The conspiracy of autophagy, stress and inflammation in acute pancreatitis

Current Opinion in Gastroenterology

Volumn 30, Issue 5, 2014, Pages 495-499

  Hall, Jason C ^a   Crawford, Howard C ^a  

^a MAYO CLINIC   (United States)

Author keywords

autophagic flux; endoplasmic reticulum stress; gallstones; Salmonella

Indexed keywords

ALCOHOL; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 4;

ACINAR CELL; ACUTE PANCREATITIS; AUTOPHAGY; BACTERIAL CELL WALL; BACTERIAL INFECTION; DISEASE SEVERITY; ENDOPLASMIC RETICULUM STRESS; EXPERIMENTAL PANCREATITIS; FEEDING; GRAM NEGATIVE BACTERIUM; HUMAN; NONHUMAN; OXIDATIVE STRESS; PROTEIN FUNCTION; REVIEW; ACUTE HEMORRHAGIC PANCREATITIS; ANIMAL; CELLULAR IMMUNITY; IMMUNOLOGY; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; AUTOPHAGY; HUMANS; IMMUNITY, CELLULAR; OXIDATIVE STRESS; PANCREATITIS, ACUTE NECROTIZING; SIGNAL TRANSDUCTION;

EID: 84906058402     PISSN: 02671379     EISSN: 15317056     Source Type: Journal    
DOI: 10.1097/MOG.0000000000000097     Document Type: Review

References (40)

