-
1
-
-
77957664665
-
Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
-
Hallek M, Fischer K, Fingerle-Rowson G, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial. Lancet 2010; 376: 1164-1174
-
(2010)
Lancet
, vol.376
, pp. 1164-1174
-
-
Hallek, M.1
Fischer, K.2
Fingerle-Rowson, G.3
-
2
-
-
76649091945
-
A systematic review and meta-Analysis of immunochemotherapy with rituximab for B-cell non-Hodgkin's lymphoma
-
Gao G, Liang X, Jiang J, et al. A systematic review and meta-Analysis of immunochemotherapy with rituximab for B-cell non-Hodgkin's lymphoma. Acta Oncol 2010; 49: 3-12
-
(2010)
Acta Oncol
, vol.49
, pp. 3-12
-
-
Gao, G.1
Liang, X.2
Jiang, J.3
-
3
-
-
44949127176
-
Chemotherapy plus rituximab versus chemotherapy alone for B-cell non-Hodgkin's lymphoma
-
Schulz H, Bohlius J, Skoetz N, et al. Chemotherapy plus rituximab versus chemotherapy alone for B-cell non-Hodgkin's lymphoma. Cochrane Database Syst Rev 2007; 4: CD003805
-
(2007)
Cochrane Database Syst Rev
, vol.4
-
-
Schulz, H.1
Bohlius, J.2
Skoetz, N.3
-
4
-
-
0036464719
-
Therapeutic activity of humanized anti-cd20 monoclonal antibody and polymorphism in igg fc receptor fcgammariiia gene
-
Cartron G, Dacheux L, Salles G, et al. Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene. Blood 2002; 99: 754-758
-
(2002)
Blood
, vol.99
, pp. 754-758
-
-
Cartron, G.1
Dacheux, L.2
Salles, G.3
-
5
-
-
7244248664
-
From the bench to the bedside: Ways to improve rituximab efficacy
-
Cartron G, Watier H, Golay J, Solal-Celigny P. From the bench to the bedside: Ways to improve rituximab efficacy. Blood 2004; 104: 2635-2642
-
(2004)
Blood
, vol.104
, pp. 2635-2642
-
-
Cartron, G.1
Watier, H.2
Golay, J.3
Solal-Celigny, P.4
-
6
-
-
84863259157
-
Results of phase i study of AME-133 v (LY2469298) an FC-engineering humanized monoclonal anti-CD20 antibody, in FcgRIIIa-genotyped patients with previously treated follicular lymphoma
-
Forero-Terres A, de Vos S, Pohlman BL, et al. Results of phase I study of AME-133 v (LY2469298) an FC-engineering humanized monoclonal anti-CD20 antibody, in FcgRIIIa-genotyped patients with previously treated follicular lymphoma. Clin Cancer Res 2012; 18: 1395-1403
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1395-1403
-
-
Forero-Terres, A.1
De Vos, S.2
Pohlman, B.L.3
-
7
-
-
84891863268
-
Multicentre phase i study with an 8-dose regimen of single agent anti-CD20 monoclonal antibody LFB-R603 in patients with relapsed chronic lymphocytic leukemia (CLL
-
Cazin B, Lepretre S, Coiffier B, et al. Multicentre phase I study with an 8-dose regimen of single agent anti-CD20 monoclonal antibody LFB-R603 in patients with relapsed chronic lymphocytic leukemia (CLL). Blood 2011; 118: 1234-1235
-
(2011)
Blood
, vol.118
, pp. 1234-1235
-
-
Cazin, B.1
Lepretre, S.2
Coiffier, B.3
-
8
-
-
77951561987
-
Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity
-
Mössner E, Brünker P, Moser S, et al. Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity. Blood 2010; 115: 4393-4402
-
(2010)
Blood
, vol.115
, pp. 4393-4402
-
-
Mössner, E.1
Brünker, P.2
Moser, S.3
-
9
-
-
84894552888
-
Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions
-
Goede V, Kirsten F, Bushe R, et al. Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N Engl J Med 2014; 370: 1101-1110
-
(2014)
N Engl J Med
, vol.370
, pp. 1101-1110
-
-
Goede, V.1
Kirsten, F.2
Bushe, R.3
-
10
-
-
0027168420
-
Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes
-
Bubien JK, Zhou LJ, Bell PD, et al. Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. J Cell Biol 1993; 121: 1121-1132
-
(1993)
J Cell Biol
, vol.121
, pp. 1121-1132
-
-
Bubien, J.K.1
Zhou, L.J.2
Bell, P.D.3
-
11
-
-
0037306946
-
Complement-mediated lysis by anti-CD20 mAb correlates with segregation into lipid rafts
-
Cragg MS, Morgan SM, Chan HT, et al. Complement-mediated lysis by anti-CD20 mAb correlates with segregation into lipid rafts. Blood 2003; 101: 1045-1052
-
(2003)
Blood
, vol.101
, pp. 1045-1052
-
-
Cragg, M.S.1
Morgan, S.M.2
Chan, H.T.3
-
12
-
-
1642306050
-
Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents
-
Cragg MS, Glennie MJ. Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents. Blood 2004; 103: 2738-2743
-
(2004)
Blood
, vol.103
, pp. 2738-2743
-
-
Cragg, M.S.1
Glennie, M.J.2
-
13
-
-
68849108368
-
Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosomemediated cell death in human lymphoma and leukemia cells
-
Ivanov A, Beers SA, Walshe CA, et al. Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosomemediated cell death in human lymphoma and leukemia cells. J Clin Invest 2009; 119: 2143-2159
-
(2009)
J Clin Invest
, vol.119
, pp. 2143-2159
-
-
Ivanov, A.1
Beers, S.A.2
Walshe, C.A.3
-
14
-
-
79955979273
-
Novel type ii anti-cd20 monoclonal antibody (ga101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in b-cell malignancies
-
Alduaij W, Ivanov A, Honeychurch J, et al. Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies. Blood 2011; 117: 4519-4529
-
(2011)
Blood
, vol.117
, pp. 4519-4529
-
-
Alduaij, W.1
Ivanov, A.2
Honeychurch, J.3
-
15
-
-
79960497321
-
Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies
-
Niederfellner G, Lammens A, Mundigl O, et al. Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies. Blood 2011; 118: 358-367
-
(2011)
Blood
, vol.118
, pp. 358-367
-
-
Niederfellner, G.1
Lammens, A.2
Mundigl, O.3
-
16
-
-
77954679392
-
Antigenic modulation limits the efficacy of anti-CD20 antibodies: Implications for antibody selection
-
Beers SA, French RR, Chan HT, et al. Antigenic modulation limits the efficacy of anti-CD20 antibodies: Implications for antibody selection. Blood 2010; 115: 5191-5201
-
(2010)
Blood
, vol.115
, pp. 5191-5201
-
-
Beers, S.A.1
French, R.R.2
Chan, H.T.3
-
17
-
-
0030611643
-
Fc gammaRIIIa-158 V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype
-
Koene HR, Kleijer M, Algra J, et al. Fc gammaRIIIa-158 V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype. Blood 1997; 90: 1109-1114
-
(1997)
Blood
, vol.90
, pp. 1109-1114
-
-
Koene, H.R.1
Kleijer, M.2
Algra, J.3
-
18
-
-
0642373290
-
Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma
-
Weng WK, Levy R. Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma. J Clin Oncol 2003; 21: 3940-3947
-
(2003)
J Clin Oncol
, vol.21
, pp. 3940-3947
-
-
Weng, W.K.1
Levy, R.2
-
19
-
-
20044363597
-
Polymorphisms in FcgIIA (CD16) receptor expression are associated with clinical response to rituximab in Waldenström's macroglobulinemia
-
Treon SP, Hansen M, Branagan AR, et al. Polymorphisms in FcgIIA (CD16) receptor expression are associated with clinical response to rituximab in Waldenström's macroglobulinemia. J Clin Oncol 2005; 23: 474-481
-
(2005)
J Clin Oncol
, vol.23
, pp. 474-481
-
-
Treon, S.P.1
Hansen, M.2
Branagan, A.R.3
-
20
-
-
42949157368
-
Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer
-
