson JM. Structure of the claudin-binding domain of Clostridium perfringens enterotoxin. J Biol Chem 2008, 283:268-74.
61. Saeki R, Kondoh M, Kakutani H, Matsuhisa K, Takahashi A, Suzuki H, Kakamu Y, Watari A, Yagi K. A claudin-targeting molecule as an inhibitor of tumor metastasis. J Pharmacol Exp Ther 2010, 334:576-82. 10.1124/jpet.110.168070, 20442222.
62. Szasz AM, Tokes AM, Micsinai M, Krenacs T, Jakab C, Lukacs L, Nemeth Z, Baranyai Z, Dede K, Madaras L, Kulka J. Prognostic significance of claudin expression changes in breast cancer with regional lymph node metastasis. Clin Exp Metastasis 2011, 28:55-63. 10.1007/s10585-010-9357-5, 20963473.
63. Merikallio H, Kaarteenaho R, Pääkkö P, Lehtonen S, Hirvikoski P, Mäkitaro R, Harju T, Soini Y. Zeb1 and twist are more commonly expressed in metastatic than primary lung tumours and show inverse associations with claudins. J Clin Pathol 2010, 1(64):136-140.
64. Bekker V, Chanock SJ, Yeager M, Hutchinson AA, von Hahn T, Chen S, Xiao N, Dotrang M, Brown M, Busch MP, Edlin BR, Rice CM, O'Brien TR. Genetic variation in CLDN1 and susceptibility to hepatitis C virus infection. J Viral Hepat 2010, 17:192-200. 10.1111/j.1365-2893.2009.01166.x, 2921226, 19674288.
65. Vermeer PD, Denker J, Estin M, Moninger TO, Keshavjee S, Karp P, Kline JN, Zabner J. MMP9 modulates tight junction integrity and cell viability in human airway epithelia. Am J Physiol Lung Cell Mol Physiol 2009, 296:L751-62. 10.1152/ajplung.90578.2008, 2681350, 19270179.
66. Rejman J, Di Gioia S, Bragonzi A, Conese M. Pseudomonas aeruginosa infection destroys the barrier function of lung epithelium and enhances polyplex-mediated transfection. Hum Gene Ther 2007, 18:642-52. 10.1089/hum.2006.192, 17638571.
67. Gillrie MR, Krishnegowda G, Lee K, Buret AG, Robbins SM, Looareesuwan S, Gowda DC, Ho M. Src-family kinase dependent disruption of endothelial barrier function by Plasmodium falciparum merozoite proteins. Blood 2007, 110:3426-35. 10.1182/blood-2007-04-084582, 2200906, 17693580.
68. Cohen TS, Gray Lawrence G, Margulies SS. Cultured alveolar epithelial cells from septic rats mimic in vivo septic lung. PLoS One 2010, 5:e11322. 10.1371/journal.pone.0011322, 2892473, 20593014.
69. Wray C, Mao Y, Pan J, Chandrasena A, Piasta F, Frank JA. Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injury. Am J Physiol Lung Cell Mol Physiol 2009, 297:L219-27. 10.1152/ajplung.00043.2009, 2742793, 19447895.
70. Xia XM, Wang FY, Wang ZK, Wan HJ, Xu WA, Lu H. Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis. World J Gastroenterol 2010, 16:2994-3001. 10.3748/wjg.v16.i24.2994, 2890939, 20572302.
71. Jang AS, Concel VJ, Bein K, Brant KA, Liu S, Pope-Varsalona H, Dopico RA, Di YP, Knoell DL, Barchowsky A, Leikauf GD. Endothelial Dysfunction and Claudin 5 Regulation during Acrolein-induced Lung Injury. Am J Respir Cell Mol Biol 2011, 44:483-490. 10.1165/rcmb.2009-0391OC, 20525806.
