-
1
-
-
0034604129
-
The acute respiratory distress syndrome
-
Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000; 342: 1334-1349.
-
(2000)
N Engl J Med
, vol.342
, pp. 1334-1349
-
-
Ware, L.B.1
Matthay, M.A.2
-
2
-
-
0037391301
-
Epidemiology and outcome of acute respiratory failure in intensive care unit patients
-
Vincent JL, Sakr Y, Ranieri VM. Epidemiology and outcome of acute respiratory failure in intensive care unit patients. Crit Care Med 2003; 31 (4 Suppl): S296-S299.
-
(2003)
Crit Care Med
, vol.31
, Issue.4 SUPPL.
-
-
Vincent, J.L.1
Sakr, Y.2
Ranieri, V.M.3
-
4
-
-
0034084438
-
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
-
Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000; 25: 187-191.
-
(2000)
Nat Genet
, vol.25
, pp. 187-191
-
-
Arbour, N.C.1
Lorenz, E.2
Schutte, B.C.3
Zabner, J.4
Kline, J.N.5
Jones, M.6
-
5
-
-
0032771370
-
Variable airway responsiveness to inhaled lipopolysaccharide
-
Kline JN, Cowden JD, Hunninghake GW, Schutte BC, Watt JL, Wohlford-lenane CL, et al. Variable airway responsiveness to inhaled lipopolysaccharide. Am J Resp Crit Care Med 1999; 160: 297-303.
-
(1999)
Am J Resp Crit Care Med
, vol.160
, pp. 297-303
-
-
Kline, J.N.1
Cowden, J.D.2
Hunninghake, G.W.3
Schutte, B.C.4
Watt, J.L.5
Wohlford-Lenane, C.L.6
-
6
-
-
36448991234
-
Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury
-
Togbe D, Schnyder-Candrian S, Schnyder B, Doz E, Noulin N, Janot L, et al. Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury. Int J Exp Pathol 2007; 88: 387-391.
-
(2007)
Int J Exp Pathol
, vol.88
, pp. 387-391
-
-
Togbe, D.1
Schnyder-Candrian, S.2
Schnyder, B.3
Doz, E.4
Noulin, N.5
Janot, L.6
-
7
-
-
0035190026
-
Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer
-
Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield MD. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol 2001; 17: 615-675.
-
(2001)
Annu Rev Cell Dev Biol
, vol.17
, pp. 615-675
-
-
Katso, R.1
Okkenhaug, K.2
Ahmadi, K.3
White, S.4
Timms, J.5
Waterfield, M.D.6
-
8
-
-
1342292522
-
Phosphoinositide 3-kinase: Diverse roles in immune cell activation
-
Deane JA, Fruman DA. Phosphoinositide 3-kinase: diverse roles in immune cell activation. Annu Rev Immunol 2004; 22: 563-598.
-
(2004)
Annu Rev Immunol
, vol.22
, pp. 563-598
-
-
Deane, J.A.1
Fruman, D.A.2
-
9
-
-
72449147738
-
The multifunctional role of mTOR in innate immunity: Implications for transplant immunity
-
Saemann MD, Haidinger M, Hecking M, Horl WH, Weichhart T. The multifunctional role of mTOR in innate immunity: implications for transplant immunity. Am J Transplant 2009: 2655-2661.
-
(2009)
Am J Transplant
, pp. 2655-2661
-
-
Saemann, M.D.1
Haidinger, M.2
Hecking, M.3
Horl, W.H.4
Weichhart, T.5
-
10
-
-
56049092542
-
Dentritic cell derived IL-18 production is inhibited by rapamycin and sanglifehrin A, but not cyclosporine A
-
Ko H, Hambly BD, Eris JM, Levidiotis V, Wyburn K, Wu H, et al. Dentritic cell derived IL-18 production is inhibited by rapamycin and sanglifehrin A, but not cyclosporine A. Transpl Immunol 2008; 20: 99-105.
-
(2008)
Transpl Immunol
, vol.20
, pp. 99-105
-
-
Ko, H.1
Hambly, B.D.2
Eris, J.M.3
Levidiotis, V.4
Wyburn, K.5
Wu, H.6
-
11
-
-
0033983617
-
Differential anti-inflammatory effects of immunosuppressive drugs: Cyclosporin, rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and PGE2 production
-
Attur MG, Patel R, Thakker G, Vyas P, Levartovsky D, Patel P, et al. Differential anti-inflammatory effects of immunosuppressive drugs: cyclosporin, rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and PGE2 production. Inflamm Res 2000; 49: 20-26.
-
(2000)
Inflamm Res
, vol.49
, pp. 20-26
-
-
Attur, M.G.1
Patel, R.2
Thakker, G.3
Vyas, P.4
Levartovsky, D.5
Patel, P.6
-
12
-
-
50949130076
-
Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells
-
Ohtani M, Nagai S, Kondo S, Mizuno S, Nakamura K, Tanabe M, et al. Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells. Blood 2008; 112: 635-643.