1. Peery AF, Dellon ES, Lund J, et al. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology 2012; 143:1179-1187.
2. Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology 2013; 144:1252-1261.
3. Testoni PA, Caporuscio S, Bagnolo F, Lella F. Idiopathic recurrent pancreatitis: Long-term results after ERCP, endoscopic sphincterotomy, or ursodeoxycholic acid treatment. Am J Gastroenterol 2000; 95:1702-1707. (Pubitemid 30485005)
4. Li J, Guo M, Hu B, et al. Does chronic ethanol intake cause chronic pancreatitis?: Evidence and mechanism. Pancreas 2008; 37:189-195.
5. Dufour MC, Adamson MD. The epidemiology of alcohol-induced pancreatitis. Pancreas 2003; 27:286-290. (Pubitemid 37337891)
6. Fortunato F, Gates LK Jr. Alcohol feeding and lipopolysaccharide injection modulate apoptotic effectors in the rat pancreas in vivo. Pancreas 2000; 21:174-180. (Pubitemid 30612858)
7. Tsukamoto H, Towner SJ, Yu GS, French SW. Potentiation of ethanolinduced pancreatic injury by dietary fat. Induction of chronic pancreatitis by alcohol in rats. Am J Pathol 1988; 131:246-257.
8. Ponnappa BC, Marciniak R, Schneider T, et al. Ethanol consumption and susceptibility of the pancreas to cerulein-induced pancreatitis. Pancreas 1997; 14:150-157. (Pubitemid 27106102)
9. Deegan S, Saveljeva S, Gorman AM, Samali A. Stress-induced self-cannibalism: On the regulation of autophagy by endoplasmic reticulum stress. Cell Mol Life Sci 2013; 70:2425-2441.
10. He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009; 43:67-93.
11. Mareninova OA, Hermann K, French SW, et al. Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis. J Clin Invest 2009; 119:3340-3355.
12. Sah RP, Dudeja V, Dawra RK, Saluja AK. Cerulein-induced chronic pancreatitis does not require intra-acinar activation of trypsinogen in mice. Gastroenterology 2013; 144:1076-1085.
13. Gukovsky I, Pandol SJ, Mareninova OA, et al. Impaired autophagy and organellar dysfunction in pancreatitis. J Gastroenterol Hepatol 2012; 27 (Suppl 2):27-32.
14. Gukovsky I, Li N, Todoric J, et al. Inflammation, autophagy, and obesity: Common features in the pathogenesis of pancreatitis and pancreatic cancer. Gastroenterology 2013; 144:1199-1209.
15. Huang H, Liu Y, Daniluk J, et al. Activation of nuclear factor-kB in acinar cells increases the severity of pancreatitis in mice. Gastroenterology 2013; 144:202-210.
16. Ardito CM, Gruner BM, Takeuchi KK, et al. EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer cell 2012; 22:304-317.
17. Li N, Wu X, Holzer RG, et al. Loss of acinar cell IKKa triggers spontaneous pancreatitis in mice. J Clin Invest 2013; 123:2231-2243.
18. Chen X, Ji B, Han B, et al. Nf-kappaB activation in pancreas induces pancreatic and systemic inflammatory response. Gastroenterology 2002; 122:448-457. (Pubitemid 34116996)
19. Vaquero E, Gukovsky I, Zaninovic V, et al. Localized pancreatic NF-kappaB activation and inflammatory response in taurocholate-induced pancreatitis. Am J Physiol Gastrointest Liver Physiol 2001; 280:G1197-G1208.
20. Lawrence T. The nuclear factor NF-kB pathway in inflammation. Cold Spring Harb Perspect Biol 2009; 1:a001651.
21. Sah RP, Dawra RK, Saluja AK. New insights into the pathogenesis of pancreatitis. Curr Opin Gastroenterol 2013; 29:523-530.
22. Zhang L, Zhang J, Shea K, et al. Autophagy in pancreatic acinar cells in caerulein-treated mice: Immunolocalization of related proteins and their potential as markers of pancreatitis. Toxicol Pathol 2014; 42:435-457.
23. Bettaieb A, Xi Y, Hosein E, et al. Pancreatic t cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis. Cell Commun Signal 2014; 12:13.
24. Reed AM, Kolodecik TR, Husain SZ, Gorelick FS. Low pH enhances connexin32 degradation in the pancreatic acinar cell. Am J Physiol Gastrointest Liver Physiol 2014. [Epub ahead of print]
25. Schmid SW, Uhl W, Friess H, et al. The role of infection in acute pancreatitis. Gut 1999; 45:311-316. (Pubitemid 29333786)
26. Vonlaufen A, Xu ZH, Daniel B, et al. Bacterial endotoxin: A trigger factor for alcoholic pancreatitis? Evidence from a novel, physiologically relevant animal model. Gastroenterology 2007; 133:1293-1303. (Pubitemid 47494445)
27. Rock KL, Latz E, Ontiveros F, Kono H. The sterile inflammatory response. Annu Rev Immunol 2010; 28:321-342.
28. Hoque R, Farooq A, Ghani A, et al. Lactate reduces liver and pancreatic injury in toll-like receptor-and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity. Gastroenterology 2014; 146: 1763-1774.
29. Sharif R, Dawra R, Wasiluk K, et al. Impact of toll-like receptor 4 on the severity of acute pancreatitis and pancreatitis-associated lung injury in mice. Gut 2009; 58:813-819.
30. Li Y, Zhou ZG, Xia QJ, et al. Toll-like receptor 4 detected in exocrine pancreas and the change of expression in cerulein-induced pancreatitis. Pancreas 2005; 30:375-381. (Pubitemid 40586819)
31. Buxbaum J, Yan A, Yeh K, et al. Aggressive hydration with lactated ringer's solution reduces pancreatitis after endoscopic retrograde cholangiopancreatography. Clin Gastroenterol Hepatol 2014; 12:303-307.
32. Wu BU, Hwang JQ, Gardner TH, et al. Lactated ringer's solution reduces systemic inflammation compared with saline in patients with acute pancreatitis. Clin Gastroenterol Hepatol 2011; 9:710-717.
33. Xue J, Habtezion A. Carbon monoxide-based therapy ameliorates acute pancreatitis via TLR4 inhibition. J Clin Invest 2014; 124:437-447.
34. Delgiorno KE, Tam JW, Hall JC, et al. Persistent salmonellosis causes pancreatitis in a murine model of infection. PLoS One 2014; 9:e92807.
35. Gonzalez-Escobedo G, La Perle KM, Gunn JS. Histopathological analysis of salmonella chronic carriage in the mouse hepatopancreatobiliary system. PLoS One 2013; 8:e84058.
36. Hampton MB, Kettle AJ, Winterbourn CC. Inside the neutrophil phagosome: Oxidants, myeloperoxidase, and bacterial killing. Blood 1998; 92:3007-3017. (Pubitemid 28492304)
37. Liou GY, Doppler H, Necela B, et al. Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-kB and MMPs. J Cell Biol 2013; 202:563-577.
38. Ishimura R, Tanaka K, Komatsu M. Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy. FEBS Lett 2014; 588:822-828.
39. Huber S, Ramsingh AI. Coxsackievirus-induced pancreatitis. Viral Immunol 2004; 17:358-369. (Pubitemid 39244758)
40. Sesti-Costa R, Silva GK, Proenca-Modena JL, et al. The IL-33/ST2 pathway controls coxsackievirus B5-induced experimental pancreatitis. J Immunol 2013; 191:283-292.