72. Kilpatrick LE, Standage SW, Li H, Raj NR, Korchak HM, Wolfson MR, Deutschman CS. Protection against sepsis-induced lung injury by selective inhibition of protein kinase C-{delta} ({delta}-PKC). J Leukoc Biol 2011, 89:3-10. 10.1189/jlb.0510281, 20724665.
73. Koizumi J, Kojima T, Ogasawara N, Kamekura R, Kurose M, Go M, Harimaya A, Murata M, Osanai M, Chiba H, Himi T, Sawada N. Protein kinase C enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation. Mol Pharmacol 2008, 74:432-42. 10.1124/mol.107.043711, 18477669.
74. Kobayashi K, Miwa H, Yasui M. Inflammatory mediators weaken the amniotic membrane barrier through disruption of tight junctions. J Physiol 2010, 588:4859-4869. 10.1113/jphysiol.2010.197764, 21041526.
75. Bouvry D, Planès C, Malbert-Colas L, Escabasse V, Clerici C. Hypoxia-induced cytoskeleton disruption in alveolar epithelial cells. Am J Respir Cell Mol Biol 2006, 35:519-27. 10.1165/rcmb.2005-0478OC, 16741163.
76. Koto T, Takubo K, Ishida S, Shinoda H, Inoue M, Tsubota K, Okada Y, Ikeda E. Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells. Am J Pathol 2007, 170:1389-97. 10.2353/ajpath.2007.060693, 1829471, 17392177.
77. Kieran NE, Doran PP, Connolly SB, Greenan MC, Higgins DF, Leonard M, Godson C, Taylor CT, Henger A, Kretzler M, Burne MJ, Rabb H, Brady HR. Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog. Kidney Int 2003, 64:480-492. 10.1046/j.1523-1755.2003.00106.x, 12846743.
78. Strieter RM. Pathogenesis and natural history of usual interstitial pneumonia: the whole story or the last chapter of a long novel. Chest 2005, 128:526S-532S. 10.1378/chest.128.5_suppl_1.526S, 16304243.
79. Rodewald M, Herr D, Fraser HM, Hack G, Kreienberg R, Wulff C. Regulation of tight junction proteins occludin and claudin 5 in the primate ovary during the ovulatory cycle and after inhibition of vascular endothelial growth factor. Mol Hum Reprod 2007, 13:781-9. 10.1093/molehr/gam066, 18006538.
80. McDonagh D, Vollmer RT, Shelburne JD. Intercellular junctions and tumor behavior in lung cancer. Mod Pathol 1991, 4:436-40.
81. Paschoud S, Bongiovanni M, Pache JC, Citi S. Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas. Mod Pathol 2007, 20:947-54. 10.1038/modpathol.3800835, 17585317.
82. Moldvay J, Jäckel M, Páska C, Soltész I, Schaff Z, Kiss A. Distinct claudin expression profile in histologic subtypes of lung cancer. Lung Cancer 2007, 57:159-67. 10.1016/j.lungcan.2007.02.018, 17418912.
83. Sormunen R, Pääkkö P, Kaarteenaho-Wiik R, Soini Y. Differential expression of adhesion molecules in lung tumours. Histopathology 2007, 50:282-4. 10.1111/j.1365-2559.2007.02574.x, 17222260.
84. Chao YC, Pan SH, Yang SC, Yu SL, Che TF, Lin CW, Tsai MS, Chang GC, Wu CH, Wu YY, Lee YC, Hong TM, Yang PC. Claudin-1 is a metastasis suppressor and correlates with clinical outcome in lung adenocarcinoma. Am J Respir Crit Care Med 2009, 179:123-33.
85. Takehara M, Nishimura T, Mima S, Hoshino T, Mizushima T. Effect of claudin expression on paracellular permeability, migration and invasion of colonic cancer cells. Biol Pharm Bull 2009, 32:825-31. 10.1248/bpb.32.825, 19420749.
86. Miyamori H, Takino T, Kobayashi Y, Tokai H, Itoh Y, Seiki M, Sato H. Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases. J Biol Chem 2001, 276:28204-11. 10.1074/jbc.M103083200, 11382769.
