Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation

American Journal of Pathology

Volumn 184, Issue 9, 2014, Pages 2382-2389

  Nadon, Aaron M ^a   Perez, Mario J ^a   Hernandez Saavedra, Daniel ^a   Smith, Lynelle P ^a   Yang, Yimu ^a   Sanders, Linda A ^a   Gandjeva, Aneta ^a   Chabon, Jacob ^a   Koyanagi, Daniel E ^a   Graham, Brian B ^a   Tuder, Rubin M ^a   Schmidt, Eric P ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; LIPOPOLYSACCHARIDE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; RAPAMYCIN; RTP801 PROTEIN; UNCLASSIFIED DRUG; DDIT4L PROTEIN, MOUSE; DNA BINDING PROTEIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL SPECIFICITY; CONTROLLED STUDY; EPITHELIUM CELL; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; LUNG INJURY; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE; ANIMAL; DISEASE MODEL; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PNEUMONIA; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

ANIMALS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; ENDOTOXINS; FLUORESCENT ANTIBODY TECHNIQUE; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MULTIPROTEIN COMPLEXES; PNEUMONIA; REAL-TIME POLYMERASE CHAIN REACTION; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS;

EID: 84906238849     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2014.06.002     Document Type: Article

References (23)

1. M. Laplante, and D. Sabatini mTOR signaling in growth control and disease Cell 149 2012 274 293
2. X.M. Ma, and J. Blenis Molecular mechanisms of mTOR-mediated translational control Nat Rev Mol Cell Biol 10 2009 307 318
3. M.A. Matthay, L.B. Ware, and G.A. Zimmerman The acute respiratory distress syndrome J Clin Invest 122 2012 2731 2740
4. T. Yoshida, I. Mett, A.K. Bhunia, J. Bowman, M. Perez, L. Zhang, A. Gandjeva, L. Zhen, U. Chukwueke, T. Mao, A. Richter, E. Brown, H. Ashush, N. Notkin, A. Gelfand, R.K. Thimmulappa, T. Rangasamy, T. Sussan, G. Cosgrove, M. Mouded, S.D. Shapiro, I. Petrache, S. Biswal, E. Feinstein, and R.M. Tuder Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema Nat Med 16 2010 767 773
5. M.P. DeYoung, P. Horak, A. Sofer, D. Sgroi, and L.W. Ellisen Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling Genes Dev 22 2008 239 251
6. D.F. Lee, H.P. Kuo, C.T. Chen, J.M. Hsu, C.K. Chou, Y. Wei, H.L. Sun, L.Y. Li, B. Ping, W.C. Huang, X. He, J.Y. Hung, C.C. Lai, Q. Ding, J.L. Su, J.Y. Yang, A.A. Sahin, G.N. Hortobagyi, F.J. Tsai, C.H. Tsai, and M.C. Hung IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway Cell 130 2007 440 455
7. E. Lorne, X. Zhao, J.W. Zmijewski, G. Liu, Y.J. Park, Y. Tsuruta, and E. Abraham Participation of mammalian target of rapamycin complex 1 in Toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury Am J Respir Cell Mol Biol 41 2009 237 245
8. J.A. Fielhaber, S.F. Carroll, A.B. Dydensborg, M. Shourian, A. Triantafillopoulos, S. Harel, S.N. Hussain, M. Bouchard, S.T. Qureshi, and A.S. Kristof Inhibition of mammalian target of rapamycin augments lipopolysaccharide-induced lung injury and apoptosis J Immunol 188 2012 4535 4542
9. L. Wang, Y.S. Gui, X.L. Tian, B.Q. Cai, D.T. Wang, D. Zhang, H. Zhao, and K.F. Xu Inactivation of mammalian target of rapamycin (mTOR) by rapamycin in a murine model of lipopolysaccharide-induced acute lung injury Chin Med J (Engl) 124 2011 3112 3117