-
(2008)
Blood
, vol.112
, pp. 635-643
-
-
Ohtani, M.1
Nagai, S.2
Kondo, S.3
Mizuno, S.4
Nakamura, K.5
Tanabe, M.6
-
13
-
-
17844385843
-
Inhibition of mammalian target of rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-kappa B activation in endothelial cells
-
Minhajuddin M, Fazal F, Bijli KM, Amin MR, Rahman A. Inhibition of mammalian target of rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-kappa B activation in endothelial cells. J Immunol 2005; 174: 5823-5829.
-
(2005)
J Immunol
, vol.174
, pp. 5823-5829
-
-
Minhajuddin, M.1
Fazal, F.2
Bijli, K.M.3
Amin, M.R.4
Rahman, A.5
-
14
-
-
0035744033
-
Mechanisms of resistance to rapamycins
-
Huang S, Houghton PJ. Mechanisms of resistance to rapamycins. Drug Resist Updat 2001; 4: 378-391.
-
(2001)
Drug Resist Updat
, vol.4
, pp. 378-391
-
-
Huang, S.1
Houghton, P.J.2
-
15
-
-
0346362997
-
Rapamycins: Mechanism of action and cellular resistance
-
Huang S, Bjornsti MA, Houghton PJ. Rapamycins: mechanism of action and cellular resistance. Cancer Biol Ther 2003; 2: 222-232.
-
(2003)
Cancer Biol Ther
, vol.2
, pp. 222-232
-
-
Huang, S.1
Bjornsti, M.A.2
Houghton, P.J.3
-
16
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004; 18: 1926-1945.
-
(2004)
Genes Dev
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
17
-
-
14544289097
-
Attenuation of acute lung injury with propofol in endotoxemia
-
Takao Y, Mikawa K, Nishina K, Obara H. Attenuation of acute lung injury with propofol in endotoxemia. Anesth Analg 2005; 100: 810-816.
-
(2005)
Anesth Analg
, vol.100
, pp. 810-816
-
-
Takao, Y.1
Mikawa, K.2
Nishina, K.3
Obara, H.4
-
18
-
-
0033968237
-
Role of interferon-gamma and nitric oxide in pulmonary edema and death induced by lipopolysaccharide
-
Heremans H, Dillen C, Groenen M, Matthys P, Billiau A. Role of interferon-gamma and nitric oxide in pulmonary edema and death induced by lipopolysaccharide. Am J Respir Crit Care Med 2000; 161: 110-117.
-
(2000)
Am J Respir Crit Care Med
, vol.161
, pp. 110-117
-
-
Heremans, H.1
Dillen, C.2
Groenen, M.3
Matthys, P.4
Billiau, A.5
-
19
-
-
9244230604
-
Transcriptional profiling of lipopolysaccharide-induced acute lung injury
-
Jeyaseelan S, Chu HW, Young SK, Worthen GS. Transcriptional profiling of lipopolysaccharide-induced acute lung injury. Infect Immun 2004; 72: 7247-7256.
-
(2004)
Infect Immun
, vol.72
, pp. 7247-7256
-
-
Jeyaseelan, S.1
Chu, H.W.2
Young, S.K.3
Worthen, G.S.4
-
20
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124: 471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
21
-
-
56749156696
-
The PI3K/Akt/mTOR pathway in innate immune cells: Emerging therapeutic applications
-
Weichhart T, Säemann MD. The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications. Ann Rheum Dis 2008; 67: i70-i74.
-
(2008)
Ann Rheum Dis
, vol.67
-
-
Weichhart, T.1
Säemann, M.D.2
-
23
-
-
0033812537
-
Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta
-
Weinstein SL, Finn AJ, Dave SH, Meng F, Lowell CA, Sanghera JS, et al. Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta. J Leukocyte Biol 2000; 67: 405-414.
-
(2000)
J Leukocyte Biol
, vol.67
, pp. 405-414
-
-
Weinstein, S.L.1
Finn, A.J.2
Dave, S.H.3
Meng, F.4
Lowell, C.A.5
Sanghera, J.S.6
-
24
-
-
67651155938
-
Participation of mammalian target of rapamycin complex 1 in Toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury
-
Lorne E, Zhao X, Zmijewski JW, Liu G, Park YJ, Tsuruta Y, et al. Participation of mammalian target of rapamycin complex 1 in Toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury. Am J Respir Cell Mol Biol 2009; 41: 237-245.
-
(2009)
Am J Respir Cell Mol Biol
, vol.41
, pp. 237-245
-
-
Lorne, E.1
Zhao, X.2
Zmijewski, J.W.3
Liu, G.4
Park, Y.J.5
Tsuruta, Y.6
-
25
-
-
26044448040
-
Involvement of c-Jun NH2 terminal kinase and p38MAPK in rapamycin-mediated inhibition of neointimal formation in rat carotid arteries
-
Omura T, Yoshiyama M, Izumi Y, Kim S, Matsumoto R, Enomoto S, et al. Involvement of c-Jun NH2 terminal kinase and p38MAPK in rapamycin-mediated inhibition of neointimal formation in rat carotid arteries. J Cardiovasc Pharmacol 2005; 46: 519-525.
