Novel alkylphospholipid-DTC hybrids as promising agents against endocrine related cancers acting via modulation of Akt-pathway

European Journal of Medicinal Chemistry

Volumn 85, Issue , 2014, Pages 638-647

  Jangir, Santosh ^a   Bala, Veenu ^a,b   Lal, Nand ^a   Kumar, Lalit ^a   Sarswat, Amit ^a   Kumar, Amit ^a   Hamidullah, ^a   Saini, Karan S ^a   Sharma, Vikas ^a   Verma, Vikas ^a   Maikhuri, Jagdamba P ^a   Konwar, Rituraj ^a   Gupta, Gopal ^a   Sharma, Vishnu L ^a,b  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

Author keywords

Akt pathway; Alkylphospholipid; Anti proliferative agent; Dithiocarbamate; Endocrine cancer; Miltefosine

Indexed keywords

2 [DECYLOXY(HYDROXY)PHOSPHORYLOXY]ETHYL 4 METHYLPIPERAZINE 1 CARBODITHIOATE; 2 [DECYLOXY(HYDROXY)PHOSPHORYLOXY]ETHYL AZEPANE 1 CARBODITHIOATE; 2 [DECYLOXY(HYDROXY)PHOSPHORYLOXY]ETHYL PIPERIDINE 1 CARBODITHIOATE; 2 [DECYLOXY(HYDROXY)PHOSPHORYLOXY]ETHYL PYRROLIDINE 1 CARBODITHIOATE; 2 [HEXADECYLOXY(HYDROXY)PHOSPHORYLOXY]ETHYL 4 METHYLPIPERAZINE 1 CARBODITHIOATE; 2 [HEXADECYLOXY(HYDROXY)PHOSPHORYLOXY]ETHYL AZEPANE 1 CARBODITHIOATE; 2 [HEXADECYLOXY(HYDROXY)PHOSPHORYLOXY]ETHYL PIPERIDINE 1 CARBODITHIOATE; 2 [HEXYLOXY(HYDROXY)PHOSPHORYLOXY]ETHYL 4 METHYLPIPERAZINE 1 CARBODITHIOATE; 2 [HEXYLOXY(HYDROXY)PHOSPHORYLOXY]ETHYL AZEPANE 1 CARBODITHIOATE; 2 [HEXYLOXY(HYDROXY)PHOSPHORYLOXY]ETHYL PIPERIDINE 1 CARBODITHIOATE; 2 [HEXYLOXY(HYDROXY)PHOSPHORYLOXY]ETHYL PYRROLIDINE 1 CARBODITHIOATE; 2 [HYDROXY(OCTYLOXY)PHOSPHORYLOXY]ETHYL 4 METHYLPIPERAZINE 1 CARBODITHIOATE; 2 [HYDROXY(OCTYLOXY)PHOSPHORYLOXY]ETHYL AZEPANE 1 CARBODITHIOATE; 2 [HYDROXY(OCTYLOXY)PHOSPHORYLOXY]ETHYL PIPERIDINE 1 CARBODITHIOATE; 2 [HYDROXY(OCTYLOXY)PHOSPHORYLOXY]ETHYL PYRROLIDINE 1 CARBODITHIOATE; 2 [HYDROXY(PROPOXY)PHOSPHORYLOXY]ETHYL 4 METHYLPIPERAZINE 1 CARBODITHIOATE; 2 [HYDROXY(PROPOXY)PHOSPHORYLOXY]ETHYL AZEPANE 1 CARBODITHIOATE; 2 [HYDROXY(PROPOXY)PHOSPHORYLOXY]ETHYL PIPERIDINE 1 CARBODITHIOATE; 2 [HYDROXY(PROPOXY)PHOSPHORYLOXY]ETHYL PYRROLIDINE 1 CARBODITHIOATE; ALKYLPHOSPHOLIPID; ANTINEOPLASTIC AGENT; DITHIOCARBAMIC ACID; MILTEFOSINE; PHOSPHOLIPID DERIVATIVE; PROTEIN KINASE B; UNCLASSIFIED DRUG; DIETHYLDITHIOCARBAMIC ACID; PHOSPHOLIPID; 2 [HEXADECYLOXY(HYDROXY)PHOSPHORYLOXY]ETHYL METHYLPIPERAZINE 1 CARBODITHIOATE; 2 [HEXADECYLOXY(HYDROXY)PHOSPHORYLOXY]ETHYL PYRROLIDINE 1 CARBODITHIOATE; CYCLIN A1; CYCLIN A2; DITHIOCARBAMIC ACID DERIVATIVE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; DOWN REGULATION; ENDOCRINE TUMOR; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; PROSTATE CANCER CELL LINE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; BREAST TUMOR; CELL CYCLE; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; MALE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROSTATE TUMOR; TUMOR CELL LINE; CANCER INHIBITION; CELL GROWTH; CELL PROLIFERATION; CYTOTOXICITY; DRUG SYNTHESIS; EMBRYO; G1 PHASE CELL CYCLE CHECKPOINT; HEK293 CELL LINE; HUMAN TISSUE; IC50; MCF 7 CELL LINE; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; DITIOCARB; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; PHOSPHOLIPIDS; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84906099891     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.08.028     Document Type: Article

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