10. T. Nakajima, K.W. Lin, J. Li, H.S. McGee, J.M. Kwan, D.L. Perkins, and P.W. Finn T cells and lung injury: impact of rapamycin Am J Respir Cell Mol Biol 51 2014 294 299
11. G. Matute-Bello, G. Downey, B.B. Moore, S.D. Groshong, M.A. Matthay, A.S. Slutsky, W.M. Kuebler Acute Lung Injury in Animals Study Group An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals Am J Respir Cell Mol Biol 44 2011 725 738
12. E.P. Schmidt, Y. Yang, W.J. Janssen, A. Gandjeva, M.J. Perez, L. Barthel, R.L. Zemans, J.C. Bowman, D.E. Koyanagi, Z.X. Yunt, L.P. Smith, S.S. Cheng, K.H. Overdier, K.R. Thompson, M.W. Geraci, I.S. Douglas, D.B. Pearse, and R.M. Tuder The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis Nat Med 18 2012 1217 1223
13. M.I. Lygizos, Y. Yang, C.J. Altmann, K. Okamura, A.A. Hernando, M.J. Perez, L.P. Smith, D.E. Koyanagi, A. Gandjeva, R. Bhargava, R.M. Tuder, S. Faubel, and E.P. Schmidt Heparanase mediates renal dysfunction during early sepsis in mice Physiol Rep 1 2013 e00153
14. H. Farhangkhoee, Z.A. Khan, S. Mukherjee, M. Cukiernik, Y.P. Barbin, M. Karmazyn, and S. Chakrabarti Heme oxygenase in diabetes-induced oxidative stress in the heart J Mol Cell Cardiol 35 2003 1439 1448
15. J.C. Duvigneau, C. Piskernik, S. Haindl, B. Kloesch, R.T. Hartl, M. Hüttemann, I. Lee, T. Ebel, R. Moldzio, M. Gemeiner, H. Redl, and A.V. Kozlov A novel endotoxin-induced pathway: upregulation of heme oxygenase 1, accumulation of free iron, and free iron-mediated mitochondrial dysfunction Lab Invest 88 2008 70 77
16. K. Katholnig, C.C. Kaltenecker, H. Hayakawa, M. Rosner, C. Lassnig, G.J. Zlabinger, M. Gaestel, M. Muller, M. Hengstschlager, W.H. Hörl, H.M. Park, M.D. Säemann, and T. Weichhart p38α Senses environmental stress to control innate immune responses via mechanistic target of rapamycin J Immunol 190 2013 1519 1527
17. S.S. Ivanov, and C.R. Roy Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR Nat Immunol 14 2013 1219 1288
18. J. Xing, Q. Wang, K. Coughlan, B. Viollet, C. Moriasi, and M.H. Zou Inhibition of AMP-activated protein kinase accentuates lipopolysaccharide- induced lung endothelial barrier dysfunction and lung injury in vivo Am J Pathol 182 2013 1021 1030
19. X. Zhao, J.W. Zmijewski, E. Lorne, G. Liu, Y.J. Park, Y. Tsuruta, and E. Abraham Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury Am J Physiol Lung Cell Mol Physiol 295 2008 L497 L504
20. C.S. Park, B.R. Bang, H.S. Kwon, K.A. Moon, T.B. Kim, K.Y. Lee, H.B. Moon, and Y.S. Cho Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase Biochem Pharmacol 84 2012 1660 1670
21. D.W. Perng, T.M. Chang, J.Y. Wang, C.C. Lee, S.H. Lu, S.K. Shyue, T.S. Lee, and Y.R. Kou Inflammatory role of AMP-activated protein kinase signaling in an experimental model of toxic smoke inhalation injury Crit Care Med 41 2013 120 132
22. S. Hulo, H. Tiesset, S. Lancel, J.L. Edmé, B. Viollet, A. Sobaszek, and R. Neviére AMP-activated protein kinase deficiency reduces ozone-induced lung injury and oxidative stress in mice Respir Res 12 2011 64
23. S.H. Bruneau, H. Nakayama, C.B. Woda, E.A. Flynn, and D.M. Briscoe DEPTOR regulates vascular endothelial cell activation and proinflammatory and angiogenic responses Blood 122 2013 1833 1842