Musolino A, Naldi N, Bortesi B, et al. Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer. J Clin Oncol 2008; 26: 1789-1796
-
(2008)
J Clin Oncol
, vol.26
, pp. 1789-1796
-
-
Musolino, A.1
Naldi, N.2
Bortesi, B.3
-
21
-
-
61449239114
-
Association of FcgRIIa and FcgRIIIa polymorphisms with clinical outcome in metastatic colorectal cancer patients (mCRC) treated with cetuximab and irinotecan
-
Bibeau F, Crapez E, Di Fiore F, et al. Association of FcgRIIa and FcgRIIIa polymorphisms with clinical outcome in metastatic colorectal cancer patients (mCRC) treated with cetuximab and irinotecan. J Clin Oncol 2009; 27: 1122-1129
-
(2009)
J Clin Oncol
, vol.27
, pp. 1122-1129
-
-
Bibeau, F.1
Crapez, E.2
Di Fiore, F.3
-
22
-
-
0035794194
-
High resolution mapping of the binding site on human IgG1 for FcgRI, Fc gRII, Fc gRIII, and FcRn and design of IgG1 variants with improved binding to the FcgR
-
Shields RL, Namenuk AK, Hong K, et al. High resolution mapping of the binding site on human IgG1 for FcgRI, Fc gRII, Fc gRIII, and FcRn and design of IgG1 variants with improved binding to the FcgR. J Biol Chem 2001; 276: 6591-6604
-
(2001)
J Biol Chem
, vol.276
, pp. 6591-6604
-
-
Shields, R.L.1
Namenuk, A.K.2
Hong, K.3
-
23
-
-
0037178791
-
Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human FcgRIII and antibody-dependent cellular toxicity
-
Shields RL, Lai J, Keck R, et al. Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human FcgRIII and antibody-dependent cellular toxicity. J Biol Chem 2002; 277: 26733-26740
-
(2002)
J Biol Chem
, vol.277
, pp. 26733-26740
-
-
Shields, R.L.1
Lai, J.2
Keck, R.3
-
24
-
-
39749086517
-
Chronic lymphocytic leukaemia cells are efficiently killed by an anti-CD20 monoclonal antibody selected for improved engagement of FcgammaRIIIA/CD16
-
De Romeuf C, Dutertre CA, Le Garff-Tavernier M, et al. Chronic lymphocytic leukaemia cells are efficiently killed by an anti-CD20 monoclonal antibody selected for improved engagement of FcgammaRIIIA/CD16. Br J Haematol 2008; 140: 635-643
-
(2008)
Br J Haematol
, vol.140
, pp. 635-643
-
-
De Romeuf, C.1
Dutertre, C.A.2
Le Garff-Tavernier, M.3
-
25
-
-
1242317024
-
Fucose depletion from human IgG1 oligosaccharide enhances binding enthalpy and association rate between IgG1 and Fc gRIIIa
-
Okazaki A, Shoji-Hosaka E, Nakamura K, et al. Fucose depletion from human IgG1 oligosaccharide enhances binding enthalpy and association rate between IgG1 and Fc gRIIIa. J Mol Biol 2004; 336: 1239-1249
-
(2004)
J Mol Biol
, vol.336
, pp. 1239-1249
-
-
Okazaki, A.1
Shoji-Hosaka, E.2
Nakamura, K.3
-
26
-
-
84896499999
-
Glycoengineering of therapeutic antibodies enhances monocyte/macrophage- mediated phagocytosis and cytotoxicity
-
Herter S, Birk MC, Klein C, et al. Glycoengineering of therapeutic antibodies enhances monocyte/macrophage-mediated phagocytosis and cytotoxicity. J Immunol 2014; 192: 2252-2260
-
(2014)
J Immunol
, vol.192
, pp. 2252-2260
-
-
Herter, S.1
Birk, M.C.2
Klein, C.3
-
27
-
-
84892422452
-
Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab
-
Golay J, Da Roit F, Bologna L, et al. Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab. Blood 2013; 122: 3482-3491
-
(2013)
Blood
, vol.122
, pp. 3482-3491
-
-
Golay, J.1
Da Roit, F.2
Bologna, L.3
-
28
-
-
84885671483
-
Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and of atumumab in vitro and in xenograft models
-