87. Singh AB, Harris RC. Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells. J Biol Chem 2004, 279:3543-52.
88. Zhang Z, Stiegler AL, Boggon TJ, Kobayashi S, Halmos B. EGFR-mutated lung cancer: a paradigm of molecular oncology. Oncotarget 2010, 1:497-514. 3001953, 21165163.
89. Mullin JM, Leatherman JM, Valenzano MC, Huerta ER, Verrechio J, Smith DM, Snetselaar K, Liu M, Francis MK, Sell C. Ras mutation impairs epithelial barrier function to a wide range of nonelectrolytes. Mol Biol Cell 2005, 16:5538-50. 10.1091/mbc.E05-04-0294, 1289400, 16176977.
90. Jin G, Kim MJ, Jeon HS, Choi JE, Kim DS, Lee EB, Cha SI, Yoon GS, Kim CH, Jung TH, Park JY. PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers. Lung Cancer 2010, 69:279-83. 10.1016/j.lungcan.2009.11.012, 20018398.
91. Osaki M, Oshimura M, Ito H. PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis 2004, 9:667-76.
92. Langlois MJ, Bergeron S, Bernatchez G, Boudreau F, Saucier C, Perreault N, Carrier JC, Rivard N. The PTEN Phosphatase Controls Intestinal Epithelial Cell Polarity and Barrier Function: Role in Colorectal Cancer Progression. PLoS One 2010, 5:e15742. 10.1371/journal.pone.0015742, 3009737, 21203412.
93. Araki K, Ishii G, Yokose T, Nagai K, Funai K, Kodama K, Nishiwaki Y, Ochiai A. Frequent overexpression of the c-kit protein in large cell neuroendocrine carcinoma of the lung. Lung Cancer 2003, 40:173-80. 10.1016/S0169-5002(03)00034-5, 12711118.
94. Schmalhofer O, Brabletz S, Brabletz T. E-cadherin, beta-catenin, and zeb1 in malignant progression of cancer. Cancer Metastasis Rev 2009, 28:151-66. 10.1007/s10555-008-9179-y, 19153669.
95. De Wever O, Pauwels P, De Craene B, Sabbah M, Emami S, Redeuilh G, Gespach C, Bracke M, Berx G. Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front. Histochem Cell Biol 2008, 130:481-494. 10.1007/s00418-008-0464-1, 2522326, 18648847.
96. Peinado H, Olmeda D, Cano A. Snail, ZEB and bHLH factors in tumour progression; and alliance against the epithelial phenotype. Nature Rev Cancer 2007, 7:415-428.
97. Angelow S, Ahlstrom R, Yu AS. Biology of claudins. Am J Physiol Renal Physiol 2008, 295:F867-76. 10.1152/ajprenal.90264.2008, 2576152, 18480174.
98. Gorin MA, Pan Q. Protein kinase C epsilon: an oncogene and emerging tumor biomarker. Mol Cancer 2009, 8:9. 10.1186/1476-4598-8-9, 2647895, 19228372.
99. French AD, Fiori JL, Camilli TC, Leotlela PD, O'Connell MP, Frank BP, Subaran S, Indig FE, Taub DD, Weeraratna AT. PKC and PKA phosphorylation affect the subcellular localization of claudin-1 in melanoma cells. Int J Med Sci 2009, 6:93-101. 2658888, 19305641.
100. Stamatovic SM, Dimitrijevic OB, Kepp RF, Andjelkovic AV. Protein kinase Cα-RhoA cross talk in CCL2-induced alterations in brain endothelial permeability. J Biol Chem 2006, 281:8379-8388. 10.1074/jbc.M513122200, 16439355.
101. Aono S, Hirai Y. Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line. Exp Cell Res 2008, 314:3326-39. 10.1016/j.yexcr.2008.08.012, 18786529.