-
(2005)
J Cardiovasc Pharmacol
, vol.46
, pp. 519-525
-
-
Omura, T.1
Yoshiyama, M.2
Izumi, Y.3
Kim, S.4
Matsumoto, R.5
Enomoto, S.6
-
26
-
-
41849129179
-
Rapamycin suppresses TLR4-triggered IL-6 and PGE(2) production of colon cancer cells by inhibiting TLR4 expression and NF-kappaB activation
-
Sun Q, Liu Q, Zheng Y, Cao X. Rapamycin suppresses TLR4-triggered IL-6 and PGE(2) production of colon cancer cells by inhibiting TLR4 expression and NF-kappaB activation. Mol Immunol 2008; 45: 2929-2936.
-
(2008)
Mol Immunol
, vol.45
, pp. 2929-2936
-
-
Sun, Q.1
Liu, Q.2
Zheng, Y.3
Cao, X.4
-
27
-
-
37349083834
-
PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism
-
Vinciguerra M, Veyrat-Durebex C, Moukil MA, Rubbia-Brandt L, Rohner-Jeanrenaud F, Foti M. PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism. Gastroenterology 2008; 134: 268-280.
-
(2008)
Gastroenterology
, vol.134
, pp. 268-280
-
-
Vinciguerra, M.1
Veyrat-Durebex, C.2
Moukil, M.A.3
Rubbia-Brandt, L.4
Rohner-Jeanrenaud, F.5
Foti, M.6
-
28
-
-
54949109311
-
The TSC-mTOR signaling pathway regulates the innate inflammatory response
-
Weichhart T, Costantino G, Poglitsch M, Rosner M, Zeyda M, Stuhlmeier KM, et al. The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 2008; 29: 565-577.
-
(2008)
Immunity
, vol.29
, pp. 565-577
-
-
Weichhart, T.1
Costantino, G.2
Poglitsch, M.3
Rosner, M.4
Zeyda, M.5
Stuhlmeier, K.M.6
-
29
-
-
58149352480
-
Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells
-
Schmitz F, Heit A, Dreher S, Eisenacher K, Mages J, Haas T, et al. Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells. Eur J Immunol 2008; 38: 2981-2992.
-
(2008)
Eur J Immunol
, vol.38
, pp. 2981-2992
-
-
Schmitz, F.1
Heit, A.2
Dreher, S.3
Eisenacher, K.4
Mages, J.5
Haas, T.6
-
30
-
-
80053526627
-
Rapamycin enhances lipopolysaccharide-induced apoptosis and lung injury
-
Fielhaber JA, Carroll SF, Dydensborg AB, Triantafillopolous A, Bouchard M, Qureshi ST, et al. Rapamycin enhances lipopolysaccharide-induced apoptosis and lung injury. Am J Respir Crit Care Med 2010, 181: A3542.
-
(2010)
Am J Respir Crit Care Med
, vol.181
-
-
Fielhaber, J.A.1
Carroll, S.F.2
Dydensborg, A.B.3
Triantafillopolous, A.4
Bouchard, M.5
Qureshi, S.T.6
-
31
-
-
0033968237
-
Role of interferon-gamma and nitric oxide in pulmonary edema and death induced by lipopolysaccharide
-
Heremans H, Dillen C, Groenen M, Matthys P, Billiau A. Role of interferon-gamma and nitric oxide in pulmonary edema and death induced by lipopolysaccharide. Am J Respir Crit Care Med 2000; 161: 110-117.
-
(2000)
Am J Respir Crit Care Med
, vol.161
, pp. 110-117
-
-
Heremans, H.1
Dillen, C.2
Groenen, M.3
Matthys, P.4
Billiau, A.5
-
32
-
-
67650280748
-
Development of animal models for the acute respiratory distress syndrome
-
Bastarache JA, Blackwell TS. Development of animal models for the acute respiratory distress syndrome. Dis Model Mech 2009; 2: 218-223.
-
(2009)
Dis Model Mech
, vol.2
, pp. 218-223
-
-
Bastarache, J.A.1
Blackwell, T.S.2
-
33
-
-
51349164790
-
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
-
Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest 2008; 118: 3065-3074.
-
(2008)
J Clin Invest
, vol.118
, pp. 3065-3074
-
-
Carracedo, A.1
Ma, L.2
Teruya-Feldstein, J.3
Rojo, F.4
Salmena, L.5
Alimonti, A.6
-
34
-
-
51349108718
-
Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells
-
Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, et al. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J Clin Invest 2008; 118: 3038-3050.
-
(2008)
J Clin Invest
, vol.118
, pp. 3038-3050
-
-
Kharas, M.G.1
Janes, M.R.2
Scarfone, V.M.3
Lilly, M.B.4
Knight, Z.A.5
Shokat, K.M.6
|