Herter S, Herting F, Mundigl O, et al. Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and of atumumab in vitro and in xenograft models. Mol Cancer Ther 2013; 12: 2031-2042
-
(2013)
Mol Cancer Ther
, vol.12
, pp. 2031-2042
-
-
Herter, S.1
Herting, F.2
Mundigl, O.3
-
29
-
-
84861835530
-
Phase 1 study results of the type II glycoengineered humanized anti-CD20 monoclonal antibody obinutuzumab (GA101) in B-cell lymphoma patients
-
Salles G, Morschhauser F, Lamy T, et al. Phase 1 study results of the type II glycoengineered humanized anti-CD20 monoclonal antibody obinutuzumab (GA101) in B-cell lymphoma patients. Blood 2012; 119: 5126-5132
-
(2012)
Blood
, vol.119
, pp. 5126-5132
-
-
Salles, G.1
Morschhauser, F.2
Lamy, T.3
-
30
-
-
76949086417
-
Phase i study of R05072759 (GA101) in relapsed/refractory chronic lymphocytic leukemia
-
Cartron G, Lamy T, Morschhauser F, et al. Phase I study of R05072759 (GA101) in relapsed/refractory chronic lymphocytic leukemia. Haematologica 2009; 94: 201-1201
-
(2009)
Haematologica
, vol.94
, pp. 201-1201
-
-
Cartron, G.1
Lamy, T.2
Morschhauser, F.3
-
31
-
-
84891398531
-
Obinutuzumab (ga101) in patients with relapsed/refractory indolent non-hodgkin lymphoma: Results from the phase ii gauguin study
-
Salles GA, Morschhauser F, Solal-Cé ligny P, et al. Obinutuzumab (GA101) in patients with relapsed/refractory indolent non-Hodgkin lymphoma: Results from the phase II GAUGUIN study. J Clin Oncol 2013; 31: 2920-2926
-
(2013)
J Clin Oncol
, vol.31
, pp. 2920-2926
-
-
Salles, G.A.1
Morschhauser, F.2
Solal-Céligny, P.3
-
32
-
-
84891442057
-
Obinutuzumab (ga101) monotherapy in relapsed/refractory diffuse large b-cell lymphoma or mantlecell lymphoma: Results from the phase ii gauguin study
-
Morschhauser FA, Cartron G, Thieblemont C, et al. Obinutuzumab (GA101) monotherapy in relapsed/refractory diffuse large b-cell lymphoma or mantlecell lymphoma: Results from the phase II GAUGUIN study. J Clin Oncol 2013; 31: 2912-2919
-
(2013)
J Clin Oncol
, vol.31
, pp. 2912-2919
-
-
Morschhauser, F.A.1
Cartron, G.2
Thieblemont, C.3
-
33
-
-
84875784514
-
Results from a phase ii study of obinutuzumab (ga101 monotherapy in relapsed/refractory chronic lymphocuyic leukemia (cll)
-
Cartron C, Morschhauser F, Thieblemont C, et al. Results from a phase II study of obinutuzumab (GA101) monotherapy in relapsed/refractory chronic lymphocuyic leukemia (CLL). Haematologica 2011; 96: 39-139
-
(2011)
Haematologica
, vol.96
, pp. 39-139
-
-
Cartron, C.1
Morschhauser, F.2
Thieblemont, C.3
-
34
-
-
84887146061
-
Obinutuzumab (ga101 plus chop or fc in relapsed/refractory follicular lymphoma: Results of the gaudi study (bo21000)
-
Radford J, Davies A, Cartron G, et al. Obinutuzumab (GA101) plus CHOP or FC in relapsed/refractory follicular lymphoma: Results of the GAUDI study (BO21000). Blood 2013; 122: 1137-1143
-
(2013)
Blood
, vol.122
, pp. 1137-1143
-
-
Radford, J.1
Davies, A.2
Cartron, G.3
-
35
-
-
84857327275
-
Randomized phase ii trial comparing ga101 (obinutuzumab) with rituximab in patients with relapsed cd20+indoindolent b-cell non-hodgkin lymphoma: Preliminary analysis of the gauss study
-
Sehn LH, Goy A, Offner FC, et al. Randomized phase II trial comparing GA101 (obinutuzumab) with rituximab in patients with relapsed CD20+indoindolent B-cell non-Hodgkin lymphoma: Preliminary analysis of the GAUSS study. Blood 2011; 118: 124-1124
-
(2011)
Blood
, vol.118
, pp. 124-1124
-
-
Sehn, L.H.1
Goy, A.2
Offner, F.C.3
|