Genipin attenuates lipopolysaccharide-induced persistent changes of emotional behaviors and neural activation in the hypothalamic paraventricular nucleus and the central amygdala nucleus

European Journal of Pharmacology

Volumn 741, Issue , 2014, Pages 1-7

  Araki, Ryota ^a   Hiraki, Yosuke ^a   Yabe, Takeshi ^a  

^a SETSUNAN UNIVERSITY   (Japan)

Author keywords

Genipin; Inflammation; Lipopolysaccharide; Sickness behavior

Indexed keywords

GENIPIN; IRIDOID; LIPOPOLYSACCHARIDE;

ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL SURVIVAL; CENTRAL NUCLEUS (AMYGDALA); DRUG EFFECTS; EMOTION; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; ILLNESS BEHAVIOR; IMMUNOLOGY; MALE; METABOLISM; MOUSE; PHYSIOLOGY; RUBIACEAE;

ANIMALS; CELL LINE; CELL SURVIVAL; CENTRAL AMYGDALOID NUCLEUS; EMOTIONS; ILLNESS BEHAVIOR; IRIDOIDS; LIPOPOLYSACCHARIDES; MALE; MICE; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RUBIACEAE;

EID: 84906098593     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.07.038     Document Type: Article

References (27)

1. R.M. Bluthé, R. Dantzer, and K.W. Kelley Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat Brain Res. 573 1992 318 320
2. R.M Bluthé, N. Castanon, F. Pousset, A. Bristow, C. Ball, J. Lestage, B. Michaud, K.W. Kelley, and R. Dantzer Central injection of IL-10 antagonizes the behavioural effects of lipopolysaccharide in rats Psychoneuroendocrinology 24 1999 301 311
3. R.M. Bluthé, S. Layé, B. Michaud, C. Combe, R. Dantzer, and P. Parnet Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour: a study with interleukin-1 type I receptor-deficient mice Eur. J. Neurosci. 12 2000 4447 4456
4. R.M. Bluthé, B. Michaud, V. Poli, and R. Dantzer Role of IL-6 in cytokine-induced sickness behavior: a study with IL-6 deficient mice Physiol. Behav. 70 2000 367 373
5. R. Dantzer, J.C. O'Connor, G.G. Freund, R.W. Johnson, and K.W. Kelley From inflammation to sickness and depression: when the immune system subjugates the brain Nat. Rev. Neurosci. 9 2008 46 56
6. V.N. de Paiva, S.N. Lima, M.M. Fernandes, R. Soncini, C.A. Andrade, and A. Giusti-Paiva Prostaglandins mediate depressive-like behaviour induced by endotoxin in mice Behav. Brain Res. 215 2010 146 151
7. N. DellaGioia, and J. Hannestad A critical review of human endotoxin administration as an experimental paradigm of depression Neurosci. Biobehav. Rev. 34 2010 130 143
8. C. Djerassi, J.D. Gray, and F.A. Kincl Naturally occurring oxygen heterocyclics. IX. Isolation and characterization of genipin J. Org. Chem. 25 1960 2174 2177
9. C. Djerassi, T. Nakano, A.N. James, L.H. Zalkow, E.J. Eisenbraun, and J.N. Shoolery Terpenoids. XLVII. The structure of genipin J. Org. Chem. 26 1961 1192 1206
10. M. Dragunow, and R. Faull The use of c-fos as a metabolic marker in neuronal pathway tracing J. Neurosci. Methods 29 1989 261 265
11. A.J. Dunn, and A.H. Swiergiel Effects of interleukin-1 and endotoxin in the forced swim and tail suspension tests in mice Pharmacol. Biochem. Behav. 81 2005 688 693
12. F. Frenois, M. Moreau, J. O'Connor, M. Lawson, C. Micon, J. Lestage, K.W. Kelley, R. Dantzer, and N. Castanon Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior Psychoneuroendocrinology 32 2007 516 531
