Immunohistochemical staining of reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma

American Journal of Surgical Pathology

Volumn 32, Issue 8, 2008, Pages 1182-1189

  Sentani, Kazuhiro ^a   Oue, Naohide ^a   Tashiro, Takashi ^e   Sakamoto, Naoya ^a   Nishisaka, Takashi ^b   Fukuhara, Toshiyuki ^b   Taniyama, Kiyomi ^f   Matsuura, Hiroo ^c   Arihiro, Koji ^d   Ochiai, Atsushi ^g   Yasui, Wataru ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA PREFECTURAL HOSPITAL   (Japan)

^c HIROSHIMA CITY HOSPITAL   (Japan)

^d HIROSHIMA UNIVERSITY HOSPITAL   (Japan)

^e Hyogo Prefectural Kakogawa Hospital   (Japan)

^f NATIONAL HOSPITAL ORGANIZATION   (Japan)

^g NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

Author keywords

Claudin 18; Gastric cancer; Reg IV; Signet ring cell carcinoma

Indexed keywords

CLAUDIN 18; MAMMAGLOBIN; MUCIN 2; MUCIN 5AC; THYROID TRANSCRIPTION FACTOR 1; TRANSCRIPTION FACTOR CDX2; CLDN18 PROTEIN, HUMAN; LECTIN; MEMBRANE PROTEIN; REG4 PROTEIN, HUMAN; TUMOR MARKER;

ARTICLE; CONTROLLED STUDY; GASTROINTESTINAL CARCINOMA; GENE EXPRESSION; GENE IDENTIFICATION; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MOLECULAR CLONING; SIGNET RING CARCINOMA; BREAST TUMOR; CHEMISTRY; COLORECTAL TUMOR; DIFFERENTIAL DIAGNOSIS; FEMALE; LUNG TUMOR; PATHOLOGY; PREDICTION AND FORECASTING; STOMACH TUMOR;

BREAST NEOPLASMS; CARCINOMA, SIGNET RING CELL; COLORECTAL NEOPLASMS; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LECTINS, C-TYPE; LUNG NEOPLASMS; MEMBRANE PROTEINS; PREDICTIVE VALUE OF TESTS; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 49249128970     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318163a8f8     Document Type: Article

References (39)

1. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol. 1998;11:155-168.
2. Antonioli DA, Goldman H. Changes in the location and type of gastric adenocarcinoma. Cancer. 1982;50:775-781.
3. Aung PP, Oue N, Mitani Y, et al. Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer. Oncogene. 2006;25: 2546-2557.
4. Bhargava R, Beriwal S, Dabbs DJ. Mammaglobin versus GCDFP-15: an immunohistologic validation survey for sensitivity and specificity. Am J Clin Pathol. 2007;127:103-113.
5. Brown RW, Campagna LB, Dunn JK, et al. Immunohistochemical identification of tumor markers in metastatic adenocarcinoma. A diagnostic adjunct in the determination of primary site. Am J Clin Pathol. 1997;107:12-19.
6. Cameron BL, Butler JA, Rutgers J, et al. Immunohistochemical determination of the estrogen receptor content of gastrointestinal adenocarcinomas. Am Surg. 1992;58:758-760.
7. Castro CY, Moran CA, Flieder DG, et al. Primary signet ring cell adenocarcinomas of the lung: a clinicopathological study of 15 cases.Histopathology. 2001;39:397-401.
8. Chu P, Wu E, Weiss LM. Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Mod Pathol. 2000;13:962-972.
9. Chu PG, Weiss LM. Keratin expression in human tissues and neoplasms. Histopathology. 2002;40:403-439.
10. Chu PG, Weiss LM. Immunohistochemical characterization of signet-ring cell carcinomas of the stomach, breast, and colon. Am J Clin Pathol. 2004;121:884-892.
11. Connelly JH, Robey-Cafferty SS, el-Naggar AK, et al. Exophytic signet-ring cell carcinoma of the colorectum. Arch Pathol Lab Med. 1991;115:134-136.
12. DeYoung BR, Wick MR. Immunohistologic evaluation of meta-static carcinomas of unknown origin: an algorithmic approach. Semin Diagn Pathol. 2000;17:184-193.
13. Fleming TP, Watson MA. Mammaglobin, a breast-specific gene, and its utility as a marker for breast cancer. Ann N Y Acad Sci. 2000;923:78-89.
14. Frost AR, Terahata S, Yeh IT, et al. The significance of signet ring cells in infiltrating lobular carcinoma of the breast. Arch Pathol Lab Med. 1995;119:64-68.
15. Kakushima N, Kamoshida T, Hirai S, et al. Early gastric cancer with Krukenberg tumor and review of cases of intramucosal gastric cancers with Krukenberg tumor. J Gastroenterol. 2003;38: 1176-1180.
16. Kaufmann O, Deidesheimer T, Muehlenberg M, et al. Immunohis-tochemical differentiation of metastatic breast carcinomas from metastatic adenocarcinomas of other common primary sites. Histopathology. 1996;29:233-240.
17. Kondo A, Ogisu B, Mitsuya H. Signet-ring cell carcinoma involving the urinary bladder. Report of a case and review of 21 cases. Urol Int. 1981;36:373-379.
18. Kuroda N, Yamasaki I, Nakayama H, et al. Prostatic signet-ring cell carcinoma: case report and literature review. Pathol Int. 1999;49: 457-461.
19. Lau SK, Luthringer DJ, Eisen RN. Thyroid transcription factor-1: a review. Appl Immunohistochem Mol Morphol. 2002;10:97-102.
20. Mallo GV, Rechreche H, Frigerio JM, et al. Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int J Cancer. 1997;74: 35-44.
21. Merchant SH, Amin MB, Tamboli P, et al. Primary signet-ring cell carcinoma of lung: immunohistochemical study and comparison with non-pulmonary signet-ring cell carcinomas. Am J Surg Pathol. 2001;25:1515-1519.
22. Mitani Y, Oue N, Matsumura S, et al. Reg IV is a serum biomarker for gastric cancer patients and predicts response to 5-fluorouracil-based chemotherapy. Oncogene. 2007;26:4383-4393.
23. Nguyen MD, Plasil B, Wen P, et al. Mucin profiles in signet-ring cell carcinoma. Arch Pathol Lab Med. 2006;130:799-804.
24. Oue N, Hamai Y, Mitani Y, et al. Gene expression profile of gastric carcinoma: identification of genes and tags potentially involved in invasion, metastasis, and carcinogenesis by serial analysis of gene expression. Cancer Res. 2004;64:2397-2405.
25. Oue N, Mitani Y, Aung PP, et al. Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma. J Pathol. 2005;207: 185-198.
26. Oue N, Kuniyasu H, Noguchi T, et al. Serum concentration of Reg IV in patients with colorectal cancer: overexpression and high Reg IV serum level is associated with liver metastasis. Oncology. In press.
27. Raju U, Ma CK, Shaw A. Signet ring variant of lobular carcinoma of the breast: a clinicopathologic and immunohistochemical study. Mod Pathol. 1993;6:516-520.
28. Randolph TL, Amin MB, Ro JY, et al. Histologic variants of adenocarcinoma and other carcinomas of prostate: pathologic criteria and clinical significance. Mod Pathol. 1997;10: 612-629.
29. Sanada Y, Oue N, Mitani Y, et al. Down-regulation of the claudin-18 gene, identified through serial analysis of gene expression data analysis, in gastric cancer with an intestinal phenotype. J Pathol. 2006;208:633-642.
30. Sjodin A, Guo D, Hofer PA, et al. Mammaglobin in normal human sweat glands and human sweat gland tumors. J Invest Dermatol. 2003;121:428-429.
31. Tornos C, Soslow R, Chen S, et al. Expression of WT1, CA 125, and GCDFP-15 as useful markers in the differential diagnosis of primary ovarian carcinomas versus metastatic breast cancer to the ovary. Am J Surg Pathol. 2005;29:1482-1489.
32. Tot T. The role of cytokeratins 20 and 7 and estrogen receptor analysis in separation of metastatic lobular carcinoma of the breast and metastatic signet ring cell carcinoma of the gastrointestinal tract. Apmis. 2000;108:467-472.
33. Tsuta K, Ishii G, Yoh K, et al. Primary lung carcinoma with signetring cell carcinoma components: clinicopathological analysis of 39 cases. Am J Surg Pathol. 2004;28:868-874.
34. Tsuta K, Ishii G, Nitadori J, et al. Comparison of the immunophe-notypes of signet-ring cell carcinoma, solid adenocarcinoma with mucin production, and mucinous bronchioloalveolar carcinoma of the lung characterized by the presence of cytoplasmic mucin. J Pathol. 2006;209:78-87.
35. Tung SY, Wu CS, Chen PC. Primary signet ring cell carcinoma of colorectum: an age- and sex-matched controlled study. Am J Gastroenterol. 1996;91:2195-2199.
36. Watson MA, Fleming TP. Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer. Cancer Res. 1996;56:860-865.
37. Watson MA, Dintzis S, Darrow CM, et al. Mammaglobin expression in primary, metastatic, and occult breast cancer. Cancer Res. 1999;59:3028-3031.
38. Yamashina M. A variant of early gastric carcinoma. Histologic and histochemical studies of early signet ring cell carcinomas discovered beneath preserved surface epithelium. Cancer. 1986;58:1333-1339.
39. Yokozaki H, Takekura N, Takanashi A, et al. Estrogen receptors in gastric adenocarcinoma: a retrospective immunohistochemical analysis. Virchows Arch A Pathol Anat Histopathol. 1988;413:297-302.