102. Itoh M, Furuse M, Morita K, Kubota K, Saitou M. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2 and ZO-3, with the COOH termini of claudins. J Cell Biol 1999, 147:1351-6136. 10.1083/jcb.147.6.1351, 2168087, 10601346.
103. Betanzos A, Huerta M, Lopez-Bayghen E, Azuara E, Amerena J, Gonzalez-Mariscal L. The tight junction protein ZO-2 associates with Jun, Fos and C/EBP transcription factors in epithelial cells. Exp Cell Res 2004, 292:51-66. 10.1016/j.yexcr.2003.08.007, 14720506.
104. Yao Q, Cao S, Li C, Mengesha A, Low P, Kong B, Dai S, Wei M. Turn a diarrhoea toxin into a receptor-mediated therapy for a plethora of CLDN-4-overexpressing cancers. Biochem Biophys Res Commun 2010, 398:413-9. 10.1016/j.bbrc.2010.06.089, 20599713.
105. Gao Z, Xu X, McClane B, Zeng Q, Litkouhi B, Welch WR, Berkowitz RS, Mok SC, Garner EI. C-Terminus of Clostridium perfringens Enterotoxin Downregulates CLDN4 and Sensitizes Ovarian Cancer Cells to Taxol and Carboplatin. Clin Cancer Res 2011, 17:1065-1074. 10.1158/1078-0432.CCR-10-1644, 21123456.
106. Mimura T, Ito A, Sakuma T, Ohbayashi C, Yoshimura M, Tsubota N, Okita Y, Okada M. Novel marker D2-40, combined with calretinin, CEA, and TTF-1: an optimal set of immunodiagnostic markers for pleural mesothelioma. Cancer 2007, 109:933-8. 10.1002/cncr.22477, 17279584.
107. Soini Y, Kinnula V, Kahlos K, Pääkkö P. Claudins in differential diagnosis between mesothelioma and metastatic adenocarcinoma of the pleura. J Clin Pathol 2006, 59:250-4. 10.1136/jcp.2005.028589, 1860350, 16505274.
108. Davidson B, Zhang Z, Kleinberg L, Li M, Flørenes VA, Wang TL, Shih I. Gene expression signatures differentiate ovarian/peritoneal serous carcinoma from diffuse malignant peritoneal mesothelioma. Clin Cancer Res 2006, 12:5944-50. 10.1158/1078-0432.CCR-06-1059, 17062665.
109. Kleinberg L, Holth A, Fridman E, Schwartz I, Shih I, Davidson B. The diagnostic role of claudins in serous effusions. Am J Clin Pathol 2007, 127:928-37. 10.1309/V025QRN3R9CJGNPX, 17509990.
110. Facchetti F, Gentili F, Lonardi S, Bercich L, Santin A. Claudin-4 in mesothelioma diagnosis. Histopathology 2007, 51:261-3. 10.1111/j.1365-2559.2007.02743.x, 17573941.
111. Kaneda K, Miyamoto K, Nomura S, Horiuchi T. Intercellular localization of occludins and ZO-1 as a solute transport barrier of the mesothelial monolayer. J Artif Organs 2006, 9:241-50. 10.1007/s10047-006-0350-3, 17171403.
112. Markov AG, Voronkova MA, Volgin GN, Yablonsky PK, Fromm M, Amasheh S. Tight junction proteins contribute to barrier properties in human pleura. Respir Physiol Neurobiol 2011, 175:331-335. 10.1016/j.resp.2010.12.012, 21187167.
113. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 2011, 6:244-85. 10.1097/JTO.0b013e318206a221, 21252716.
114. Klamp T, Schumacher J, Huber G, Kühne C, Meissner U, Selmi A, Hiller T, Kreiter S, Markl J, Türeci T, Sahin U. Highly specific auto-antibodies against claudin-18 isoform 2 induced by a chimeric HBcAg virus-like particle vaccine kill tumor cells and inhibit the growth of lung metastases. Cancer Res 2011, 71:516-27. 10.1158/0008-5472.CAN-10-2292, 21224362.