In vitro and in vivo anticancer activity of 2-deacetoxytaxinine J and synthesis of novel taxoids and their in vitro anticancer activity

European Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2009, Pages 3947-3953

  Reddy, K Papi ^a   Bid, Hemant K ^a   Nayak, V Lakshma ^a   Chaudhary, Preeti ^a   Chaturvedi, J P ^a   Arya, K R ^a   Konwar, Rituraj ^a   Narender, T ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

2 Deacetoxytaxinine J (2 DAT J); Anticancer activity; Taxol; Taxus wallichiana

Indexed keywords

2 DEACETOXYTAXININE J; 2,3 DIHYDROXY 3 PHENYLPROPIONIC ACID 7,9,10,13 TETRAACETOXY 8,12,15,15 TETRAMETHYL 4 METHYLENETRICYCLO[9.3.1.03,8]PENTADEC 11 EN 5 YL ESTER; 3 PHENYLPROPIONIC ACID 7,9,10,13 TETRAACETOXY 8,12,15,15 TETRAMETHYL 4 METHYLENETRICYCLO[9.3.1.03,8]PENTADEC 11 EN 5 YL ESTER; ANTINEOPLASTIC AGENT; BACCATIN III; DIMETHYLBENZ[A]ANTHRACENE; PACLITAXEL; TAMOXIFEN; TAXANE DERIVATIVE; TAXOID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST TUMOR; CELL STRAIN HEK293; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; NONHUMAN; RAT; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; TAXUS BACCATA; TUMOR CELL LINE; TUMOR REGRESSION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BREAST NEOPLASMS; CELL LINE; CELL LINE, TUMOR; EPITHELIAL CELLS; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; KIDNEY; PLANT BARK; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; TAXOIDS; TAXUS;

EID: 67651175869     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.04.022     Document Type: Article

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