13. J. Gibb, S. Hayley, M.O. Poulter, and H. Anisman Effects of stressors and immune activating agents on peripheral and central cytokines in mouse strains that differ in stressor responsivity Brain Behav. Immun. 25 2011 468 482
14. L.E. Goehler, J.K. Relton, D. Dripps, R. Kiechle, N. Tartaglia, S.F. Maier, and L.R. Watkins Vagal paraganglia bind biotinylated interleukin-1 receptor antagonist: a possible mechanism for immune-to-brain communication Brain Res. Bull. 43 1997 357 364
15. L.E. Goehler, R.P. Gaykema, K.T. Nguyen, J.E. Lee, F.J. Tilders, S.F. Maier, and L.R. Watkins Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems? J. Neurosci. 19 1999 2799 2806
16. R. Haba, N. Shintani, Y. Onaka, H. Wang, R. Takenaga, A. Hayata, A. Baba, and H. Hashimoto Lipopolysaccharide affects exploratory behaviors toward novel objects by impairing cognition and/or motivation in mice: possible role of activation of the central amygdala Behav. Brain Res. 228 2012 423 431
17. C.J. Henry, Y. Huang, A. Wynne, M. Hanke, J. Himler, M.T. Bailey, J.F. Sheridan, and J.P. Godbout Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia J. Neuroinflamm. 5 2008 15
18. S. Kent, R.M. Bluthe, R. Dantzer, A.J. Hardwick, K.W. Kelley, N.J. Rothwell, and J.L. Vannice Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1 Proc. Natl. Acad. Sci. USA 89 1992 9117 9120
19. J.P. Konsman, G.N. Luheshi, R.M. Bluthé, and R. Dantzer The vagus nerve mediates behavioural depression, but not fever, in response to peripheral immune signals; a functional anatomical analysis Eur. J. Neurosci. 12 2000 4434 4446
20. H.J. Koo, Y.S. Song, H.J. Kim, Y.H. Lee, S.M. Hong, S.J. Kim, B.C. Kim, C. Jin, C.J. Lim, and E.H. Park Antiinflammatory effects of genipin, an active principle of gardenia Eur. J. Pharmacol. 495 2004 201 208
21. Z. Kronfol, and D.G. Remick Cytokines and the brain: implications for clinical psychiatry Am. J. Psychiatry 157 2000 683 694
22. F.A. Marvel, C.C. Chen, N. Badr, R.P. Gaykema, and L.E. Goehler Reversible inactivation of the dorsal vagal complex blocks lipopolysaccharide-induced social withdrawal and c-Fos expression in central autonomic nuclei Brain Behav. Immun. 18 2004 123 134
23. K.N. Nam, Y.S. Choi, H.J. Jung, G.H. Park, J.M. Park, S.K. Moon, K.H. Cho, C. Kang, I. Kang, M.S. Oh, and E.H. Lee Genipin inhibits the inflammatory response of rat brain microglial cells Int. Immunopharmacol. 10 2010 493 499
24. M.D. Nguyen, J.P. Julien, and S. Rivest Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat. Rev. Neurosci. 3 2002 216 227
25. A.H. Swiergiel, G.N. Smagin, L.J. Johnson, and A.J. Dunn The role of cytokines in the behavioral responses to endotoxin and influenza virus infection in mice: effects of acute and chronic administration of the interleukin-1-receptor antagonist (IL-1ra) Brain Res. 776 1997 96 104
26. J.S. Tian, Y.L. Cui, L.M. Hu, S. Gao, W. Chi, T.J. Dong, and L.P. Liu Antidepressant-like effect of genipin in mice Neurosci. Lett. 479 2010 236 239
27. R. Yirmiya, D.L. Tio, and A.N. Tylor Effects of fetal alcohol exposure on fever, sickness behavior, and pituitary-adrenal activation induced by interleukin-1 beta in young adult rats Brain Behav. Immun. 10 1996 205 220