Chronic lymphocytic leukaemia cells are efficiently killed by an anti-CD20 monoclonal antibody selected for improved engagement of FcγRIIIA/CD16

British Journal of Haematology

Volumn 140, Issue 6, 2008, Pages 635-643

  De Romeuf, Christophe ^a,b   Dutertre, Charles Antoine ^b,c,d   Le Garff Tavernier, Magali ^e,f   Fournier, Nathalie ^b   Gaucher, Christine ^b   Glacet, Arnaud ^b   Jorieux, Sylvie ^b   Bihoreau, Nicolas ^b   Behrens, Christian K ^b   Béliard, Roland ^b   Vieillard, Vincent ^e,f   Cazin, Bruno ^g   Bourel, Dominique ^b   Prost, Jean François ^b   Teillaud, Jean Luc ^c,d   Merle Béral, Hélène ^e,f,h  

^a LFB Research Department   (France)

^b Clinical Development   (France)

^c CENTRE DE RECHERCHE DES CORDELIERS   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e INSERM   (France)

^f SORBONNE UNIVERSITÉ   (France)

^g LILLE UNIVERSITY HOSPITAL   (France)

^h PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Antibody dependent cellular cytotoxicity; CD20; Chronic lymphocytic leukaemia; Fc receptor; Monoclonal antibody

Indexed keywords

CD16 ANTIGEN; CD20 ANTIBODY; CD20 ANTIGEN; CHIMERIC ANTIBODY; COMPLEMENT; CYCLOPHOSPHAMIDE; FC RECEPTOR IIIA; FLUDARABINE; FUCOSE; INTERLEUKIN 2; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY EMAB 6; RITUXIMAB; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CANCER IMMUNOTHERAPY; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MALE; PRIORITY JOURNAL; TREATMENT RESPONSE;

AGED; AGED, 80 AND OVER; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ANTIGENS, CD20; APOPTOSIS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FEMALE; HUMANS; INTERLEUKIN-2; KILLER CELLS, NATURAL; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; RECEPTORS, IGG; TUMOR CELLS, CULTURED;

EID: 39749086517     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2007.06974.x     Document Type: Article

References (46)