Poly-lysine peptidomimetics having potent antimicrobial activity without hemolytic activity

Amino Acids

Volumn 46, Issue 9, 2014, Pages 2259-2269

  Ahn, Mija ^a   Jacob, Binu ^b,c   Gunasekaran, Pethaiah ^d   Murugan, Ravichandran N ^a   Ryu, Eun Kyoung ^a   Lee, Ga Hyang ^d   Hyun, Jae Kyung ^a   Cheong, Chaejoon ^a   Kim, Nam Hyung ^d   Shin, Song Yub ^b,c   Bang, Jeong Kyu ^a  

^a Korea Basic Science Institute (KBSI)   (South Korea)

^b Chosun University   (South Korea)

^c Chosun University College of Medicine   (South Korea)

^d Chungbuk National University   (South Korea)

Author keywords

Antimicrobial activity; Hemolytic activity; Poly Lys peptidomimetics; Short peptidomimetics; Structure activity relationship (SAR) study

Indexed keywords

AROMATIC COMPOUND; CYCLOHEXYL GROUP; FUNCTIONAL GROUP; HYDROCARBON; LYSINE; PEPTIDOMIMETIC AGENT; UNCLASSIFIED DRUG; ANTI-INFECTIVE AGENTS; PEPTIDOMIMETICS; POLYLYSINE;

ANIMAL CELL; ARTICLE; BACILLUS SUBTILIS; BACTERICIDAL ACTIVITY; CHEMICAL PARAMETERS; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; HEMOLYSIS; HYDROCARBON TAIL LENGTH; HYDROPHOBICITY; MEMBRANE DEPOLARIZATION; MEMBRANE PERMEABILITY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHIMURIUM; STAPHYLOCOCCUS EPIDERMIDIS; STRUCTURE ACTIVITY RELATION; SURFACE CHARGE; CHEMICAL SYNTHESIS; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ERYTHROCYTES; GROWTH AND DEVELOPMENT; HUMANS; METABOLISM; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS;

ANTI-INFECTIVE AGENTS; ERYTHROCYTES; HEMOLYSIS; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PEPTIDOMIMETICS; POLYLYSINE;

EID: 84906249235     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-014-1778-z     Document Type: Article

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